Iron Bisglycinate 27mg | Chelated Ferrous Iron | Red Blood Cell Formation | 60 Vegan Capsules

Each capsule delivers 27mg of elemental iron as Iron (II) Bisglycinate, a chelated ferrous iron in which the iron ion is bound to two glycine molecules, protecting it from forming insoluble complexes in the GI tract and supporting absorption via amino acid transport pathways in addition to the standard iron transport channel. Helps to form red blood cells and helps in their proper function. Health Canada approved (NPN 80076149). 100% vegan, non GMO, gluten free, soy free, dairy free. Made in Canada in a quality controlled facility. 60 vegan capsules (60 day supply at 1 capsule per day).

Warning: Keep out of reach of children. There is enough iron in this package to seriously harm a child.

Key Features

• Helps to form red blood cells and helps in their proper function
• 27mg elemental iron per capsule as Iron (II) Bisglycinate
• Chelated ferrous iron: iron ion bound to two glycine molecules
• Absorbed via amino acid transport pathways in addition to DMT1
• Protected from insoluble complex formation with phytates, oxalates, and tannins
• Gentler on the digestive system than non-chelated iron salts
• Take with food; take a few hours before or after other medications
• 1 capsule per day: simple daily routine
• 60 vegan capsules (60 day supply)
• Health Canada approved (NPN 80076149)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free, dairy free

Iron (II) Bisglycinate: Chelated Ferrous Iron

Iron supplements are available in multiple forms that differ significantly in their bioavailability and GI tolerability. Understanding the chemistry of iron bisglycinate explains why it is considered one of the most bioavailable and gentle forms of supplemental iron.

Ferrous vs. Ferric Iron: Iron exists in two oxidation states relevant to supplementation: ferrous iron (Fe2+, Iron II) and ferric iron (Fe3+, Iron III). The primary intestinal iron transporter, DMT1 (divalent metal transporter 1), located on the apical surface of duodenal enterocytes, transports ferrous iron (Fe2+) specifically. Ferric iron (Fe3+) must first be reduced to ferrous iron by the enzyme duodenal cytochrome b (Dcytb) on the enterocyte surface before it can be transported by DMT1. Iron bisglycinate provides iron in the ferrous (Fe2+) form, which is directly compatible with DMT1 without requiring prior reduction.

The Bisglycinate Chelate: In Iron (II) Bisglycinate, one ferrous iron ion (Fe2+) is bound to two glycine molecules (hence bisglycinate: bis = two, glycinate = glycine ligand) through coordinate bonds involving the amino and carboxyl groups of each glycine. This chelated structure encases the iron ion, protecting it from two key problems that limit the absorption of non-chelated iron salts.

Protection from Inhibitory Complexes: Non-chelated iron salts (such as ferrous sulfate and ferrous fumarate) dissociate in the GI tract, releasing free iron ions. Free iron ions readily form insoluble complexes with phytates (found in grains and legumes), oxalates (found in many vegetables), tannins (found in tea and coffee), and phosphates in the intestinal environment. These insoluble complexes cannot be absorbed and are excreted, reducing the amount of iron available for absorption. The bisglycinate chelate protects the iron from these interactions, keeping it in a soluble, absorbable form throughout the GI tract.

Dual Absorption Pathway: The bisglycinate chelate is absorbed not only via DMT1 (the standard iron transport channel) but also via amino acid and peptide transport pathways in the intestinal wall, the same pathways used to absorb dietary amino acids and small peptides. This dual absorption pathway contributes to the superior bioavailability of chelated iron bisglycinate compared to non-chelated iron salts.

Why Bisglycinate Is Gentler on the Digestive System: Non-chelated iron salts release free iron ions in the GI tract. Free ferrous iron (Fe2+) is a pro-oxidant that can generate reactive oxygen species through the Fenton reaction (Fe2+ + H2O2 → Fe3+ + OH• + OH-), causing oxidative damage to the intestinal mucosa. This mucosal irritation is the primary cause of the nausea, constipation, abdominal cramping, and dark stools commonly associated with non-chelated iron supplements such as ferrous sulfate. Iron bisglycinate, by remaining chelated longer in the GI tract, reduces the exposure of the intestinal mucosa to free iron ions, making it significantly gentler on the digestive system.

Iron and Red Blood Cell Formation

Iron is an essential mineral and the central atom of heme, the iron-containing prosthetic group that gives hemoglobin its oxygen-carrying capacity. Hemoglobin is the protein in red blood cells (erythrocytes) responsible for transporting oxygen from the lungs to tissues throughout the body and returning carbon dioxide from tissues to the lungs for exhalation.

Heme Synthesis: The synthesis of heme requires iron at its final step: ferrochelatase inserts a ferrous iron ion (Fe2+) into protoporphyrin IX to form heme. Four heme groups are incorporated into each hemoglobin molecule (two alpha and two beta globin chains, each carrying one heme). Each heme group can reversibly bind one oxygen molecule, giving each hemoglobin molecule the capacity to carry four oxygen molecules. Adequate iron availability is essential for maintaining this heme synthesis pathway and therefore for the production of functional hemoglobin and red blood cells.

Iron Beyond Hemoglobin: Iron is also the central atom of myoglobin, the oxygen-storing protein in muscle tissue, and of the cytochromes, the iron-containing proteins of the mitochondrial electron transport chain that are essential for cellular energy production (oxidative phosphorylation). Iron is therefore required not only for red blood cell function but for oxygen utilization and energy metabolism in all cells.

Understanding the 27mg Dose

The 27mg elemental iron dose in this formula is a commonly used therapeutic supplementation dose. For context, the Canadian recommended dietary allowance (RDA) for iron is 8mg per day for adult men and postmenopausal women, 18mg per day for premenopausal women, and 27mg per day for pregnant women. The 27mg dose in this formula is specifically aligned with the pregnancy RDA and is a standard dose used in iron supplementation. Consult your healthcare provider to determine whether this dose is appropriate for your individual needs and iron status.

Understanding the Dosage

Iron (II) Bisglycinate (elemental iron): 27mg per capsule
Suggested Use: Adults: 1 capsule per day. Take with food. Take a few hours before or after taking other medications
Total Capsules: 60 (60 day supply)
Non Medicinal Ingredients: Hypromellose (capsule shell), Magnesium stearate

Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs and iron status.

Why Take Iron with Food and Separate from Medications

Take with food: Taking iron with food reduces the likelihood of gastrointestinal discomfort. Note that certain foods (particularly those high in phytates, oxalates, or tannins such as tea and coffee) can reduce iron absorption. Taking iron with a small meal or snack that does not contain these inhibitors, or with a source of vitamin C (which enhances iron absorption by reducing Fe3+ to Fe2+), is optimal.

Take a few hours before or after other medications: Iron can chelate with and reduce the absorption of several medications, including tetracycline and fluoroquinolone antibiotics, levothyroxine (thyroid medication), levodopa (Parkinson's medication), and bisphosphonates (bone density medications). Separating iron supplementation from these medications by at least 2 hours before or 4 hours after helps prevent this interaction.

Who May Consider This Product

• Adults seeking to support red blood cell formation and function
• Those wanting a chelated iron form with dual absorption pathway and gentle GI profile
• Individuals who have experienced digestive discomfort with non-chelated iron supplements such as ferrous sulfate
• Those wanting a clean formula: vegan, non GMO, gluten free, soy free, dairy free
• Those seeking a Health Canada approved, Canadian made iron supplement

Quality and Purity

• Health Canada approved (NPN 80076149)
• 27mg elemental iron per capsule as Iron (II) Bisglycinate
• Vegan hypromellose capsule
• 60 capsules (60 day supply)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free, dairy free

Storage

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed after each use.

Safety Information

Warning: Keep out of reach of children. There is enough iron in this package to seriously harm a child. Iron overdose is a leading cause of fatal poisoning in young children. Store this product in a location that is completely inaccessible to children.

Take with food. Take a few hours before or after taking other medications, as iron can reduce the absorption of certain medications including antibiotics (tetracyclines and fluoroquinolones), thyroid medications (levothyroxine), and bisphosphonates. Consult a healthcare professional before use if you are pregnant or breastfeeding. Consult a healthcare professional before use if you have a medical condition affecting iron metabolism, including hemochromatosis or other iron overload conditions. Do not exceed the recommended dose. This product is not intended to diagnose, treat, cure, or prevent any disease.

This product is approved by Health Canada (NPN 80076149).

About Iron Bisglycinate 27mg | Chelated Ferrous Iron | Red Blood Cell Formation

Iron (II) Bisglycinate delivers 27mg of elemental iron per capsule as a chelated ferrous iron in which the Fe2+ ion is bound to two glycine molecules, protecting it from forming insoluble complexes with phytates, oxalates, and tannins in the GI tract and enabling absorption via amino acid transport pathways in addition to the standard DMT1 iron transporter. By remaining chelated longer in the GI tract, iron bisglycinate reduces free iron exposure to the intestinal mucosa, avoiding the pro-oxidant Fenton reaction that causes the nausea, constipation, and abdominal discomfort commonly associated with non-chelated iron salts such as ferrous sulfate. Iron is the central atom of heme in hemoglobin, essential for red blood cell formation and oxygen transport. Health Canada approved (NPN 80076149) for helping to form red blood cells and helping in their proper function. Warning: keep out of reach of children; there is enough iron in this package to seriously harm a child. 100% vegan and made in Canada in a quality controlled facility. 60 capsules.