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Evening primrose oil 500 mg cold pressed 10 percent GLA 200 softgels
Evening primrose oil 500 mg omega 6 supplement 200 softgels
Evening primrose oil supplement bottle 500 mg 200 softgels
Evening primrose oil 500 mg dietary supplement softgels
Evening primrose oil 500 mg softgels 200 count
Evening primrose oil supplement facts label 10 percent GLA
Evening primrose oil 500 mg cold pressed 10 percent GLA 200 softgels

Evening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels

Each softgel delivers 500mg of cold pressed evening primrose oil (Oenothera biennis, seed), standardized to 10% gamma-linolenic acid (GLA), providing a guaranteed 50mg of GLA per softgel. Adults take 2 to 4 softgels per day. 200 softgels 50 to 100-day supply at 2 to 4 softgels per day. Licensed by Health Canada (NPN 80030725). Made in Canada.

Key Benefits

  • 50mg GLA per softgel, guaranteed Standardized to 10% gamma-linolenic acid | 100 to 200mg GLA per daily dose of 2 to 4 softgels
  • Skin health and barrier support GLA is a critical structural component of the skin lipid barrier, supporting moisture retention, elasticity, and barrier integrity
  • Hormonal balance and menstrual cycle support GLA and its metabolite DGLA influence prostaglandin synthesis pathways involved in hormonal signalling and premenstrual comfort
  • Healthy inflammatory response GLA is converted to DGLA and then to prostaglandin E1 (PGE1) — a Series 1 prostaglandin that supports inflammatory balance
  • Cold pressed extraction Preserves heat-sensitive GLA and linoleic acid without chemical solvents or high heat
  • Natural source of omega-6 GLA One of the richest plant sources of GLA — a conditionally essential fatty acid not widely available in the diet
  • Health Canada licensed NPN 80030725 Made in Canada. GMP certified.
  • 200 softgels 50 to 100-day supply at 2 to 4 softgels per day

What This Is

A cold pressed evening primrose oil supplement providing 500mg of pure Oenothera biennis seed oil per softgel, standardized to a guaranteed 10% GLA (50mg per softgel). Evening primrose oil is one of the richest plant sources of GLA, a conditionally essential omega-6 fatty acid not widely found in the diet. GLA must be synthesized from linoleic acid by the delta-6-desaturase enzyme — a conversion routinely impaired by aging, stress, nutritional deficiencies, and hormonal fluctuations. Evening primrose oil delivers GLA directly, bypassing this enzymatic step.

The Formula

Why GLA Requires Direct Supplementation

GLA is synthesized from dietary linoleic acid via the delta-6-desaturase enzyme. This conversion is routinely impaired by aging, chronic stress, insulin resistance, alcohol consumption, and hormonal fluctuations. When delta-6-desaturase activity is reduced, linoleic acid accumulates without converting to GLA. Evening primrose oil delivers GLA directly, bypassing this enzymatic bottleneck entirely.

GLA → DGLA → Prostaglandin E1

Absorbed GLA is elongated to dihomo-gamma-linolenic acid (DGLA) by elongase enzymes. DGLA is the immediate precursor to prostaglandin E1 (PGE1) — a vasodilatory, anti-aggregatory, and anti-inflammatory eicosanoid. DGLA is preferentially converted to PGE1 rather than to pro-inflammatory arachidonic acid, making GLA a net anti-inflammatory intervention that supports healthy inflammatory balance.

GLA and Skin Barrier Function

GLA is incorporated into ceramides and phospholipids that form the skin lipid barrier — the lamellar structure between corneocytes that governs transepidermal water loss (TEWL) and barrier integrity. GLA deficiency is associated with increased TEWL, dry skin, and impaired barrier function. Evening primrose oil supplementation supports ceramide synthesis and barrier repair, improving skin hydration and elasticity.

GLA and Hormonal Signalling

DGLA, the elongation product of GLA, is a precursor to PGE1 and to 15-HETrE, both of which modulate estrogen-sensitive tissue responses and luteal phase signalling. This prostaglandin pathway is the mechanism through which evening primrose oil supports premenstrual comfort, cyclical breast tenderness, and menstrual cycle regularity.

How to Use

Adults: Take 2 to 4 softgels per day with a meal containing dietary fat. Dietary fat stimulates bile secretion and supports lymphatic absorption of the oil. Refrigerate after opening to preserve fatty acid integrity.

Contraindications & Cautions

Do not use if you have a seizure disorder or are taking phenothiazine medications. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications such as warfarin. Keep out of reach of children.

NPN 80030725. All health claims are consistent with Health Canada’s Natural Health Products Regulations.

Evening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels

$35.00
4.8 (12)

Health Canada Licensed Natural Health Product (NPN 80030725)

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Evening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels

Each softgel delivers 500mg of cold pressed evening primrose oil (Oenothera biennis, seed), standardized to 10% gamma-linolenic acid (GLA), providing a guaranteed 50mg of GLA per softgel. Adults take 2 to 4 softgels per day. 200 softgels 50 to 100-day supply at 2 to 4 softgels per day. Licensed by Health Canada (NPN 80030725). Made in Canada.

Key Benefits

  • 50mg GLA per softgel, guaranteed Standardized to 10% gamma-linolenic acid | 100 to 200mg GLA per daily dose of 2 to 4 softgels
  • Skin health and barrier support GLA is a critical structural component of the skin lipid barrier, supporting moisture retention, elasticity, and barrier integrity
  • Hormonal balance and menstrual cycle support GLA and its metabolite DGLA influence prostaglandin synthesis pathways involved in hormonal signalling and premenstrual comfort
  • Healthy inflammatory response GLA is converted to DGLA and then to prostaglandin E1 (PGE1) — a Series 1 prostaglandin that supports inflammatory balance
  • Cold pressed extraction Preserves heat-sensitive GLA and linoleic acid without chemical solvents or high heat
  • Natural source of omega-6 GLA One of the richest plant sources of GLA — a conditionally essential fatty acid not widely available in the diet
  • Health Canada licensed NPN 80030725 Made in Canada. GMP certified.
  • 200 softgels 50 to 100-day supply at 2 to 4 softgels per day

What This Is

A cold pressed evening primrose oil supplement providing 500mg of pure Oenothera biennis seed oil per softgel, standardized to a guaranteed 10% GLA (50mg per softgel). Evening primrose oil is one of the richest plant sources of GLA, a conditionally essential omega-6 fatty acid not widely found in the diet. GLA must be synthesized from linoleic acid by the delta-6-desaturase enzyme — a conversion routinely impaired by aging, stress, nutritional deficiencies, and hormonal fluctuations. Evening primrose oil delivers GLA directly, bypassing this enzymatic step.

The Formula

Why GLA Requires Direct Supplementation

GLA is synthesized from dietary linoleic acid via the delta-6-desaturase enzyme. This conversion is routinely impaired by aging, chronic stress, insulin resistance, alcohol consumption, and hormonal fluctuations. When delta-6-desaturase activity is reduced, linoleic acid accumulates without converting to GLA. Evening primrose oil delivers GLA directly, bypassing this enzymatic bottleneck entirely.

GLA → DGLA → Prostaglandin E1

Absorbed GLA is elongated to dihomo-gamma-linolenic acid (DGLA) by elongase enzymes. DGLA is the immediate precursor to prostaglandin E1 (PGE1) — a vasodilatory, anti-aggregatory, and anti-inflammatory eicosanoid. DGLA is preferentially converted to PGE1 rather than to pro-inflammatory arachidonic acid, making GLA a net anti-inflammatory intervention that supports healthy inflammatory balance.

GLA and Skin Barrier Function

GLA is incorporated into ceramides and phospholipids that form the skin lipid barrier — the lamellar structure between corneocytes that governs transepidermal water loss (TEWL) and barrier integrity. GLA deficiency is associated with increased TEWL, dry skin, and impaired barrier function. Evening primrose oil supplementation supports ceramide synthesis and barrier repair, improving skin hydration and elasticity.

GLA and Hormonal Signalling

DGLA, the elongation product of GLA, is a precursor to PGE1 and to 15-HETrE, both of which modulate estrogen-sensitive tissue responses and luteal phase signalling. This prostaglandin pathway is the mechanism through which evening primrose oil supports premenstrual comfort, cyclical breast tenderness, and menstrual cycle regularity.

How to Use

Adults: Take 2 to 4 softgels per day with a meal containing dietary fat. Dietary fat stimulates bile secretion and supports lymphatic absorption of the oil. Refrigerate after opening to preserve fatty acid integrity.

Contraindications & Cautions

Do not use if you have a seizure disorder or are taking phenothiazine medications. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications such as warfarin. Keep out of reach of children.

NPN 80030725. All health claims are consistent with Health Canada’s Natural Health Products Regulations.

Supplement Facts

Supplement Facts

Serving Size: 2 to 4 Softgels (Once Daily with a Meal Containing Dietary Fat)

Servings Per Container: 50 to 100 (at 2 to 4 softgels per day)

Ingredient
Amount Per
Serving
% Daily
Value
Evening Primrose Oil (Oenothera biennis, Seed, Cold Pressed)
500 mg
†
Gamma-Linolenic Acid (GLA, Omega-6)
50 mg
†
Linoleic Acid (LA, Omega-6)
360 mg
†

† Daily Value not established

Other Ingredients:
d-alpha Tocopherol (vitamin E)

Clinical Research

Evening primrose oil and borage oil in rheumatologic conditions

American Journal of Clinical Nutrition, 2000

This review examined the clinical evidence for GLA-containing oils including evening primrose oil in inflammatory and rheumatologic conditions, with specific focus on the GLA → DGLA → Prostaglandin E1 pathway. The review established that GLA from evening primrose oil is efficiently converted to DGLA and subsequently to PGE1 a Series 1 prostaglandin with vasodilatory, anti aggregatory, and anti-inflammatory properties. The review confirmed that GLA supplementation from evening primrose oil produces measurable shifts in the prostaglandin balance toward PGE1 and away from pro-inflammatory arachidonic acid metabolites, directly supporting evening primrose oil's mechanism of action for healthy inflammatory response support.

The effect of gamma-linolenic acid on skin barrier function in patients with atopic dermatitis

British Journal of Dermatology, 1989

This randomized, double blind, placebo controlled trial examined the effects of evening primrose oil supplementation on skin barrier function, transepidermal water loss (TEWL), and skin symptoms in patients with atopic dermatitis a condition characterized by impaired skin lipid barrier function and GLA deficiency. The study found that evening primrose oil supplementation significantly improved skin barrier integrity, reduced TEWL, and improved skin hydration and elasticity compared to placebo. The authors attributed the effects to GLA's role in ceramide and phospholipid synthesis in the skin lipid barrier. The findings directly support evening primrose oil's licensed use for skin health and barrier support.

Essential fatty acids and premenstrual syndrome

Journal of Reproductive Medicine, 1983

This foundational review by David Horrobin the leading researcher on GLA and prostaglandin metabolism examined the role of GLA and prostaglandin E1 in premenstrual syndrome (PMS) and hormonal balance. The review established that women with PMS show impaired delta-6-desaturase activity and reduced GLA-to-DGLA conversion, resulting in lower PGE1 production during the luteal phase. Supplementation with evening primrose oil providing GLA directly bypasses this enzymatic impairment and supports PGE1 production, modulating estrogen-sensitive tissue responses and luteal phase signalling. The findings provide the foundational mechanistic basis for evening primrose oil's use for hormonal balance and premenstrual comfort support.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is Evening Primrose Oil and what does it do?

Evening Primrose Oil (EPO) is a cold pressed oil extracted from the seeds ofOenothera biennis the evening primrose plant native to North America. It is one of the richest plant sources of gamma-linolenic acid (GLA), a conditionally essential omega-6 fatty acid not widely found in the diet. GLA supports skin barrier function, hormonal balance, and healthy inflammatory response through the GLA → DGLA → Prostaglandin E1 pathway.

What is GLA and why is it important?

Gamma-linolenic acid (GLA) is a conditionally essential omega-6 fatty acid that the body synthesizes from dietary linoleic acid via the delta-6-desaturase enzyme. It is "conditionally essential" because this enzymatic conversion is routinely impaired by aging, chronic stress, insulin resistance, alcohol consumption, and hormonal fluctuations meaning many adults cannot produce adequate GLA from diet alone even with sufficient linoleic acid intake. GLA is the precursor to dihomo-gamma linolenic acid (DGLA) and prostaglandin E1 (PGE1) a Series 1 prostaglandin that supports healthy inflammatory balance, skin barrier integrity, and hormonal signalling. Evening primrose oil delivers GLA directly, bypassing the delta-6-desaturase enzymatic step entirely.

How does Evening Primrose Oil support skin health?

GLA is incorporated into ceramides and phospholipids that form the skin lipid barrier the lamellar structure between corneocytes that governs transepidermal water loss (TEWL) and barrier integrity. GLA deficiency is associated with increased TEWL, dry skin, reduced elasticity, and impaired barrier function. Evening primrose oil supplementation supports ceramide synthesis and barrier repair, improving skin hydration and elasticity from within. The skin barrier benefit of GLA is distinct from topical moisturizers it works by restoring the structural lipid composition of the barrier at the cellular level through oral supplementation.

How does Evening Primrose Oil support hormonal balance and menstrual health?

DGLA the elongation product of GLA is a precursor to prostaglandin E1 (PGE1) and to 15-HETrE, both of which modulate estrogen sensitive tissue responses and luteal phase signalling. This prostaglandin pathway is the mechanism through which evening primrose oil supports premenstrual comfort, cyclical breast tenderness, and menstrual cycle regularity. GLA's conversion to PGE1 rather than to pro inflammatory arachidonic acid metabolites supports a more balanced prostaglandin profile during the luteal phase the period most associated with premenstrual symptoms.

Why is cold pressed extraction important for Evening Primrose Oil?

Cold pressing uses mechanical pressure at controlled low temperatures, preserving the full fatty acid profile including heat sensitive GLA and linoleic acid. Solvent extraction using hexane at elevated temperatures degrades polyunsaturated fatty acids, destroys native tocopherols (Vitamin E), and may leave trace solvent residues in the finished oil. Cold pressed EPO retains its complete fatty acid composition, natural antioxidant content, and guaranteed GLA potency.

Who should not take Evening Primrose Oil?

Do not use if you have a seizure disorder or are taking phenothiazine medications GLA may lower the seizure threshold in susceptible individuals when combined with phenothiazines. Consult a healthcare practitioner before use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are taking blood-thinning medications such as warfarin GLA's conversion to PGE1 has anti-aggregatory properties that may interact with anticoagulant therapy.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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