Alpha GPC 400mg | 99% Purity | L-alpha-Glycerophosphorylcholine | Source of Choline | Cognitive Function Support

Each capsule contains 400mg of Alpha GPC (L-alpha-Glycerophosphorylcholine, also known as choline alfoscerate) at 99% purity, delivering approximately 396mg of actual Alpha GPC per capsule. Alpha GPC is the most bioavailable form of choline available in supplement form, crossing the blood-brain barrier efficiently to support brain choline levels and acetylcholine synthesis. As a source of choline, Alpha GPC supports cognitive function, memory, and overall brain health. The 99% purity specification is a critical quality distinction that sets this formula apart from the majority of Alpha GPC supplements on the market. Health Canada approved (NPN 80125440). 100% vegan, non-GMO, gluten-free, and soy-free. Made in Canada in a quality-controlled facility. 90 vegan capsules.

Key Benefits

• Source of choline
• Supports cognitive function
• Supports memory
• Most bioavailable form of choline supplement
• Crosses the blood-brain barrier efficiently
• Supports acetylcholine synthesis in the brain
• 400mg Alpha GPC per capsule at 99% purity
• Approximately 396mg actual Alpha GPC per capsule
• L-alpha-Glycerophosphorylcholine (choline alfoscerate)
• Health Canada approved (NPN 80125440)
• 90 vegan capsules
• Made in Canada in a quality-controlled facility
• 100% vegan and non-GMO
• Gluten-free, dairy-free, soy-free

Why 99% Purity Matters: The Most Important Alpha GPC Specification

Purity is the single most important specification when evaluating Alpha GPC supplements, yet it is frequently overlooked or misunderstood by consumers. Understanding purity is essential for comparing Alpha GPC products accurately.

The 50% vs. 99% Purity Difference: The majority of Alpha GPC supplements sold globally use 50% purity Alpha GPC. At 50% purity, a capsule labeled as containing 400mg of Alpha GPC actually contains only 200mg of actual L-alpha-Glycerophosphorylcholine, with the remaining 200mg being silica or other carrier material used to stabilize the hygroscopic compound. A 99% purity Alpha GPC capsule at 400mg contains approximately 396mg of actual L-alpha-Glycerophosphorylcholine, nearly double the actual active compound of a 50% purity product at the same labeled dose.

Why 50% Purity Is the Industry Standard: Pure Alpha GPC is highly hygroscopic, meaning it readily absorbs moisture from the air and becomes sticky and difficult to handle in manufacturing. To make it easier to process and encapsulate, most manufacturers blend Alpha GPC with silica at a 1:1 ratio, producing a 50% purity powder that is stable and free-flowing. This is a manufacturing convenience, not a quality standard.

Why 99% Purity Is Superior: At 99% purity, the Alpha GPC is processed to remove the carrier material, delivering nearly pure L-alpha-Glycerophosphorylcholine in each capsule. This requires more sophisticated manufacturing processes and higher quality raw material, but results in a significantly higher actual dose of Alpha GPC per capsule at the same labeled weight.

Practical Implication: A consumer taking one 400mg capsule of 99% purity Alpha GPC receives approximately 396mg of actual Alpha GPC. A consumer taking one 400mg capsule of 50% purity Alpha GPC receives only approximately 200mg of actual Alpha GPC. To match the actual Alpha GPC content of one 99% purity capsule, a consumer would need to take two 50% purity capsules.

What Is Alpha GPC?

Alpha GPC (L-alpha-Glycerophosphorylcholine, also known as choline alfoscerate) is a naturally occurring choline compound found in small amounts in the brain and in foods such as eggs, liver, and dairy products. It is a phospholipid precursor and the most bioavailable form of choline available in supplement form. Alpha GPC is distinct from other choline supplements such as choline bitartrate and CDP-choline (citicoline) in its ability to efficiently cross the blood-brain barrier and directly support brain choline levels.

Choline Alfoscerate: The pharmaceutical name for Alpha GPC is choline alfoscerate, the name used in Health Canada NPN labelling. Both names refer to the same compound: L-alpha-Glycerophosphorylcholine.

Natural Occurrence: Alpha GPC is found naturally in the brain as a breakdown product of phosphatidylcholine, a phospholipid that is a major structural component of cell membranes. It is also found in small amounts in foods including eggs, liver, wheat germ, and dairy products, though dietary amounts are far lower than supplemental doses.

Choline: An Essential Nutrient for Brain Health

Choline is an essential nutrient required for multiple critical functions in the body, with particular importance for brain health and nervous system function:

Acetylcholine Synthesis: Choline is the direct precursor to acetylcholine, one of the most important neurotransmitters in the brain and nervous system. Acetylcholine is involved in memory formation, learning, attention, and neuromuscular signaling. Alpha GPC supports brain choline levels, which in turn supports acetylcholine synthesis.

Phospholipid Synthesis: Choline is required for the synthesis of phosphatidylcholine, the primary phospholipid in cell membranes. Phosphatidylcholine is essential for the structural integrity and fluidity of cell membranes throughout the body, with particular importance in the brain where phospholipids are a major component of neuronal membranes.

Methyl Group Donor: Choline is a methyl group donor involved in methylation reactions throughout the body, including the methylation of homocysteine to methionine, contributing to normal homocysteine metabolism.

Essential Nutrient Status: Choline was recognized as an essential nutrient by the Institute of Medicine in 1998. The body can synthesize some choline endogenously, but not in sufficient amounts to meet daily requirements, making dietary and supplemental choline important for maintaining adequate choline status.

Alpha GPC vs. Other Choline Forms

Alpha GPC vs. Choline Bitartrate: Choline bitartrate is the most common and least expensive form of choline supplement. It has lower bioavailability for brain choline support compared to Alpha GPC because it does not cross the blood-brain barrier as efficiently. Choline bitartrate is primarily used as a general choline source rather than a targeted brain choline supplement.

Alpha GPC vs. CDP-Choline (Citicoline): CDP-choline (citicoline) is another highly bioavailable choline form that crosses the blood-brain barrier. CDP-choline is converted to both choline and cytidine in the body, with cytidine further converted to uridine, a nucleotide with its own neurological effects. Alpha GPC delivers choline more directly and at a higher choline content per gram than CDP-choline. Alpha GPC contains approximately 40% choline by weight, while CDP-choline contains approximately 18% choline by weight.

Alpha GPC vs. Phosphatidylcholine: Phosphatidylcholine is a phospholipid found in lecithin supplements. While it is a natural choline source, it has lower bioavailability for brain choline support compared to Alpha GPC and contains a lower percentage of choline by weight.

Why Alpha GPC Is the Premium Choline Form: Alpha GPC is the most bioavailable form of choline for brain support, crosses the blood-brain barrier efficiently, and delivers the highest choline content per gram among commonly available choline supplements. The 99% purity specification in this formula ensures that the full 400mg capsule weight is delivering actual Alpha GPC rather than carrier material.

Cognitive Function and Memory Support

Alpha GPC supports cognitive function and memory through its role as a source of choline for acetylcholine synthesis in the brain. Acetylcholine is the primary neurotransmitter of the cholinergic system, which is involved in attention, learning, memory formation, and memory retrieval. By supporting brain choline levels, Alpha GPC supports the cholinergic system's ability to synthesize acetylcholine as needed for cognitive processes. Alpha GPC is one of the most studied choline supplements for cognitive function support and is used in clinical settings in Europe as a pharmaceutical-grade choline supplement.

Understanding the Dosage

Alpha GPC (L-alpha-Glycerophosphorylcholine): 400mg per capsule
Purity: 99%
Actual Alpha GPC per Capsule: approximately 396mg
Suggested Use: As directed by a healthcare practitioner
Total Capsules: 90
Non-Medicinal Ingredients: Hypromellose (vegetable capsule shell), magnesium stearate, silica, cellulose

Consult your healthcare provider to determine the appropriate dosage and timing for your individual needs.

Who May Consider This Product

• Individuals seeking a source of choline for brain health support
• Those wanting cognitive function and memory support
• People wanting the most bioavailable form of choline supplement
• Those wanting 99% purity Alpha GPC for maximum actual Alpha GPC per capsule
• Individuals interested in acetylcholine precursor supplementation
• Those wanting a Health Canada approved choline supplement
• Vegans and vegetarians seeking a plant-based choline source
• Those seeking Canadian-made cognitive support supplements

Quality and Purity

• Health Canada approved (NPN 80125440)
• 400mg Alpha GPC per capsule (L-alpha-Glycerophosphorylcholine)
• 99% purity (approximately 396mg actual Alpha GPC per capsule)
• Vegan capsules (hypromellose)
• 90 capsules
• Made in Canada in a quality-controlled facility
• 100% vegan and non-GMO
• Gluten-free, dairy-free, soy-free

Storage

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Alpha GPC is hygroscopic and sensitive to moisture. Proper storage with the bottle tightly sealed preserves product quality and prevents moisture absorption.

Safety Information

Consult a healthcare professional before use if you are pregnant or breastfeeding, taking medications (particularly anticholinergic medications or scopolamine), or have a medical condition. Alpha GPC may interact with scopolamine and other anticholinergic drugs by opposing their effects. Do not exceed the recommended dose. This product is not intended to diagnose, treat, cure, or prevent any disease.

Keep out of reach of children.

This product is approved by Health Canada (NPN 80125440).

About Alpha GPC 400mg | 99% Purity | Source of Choline for Cognitive Function Support

Alpha GPC (L-alpha-Glycerophosphorylcholine) is the most bioavailable form of choline supplement, crossing the blood-brain barrier efficiently to support brain choline levels and acetylcholine synthesis. At 400mg per capsule with 99% purity, this formula delivers approximately 396mg of actual Alpha GPC per capsule, nearly double the actual Alpha GPC content of a 50% purity product at the same labeled dose. As a source of choline, Alpha GPC supports cognitive function and memory. Health Canada approved (NPN 80125440), 100% vegan, and made in Canada in a quality-controlled facility.