Curcumin with Piperine | Turmeric Rhizome and Black Pepper | Joint Inflammation

Each vegan capsule delivers Curcumin 400mg (Curcuma longa, rhizome) and Piperine 4mg from Black Pepper extract 80mg (Piper nigrum, fruit, 2:1, QCE 160mg). Piperine inhibits the enzymes that break down curcumin, significantly enhancing its absorption.

Used in Herbal Medicine to help relieve joint inflammation. Health Canada licensed NPN 80068970. Vegan. Non-GMO. Gluten free. Dairy free. Made in Canada. 60 vegan capsules, 20 day supply at 3 capsules per day.

Source

Curcumin source: Curcuma longa rhizome (underground stem), a member of the Zingiberaceae (ginger) family native to South and Southeast Asia. Raw turmeric rhizome contains approximately 2 to 5% curcuminoids by weight, of which curcumin is the most abundant. Curcumin is what gives turmeric its characteristic yellow colour.

Piperine source: Piper nigrum fruit (black pepper), 2:1 concentrated extract providing 4mg of piperine per 80mg of extract (QCE 160mg raw black pepper fruit). Piperine is the alkaloid responsible for black pepper's pungent taste and its enzyme-inhibiting properties.

What Is Curcumin and Why Does It Need Piperine?

Curcumin is the primary active curcuminoid in turmeric (Curcuma longa), used in Herbal Medicine to help relieve joint inflammation. On its own, curcumin has low oral bioavailability: it is rapidly broken down by gut and liver enzymes (particularly CYP3A4) and eliminated before meaningful amounts reach the bloodstream. Piperine inhibits CYP3A4 and the P-glycoprotein transporter, slowing curcumin's breakdown and significantly increasing the amount absorbed into systemic circulation.

What Is Piperine and How Does It Enhance Absorption?

Piperine is the active alkaloid in black pepper (Piper nigrum). It inhibits CYP3A4, the primary liver enzyme responsible for curcumin metabolism, and P-glycoprotein, an intestinal efflux transporter that pumps curcumin back into the gut lumen before it can be absorbed. By inhibiting both pathways, piperine slows curcumin's breakdown and increases its bioavailability. Because piperine inhibits the same enzymes that metabolize many medications, it can also increase blood levels of other drugs and natural health products, which is the basis for the medication interaction caution.

Key Benefits

• Used in Herbal Medicine to help relieve joint inflammation Health Canada licensed claim under NPN 80068970
• Curcumin 400mg per capsule Curcuma longa rhizome | Primary active curcuminoid in turmeric
• Piperine 4mg per capsule From 80mg Black Pepper extract (Piper nigrum, fruit, 2:1, QCE 160mg) | Inhibits CYP3A4 and P-glycoprotein for enhanced curcumin absorption
• Source: Curcuma longa rhizome South and Southeast Asian ginger family plant | Ayurvedic and traditional herbal medicine use
• Source: Piper nigrum fruit extract 2:1 concentrate | QCE 160mg raw black pepper fruit per capsule
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Health Canada licensed NPN 80068970 | GMP certified | Made in Canada
• 60 vegan capsules 20 day supply at 3 capsules per day

How It Works

Curcumin and Joint Inflammation

Curcumin is the primary curcuminoid in turmeric rhizome and the compound responsible for its traditional use in Herbal Medicine to help relieve joint inflammation. The Health Canada licensed use for this formula is: used in Herbal Medicine to help relieve joint inflammation (NPN 80068970).

Why Curcumin Has Low Bioavailability Without Piperine

Curcumin is rapidly metabolized by CYP3A4 in the intestinal wall and liver, and actively pumped back into the gut lumen by P-glycoprotein before it can be absorbed. These two mechanisms together result in very low systemic bioavailability from oral curcumin alone. Piperine inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and increasing the amount that reaches systemic circulation.

Why Piperine Affects Other Medications

CYP3A4 and P-glycoprotein are responsible for the metabolism and elimination of a wide range of medications, not just curcumin. By inhibiting these pathways, piperine can increase the blood levels of other drugs and natural health products that use the same routes, potentially altering their effectiveness or increasing side effect risk. This is why it is important to consult a healthcare practitioner before use if taking any medications or natural health products.

Understanding the QCE: Black Pepper Extract Potency

The black pepper component is a 2:1 concentrated extract, meaning 2 grams of raw black pepper fruit were used to produce 1 gram of extract. Each 80mg capsule therefore contains the concentrated compounds from 160mg of raw black pepper fruit (QCE 160mg), providing 4mg of piperine per capsule.

Medicinal Ingredients (per capsule)

• Curcumin (Curcuma longa, rhizome) 400mg Source: turmeric rhizome, South and Southeast Asia | Used in Herbal Medicine to help relieve joint inflammation | NPN 80068970
• Black Pepper Extract (Piper nigrum, fruit, 2:1) 80mg QCE 160mg | Providing Piperine 4mg | Source: black pepper fruit concentrate | Enhances curcumin absorption via CYP3A4 and P-glycoprotein inhibition | NPN 80068970

Non-medicinal ingredients: Magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.

Per Daily Dose (3 Capsules)

• Curcumin (Curcuma longa, rhizome): 1200mg
• Black Pepper Extract (Piper nigrum, fruit, 2:1): 240mg | QCE 480mg
• Piperine: 12mg

Quality and Trust

• NPN 80068970 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Curcumin from Curcuma longa rhizome Traditional Ayurvedic and herbal medicine source
• Piperine from Piper nigrum fruit extract 2:1 concentrate | QCE 160mg per capsule
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Non-GMO, gluten free, dairy free
• 60 vegan capsules 20 day supply at 3 capsules per day

Who This Is For

Adults seeking a Herbal Medicine remedy to help relieve joint inflammation, using curcumin from turmeric rhizome combined with piperine from black pepper for enhanced absorption. A good fit if you want a Health Canada licensed, vegan, Canadian-made curcumin and piperine formula.

Consult a healthcare practitioner before use if you are taking antiplatelet medications, blood thinners, or any other medications or natural health products, as piperine may increase their blood levels. Also consult before use if you are pregnant or breastfeeding, or have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid. For use beyond 12 weeks, consult a healthcare practitioner.

How to Use

Adults: Take 1 capsule, 3 times per day, or as directed by a healthcare practitioner. For use beyond 12 weeks, consult a healthcare practitioner.

At 3 capsules per day, 60 capsules provides a 20 day supply.

Safety and Cautions

For use beyond 12 weeks, consult a healthcare practitioner. Consult a healthcare practitioner before use if you are taking antiplatelet medication, blood thinners, or any other medications or natural health products, as piperine may alter their effectiveness. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid. Consult a healthcare practitioner if symptoms persist or worsen. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80068970. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.