Acetyl L-Carnitine 637.5mg | ALCAR | Source of Carnitine | 120 Vcaps x 6 | NPN 80141963

Each capsule delivers 637.5mg of Acetyl L-Carnitine (ALCAR), derived from 750mg of Acetyl L-Carnitine HCl. A source of carnitine. Health Canada approved (NPN 80141963). 100% vegan, non GMO, gluten free, soy free. Made in Canada. This listing is a 6-pack: 6 x 120 capsules = 720 capsules total (40 day supply per bottle at 3 capsules per day; 240 day supply total).

Note: Verify the complete NPN 80141963 approved use language against your Health Canada NPN licence before publishing.

Why Choose This Formula

• 637.5mg Acetyl L-Carnitine (ALCAR) per capsule (from 750mg ALCAR HCl)
• Source of carnitine (Health Canada approved, NPN 80141963)
• ALCAR crosses the blood-brain barrier more readily than plain L-carnitine
• Acetyl group donates to acetyl-CoA, the precursor to acetylcholine synthesis
• 3 capsules per day: 1,912.5mg ALCAR daily (from 2,250mg ALCAR HCl)
• 6-pack best value: 720 capsules total, 40 day supply per bottle, 240 day supply total
• 100% vegan, non GMO, gluten free, soy free, made in Canada

Who Should Use This

• Adults seeking a source of carnitine in the acetylated ALCAR form that crosses the blood-brain barrier more readily than plain L-carnitine
• Those who want a high-dose ALCAR formula: 637.5mg per capsule, 1,912.5mg per day at 3 capsules
• Those committed to long-term consistent daily ALCAR use who want the maximum value: 720 capsules, 240 day supply total
• Those who want a 100% vegan, single-ingredient ALCAR capsule made in Canada

Do not use if: you have a known allergy to carnitine. Consult a healthcare practitioner before use if pregnant or breastfeeding, have kidney disease, or have a seizure disorder. See full safety information below.

What This Product Does

Acetyl L-Carnitine is a source of carnitine. That is the Health Canada approved use (NPN 80141963). Carnitine plays an essential role in energy metabolism: it is required for the transport of long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation, the process by which fatty acids are broken down to generate ATP. Without carnitine, long-chain fatty acids cannot enter the mitochondria for energy production.

The acetylated form (ALCAR) has two additional properties compared to plain L-carnitine: it crosses the blood-brain barrier more readily, and its acetyl group can be donated to coenzyme A (CoA) to form acetyl-CoA, the central metabolite of the citric acid cycle and the substrate for acetylcholine synthesis in the brain.

ALCAR vs. L-Carnitine: The Key Differences

Blood-Brain Barrier Penetration: The blood-brain barrier (BBB) restricts the passage of most molecules from the bloodstream into the brain. L-carnitine crosses the BBB poorly due to its hydrophilic nature. ALCAR crosses the BBB more readily due to its acetyl group, which increases lipophilicity and facilitates transport via the organic cation transporter OCTN2 as well as passive diffusion. This makes ALCAR the preferred carnitine form for applications targeting the central nervous system.

Acetyl-CoA Donation: ALCAR can transfer its acetyl group to coenzyme A (CoA) to form acetyl-CoA, the substrate for choline acetyltransferase (ChAT), the enzyme that synthesizes acetylcholine (ACh) from acetyl-CoA and choline. Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system and is critical for memory formation and cognitive function. This acetyl-CoA donation is unique to ALCAR and does not occur with plain L-carnitine.

Carnitine's Role in Fatty Acid Transport: Carnitine is essential for the carnitine shuttle system. Long-chain fatty acids must be conjugated to carnitine by carnitine palmitoyltransferase I (CPT-I) to form acylcarnitine, transported across the inner mitochondrial membrane by carnitine-acylcarnitine translocase (CACT), and released by CPT-II for beta-oxidation. Both L-carnitine and ALCAR serve as sources of carnitine for this system.

Understanding 637.5mg from 750mg ALCAR HCl

Acetyl L-Carnitine HCl is the hydrochloride salt form used for improved stability and solubility. The HCl salt is approximately 85% active ALCAR free base by weight: 750mg of ALCAR HCl yields 637.5mg of active Acetyl L-Carnitine. This is standard pharmaceutical salt conversion and is how the medicinal ingredient is expressed on the Health Canada NPN label.

The 6-Pack: Maximum Value for Long-Term Daily Use

This listing contains 6 bottles of 120 capsules each, for a total of 720 capsules. At the suggested dose of 3 capsules per day, each 120-capsule bottle provides a 40 day supply. The 6-pack provides 240 days of total supply, making it the maximum value option in the Nutridom ALCAR range for those who use ALCAR as a consistent long-term daily supplement and want to minimize reorder frequency and cost per capsule.

ALCAR range comparison:
• Single bottle: 120 capsules, 40 day supply
• 2-pack: 240 capsules, 80 day supply
• 3-pack: 360 capsules, 120 day supply
• 6-pack (this listing): 720 capsules, 240 day supply

Dosage and Supply

Acetyl L-Carnitine: 637.5mg per capsule (from 750mg Acetyl L-Carnitine HCl)
Suggested Use: Adults: 1 capsule, 3 times per day
Daily intake: 1,912.5mg ALCAR (from 2,250mg ALCAR HCl)
Capsules per bottle: 120
Bottles in this listing: 6 (720 capsules total)
Supply per bottle: 40 days at 3 capsules per day
Total supply (6-pack): 240 days at 3 capsules per day
Non Medicinal Ingredients: Hypromellose, Magnesium Stearate, Microcrystalline Cellulose

Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs.

Quality and Purity

• Health Canada approved (NPN 80141963)
• 637.5mg Acetyl L-Carnitine per capsule (from 750mg ALCAR HCl)
• Vegan hypromellose capsule
• 100% vegan, non GMO, gluten free, soy free
• 6 x 120 capsules (720 total, 240 day supply)
• Made in Canada

Storage

Store in a cool, dry place away from direct sunlight. Keep bottles tightly sealed after each use.

Safety Information and Cautions

Contraindication: Do not use if you have a known allergy to carnitine.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, have kidney disease, or have a seizure disorder.

May cause gastrointestinal discomfort or disturbances; taking with food may help minimize this.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Keep out of reach of children.

This product is approved by Health Canada (NPN 80141963).

Frequently Asked Questions

What is the difference between Acetyl L-Carnitine and L-Carnitine?
ALCAR has an acetyl group attached to the nitrogen of L-carnitine. This increases lipophilicity, allowing ALCAR to cross the blood-brain barrier more readily than plain L-carnitine via OCTN2 transporter and passive diffusion. ALCAR can also donate its acetyl group to coenzyme A to form acetyl-CoA, the substrate for acetylcholine synthesis via choline acetyltransferase (ChAT). Plain L-carnitine does not have these properties.

Why does the label say 637.5mg from 750mg ALCAR HCl?
Acetyl L-Carnitine HCl is the hydrochloride salt form used for stability and solubility. The HCl salt is approximately 85% active ALCAR free base by weight: 750mg HCl salt yields 637.5mg of active Acetyl L-Carnitine. This is standard pharmaceutical salt conversion.

Is Acetyl L-Carnitine vegan?
Yes. Despite the name carnitine coming from Latin carnis (meat, where it was first isolated), ALCAR used in supplements is synthetically produced and is not animal-derived. All non-medicinal ingredients (hypromellose, magnesium stearate, microcrystalline cellulose) are also vegan.

Why is there a caution for seizure disorders?
Carnitine modulates GABA-A receptor activity and may affect seizure threshold in some individuals. Additionally, valproic acid (a common anticonvulsant) depletes carnitine, creating complex interactions. Those with a seizure disorder should consult a healthcare practitioner before use.

Why is there a caution for kidney disease?
Carnitine and its metabolites (acylcarnitines) are primarily excreted by the kidneys. In kidney disease, these compounds can accumulate. Supplementation in the context of kidney disease requires medical supervision.

How does the 6-pack compare to other pack sizes?
All listings contain the same 120-capsule bottles of Acetyl L-Carnitine 637.5mg (NPN 80141963) at 3 capsules per day. Single bottle: 40 day supply. 2-pack: 80 days. 3-pack: 120 days. 6-pack: 240 days. The 6-pack is the maximum value option for those committed to consistent long-term daily ALCAR use.

About Acetyl L-Carnitine 637.5mg | ALCAR | Source of Carnitine | 120 Vcaps x 6

Acetyl L-Carnitine (ALCAR) delivers 637.5mg per capsule (from 750mg ALCAR HCl) as a source of carnitine. ALCAR is the acetylated form of L-carnitine: the acetyl group increases BBB penetration via OCTN2 transporter and passive diffusion, and enables acetyl-CoA donation for the citric acid cycle and acetylcholine synthesis via choline acetyltransferase (ChAT). Carnitine is essential for the CPT-I/CACT/CPT-II shuttle that transports long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation. At 3 capsules per day: 1,912.5mg ALCAR daily. Health Canada approved (NPN 80141963). 100% vegan (synthetically produced). 6-pack: 720 capsules, 240 day supply. Do not use if allergic to carnitine. Consult a healthcare practitioner if pregnant, breastfeeding, have kidney disease, or have a seizure disorder. Made in Canada.