L-Citrulline 750mg | Free Form | Circulation and Nitric Oxide Support | 120 Vcaps x 2 Pack
Each capsule delivers 750mg of pure free form L-Citrulline, the amino acid that serves as the most effective oral precursor to L-Arginine and nitric oxide. Unlike oral L-Arginine, which is significantly broken down by intestinal and hepatic arginase before reaching systemic circulation, L-Citrulline bypasses this first-pass metabolism entirely, is absorbed intact, and is converted to L-Arginine in the kidneys, producing higher and more sustained plasma L-Arginine levels. Helps support cardiovascular health. Helps support healthy circulation. Source of amino acids involved in protein synthesis. Health Canada approved (NPN 80139498). 100% vegan, non GMO, gluten free, soy free. Made in Canada in a quality controlled facility. 2 pack: 2 x 120 vegan capsules (240 capsules total, approximately 60 day supply at the suggested dose).
Key Features
• Helps support cardiovascular health
• Helps support healthy circulation
• Source of amino acids involved in protein synthesis
• 750mg pure free form L-Citrulline per capsule
• More effective than oral L-Arginine at raising plasma L-Arginine levels
• Bypasses intestinal and hepatic first-pass arginase metabolism
• Converted to L-Arginine in the kidneys: sustained systemic arginine supply
• Free form: pure L-Citrulline, not citrulline malate
• 3,000mg L-Citrulline per day at the suggested dose
• 2 pack: 240 capsules total (approximately 60 day supply)
• Health Canada approved (NPN 80139498)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free
Why L-Citrulline Outperforms Oral L-Arginine
L-Citrulline and L-Arginine both support nitric oxide production through the same endpoint: L-Arginine is the substrate for nitric oxide synthase (NOS) in endothelial cells. The critical difference is how efficiently each reaches systemic circulation when taken orally.
The First-Pass Metabolism Problem with Oral L-Arginine: The intestinal epithelium and liver both express arginase, the enzyme that converts L-Arginine to ornithine and urea. When L-Arginine is taken orally, a substantial portion is broken down by intestinal and hepatic arginase before it reaches the bloodstream, a process called first-pass metabolism. This limits how much orally ingested L-Arginine actually reaches endothelial cells for nitric oxide synthesis. High oral doses of L-Arginine are also associated with gastrointestinal discomfort because the intestinal arginase system becomes saturated.
How L-Citrulline Bypasses This: L-Citrulline is not a substrate for arginase and passes through the intestine and liver intact. It enters systemic circulation and is taken up by the kidneys, where argininosuccinate synthetase and argininosuccinate lyase convert it to L-Arginine. This renally produced L-Arginine is released into systemic circulation, providing a sustained supply to endothelial cells. Multiple studies have demonstrated that oral L-Citrulline raises plasma L-Arginine levels more effectively and more sustainably than equivalent doses of oral L-Arginine, without the gastrointestinal side effects.
The Citrulline-Arginine Recycling Cycle
A further advantage of L-Citrulline is its role in the intracellular recycling cycle within endothelial cells. When nitric oxide synthase converts L-Arginine to nitric oxide, L-Citrulline is produced as a byproduct. This L-Citrulline can be recycled back to L-Arginine within the endothelial cell itself via argininosuccinate synthetase and argininosuccinate lyase, creating a local self-sustaining cycle that maintains nitric oxide production. Supplemental L-Citrulline feeds into this cycle both by replenishing systemic L-Arginine via the kidneys and by directly supporting the intracellular recycling pathway in endothelial cells, providing a more complete and sustained support for nitric oxide production than L-Arginine supplementation alone.
Free Form L-Citrulline vs. Citrulline Malate
This formula uses free form L-Citrulline, the pure amino acid in its unbound state. It is important to distinguish this from citrulline malate, a common alternative form found in many sports nutrition products.
Citrulline Malate: Citrulline malate is L-Citrulline bound to malic acid (malate) in a 2:1 or 1:1 ratio. When a citrulline malate product states a milligram amount, that amount includes the weight of both the citrulline and the malate components. In a 2:1 citrulline malate, approximately 57% of the stated weight is L-Citrulline and 43% is malate. A product stating 750mg of citrulline malate (2:1) therefore contains approximately 430mg of actual L-Citrulline per serving.
Free Form L-Citrulline: This formula provides 750mg of pure L-Citrulline per capsule with no malate component. The full 750mg is L-Citrulline. For consumers focused on maximizing L-Citrulline dose per capsule, free form delivers more L-Citrulline per gram of product than citrulline malate.
L-Citrulline: Origin and Biochemical Context
L-Citrulline is a non-proteinogenic amino acid (not incorporated into proteins) and an intermediate in the urea cycle, the metabolic pathway by which the liver converts ammonia to urea for excretion. It was first isolated from watermelon (Citrullus lanatus) in 1914, and its name derives from Citrullus, the genus name of watermelon. Watermelon is the richest known dietary source of L-Citrulline, with the rind containing higher concentrations than the flesh. Other dietary sources include cucumbers, bitter melon, and pumpkin. Dietary intake from food sources is generally insufficient to achieve the plasma L-Arginine raising effects associated with supplemental doses.
Understanding the Dosage and the 2 Pack
Per capsule: L-Citrulline (free form): 750mg
Suggested Use: Adults: 2 capsules, 2 times per day (4 capsules per day, 3,000mg L-Citrulline per day)
Per bottle: 120 vegan capsules
2 Pack total: 240 capsules (approximately 60 day supply at the suggested dose)
Non Medicinal Ingredients: Hypromellose (vegetable capsule), Microcrystalline cellulose, Magnesium Stearate
Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs.
Who May Consider This Product
• Adults seeking support for cardiovascular health and healthy circulation
• Those wanting the most effective oral amino acid strategy for raising plasma L-Arginine levels
• Individuals who have experienced gastrointestinal discomfort with high-dose oral L-Arginine supplements
• Those wanting pure free form L-Citrulline rather than citrulline malate
• Those wanting a 2 pack for approximately 60 days of supply at the suggested dose
• Vegans and vegetarians
• Those seeking a Health Canada approved, Canadian made L-Citrulline supplement
Quality and Purity
• Health Canada approved (NPN 80139498)
• 750mg pure free form L-Citrulline per capsule
• Vegan hypromellose capsule
• 2 pack: 240 capsules (approximately 60 day supply at suggested dose)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free
Storage
Store in a cool, dry place away from direct sunlight. Keep bottles tightly sealed after each use.
Safety Information and Cautions
Consult a healthcare practitioner before use if you are taking medication for cardiovascular diseases. Consult a healthcare practitioner before use if you are taking medication for erectile dysfunction. L-Citrulline raises nitric oxide through the L-Arginine pathway; PDE5 inhibitors (such as sildenafil and tadalafil) also act through the nitric oxide pathway, and combining them can cause severe hypotension. Consult a healthcare practitioner before use if you are taking blood thinners. Consult a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Consult a healthcare practitioner before use if you are pregnant or breastfeeding. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children.
This product is approved by Health Canada (NPN 80139498).
About L-Citrulline 750mg | Free Form | Circulation and Nitric Oxide Support | 2 Pack
L-Citrulline is the most effective oral precursor to L-Arginine because it bypasses the intestinal and hepatic arginase metabolism that limits oral L-Arginine bioavailability. Absorbed intact and converted to L-Arginine in the kidneys, supplemental L-Citrulline raises plasma L-Arginine levels more effectively and more sustainably than equivalent doses of oral L-Arginine, without gastrointestinal side effects. L-Citrulline also feeds the intracellular citrulline-arginine recycling cycle within endothelial cells, providing sustained support for nitric oxide production. At 750mg of pure free form L-Citrulline per capsule (not citrulline malate), the full stated dose is L-Citrulline with no malate weight dilution. At the suggested dose of 4 capsules per day (3,000mg), this 2 pack provides 240 capsules for approximately 60 days. Health Canada approved (NPN 80139498) for helping support cardiovascular health, helping support healthy circulation, and as a source of amino acids involved in protein synthesis. 100% vegan and made in Canada in a quality controlled facility.
L-Citrulline 750mg | Free Form | Circulation and Nitric Oxide Support | 120 Vcaps x 2 Pack
Each capsule delivers 750mg of pure free form L-Citrulline, the amino acid that serves as the most effective oral precursor to L-Arginine and nitric oxide. Unlike oral L-Arginine, which is significantly broken down by intestinal and hepatic arginase before reaching systemic circulation, L-Citrulline bypasses this first-pass metabolism entirely, is absorbed intact, and is converted to L-Arginine in the kidneys, producing higher and more sustained plasma L-Arginine levels. Helps support cardiovascular health. Helps support healthy circulation. Source of amino acids involved in protein synthesis. Health Canada approved (NPN 80139498). 100% vegan, non GMO, gluten free, soy free. Made in Canada in a quality controlled facility. 2 pack: 2 x 120 vegan capsules (240 capsules total, approximately 60 day supply at the suggested dose).
Key Features
• Helps support cardiovascular health
• Helps support healthy circulation
• Source of amino acids involved in protein synthesis
• 750mg pure free form L-Citrulline per capsule
• More effective than oral L-Arginine at raising plasma L-Arginine levels
• Bypasses intestinal and hepatic first-pass arginase metabolism
• Converted to L-Arginine in the kidneys: sustained systemic arginine supply
• Free form: pure L-Citrulline, not citrulline malate
• 3,000mg L-Citrulline per day at the suggested dose
• 2 pack: 240 capsules total (approximately 60 day supply)
• Health Canada approved (NPN 80139498)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free
Why L-Citrulline Outperforms Oral L-Arginine
L-Citrulline and L-Arginine both support nitric oxide production through the same endpoint: L-Arginine is the substrate for nitric oxide synthase (NOS) in endothelial cells. The critical difference is how efficiently each reaches systemic circulation when taken orally.
The First-Pass Metabolism Problem with Oral L-Arginine: The intestinal epithelium and liver both express arginase, the enzyme that converts L-Arginine to ornithine and urea. When L-Arginine is taken orally, a substantial portion is broken down by intestinal and hepatic arginase before it reaches the bloodstream, a process called first-pass metabolism. This limits how much orally ingested L-Arginine actually reaches endothelial cells for nitric oxide synthesis. High oral doses of L-Arginine are also associated with gastrointestinal discomfort because the intestinal arginase system becomes saturated.
How L-Citrulline Bypasses This: L-Citrulline is not a substrate for arginase and passes through the intestine and liver intact. It enters systemic circulation and is taken up by the kidneys, where argininosuccinate synthetase and argininosuccinate lyase convert it to L-Arginine. This renally produced L-Arginine is released into systemic circulation, providing a sustained supply to endothelial cells. Multiple studies have demonstrated that oral L-Citrulline raises plasma L-Arginine levels more effectively and more sustainably than equivalent doses of oral L-Arginine, without the gastrointestinal side effects.
The Citrulline-Arginine Recycling Cycle
A further advantage of L-Citrulline is its role in the intracellular recycling cycle within endothelial cells. When nitric oxide synthase converts L-Arginine to nitric oxide, L-Citrulline is produced as a byproduct. This L-Citrulline can be recycled back to L-Arginine within the endothelial cell itself via argininosuccinate synthetase and argininosuccinate lyase, creating a local self-sustaining cycle that maintains nitric oxide production. Supplemental L-Citrulline feeds into this cycle both by replenishing systemic L-Arginine via the kidneys and by directly supporting the intracellular recycling pathway in endothelial cells, providing a more complete and sustained support for nitric oxide production than L-Arginine supplementation alone.
Free Form L-Citrulline vs. Citrulline Malate
This formula uses free form L-Citrulline, the pure amino acid in its unbound state. It is important to distinguish this from citrulline malate, a common alternative form found in many sports nutrition products.
Citrulline Malate: Citrulline malate is L-Citrulline bound to malic acid (malate) in a 2:1 or 1:1 ratio. When a citrulline malate product states a milligram amount, that amount includes the weight of both the citrulline and the malate components. In a 2:1 citrulline malate, approximately 57% of the stated weight is L-Citrulline and 43% is malate. A product stating 750mg of citrulline malate (2:1) therefore contains approximately 430mg of actual L-Citrulline per serving.
Free Form L-Citrulline: This formula provides 750mg of pure L-Citrulline per capsule with no malate component. The full 750mg is L-Citrulline. For consumers focused on maximizing L-Citrulline dose per capsule, free form delivers more L-Citrulline per gram of product than citrulline malate.
L-Citrulline: Origin and Biochemical Context
L-Citrulline is a non-proteinogenic amino acid (not incorporated into proteins) and an intermediate in the urea cycle, the metabolic pathway by which the liver converts ammonia to urea for excretion. It was first isolated from watermelon (Citrullus lanatus) in 1914, and its name derives from Citrullus, the genus name of watermelon. Watermelon is the richest known dietary source of L-Citrulline, with the rind containing higher concentrations than the flesh. Other dietary sources include cucumbers, bitter melon, and pumpkin. Dietary intake from food sources is generally insufficient to achieve the plasma L-Arginine raising effects associated with supplemental doses.
Understanding the Dosage and the 2 Pack
Per capsule: L-Citrulline (free form): 750mg
Suggested Use: Adults: 2 capsules, 2 times per day (4 capsules per day, 3,000mg L-Citrulline per day)
Per bottle: 120 vegan capsules
2 Pack total: 240 capsules (approximately 60 day supply at the suggested dose)
Non Medicinal Ingredients: Hypromellose (vegetable capsule), Microcrystalline cellulose, Magnesium Stearate
Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs.
Who May Consider This Product
• Adults seeking support for cardiovascular health and healthy circulation
• Those wanting the most effective oral amino acid strategy for raising plasma L-Arginine levels
• Individuals who have experienced gastrointestinal discomfort with high-dose oral L-Arginine supplements
• Those wanting pure free form L-Citrulline rather than citrulline malate
• Those wanting a 2 pack for approximately 60 days of supply at the suggested dose
• Vegans and vegetarians
• Those seeking a Health Canada approved, Canadian made L-Citrulline supplement
Quality and Purity
• Health Canada approved (NPN 80139498)
• 750mg pure free form L-Citrulline per capsule
• Vegan hypromellose capsule
• 2 pack: 240 capsules (approximately 60 day supply at suggested dose)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free, soy free
Storage
Store in a cool, dry place away from direct sunlight. Keep bottles tightly sealed after each use.
Safety Information and Cautions
Consult a healthcare practitioner before use if you are taking medication for cardiovascular diseases. Consult a healthcare practitioner before use if you are taking medication for erectile dysfunction. L-Citrulline raises nitric oxide through the L-Arginine pathway; PDE5 inhibitors (such as sildenafil and tadalafil) also act through the nitric oxide pathway, and combining them can cause severe hypotension. Consult a healthcare practitioner before use if you are taking blood thinners. Consult a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Consult a healthcare practitioner before use if you are pregnant or breastfeeding. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children.
This product is approved by Health Canada (NPN 80139498).
About L-Citrulline 750mg | Free Form | Circulation and Nitric Oxide Support | 2 Pack
L-Citrulline is the most effective oral precursor to L-Arginine because it bypasses the intestinal and hepatic arginase metabolism that limits oral L-Arginine bioavailability. Absorbed intact and converted to L-Arginine in the kidneys, supplemental L-Citrulline raises plasma L-Arginine levels more effectively and more sustainably than equivalent doses of oral L-Arginine, without gastrointestinal side effects. L-Citrulline also feeds the intracellular citrulline-arginine recycling cycle within endothelial cells, providing sustained support for nitric oxide production. At 750mg of pure free form L-Citrulline per capsule (not citrulline malate), the full stated dose is L-Citrulline with no malate weight dilution. At the suggested dose of 4 capsules per day (3,000mg), this 2 pack provides 240 capsules for approximately 60 days. Health Canada approved (NPN 80139498) for helping support cardiovascular health, helping support healthy circulation, and as a source of amino acids involved in protein synthesis. 100% vegan and made in Canada in a quality controlled facility.
Canadian-Made
Lab-Tested
Health Canada Approved
