Nicotinamide mononucleotide (NMN) supplementation increases blood NAD+ levels in healthy adults: a randomized, double blind, placebo controlled trial
npj Aging and Mechanisms of Disease, 2022
Each capsule delivers 500mg of pure nicotinamide mononucleotide (NMN), the immediate biosynthetic precursor to NAD+ (nicotinamide adenine dinucleotide). One step from NAD+. No fillers beyond standard capsule excipients.
Health Canada licensed NPN 80132879. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.
A pure nicotinamide mononucleotide (NMN) supplement providing 500mg per vegan capsule. NMN is a naturally occurring nucleotide and the immediate precursor to NAD+ in the Preiss-Handler biosynthesis pathway.
NAD+ is a coenzyme found in every living cell, essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes. NAD+ levels decline significantly with age, a decline now recognized as a central mechanism in the biology of aging. NMN supplementation supports NAD+ biosynthesis, helping to restore the NAD+ levels needed for healthy cellular function.
Licensed by Health Canada under NPN 80132879. Manufactured in Canada to GMP standards. Vegan. Gluten free. Non-GMO.
NAD+ participates in over 500 enzymatic reactions in the human body. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age. This decline is driven by increased NAD+ consumption by PARP enzymes responding to accumulated DNA damage, and by CD38, an NAD+-consuming enzyme that increases with age, combined with reduced biosynthesis capacity.
NMN is produced endogenously from nicotinamide riboside (NR) by the enzyme NRK, and is converted directly to NAD+ by NMNAT (nicotinamide mononucleotide adenylyltransferase). Because NMN is one step closer to NAD+ than other precursors such as niacin or nicotinamide, it is one of the most direct and efficient routes to raising cellular NAD+ levels. Human clinical studies show significant increases in blood NAD+ levels within hours of oral NMN supplementation.
NAD+ is the primary electron carrier in oxidative phosphorylation, the mitochondrial process that produces ATP. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy-dependent functions. NMN supports NAD+ biosynthesis, helping to maintain mitochondrial function and energy production capacity across tissues.
Sirtuins (SIRT1 through SIRT7) are NAD+-dependent enzymes that regulate gene expression, DNA repair, mitochondrial biogenesis, inflammatory response, and metabolic adaptation. Sirtuin activity is directly proportional to NAD+ availability. By supporting NAD+ biosynthesis, NMN helps maintain sirtuin-mediated cellular regulatory functions in aging tissues.
PARP enzymes are the primary DNA repair enzymes in human cells, consuming NAD+ to synthesize poly ADP-ribose chains that coordinate the DNA repair response. Maintaining NAD+ substrate availability through NMN supplementation supports healthy PARP-mediated DNA repair activity and genomic integrity.
Human studies have examined NMN supplementation at doses of 250mg to 1200mg per day. The 500mg dose in this formula falls within the range most commonly studied. Research outcomes include increases in blood NAD+ levels, improvements in muscle insulin sensitivity, support for physical performance and endurance, and favorable effects on markers of metabolic health.
Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.
Adults: Take 1 capsule daily with or without food, or as directed by a healthcare practitioner.
NMN can be taken at any time of day. Some individuals prefer morning dosing to align with the circadian rhythm of NAD+ metabolism. Consistent daily use over several weeks is recommended before assessing effects on energy and cellular function.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism.
Store in a cool, dry place away from direct sunlight and moisture. NMN is sensitive to heat and humidity. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.
NPN 80132879. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Each capsule delivers 500mg of pure nicotinamide mononucleotide (NMN), the immediate biosynthetic precursor to NAD+ (nicotinamide adenine dinucleotide). One step from NAD+. No fillers beyond standard capsule excipients.
Health Canada licensed NPN 80132879. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.
A pure nicotinamide mononucleotide (NMN) supplement providing 500mg per vegan capsule. NMN is a naturally occurring nucleotide and the immediate precursor to NAD+ in the Preiss-Handler biosynthesis pathway.
NAD+ is a coenzyme found in every living cell, essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes. NAD+ levels decline significantly with age, a decline now recognized as a central mechanism in the biology of aging. NMN supplementation supports NAD+ biosynthesis, helping to restore the NAD+ levels needed for healthy cellular function.
Licensed by Health Canada under NPN 80132879. Manufactured in Canada to GMP standards. Vegan. Gluten free. Non-GMO.
NAD+ participates in over 500 enzymatic reactions in the human body. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age. This decline is driven by increased NAD+ consumption by PARP enzymes responding to accumulated DNA damage, and by CD38, an NAD+-consuming enzyme that increases with age, combined with reduced biosynthesis capacity.
NMN is produced endogenously from nicotinamide riboside (NR) by the enzyme NRK, and is converted directly to NAD+ by NMNAT (nicotinamide mononucleotide adenylyltransferase). Because NMN is one step closer to NAD+ than other precursors such as niacin or nicotinamide, it is one of the most direct and efficient routes to raising cellular NAD+ levels. Human clinical studies show significant increases in blood NAD+ levels within hours of oral NMN supplementation.
NAD+ is the primary electron carrier in oxidative phosphorylation, the mitochondrial process that produces ATP. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy-dependent functions. NMN supports NAD+ biosynthesis, helping to maintain mitochondrial function and energy production capacity across tissues.
Sirtuins (SIRT1 through SIRT7) are NAD+-dependent enzymes that regulate gene expression, DNA repair, mitochondrial biogenesis, inflammatory response, and metabolic adaptation. Sirtuin activity is directly proportional to NAD+ availability. By supporting NAD+ biosynthesis, NMN helps maintain sirtuin-mediated cellular regulatory functions in aging tissues.
PARP enzymes are the primary DNA repair enzymes in human cells, consuming NAD+ to synthesize poly ADP-ribose chains that coordinate the DNA repair response. Maintaining NAD+ substrate availability through NMN supplementation supports healthy PARP-mediated DNA repair activity and genomic integrity.
Human studies have examined NMN supplementation at doses of 250mg to 1200mg per day. The 500mg dose in this formula falls within the range most commonly studied. Research outcomes include increases in blood NAD+ levels, improvements in muscle insulin sensitivity, support for physical performance and endurance, and favorable effects on markers of metabolic health.
Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.
Adults: Take 1 capsule daily with or without food, or as directed by a healthcare practitioner.
NMN can be taken at any time of day. Some individuals prefer morning dosing to align with the circadian rhythm of NAD+ metabolism. Consistent daily use over several weeks is recommended before assessing effects on energy and cellular function.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism.
Store in a cool, dry place away from direct sunlight and moisture. NMN is sensitive to heat and humidity. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.
NPN 80132879. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Serving Size: 1 Capsule
Servings Per Container: 60
† Daily Value not established
npj Aging and Mechanisms of Disease, 2022
Frontiers in Nutrition, 2022
Nature Reviews Molecular Cell Biology, 2021
Research information is provided for educational purposes and does not replace the product's approved label information.