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Berberine HCL 500mg | Blood Sugar & Metabolic Support | 60 Vcaps
Berberine HCl 500 mg supplement 97 percent purity plant based formula
Berberine HCl 500 mg bottle 60 vegetable capsules
Berberine HCl 500 mg vegan capsules metabolic support formula
Berberine HCl supplement facts label 500 mg 97 percent pure
Berberine HCL 500mg | Blood Sugar & Metabolic Support | 60 Vcaps

Each vegan capsule delivers 500 mg of 97% pure berberine hydrochloride (berberine HCl), extracted from Berberis aristata root. At the recommended dose of 1 capsule twice daily with meals, each daily serving provides 1,000 mg of berberine HCl the dose used in the majority of clinical berberine research. Activates AMPK through five complementary mechanisms to support healthy blood glucose metabolism. 

What Is Berberine HCl?

Berberine (berberina) is a quaternary ammonium alkaloid found in the root of Berberis aristata (barberry) and several other plants. It is one of the most extensively studied botanical compounds in metabolic health research. This pure berberine HCl supplement delivers 97% pure berberine hydrochloride the most bioavailable and research supported berberine salt form in a clean vegan capsule with only three non medicinal ingredients.

AMPK Activation Five Complementary Mechanisms

This berberine AMPK activator supports healthy glucose metabolism through five distinct and complementary pathways:

1. AMPK activation: Berberine inhibits mitochondrial complex I, raising the AMP to ATP ratio and triggering the AMPK signalling cascade governing glucose uptake, fatty acid oxidation, and suppression of gluconeogenesis. This berberine AMPK mechanism is analogous to that of metformin, though berberine operates through partially distinct downstream pathways.

2. GLUT4 translocation: AMPK activation promotes insulin-independent GLUT4 transporter translocation to skeletal muscle cell membranes, increasing cellular glucose uptake even in conditions of reduced insulin sensitivity.

3. Reduced hepatic glucose output: Berberine-mediated AMPK activation in hepatocytes downregulates PEPCK and G6Pase, suppressing gluconeogenesis and glycogenolysis and reducing fasting glucose output from the liver.

4. Alpha glucosidase inhibition: Berberine inhibits intestinal alpha glucosidase enzymes, slowing carbohydrate digestion and blunting the postprandial blood glucose rise making it important to take berberine HCl 500mg capsules with meals.

5. Gut microbiome modulation: Despite oral bioavailability estimated below 5%, berberine produces significant metabolic effects in the GI tract by selectively modulating gut microbiota, increasing short-chain fatty acid producing bacteria, and improving gut barrier integrity and insulin receptor expression.

Berberine HCL 500mg | Blood Sugar & Metabolic Support | 60 Vcaps

$28.99
5.0 (6)

Health Canada Licensed Natural Health Product (NPN 80129371)

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Each vegan capsule delivers 500 mg of 97% pure berberine hydrochloride (berberine HCl), extracted from Berberis aristata root. At the recommended dose of 1 capsule twice daily with meals, each daily serving provides 1,000 mg of berberine HCl the dose used in the majority of clinical berberine research. Activates AMPK through five complementary mechanisms to support healthy blood glucose metabolism. 

What Is Berberine HCl?

Berberine (berberina) is a quaternary ammonium alkaloid found in the root of Berberis aristata (barberry) and several other plants. It is one of the most extensively studied botanical compounds in metabolic health research. This pure berberine HCl supplement delivers 97% pure berberine hydrochloride the most bioavailable and research supported berberine salt form in a clean vegan capsule with only three non medicinal ingredients.

AMPK Activation Five Complementary Mechanisms

This berberine AMPK activator supports healthy glucose metabolism through five distinct and complementary pathways:

1. AMPK activation: Berberine inhibits mitochondrial complex I, raising the AMP to ATP ratio and triggering the AMPK signalling cascade governing glucose uptake, fatty acid oxidation, and suppression of gluconeogenesis. This berberine AMPK mechanism is analogous to that of metformin, though berberine operates through partially distinct downstream pathways.

2. GLUT4 translocation: AMPK activation promotes insulin-independent GLUT4 transporter translocation to skeletal muscle cell membranes, increasing cellular glucose uptake even in conditions of reduced insulin sensitivity.

3. Reduced hepatic glucose output: Berberine-mediated AMPK activation in hepatocytes downregulates PEPCK and G6Pase, suppressing gluconeogenesis and glycogenolysis and reducing fasting glucose output from the liver.

4. Alpha glucosidase inhibition: Berberine inhibits intestinal alpha glucosidase enzymes, slowing carbohydrate digestion and blunting the postprandial blood glucose rise making it important to take berberine HCl 500mg capsules with meals.

5. Gut microbiome modulation: Despite oral bioavailability estimated below 5%, berberine produces significant metabolic effects in the GI tract by selectively modulating gut microbiota, increasing short-chain fatty acid producing bacteria, and improving gut barrier integrity and insulin receptor expression.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Ingredient
Amount Per
Serving
% Daily
Value
Berberine HCl (Berberis aristata, Root)
500 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source).

Clinical Research

Berberine and its more bioavailable derivative dihydroberberine inhibit mitochondrial complex I: a mechanism for the action of berberine to activate AMP activated protein kinase and improve insulin action

Diabetes, 2010

Demonstrates that berberine inhibits mitochondrial complex I, raising the cellular AMP to ATP ratio and activating AMPK the master metabolic regulator governing glucose uptake, fatty acid oxidation, and suppression of hepatic gluconeogenesis. Establishes the primary mechanism by which berberine HCl supports healthy blood glucose metabolism and insulin sensitivity.

Efficacy of berberine in patients with type 2 diabetes mellitus

Metabolism, 2008

A randomized controlled trial showing that berberine 500mg twice daily significantly reduced fasting blood glucose, postprandial blood glucose, and HbA1c compared to placebo over 3 months. Provides clinical evidence for berberine HCl 500mg capsules taken with meals as a metabolic and blood sugar support supplement.

Modulation of gut microbiota by berberine and metformin in the treatment of type 2 diabetes: a combined analysis

Frontiers in Microbiology, 2020

Demonstrates that berberine modulates gut microbiota composition by increasing short-chain fatty acid producing bacteria and reducing pathogenic strains, improving gut barrier integrity and insulin receptor expression providing mechanistic insight into berberine's metabolic effects despite its low oral bioavailability.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is Berberine HCL 500mg?

Berberine HCL is a concentrated form of berberine, a naturally occurring plant compound found in botanicals such as barberry and goldenseal. Each specified serving provides 500 mg of Berberine HCL.

What is Berberine used for?

Berberine is commonly used in supplements designed to support healthy glucose metabolism, metabolic health, and overall cardiovascular wellness.

How does Berberine support blood sugar metabolism?

Berberine has been studied for its effects on several metabolic pathways involved in glucose utilization and insulin signaling. It should complement, not replace, a balanced diet, exercise, or prescribed treatment.

What does HCL mean in Berberine HCL?

HCL stands for hydrochloride. Berberine hydrochloride is a commonly used supplemental form of berberine because it provides a standardized and stable form of the compound.

Can Berberine support metabolic health?

Yes. Berberine is widely studied for its potential role in supporting glucose metabolism, lipid metabolism, and overall metabolic function.

Does Berberine support healthy cholesterol levels?

Berberine has been researched for its potential effects on lipid and cholesterol metabolism. Individual responses can vary, and it should be used alongside healthy dietary and lifestyle habits.

Can Berberine be taken with diabetes medication?

People taking insulin, metformin, or other blood glucose lowering medications should consult a healthcare professional before taking berberine, as the combination may lower blood sugar too much.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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