Piperine Enhancement of Curcumin Bioavailability A Pharmacokinetic Study in Healthy Human Volunteers
Planta Medica, 1998
Each vegan capsule delivers Curcumin 400mg (Curcuma longa, rhizome) and Piperine 4mg from Black Pepper extract 80mg (Piper nigrum, fruit, 2:1, QCE 160mg). Piperine inhibits CYP3A4 and P-glycoprotein the two primary mechanisms responsible for curcumin's low oral bioavailability significantly increasing the amount absorbed into systemic circulation.
Curcumin is the primary active curcuminoid in turmeric rhizome. On its own, it has very low oral bioavailability: CYP3A4 enzymes in the intestinal wall and liver rapidly break it down, and P-glycoprotein transporters actively pump it back into the gut lumen before it can be absorbed. Together, these two mechanisms eliminate most of an oral curcumin dose before it reaches systemic circulation.
Piperine the active alkaloid in black pepper inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and blocking its efflux. The result is significantly more curcumin reaching the bloodstream from the same oral dose. This is why piperine is the standard bioavailability enhancer for curcumin supplements.
Because piperine inhibits CYP3A4 and P-glycoprotein the same pathways used to metabolize many medications it can increase blood levels of other drugs and natural health products. Consult a healthcare practitioner before use if taking antiplatelet medications, blood thinners, or any other medications or natural health products. Also consult before use if pregnant, breastfeeding, or if you have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid.
Adults seeking a Herbal Medicine remedy to help relieve joint inflammation using curcumin from turmeric rhizome with piperine from black pepper for enhanced absorption. Vegan, non-GMO, gluten free, and dairy free.
Consult a healthcare practitioner if symptoms persist or worsen. For use beyond 12 weeks, consult a healthcare practitioner. Keep out of reach of children.
Each vegan capsule delivers Curcumin 400mg (Curcuma longa, rhizome) and Piperine 4mg from Black Pepper extract 80mg (Piper nigrum, fruit, 2:1, QCE 160mg). Piperine inhibits CYP3A4 and P-glycoprotein the two primary mechanisms responsible for curcumin's low oral bioavailability significantly increasing the amount absorbed into systemic circulation.
Curcumin is the primary active curcuminoid in turmeric rhizome. On its own, it has very low oral bioavailability: CYP3A4 enzymes in the intestinal wall and liver rapidly break it down, and P-glycoprotein transporters actively pump it back into the gut lumen before it can be absorbed. Together, these two mechanisms eliminate most of an oral curcumin dose before it reaches systemic circulation.
Piperine the active alkaloid in black pepper inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and blocking its efflux. The result is significantly more curcumin reaching the bloodstream from the same oral dose. This is why piperine is the standard bioavailability enhancer for curcumin supplements.
Because piperine inhibits CYP3A4 and P-glycoprotein the same pathways used to metabolize many medications it can increase blood levels of other drugs and natural health products. Consult a healthcare practitioner before use if taking antiplatelet medications, blood thinners, or any other medications or natural health products. Also consult before use if pregnant, breastfeeding, or if you have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid.
Adults seeking a Herbal Medicine remedy to help relieve joint inflammation using curcumin from turmeric rhizome with piperine from black pepper for enhanced absorption. Vegan, non-GMO, gluten free, and dairy free.
Consult a healthcare practitioner if symptoms persist or worsen. For use beyond 12 weeks, consult a healthcare practitioner. Keep out of reach of children.
Serving Size: 1 Capsule
Servings Per Container: 60
† Daily Value not established
Planta Medica, 1998
Journal of Medicinal Food, 2016
Drug Metabolism and Disposition, 2002
Research information is provided for educational purposes and does not replace the product's approved label information.