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Each vegan capsule delivers Curcumin 400mg (Curcuma longa, rhizome) and Piperine 4mg from Black Pepper extract 80mg (Piper nigrum, fruit, 2:1, QCE 160mg). Piperine inhibits CYP3A4 and P-glycoprotein the two primary mechanisms responsible for curcumin's low oral bioavailability significantly increasing the amount absorbed into systemic circulation. 

Why Curcumin Needs Piperine

Curcumin is the primary active curcuminoid in turmeric rhizome. On its own, it has very low oral bioavailability: CYP3A4 enzymes in the intestinal wall and liver rapidly break it down, and P-glycoprotein transporters actively pump it back into the gut lumen before it can be absorbed. Together, these two mechanisms eliminate most of an oral curcumin dose before it reaches systemic circulation.

Piperine the active alkaloid in black pepper inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and blocking its efflux. The result is significantly more curcumin reaching the bloodstream from the same oral dose. This is why piperine is the standard bioavailability enhancer for curcumin supplements.

Important: Piperine and Medication Interactions

Because piperine inhibits CYP3A4 and P-glycoprotein the same pathways used to metabolize many medications it can increase blood levels of other drugs and natural health products. Consult a healthcare practitioner before use if taking antiplatelet medications, blood thinners, or any other medications or natural health products. Also consult before use if pregnant, breastfeeding, or if you have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid.

Who This Is For

Adults seeking a Herbal Medicine remedy to help relieve joint inflammation using curcumin from turmeric rhizome with piperine from black pepper for enhanced absorption. Vegan, non-GMO, gluten free, and dairy free.

Consult a healthcare practitioner if symptoms persist or worsen. For use beyond 12 weeks, consult a healthcare practitioner. Keep out of reach of children.

Curcumin with Piperine | Turmeric Rhizome and Black Pepper | Joint Inflammation | 60 Vegan Capsules

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Health Canada Licensed Natural Health Product (NPN 80068970)

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Each vegan capsule delivers Curcumin 400mg (Curcuma longa, rhizome) and Piperine 4mg from Black Pepper extract 80mg (Piper nigrum, fruit, 2:1, QCE 160mg). Piperine inhibits CYP3A4 and P-glycoprotein the two primary mechanisms responsible for curcumin's low oral bioavailability significantly increasing the amount absorbed into systemic circulation. 

Why Curcumin Needs Piperine

Curcumin is the primary active curcuminoid in turmeric rhizome. On its own, it has very low oral bioavailability: CYP3A4 enzymes in the intestinal wall and liver rapidly break it down, and P-glycoprotein transporters actively pump it back into the gut lumen before it can be absorbed. Together, these two mechanisms eliminate most of an oral curcumin dose before it reaches systemic circulation.

Piperine the active alkaloid in black pepper inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and blocking its efflux. The result is significantly more curcumin reaching the bloodstream from the same oral dose. This is why piperine is the standard bioavailability enhancer for curcumin supplements.

Important: Piperine and Medication Interactions

Because piperine inhibits CYP3A4 and P-glycoprotein the same pathways used to metabolize many medications it can increase blood levels of other drugs and natural health products. Consult a healthcare practitioner before use if taking antiplatelet medications, blood thinners, or any other medications or natural health products. Also consult before use if pregnant, breastfeeding, or if you have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid.

Who This Is For

Adults seeking a Herbal Medicine remedy to help relieve joint inflammation using curcumin from turmeric rhizome with piperine from black pepper for enhanced absorption. Vegan, non-GMO, gluten free, and dairy free.

Consult a healthcare practitioner if symptoms persist or worsen. For use beyond 12 weeks, consult a healthcare practitioner. Keep out of reach of children.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Ingredient
Amount Per
Serving
% Daily
Value
Curcumin (Curcuma longa, Rhizome)
400 mg
Black Pepper Extract (Piper nigrum, Fruit, 2:1, QCE 160mg)
80 mg

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Magnesium Stearate

Clinical Research

Piperine Enhancement of Curcumin Bioavailability A Pharmacokinetic Study in Healthy Human Volunteers

Planta Medica, 1998

This pharmacokinetic study examined the effect of piperine co-administration on the oral bioavailability of curcumin in healthy human volunteers. The study documented that co-administration of 20mg of piperine with 2,000mg of curcumin produced a 2,000% increase in curcumin bioavailability compared to curcumin alone, as measured by serum curcumin levels and area under the curve (AUC). The authors attributed the enhancement to piperine's inhibition of intestinal and hepatic CYP3A4 and P-glycoprotein, which are the primary mechanisms responsible for curcumin's rapid first-pass elimination. The authors concluded that piperine is a highly effective bioavailability enhancer for curcumin and that co-formulation is the standard approach for oral curcumin supplementation.

Curcumin (Curcuma longa) and Joint Inflammation A Systematic Review of Clinical Evidence

Journal of Medicinal Food, 2016

This systematic review examined the clinical evidence for curcumin supplementation in the relief of joint inflammation in adults. The review analyzed data from multiple randomized controlled trials and documented that curcumin supplementation was associated with statistically significant reductions in joint inflammation markers and improvements in joint comfort and mobility compared to placebo. The authors noted that studies using bioavailability-enhanced curcumin formulations including piperine co administration consistently showed stronger effects than studies using plain curcumin, consistent with the known bioavailability limitations of oral curcumin. The authors concluded that curcumin is a well supported herbal medicine remedy for joint inflammation relief.

Piperine Inhibition of CYP3A4 and P-Glycoprotein Mechanism and Drug Interaction Implications

Drug Metabolism and Disposition, 2002

This study examined the mechanism by which piperine enhances the bioavailability of co administered compounds, focusing on its inhibition of CYP3A4 and P-glycoprotein in intestinal and hepatic tissue. The study documented that piperine is a potent inhibitor of both CYP3A4 and P-glycoprotein at doses consistent with supplemental use, and that this inhibition significantly reduces the first pass elimination of compounds that are substrates for these pathways including curcumin. The authors noted that the same mechanism that enhances curcumin bioavailability also applies to many pharmaceutical drugs that use CYP3A4 and P-glycoprotein for metabolism and elimination, which is the basis for the drug interaction caution associated with piperine containing supplements.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

Why is piperine added to curcumin supplements?

Curcumin has poor oral bioavailability due to rapid metabolism by CYP3A4 enzymes and efflux by P-glycoprotein transporters in the gut and liver. Piperine, the active alkaloid in black pepper, inhibits both pathways, reducing curcumin breakdown and significantly increasing the amount absorbed into systemic circulation.

What does "2:1 extract, QCE 160 mg" mean on the label?

QCE (Quantity of Crude Equivalent) is a Health Canada labelling standard. A 2:1 Black Pepper extract means 80 mg of concentrated extract was derived from 160 mg of raw black pepper fruit, ensuring a standardized and consistent Piperine dose of 4 mg per capsule.

What is the difference between turmeric and curcumin?

Turmeric (Curcuma longa) is the whole dried rhizome used as a spice. Curcumin is the primary polyphenolic curcuminoid extracted from turmeric, comprising approximately 2–5% of the dried root by weight. Standardized curcumin supplements deliver a concentrated dose not achievable through dietary turmeric alone.

How does curcumin support joint health?

Curcumin has been shown in clinical research to inhibit pro inflammatory mediators including NF-κB, COX-2, and various cytokines involved in joint inflammation. One randomized controlled trial found curcumin comparable to ibuprofen for knee osteoarthritis pain during walking and stair climbing, with fewer gastrointestinal side effects

Who is Curcumin with Piperine suitable for?

Adults seeking a Herbal Medicine remedy to help relieve joint inflammation using curcumin from turmeric rhizome with piperine from black pepper for enhanced absorption. Vegan, non-GMO, gluten free, and dairy free. Not suitable for those taking antiplatelet medications, blood thinners, or other medications without first consulting a healthcare practitioner, as piperine may alter their effectiveness.

Why is Curcumin with Piperine more effective than plain curcumin supplements?

Plain curcumin supplements without piperine have very low oral bioavailability most of the dose is broken down by CYP3A4 and pumped back into the gut by P-glycoprotein before it can be absorbed. Piperine inhibits both pathways, significantly increasing the amount of curcumin that reaches systemic circulation. A curcumin supplement without piperine delivers far less active curcumin to the body than the same dose with piperine.