Medicinal Ingredient (per 1 capsule)
Glycine (Aminoacetic acid)……………..1000 mg

Non-Medicinal Ingredients
Hypromellose, Microcrystalline cellulose, Magnesium Stearate

Recommended Dosage
Adults: 1 capsule 1 time per day

Cautions and Warnings
Ask a health care practitioner before use if you are pregnant or breastfeeding.

Q1: What is glycine supplement used for?
Glycine supports sleep quality and helps maintain healthy sleep onset and depth, supports collagen synthesis and helps maintain healthy connective tissue, skin, and joint integrity, supports cognitive function and mental clarity, supports protein synthesis as a fundamental non essential amino acid, and helps maintain a healthy inflammatory response. Glycine is also a precursor to creatine, glutathione, heme, and bile acids, making it one of the most metabolically versatile amino acids in human biochemistry. Health Canada licensed with NPN 80139967.

Q2: Is glycine a non essential amino acid?
Yes. Glycine is classified as a non essential amino acid, meaning the body can synthesize it endogenously from serine, threonine, choline, and hydroxyproline. However, research suggests that endogenous synthesis provides only approximately 2 to 3 grams per day, while total physiological demand may be as high as 10 to 15 grams per day. This significant glycine gap makes glycine conditionally essential, and dietary and supplemental glycine play an important role in meeting full physiological demand, particularly during periods of increased collagen turnover, oxidative stress, or physical training.

Q3: How does glycine support sleep quality?
Glycine is an inhibitory neurotransmitter in the spinal cord and brainstem that supports sleep quality through two primary mechanisms. First, it promotes peripheral vasodilation, lowering core body temperature, which is a key physiological signal for sleep onset. Second, it modulates neurotransmitter activity in the suprachiasmatic nucleus (the brain's circadian clock), supporting healthy sleep architecture. Clinical research on glycine supplementation (typically 3 grams taken before bed) demonstrates improvements in subjective sleep quality, reduced time to sleep onset, and improved next day cognitive performance and alertness without sedation or grogginess.

Q4: How does glycine support collagen synthesis?
Glycine is the most abundant amino acid in collagen, comprising every third amino acid in the collagen triple helix structure (the repeating Gly X Y sequence). Collagen is the primary structural protein in skin, tendons, ligaments, cartilage, bone, and blood vessels. Research suggests that the body's endogenous glycine synthesis is insufficient to fully support collagen production at optimal rates, making supplemental glycine an important contributor to collagen synthesis, skin integrity, joint health, and connective tissue maintenance.

Q5: How does glycine support protein synthesis?
As a non essential amino acid, glycine participates directly in protein synthesis as a building block for structural and functional proteins throughout the body. It is particularly critical for collagen synthesis, where it occupies every third position in the collagen triple helix. Beyond collagen, glycine is a precursor for creatine synthesis (alongside arginine and methionine), contributing to the body's creatine pool which supports ATP regeneration in muscle tissue during exercise. Glycine also contributes to the synthesis of glutathione, heme, purines, and bile acids.

Q6: Is glycine a good workout supplement?
Glycine supports workout recovery and physical performance through multiple pathways. As a precursor to creatine, it contributes to the body's creatine pool which supports ATP regeneration in muscle tissue during high intensity exercise. As the primary amino acid in collagen, it supports the synthesis and repair of connective tissue including tendons, ligaments, and cartilage stressed during training. Glycine also supports sleep quality, and adequate sleep is one of the most important factors in workout recovery, muscle protein synthesis, and physical adaptation to training.

Q7: How does glycine support cognitive function?
Glycine functions as both an inhibitory neurotransmitter via glycine receptors in the spinal cord and brainstem, and as a co agonist at NMDA (N methyl D aspartate) glutamate receptors in the brain. NMDA receptor activity is essential for synaptic plasticity, learning, and memory consolidation. By supporting healthy NMDA receptor function, glycine contributes to cognitive processes including learning, memory, and mental clarity. Its sleep quality benefits also contribute to next day cognitive performance and alertness.

Q8: How does glycine support glutathione production?
Glycine is one of three amino acids (along with glutamate and cysteine) required for the synthesis of glutathione, the body's primary endogenous antioxidant. Glycine availability is often the rate limiting factor in glutathione synthesis, particularly in older adults whose glycine status tends to decline with age. By supporting glutathione synthesis, glycine supplementation contributes to the body's antioxidant defence capacity and helps maintain cellular protection against oxidative stress.

Q9: How much glycine should I take for sleep?
Clinical research on glycine and sleep quality typically uses 3 grams (3000mg) taken 30 to 60 minutes before bedtime. At 1000mg per capsule, 3 capsules taken before bed provides this research aligned dose. For general collagen, protein synthesis, and cognitive support, 1 to 2 capsules daily with or without food is appropriate. Use as directed by a healthcare practitioner for personalized dosing guidance.

Q10: Is this glycine supplement licensed by Health Canada?
Yes. This product is a licensed Natural Health Product with NPN 80139967, approved by Health Canada under the Natural Health Products Regulations. It is manufactured in a GMP certified facility in Canada.

Q11: Is this glycine supplement vegan and gluten free?
Yes. This product uses a hypromellose vegetable capsule with no gelatin or animal derived ingredients. It is also gluten free and non GMO, with no artificial colours, flavours, sweeteners, or preservatives.

Q12: How long does one bottle of Glycine 1000mg last?
Each bottle contains 120 vegan capsules. At 1 capsule per day it provides up to a 4 month supply. At 3 capsules per day (the research aligned sleep dose) it provides a 40 day supply.