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Berberine HCL 500mg | Blood Sugar and Metabolic Support | AMPK Activator | 120 Vcaps
Berberine 500 mg herbal supplement weight and glucose metabolism support
Berberine 500 mg vegan capsules plant based formula
Berberine supplement facts label 500 mg 120 capsules
Berberine supplement for metabolic health support 500 mg
Berberine HCL 500mg | Blood Sugar and Metabolic Support | AMPK Activator | 120 Vcaps

The 120 capsule format of Berberine HClโ€ฏ500mg a full 60-day supply at the recommended dose of 2 capsules per day. Each vegan capsule delivers 500โ€ฏmg of 97% pure berberine hydrochloride extracted fromย Berberis aristata root. Berberineโ€ฏHCl activates AMPK (AMP activated protein kinase), the cellular energy sensor that governs glucose uptake, insulin sensitivity, hepatic glucose output, and fatty acid oxidation.

Berberine HCl 500mg How It Works

Berberine is an isoquinoline alkaloid from Berberis aristata (Indian barberry) root, with a clinical research profile spanning hundreds of human studies. Its primary mechanism is inhibition of mitochondrial complexโ€ฏI, which raises the intracellular AMP to ATP ratio and triggers AMPK activation. AMPK coordinates: increased GLUT4-mediated glucose uptake in skeletal muscle; suppression of hepatic gluconeogenesis via PEPCK and G6Pase downregulation; inhibition of intestinal alpha glucosidase to blunt postprandial glucose rise; and selective modulation of gut microbiota to improve gut barrier integrity and insulin receptor expression.

Berberine HCL 500mg | Blood Sugar and Metabolic Support | AMPK Activator | 120 Vcaps

$43.99

Health Canada Licensed Natural Health Product (NPN 80129371)

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The 120 capsule format of Berberine HClโ€ฏ500mg a full 60-day supply at the recommended dose of 2 capsules per day. Each vegan capsule delivers 500โ€ฏmg of 97% pure berberine hydrochloride extracted fromย Berberis aristata root. Berberineโ€ฏHCl activates AMPK (AMP activated protein kinase), the cellular energy sensor that governs glucose uptake, insulin sensitivity, hepatic glucose output, and fatty acid oxidation.

Berberine HCl 500mg How It Works

Berberine is an isoquinoline alkaloid from Berberis aristata (Indian barberry) root, with a clinical research profile spanning hundreds of human studies. Its primary mechanism is inhibition of mitochondrial complexโ€ฏI, which raises the intracellular AMP to ATP ratio and triggers AMPK activation. AMPK coordinates: increased GLUT4-mediated glucose uptake in skeletal muscle; suppression of hepatic gluconeogenesis via PEPCK and G6Pase downregulation; inhibition of intestinal alpha glucosidase to blunt postprandial glucose rise; and selective modulation of gut microbiota to improve gut barrier integrity and insulin receptor expression.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Ingredient
Amount Per
Serving
% Daily
Value
Berberine HCl (Berberis aristata, Root)
500 mg
โ€ 

โ€  Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source).

Clinical Research

Berberine and its more bioavailable derivative dihydroberberine inhibit mitochondrial complex I: a mechanism for the action of berberine to activate AMP activated protein kinase and improve insulin action

Diabetes, 2010

Demonstrates that berberine inhibits mitochondrial complex I, raising the cellular AMP to ATP ratio and activating AMPK the master metabolic regulator governing glucose uptake, fatty acid oxidation, and suppression of hepatic gluconeogenesis. Establishes the primary mechanism by which berberine HCl supports healthy blood glucose metabolism and insulin sensitivity.

Efficacy of berberine in patients with type 2 diabetes mellitus

Metabolism, 2008

A randomized controlled trial showing that berberine 500mg twice daily significantly reduced fasting blood glucose, postprandial blood glucose, and HbA1c compared to placebo over 3 months. Provides clinical evidence for berberine HCl 500mg capsules taken with meals as a metabolic and blood sugar support supplement.

Modulation of gut microbiota by berberine and metformin in the treatment of type 2 diabetes: a combined analysis

Frontiers in Microbiology, 2020

Demonstrates that berberine modulates gut microbiota composition by increasing short-chain fatty acid producing bacteria and reducing pathogenic strains, improving gut barrier integrity and insulin receptor expression providing mechanistic insight into berberine's metabolic effects despite its low oral bioavailability.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is Berberine HCL 500mg?

Berberine HCL is a concentrated form of berberine, a naturally occurring plant compound found in botanicals such as barberry and goldenseal. Each specified serving provides 500 mg of Berberine HCL.

What is Berberine used for?

Berberine is commonly used in supplements designed to support healthy glucose metabolism, metabolic health, and overall cardiovascular wellness.

How does Berberine support blood sugar metabolism?

Berberine has been studied for its effects on several metabolic pathways involved in glucose utilization and insulin signaling. It should complement, not replace, a balanced diet, exercise, or prescribed treatment.

What does HCL mean in Berberine HCL?

HCL stands for hydrochloride. Berberine hydrochloride is a commonly used supplemental form of berberine because it provides a standardized and stable form of the compound.

Can Berberine support metabolic health?

Yes. Berberine is widely studied for its potential role in supporting glucose metabolism, lipid metabolism, and overall metabolic function.

Does Berberine support healthy cholesterol levels?

Berberine has been researched for its potential effects on lipid and cholesterol metabolism. Individual responses can vary, and it should be used alongside healthy dietary and lifestyle habits.

Can Berberine be taken with diabetes medication?

People taking insulin, metformin, or other blood glucose lowering medications should consult a healthcare professional before taking berberine, as the combination may lower blood sugar too much.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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