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DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps
DIM 200 mg supplement bottle Diindolylmethane 120 V-Capsules made in Canada
DIM 200 mg hormone balance supplement for estrogen metabolism support
DIM 200 mg vegan capsules Diindolylmethane dietary supplement
Nutridom DIM 200 mg supplement facts label Diindolylmethane hormone metabolism support
DIM 200 mg
DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

Each vegan capsule delivers 200 mg of pure 3,3’-Diindolylmethane (DIM) the bioactive end-product formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. This DIM supplement supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of favorable estrogen metabolites, supporting hormone balance in both women and men.

What Is DIM (Diindolylmethane)?

DIM (3,3’-Diindolylmethane) is not found directly in food. It is formed in the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage, undergoes acid-catalyzed condensation during digestion. DIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with this diindolylmethane supplement delivers 200 mg of the active compound directly bypassing the variable conversion efficiency of dietary I3C, which would otherwise require consuming several pounds of cruciferous vegetables daily to match this dose.

Estrogen Metabolism Support

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a more potently estrogenic metabolite. DIM estrogen metabolism support works by promoting the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio — the primary mechanism through which this DIM supplement supports healthy estrogen metabolism and hormone balance.

DIM Hormone Balance For Women and Men

This DIM supplement for women supports healthy estrogen clearance, hormone balance, and estrogen 2-hydroxylation. Consistent with DIM’s role in estrogen metabolism support, it is also relevant as a DIM supplement for men: men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormone balance, particularly in the context of age related increases in aromatase activity. DIM 200mg daily supports healthy estrogen metabolism and hormone balance in both sexes.

Phase I & II Liver Detoxification

DIM induces cytochrome P450 enzymes (CYP1A1, CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.

DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

$26.99
5.0 (1)

Health Canada Licensed Natural Health Product (NPN 80141933)

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Each vegan capsule delivers 200 mg of pure 3,3’-Diindolylmethane (DIM) the bioactive end-product formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. This DIM supplement supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of favorable estrogen metabolites, supporting hormone balance in both women and men.

What Is DIM (Diindolylmethane)?

DIM (3,3’-Diindolylmethane) is not found directly in food. It is formed in the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage, undergoes acid-catalyzed condensation during digestion. DIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with this diindolylmethane supplement delivers 200 mg of the active compound directly bypassing the variable conversion efficiency of dietary I3C, which would otherwise require consuming several pounds of cruciferous vegetables daily to match this dose.

Estrogen Metabolism Support

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a more potently estrogenic metabolite. DIM estrogen metabolism support works by promoting the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio — the primary mechanism through which this DIM supplement supports healthy estrogen metabolism and hormone balance.

DIM Hormone Balance For Women and Men

This DIM supplement for women supports healthy estrogen clearance, hormone balance, and estrogen 2-hydroxylation. Consistent with DIM’s role in estrogen metabolism support, it is also relevant as a DIM supplement for men: men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormone balance, particularly in the context of age related increases in aromatase activity. DIM 200mg daily supports healthy estrogen metabolism and hormone balance in both sexes.

Phase I & II Liver Detoxification

DIM induces cytochrome P450 enzymes (CYP1A1, CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule (Once Daily with Food)

Servings Per Container: 120 (2 to 4-month supply at 1 capsule per day)

Ingredient
Amount Per
Serving
% Daily
Value
3,3'-Diindolylmethane (DIM)
200 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Clinical pharmacology of 3,3'-diindolylmethane administered as a single agent and in combination with tamoxifen in women with breast cancer

Nutrition and Cancer, 2004

This clinical study examined the pharmacokinetics and effects of oral DIM supplementation on urinary estrogen metabolite ratios in women. The study found that DIM supplementation significantly increased the urinary 2-OHE1 to 16-OHE1 ratio confirming that oral DIM supplementation produces measurable shifts in estrogen metabolism toward the favorable 2-hydroxylation pathway in humans. This is one of the key clinical studies confirming that the mechanism observed in cell studies translates to measurable estrogen metabolism changes in human subjects, directly supporting DIM's licensed use for estrogen metabolism and hormone balance support.

Diindolylmethane (DIM) selectively inhibits cancer stem cells

Annals of the New York Academy of Sciences, 1999

This comprehensive review by Bradlow and colleagues the leading researchers on indole phytochemicals and estrogen metabolism examined the multifunctional mechanisms of indole-3-carbinol and its primary metabolite DIM on estrogen metabolism and hormonal balance. The review established that DIM promotes the 2-hydroxylation pathway of estrogen metabolism, supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing, and modulates aromatase activity. The review confirmed DIM as the primary bioactive end product of I3C metabolism responsible for the estrogen-modulating effects of cruciferous vegetable consumption directly supporting all three of this formula's licensed mechanism claims.

Indole-3-carbinol and 3,3'-diindolylmethane induce expression of estrogen metabolism genes in normal breast epithelial cells

Journal of Nutrition, 2003

This study examined the effects of DIM (3,3'-Diindolylmethane) on estrogen metabolism gene expression in normal human breast epithelial cells. The study found that DIM significantly induced the expression of CYP1A1 and CYP1A2 the cytochrome P450 enzymes responsible for 2-hydroxylation of estrogen increasing the production of 2-hydroxyestrone (2-OHE1) relative to 16-alpha-hydroxyestrone (16-OHE1). The findings directly establish DIM's mechanism of action for supporting healthy estrogen metabolism via the 2-hydroxylation pathway the primary licensed mechanism underlying this formula's estrogen metabolism and hormone balance support claims.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is DIM and what does it do?

DIM (3,3'-Diindolylmethane) is the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables such as broccoli, cauliflower, Brussels sprouts, and cabbage. DIM is not found directly in food it is produced in the acidic environment of the stomach when I3C undergoes acid-catalyzed condensation during digestion. DIM supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway increasing the ratio of beneficial 2-hydroxyestrone (2-OHE1) to less favorable 16-alpha-hydroxyestrone (16-OHE1). It also supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination.

How does DIM support estrogen metabolism?

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1) a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1) a strongly estrogenic metabolite associated with less favorable hormonal activity. DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance. DIM also induces cytochrome P450 enzymes (CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation and supports Phase II conjugation enzymes that facilitate estrogen elimination.

Is DIM only for women or can men take it too?

DIM supports healthy estrogen metabolism in both women and men. While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone the enzyme aromatase (CYP19A1) converts androgens to estrogens. Age related increases in aromatase activity can shift the testosterone to estrogen ratio unfavorably in men. DIM supports healthy aromatase regulation and healthy estrogen clearance, making it relevant for men seeking to support healthy testosterone to estrogen balance. Ask a healthcare practitioner before use if you are taking medications or natural health products.

How does DIM support liver detoxification?

DIM supports both Phase I and Phase II hepatic detoxification pathways involved in estrogen processing and elimination. In Phase I, DIM induces cytochrome P450 enzymes particularly CYP1A1 and CYP1A2 that hydroxylate estrogen into water soluble metabolites for further processing. In Phase II, DIM supports conjugation enzymes including glutathione S-transferase that attach polar groups to estrogen metabolites, making them water soluble and ready for excretion in bile or urine. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently. Consult a healthcare practitioner before use if you have a liver disorder.

Who should not take DIM?

Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner before use if you are attempting to conceive. Ask a healthcare practitioner before use if you are taking any medications or natural health products. Ask a healthcare practitioner before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruation. Ask a healthcare practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance. Stop use and ask a healthcare practitioner if you develop liver related symptoms such as yellowing of the eyes or skin, dark urine, abdominal pain, or jaundice, or if symptoms of low estrogen develop.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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