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Vitamin B12 5000 mcg methylcobalamin supplement 60 capsules
Methylcobalamin vitamin B12 5000 mcg high potency supplement
Vitamin B12 5000 mcg supplement bottle 60 capsules
Methylcobalamin vitamin B12 active form supplement 60 capsules
Vitamin B12 methylcobalamin supplement facts label 5000 mcg
Vitamin B12 5000 mcg methylcobalamin supplement 60 capsules

Vitamin B12 5000mcg | Methylcobalamin | Active Coenzyme Form | High Potency | 60 Vegan Capsules

Each vegan capsule delivers 5000mcg of Vitamin B12 as methylcobalamin, the active coenzyme form found in human blood and tissues, directly usable without conversion. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, effective even for those with reduced intrinsic factor function.

Helps to form red blood cells. Helps in energy metabolism in the body. Helps in the normal function of the immune system. Helps to maintain the body's ability to metabolize nutrients. Health Canada licensed NPN 80070568. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.

Source

Methylcobalamin is produced synthetically via microbial fermentation and chemical synthesis, yielding pharmaceutical-grade vitamin B12 in the active coenzyme form. It is not derived from animal sources and is suitable for vegans and vegetarians. Methylcobalamin is the form of B12 found naturally in human blood and tissues, identical in structure to the endogenous active form.

What Is Vitamin B12?

Vitamin B12 (cobalamin) is an essential water-soluble vitamin and the largest and most structurally complex of all vitamins. It is unique in containing a metal ion (cobalt) at its centre, which is why it is called cobalamin. B12 is found almost exclusively in animal-derived foods including meat, fish, shellfish, dairy, and eggs. Plant foods do not contain meaningful amounts of bioavailable B12, making supplementation particularly important for vegans and vegetarians. B12 is required for DNA synthesis, red blood cell formation, and normal nervous system function, and works closely with folate (vitamin B9) in one-carbon metabolism.

What Is the Difference Between Methylcobalamin and Cyanocobalamin?

Cyanocobalamin is the synthetic form used in most B12 supplements and fortified foods. It must be converted to methylcobalamin or adenosylcobalamin in the body before it can be used, releasing a small amount of cyanide in the process (at non-toxic levels). Methylcobalamin is the active coenzyme form found in human blood and tissues and is directly usable without conversion. This formula provides methylcobalamin exclusively, the form the body uses without any intermediate metabolic step.

Key Benefits

  • Helps to form red blood cells Health Canada licensed claim under NPN 80070568
  • Helps in energy metabolism in the body Health Canada licensed claim under NPN 80070568
  • Helps in the normal function of the immune system Health Canada licensed claim under NPN 80070568
  • Helps to maintain the body's ability to metabolize nutrients Health Canada licensed claim under NPN 80070568
  • 5000mcg methylcobalamin per capsule Active coenzyme form | Directly usable without conversion
  • High potency dose At 5000mcg, passive diffusion absorbs approximately 50mcg independent of intrinsic factor | Effective for those with reduced intrinsic factor function
  • Source: synthetically produced methylcobalamin Vegan, not animal derived | Identical to the endogenous active form in human blood and tissues
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed NPN 80070568 | GMP certified | Made in Canada
  • 60 vegan capsules 60 day supply at 1 capsule per day

How It Works

B12 Absorption: Intrinsic Factor and Passive Diffusion

B12 is absorbed through two distinct mechanisms. The primary mechanism is intrinsic factor (IF) mediated absorption: intrinsic factor is a protein produced by the parietal cells of the stomach lining, and the B12-IF complex is absorbed in the terminal ileum. This mechanism is highly efficient but saturable, absorbing a maximum of approximately 1.5 to 2mcg per meal regardless of dose. The secondary mechanism is passive diffusion: approximately 1% of any oral B12 dose is absorbed by passive diffusion across the intestinal lining, independent of intrinsic factor and without saturation. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, a clinically meaningful amount that does not depend on intrinsic factor function.

Why Intrinsic Factor Function Matters

Intrinsic factor production can be impaired by aging, autoimmune conditions (pernicious anemia), gastric surgery, atrophic gastritis, and long-term use of proton pump inhibitors or H2 blockers. Metformin also reduces B12 absorption in the intestine. When intrinsic factor function is reduced, the high potency 5000mcg dose ensures that passive diffusion alone delivers a meaningful amount of B12, making this formula effective across a wide range of absorption capacities.

Methylcobalamin in One-Carbon Metabolism

Methylcobalamin is the active coenzyme form of B12 required for methionine synthase, the enzyme that converts homocysteine to methionine using a methyl group donated by methyltetrahydrofolate (MTHF). This reaction is central to one-carbon metabolism, which supports DNA synthesis, red blood cell formation, and methylation reactions throughout the body. B12 and folate work together in this pathway, which is why B12 deficiency and folate deficiency produce similar hematological effects (megaloblastic anemia).

Who May Particularly Benefit from High Potency B12

Vegans and vegetarians, as B12 is found almost exclusively in animal-derived foods. Older adults, as intrinsic factor production declines with age. Those taking metformin, proton pump inhibitors, or H2 blockers long-term, as these reduce B12 absorption. Those with confirmed low B12 levels who want a high-potency oral supplement. Those who prefer methylcobalamin (active form) over cyanocobalamin (synthetic form requiring conversion).

Medicinal Ingredient (per capsule)

  • Vitamin B12 (Methylcobalamin) 5000mcg Source: synthetically produced methylcobalamin | Active coenzyme form | Directly usable without conversion | Helps to form red blood cells | Helps in energy metabolism | Helps in the normal function of the immune system | Helps to maintain the body's ability to metabolize nutrients | NPN 80070568

Non-medicinal ingredients: Magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO.

Quality and Trust

  • NPN 80070568 Licensed by Health Canada as a Natural Health Product
  • Made in Canada GMP certified facility under Health Canada oversight
  • Methylcobalamin form Active coenzyme B12, directly usable without conversion
  • Source: synthetically produced methylcobalamin Vegan, not animal derived
  • 5000mcg per capsule High potency dose supporting absorption via passive diffusion
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO
  • 60 vegan capsules 60 day supply at 1 capsule per day

Who This Is For

  • Consult a healthcare practitioner for use beyond 4 months Health Canada licensed duration of use restriction
  • Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes
  • Adults seeking high-potency methylcobalamin B12 for red blood cell formation, energy metabolism, immune function, and nutrient metabolism support
  • Vegans and vegetarians with limited dietary B12 intake
  • Older adults, those taking metformin, or those on long-term proton pump inhibitors or H2 blockers with reduced B12 absorption capacity
  • Those who prefer the active methylcobalamin form over cyanocobalamin

How to Use

Adults: Take 1 capsule once daily, with or without food. Consult a healthcare practitioner for use beyond 4 months.

Safety and Cautions

Consult a healthcare practitioner for use beyond 4 months. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Store in a cool, dry place away from direct sunlight and moisture. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80070568. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Vitamin B12 5000mcg | Methylcobalamin | Active Coenzyme Form | High Potency | 60 Vegan Capsules

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Health Canada Licensed Natural Health Product (NPN 80070568)

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Vitamin B12 5000mcg | Methylcobalamin | Active Coenzyme Form | High Potency | 60 Vegan Capsules

Each vegan capsule delivers 5000mcg of Vitamin B12 as methylcobalamin, the active coenzyme form found in human blood and tissues, directly usable without conversion. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, effective even for those with reduced intrinsic factor function.

Helps to form red blood cells. Helps in energy metabolism in the body. Helps in the normal function of the immune system. Helps to maintain the body's ability to metabolize nutrients. Health Canada licensed NPN 80070568. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.

Source

Methylcobalamin is produced synthetically via microbial fermentation and chemical synthesis, yielding pharmaceutical-grade vitamin B12 in the active coenzyme form. It is not derived from animal sources and is suitable for vegans and vegetarians. Methylcobalamin is the form of B12 found naturally in human blood and tissues, identical in structure to the endogenous active form.

What Is Vitamin B12?

Vitamin B12 (cobalamin) is an essential water-soluble vitamin and the largest and most structurally complex of all vitamins. It is unique in containing a metal ion (cobalt) at its centre, which is why it is called cobalamin. B12 is found almost exclusively in animal-derived foods including meat, fish, shellfish, dairy, and eggs. Plant foods do not contain meaningful amounts of bioavailable B12, making supplementation particularly important for vegans and vegetarians. B12 is required for DNA synthesis, red blood cell formation, and normal nervous system function, and works closely with folate (vitamin B9) in one-carbon metabolism.

What Is the Difference Between Methylcobalamin and Cyanocobalamin?

Cyanocobalamin is the synthetic form used in most B12 supplements and fortified foods. It must be converted to methylcobalamin or adenosylcobalamin in the body before it can be used, releasing a small amount of cyanide in the process (at non-toxic levels). Methylcobalamin is the active coenzyme form found in human blood and tissues and is directly usable without conversion. This formula provides methylcobalamin exclusively, the form the body uses without any intermediate metabolic step.

Key Benefits

  • Helps to form red blood cells Health Canada licensed claim under NPN 80070568
  • Helps in energy metabolism in the body Health Canada licensed claim under NPN 80070568
  • Helps in the normal function of the immune system Health Canada licensed claim under NPN 80070568
  • Helps to maintain the body's ability to metabolize nutrients Health Canada licensed claim under NPN 80070568
  • 5000mcg methylcobalamin per capsule Active coenzyme form | Directly usable without conversion
  • High potency dose At 5000mcg, passive diffusion absorbs approximately 50mcg independent of intrinsic factor | Effective for those with reduced intrinsic factor function
  • Source: synthetically produced methylcobalamin Vegan, not animal derived | Identical to the endogenous active form in human blood and tissues
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed NPN 80070568 | GMP certified | Made in Canada
  • 60 vegan capsules 60 day supply at 1 capsule per day

How It Works

B12 Absorption: Intrinsic Factor and Passive Diffusion

B12 is absorbed through two distinct mechanisms. The primary mechanism is intrinsic factor (IF) mediated absorption: intrinsic factor is a protein produced by the parietal cells of the stomach lining, and the B12-IF complex is absorbed in the terminal ileum. This mechanism is highly efficient but saturable, absorbing a maximum of approximately 1.5 to 2mcg per meal regardless of dose. The secondary mechanism is passive diffusion: approximately 1% of any oral B12 dose is absorbed by passive diffusion across the intestinal lining, independent of intrinsic factor and without saturation. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, a clinically meaningful amount that does not depend on intrinsic factor function.

Why Intrinsic Factor Function Matters

Intrinsic factor production can be impaired by aging, autoimmune conditions (pernicious anemia), gastric surgery, atrophic gastritis, and long-term use of proton pump inhibitors or H2 blockers. Metformin also reduces B12 absorption in the intestine. When intrinsic factor function is reduced, the high potency 5000mcg dose ensures that passive diffusion alone delivers a meaningful amount of B12, making this formula effective across a wide range of absorption capacities.

Methylcobalamin in One-Carbon Metabolism

Methylcobalamin is the active coenzyme form of B12 required for methionine synthase, the enzyme that converts homocysteine to methionine using a methyl group donated by methyltetrahydrofolate (MTHF). This reaction is central to one-carbon metabolism, which supports DNA synthesis, red blood cell formation, and methylation reactions throughout the body. B12 and folate work together in this pathway, which is why B12 deficiency and folate deficiency produce similar hematological effects (megaloblastic anemia).

Who May Particularly Benefit from High Potency B12

Vegans and vegetarians, as B12 is found almost exclusively in animal-derived foods. Older adults, as intrinsic factor production declines with age. Those taking metformin, proton pump inhibitors, or H2 blockers long-term, as these reduce B12 absorption. Those with confirmed low B12 levels who want a high-potency oral supplement. Those who prefer methylcobalamin (active form) over cyanocobalamin (synthetic form requiring conversion).

Medicinal Ingredient (per capsule)

  • Vitamin B12 (Methylcobalamin) 5000mcg Source: synthetically produced methylcobalamin | Active coenzyme form | Directly usable without conversion | Helps to form red blood cells | Helps in energy metabolism | Helps in the normal function of the immune system | Helps to maintain the body's ability to metabolize nutrients | NPN 80070568

Non-medicinal ingredients: Magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO.

Quality and Trust

  • NPN 80070568 Licensed by Health Canada as a Natural Health Product
  • Made in Canada GMP certified facility under Health Canada oversight
  • Methylcobalamin form Active coenzyme B12, directly usable without conversion
  • Source: synthetically produced methylcobalamin Vegan, not animal derived
  • 5000mcg per capsule High potency dose supporting absorption via passive diffusion
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO
  • 60 vegan capsules 60 day supply at 1 capsule per day

Who This Is For

  • Consult a healthcare practitioner for use beyond 4 months Health Canada licensed duration of use restriction
  • Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes
  • Adults seeking high-potency methylcobalamin B12 for red blood cell formation, energy metabolism, immune function, and nutrient metabolism support
  • Vegans and vegetarians with limited dietary B12 intake
  • Older adults, those taking metformin, or those on long-term proton pump inhibitors or H2 blockers with reduced B12 absorption capacity
  • Those who prefer the active methylcobalamin form over cyanocobalamin

How to Use

Adults: Take 1 capsule once daily, with or without food. Consult a healthcare practitioner for use beyond 4 months.

Safety and Cautions

Consult a healthcare practitioner for use beyond 4 months. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Store in a cool, dry place away from direct sunlight and moisture. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80070568. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Ingredient
Amount Per
Serving
% Daily
Value
Vitamin B12 (Methylcobalamin)
5,000 mcg
†

† Daily Value not established

Other Ingredients:
Magnesium Stearate, Hypromellose (Vegetable Capsule Shell)

Clinical Research

Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review

Cochrane Database of Systematic Reviews, 2005

This Cochrane systematic review compared the efficacy of high-dose oral vitamin B12 supplementation versus intramuscular B12 injections for correcting B12 deficiency. The review found that high dose oral B12 (1000–2000mcg daily) was as effective as intramuscular injections in normalizing B12 blood levels, with passive diffusion absorbing approximately 1% of the oral dose independent of intrinsic factor. The authors concluded that high dose oral B12 is an effective alternative to injections for most individuals with B12 deficiency.

Methylcobalamin: a potential vitamin of pain killer

Neural Plasticity, 2013

This review examined the biochemical roles of methylcobalamin as the active coenzyme form of vitamin B12 in neurological and metabolic function. The review confirmed that methylcobalamin is the form of B12 found in human blood and cerebrospinal fluid, is directly usable without conversion, and is required for methionine synthase activity in one carbon metabolism supporting DNA synthesis, red blood cell formation, and homocysteine to methionine conversion. The authors documented methylcobalamin's role in supporting normal nervous system function and energy metabolism.

Vitamin B12 deficiency in older adults: a review of current evidence and recommendations

Nutrients, 2019

This comprehensive review examined the prevalence, causes, and management of vitamin B12 deficiency in older adults. The review found that B12 deficiency is common in aging populations due to declining intrinsic factor production and atrophic gastritis, and that high dose oral supplementation (≥1000mcg) effectively corrects deficiency via passive diffusion independent of intrinsic factor. The authors recommended high potency oral methylcobalamin as a practical and effective supplementation strategy for older adults with reduced absorption capacity.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is methylcobalamin and what is it used for?

Methylcobalamin is the active coenzyme form of vitamin B12 found naturally in human blood and tissues. Unlike cyanocobalamin, it is directly usable by the body without conversion. Vitamin B12 as methylcobalamin helps to form red blood cells, supports energy metabolism, supports normal immune function, and helps maintain the body's ability to metabolize nutrients. Consult a healthcare practitioner for use beyond 4 months.

What is the difference between methylcobalamin and cyanocobalamin?

Cyanocobalamin is the synthetic form of B12 used in most supplements and fortified foods. It must be converted to methylcobalamin or adenosylcobalamin in the body before it can be used, releasing a small amount of cyanide in the process (at non-toxic levels). Methylcobalamin is the active coenzyme form found in human blood and tissues directly usable without any intermediate conversion step. Methylcobalamin is the preferred form for those who want active B12 without relying on the body's conversion capacity.

Why take 5000mcg of vitamin B12?

Vitamin B12 is absorbed through two mechanisms: intrinsic factor-mediated absorption (efficient but saturable at ~1.5–2mcg per dose) and passive diffusion (approximately 1% of any oral dose, independent of intrinsic factor). At 5000mcg, passive diffusion alone absorbs approximately 50mcg a clinically meaningful amount that does not depend on intrinsic factor function. This high-potency dose is particularly relevant for older adults, those taking metformin or proton pump inhibitors, and anyone with reduced intrinsic factor production.

Who is most likely to be deficient in vitamin B12?

Vitamin B12 is found almost exclusively in animal derived foods meat, fish, shellfish, dairy, and eggs. Those most at risk of deficiency include vegans and vegetarians with limited dietary B12 intake, older adults (intrinsic factor production declines with age), individuals taking metformin long-term (reduces intestinal B12 absorption), those on long term proton pump inhibitors or H2 blockers, and those with atrophic gastritis, pernicious anemia, or a history of gastric surgery.

Does vitamin B12 help with energy and fatigue?

Vitamin B12 supports energy metabolism at the cellular level it is required for the conversion of homocysteine to methionine and for normal DNA synthesis and red blood cell formation. Fatigue is a recognized symptom of B12 deficiency. Supplementing with methylcobalamin supports the body's energy metabolism pathways. Consult a healthcare practitioner if fatigue persists, as it may have multiple causes.

Who should consult a healthcare practitioner before taking vitamin B12?

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Consult a healthcare practitioner for use beyond 4 months. Those taking metformin, proton pump inhibitors, H2 blockers, or other medications that affect B12 absorption or metabolism should seek professional guidance on dosing and monitoring.

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20 Years of Research

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