Calcium plus vitamin D supplementation and the risk of fractures
New England Journal of Medicine, 2006 Randomized controlled trial (Women's Health Initiative)
Each softgel delivers Calcium 750mg (Calcium Carbonate) | Magnesium 250mg (Magnesium Oxide) | Vitamin D3 200IU / 5mcg (Cholecalciferol) three nutrients with distinct and interdependent roles in bone mineral metabolism.
Calcium is the primary structural mineral of bone and tooth tissue, comprising approximately 70% of bone mineral as hydroxyapatite. Adequate calcium intake is the foundational requirement for bone mineral density throughout life. Vitamin D3 (Cholecalciferol) is converted in the liver to 25-hydroxyvitamin D and then in the kidneys to calcitriol Its active hormonal form. Calcitriol stimulates the production of calcium-binding proteins (calbindins) in the intestinal wall, increasing calcium absorption from 10–15% (without adequate vitamin D) to 30–40% (with sufficient vitamin D). Without adequate Vitamin D3, dietary calcium cannot be efficiently absorbed regardless of intake. Magnesium is required for the enzymatic activation of Vitamin D specifically, the hepatic and renal hydroxylation steps that convert cholecalciferol to calcitriol. It also supports the active transport of calcium into bone tissue and is itself a structural component of the bone mineral matrix, with approximately 60% of the body’s magnesium stored in bone.
Calcium Carbonate is the most concentrated form of supplemental calcium by elemental weight (40% elemental calcium), providing 750mg of elemental calcium per softgel. It is best absorbed when taken with food, as gastric acid produced during digestion facilitates its dissolution and ionization. At 2 softgels per day, this formula provides 1,500mg of elemental calcium meeting the recommended dietary allowance for most adults.
Magnesium Oxide provides 250mg of elemental magnesium per softgel (500mg per daily dose of 2 softgels). Magnesium is the fourth most abundant mineral in the body and a cofactor in over 300 enzymatic reactions, including those involved in ATP synthesis, protein synthesis, and DNA repair. Its role in Vitamin D activation makes it particularly relevant in a calcium-magnesium-vitamin D formula magnesium deficiency impairs the conversion of Vitamin D to its active form, limiting the effectiveness of calcium supplementation.
Cholecalciferol (D3) is the same form of Vitamin D produced in human skin upon UV-B exposure and is the preferred supplemental form for raising serum 25(OH)D levels. At 200IU (5mcg) per softgel, the daily dose of 2 softgels provides 400IU (10mcg) a foundational dose supporting calcium absorption and bone mineralization.
Adults seeking a combined calcium, magnesium, and vitamin D3 supplement for bone and teeth support. Suitable for those who consume soy and gelatin. Not suitable for vegans or vegetarians. Consult a healthcare practitioner before use if you have kidney disease, hypercalcemia, or are taking prescription medications.
Each softgel delivers Calcium 750mg (Calcium Carbonate) | Magnesium 250mg (Magnesium Oxide) | Vitamin D3 200IU / 5mcg (Cholecalciferol) three nutrients with distinct and interdependent roles in bone mineral metabolism.
Calcium is the primary structural mineral of bone and tooth tissue, comprising approximately 70% of bone mineral as hydroxyapatite. Adequate calcium intake is the foundational requirement for bone mineral density throughout life. Vitamin D3 (Cholecalciferol) is converted in the liver to 25-hydroxyvitamin D and then in the kidneys to calcitriol Its active hormonal form. Calcitriol stimulates the production of calcium-binding proteins (calbindins) in the intestinal wall, increasing calcium absorption from 10–15% (without adequate vitamin D) to 30–40% (with sufficient vitamin D). Without adequate Vitamin D3, dietary calcium cannot be efficiently absorbed regardless of intake. Magnesium is required for the enzymatic activation of Vitamin D specifically, the hepatic and renal hydroxylation steps that convert cholecalciferol to calcitriol. It also supports the active transport of calcium into bone tissue and is itself a structural component of the bone mineral matrix, with approximately 60% of the body’s magnesium stored in bone.
Calcium Carbonate is the most concentrated form of supplemental calcium by elemental weight (40% elemental calcium), providing 750mg of elemental calcium per softgel. It is best absorbed when taken with food, as gastric acid produced during digestion facilitates its dissolution and ionization. At 2 softgels per day, this formula provides 1,500mg of elemental calcium meeting the recommended dietary allowance for most adults.
Magnesium Oxide provides 250mg of elemental magnesium per softgel (500mg per daily dose of 2 softgels). Magnesium is the fourth most abundant mineral in the body and a cofactor in over 300 enzymatic reactions, including those involved in ATP synthesis, protein synthesis, and DNA repair. Its role in Vitamin D activation makes it particularly relevant in a calcium-magnesium-vitamin D formula magnesium deficiency impairs the conversion of Vitamin D to its active form, limiting the effectiveness of calcium supplementation.
Cholecalciferol (D3) is the same form of Vitamin D produced in human skin upon UV-B exposure and is the preferred supplemental form for raising serum 25(OH)D levels. At 200IU (5mcg) per softgel, the daily dose of 2 softgels provides 400IU (10mcg) a foundational dose supporting calcium absorption and bone mineralization.
Adults seeking a combined calcium, magnesium, and vitamin D3 supplement for bone and teeth support. Suitable for those who consume soy and gelatin. Not suitable for vegans or vegetarians. Consult a healthcare practitioner before use if you have kidney disease, hypercalcemia, or are taking prescription medications.
Serving Size: 1 Softgel
Servings Per Container: 120
† Daily Value not established.
New England Journal of Medicine, 2006 Randomized controlled trial (Women's Health Initiative)
Molecular and Cellular Endocrinology, 2011 Peer reviewed review
Magnesium Research, 2021 Peer reviewed review
Research information is provided for educational purposes and does not replace the product's approved label information.