Magnesium malate and malic acid supplementation in fibromyalgia: a randomized double blind placebo controlled crossover trial
Journal of Rheumatology, 1995
Each vegan capsule delivers 100mg of elemental magnesium from 500mg of magnesium malate. Magnesium paired with malic acid, a direct intermediate in the Krebs cycle, for dual support of magnesium replenishment and cellular energy metabolism. Gentle on digestion.
Health Canada licensed NPN 80142901. Made in Canada. 300 vegan capsules, 75 to 150 day supply at 2 to 4 capsules per day.
A magnesium malate supplement providing 100mg of elemental magnesium per vegan capsule from 500mg of magnesium malate. Magnesium malate is a chelated form in which magnesium is bound to malic acid, an organic acid that is both a natural component of fruit and a direct intermediate in the Krebs cycle.
This dual-function form supports magnesium replenishment and cellular energy metabolism simultaneously. It is the preferred magnesium form for energy, muscle, and metabolic support, and is well tolerated by individuals who experience digestive discomfort with inorganic magnesium forms such as magnesium oxide.
Licensed by Health Canada under NPN 80142901. Manufactured in Canada to GMP standards. Vegan. Gluten free. Non-GMO.
Malic acid is a four-carbon dicarboxylic acid and a direct intermediate in the Krebs cycle (citric acid cycle), the mitochondrial pathway that oxidizes acetyl-CoA to generate NADH and FADH2 for ATP production via oxidative phosphorylation. By delivering malic acid alongside magnesium, magnesium malate provides substrate directly to the Krebs cycle while simultaneously replenishing the magnesium required to activate the ATP synthase and other Krebs cycle enzymes. ATP itself exists primarily as a magnesium-ATP complex in cells, making magnesium essential for every ATP-dependent reaction in the body.
Muscle contraction is initiated by calcium influx into muscle cells. Magnesium acts as a physiological calcium antagonist, facilitating muscle relaxation after contraction by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. This calcium-magnesium balance governs normal skeletal and cardiac muscle function. Magnesium deficiency is associated with impaired muscle relaxation, increased susceptibility to cramps, and reduced physical performance.
Approximately 60% of the body's total magnesium is stored in bone, where it is incorporated into the hydroxyapatite crystal lattice and influences bone mineral density and crystal structure. Magnesium is also required for the enzymatic activation of vitamin D, which in turn regulates intestinal calcium absorption. Without adequate magnesium, vitamin D cannot be fully activated and calcium cannot be efficiently absorbed or deposited into bone tissue.
Magnesium is one of the four primary intracellular electrolytes alongside sodium, potassium, and calcium. It is required for the sodium-potassium ATPase pump that maintains electrochemical gradients across cell membranes, which are essential for nerve impulse transmission, muscle contraction, and cellular hydration. Active individuals lose magnesium through sweat and have elevated daily requirements compared to sedentary adults.
Magnesium oxide has high elemental magnesium content by weight but poor bioavailability, with absorption rates as low as 4%. Unabsorbed magnesium oxide draws water into the colon via osmotic action, causing the laxative effect commonly associated with magnesium supplementation. Magnesium malate, as a chelated organic acid salt, is absorbed more efficiently in the small intestine, leaving less unabsorbed magnesium to reach the colon and significantly reducing the risk of digestive discomfort.
Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). Non-GMO. Gluten free. Dairy free. Soy free.
Adults 19 years and older: Take 1 to 2 capsules, 2 times per day, with or without food.
Start at the lower end of the dosage range and adjust as tolerated. Excessive intake may cause loose stools. Ask a healthcare practitioner for guidance on dosing for specific health conditions.
Do not use without medical supervision if you have kidney disease. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or are taking antibiotics, diuretics, or heart medications.
Excessive intake may cause loose stools. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Keep out of reach of children.
NPN 80142901. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Each vegan capsule delivers 100mg of elemental magnesium from 500mg of magnesium malate. Magnesium paired with malic acid, a direct intermediate in the Krebs cycle, for dual support of magnesium replenishment and cellular energy metabolism. Gentle on digestion.
Health Canada licensed NPN 80142901. Made in Canada. 300 vegan capsules, 75 to 150 day supply at 2 to 4 capsules per day.
A magnesium malate supplement providing 100mg of elemental magnesium per vegan capsule from 500mg of magnesium malate. Magnesium malate is a chelated form in which magnesium is bound to malic acid, an organic acid that is both a natural component of fruit and a direct intermediate in the Krebs cycle.
This dual-function form supports magnesium replenishment and cellular energy metabolism simultaneously. It is the preferred magnesium form for energy, muscle, and metabolic support, and is well tolerated by individuals who experience digestive discomfort with inorganic magnesium forms such as magnesium oxide.
Licensed by Health Canada under NPN 80142901. Manufactured in Canada to GMP standards. Vegan. Gluten free. Non-GMO.
Malic acid is a four-carbon dicarboxylic acid and a direct intermediate in the Krebs cycle (citric acid cycle), the mitochondrial pathway that oxidizes acetyl-CoA to generate NADH and FADH2 for ATP production via oxidative phosphorylation. By delivering malic acid alongside magnesium, magnesium malate provides substrate directly to the Krebs cycle while simultaneously replenishing the magnesium required to activate the ATP synthase and other Krebs cycle enzymes. ATP itself exists primarily as a magnesium-ATP complex in cells, making magnesium essential for every ATP-dependent reaction in the body.
Muscle contraction is initiated by calcium influx into muscle cells. Magnesium acts as a physiological calcium antagonist, facilitating muscle relaxation after contraction by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. This calcium-magnesium balance governs normal skeletal and cardiac muscle function. Magnesium deficiency is associated with impaired muscle relaxation, increased susceptibility to cramps, and reduced physical performance.
Approximately 60% of the body's total magnesium is stored in bone, where it is incorporated into the hydroxyapatite crystal lattice and influences bone mineral density and crystal structure. Magnesium is also required for the enzymatic activation of vitamin D, which in turn regulates intestinal calcium absorption. Without adequate magnesium, vitamin D cannot be fully activated and calcium cannot be efficiently absorbed or deposited into bone tissue.
Magnesium is one of the four primary intracellular electrolytes alongside sodium, potassium, and calcium. It is required for the sodium-potassium ATPase pump that maintains electrochemical gradients across cell membranes, which are essential for nerve impulse transmission, muscle contraction, and cellular hydration. Active individuals lose magnesium through sweat and have elevated daily requirements compared to sedentary adults.
Magnesium oxide has high elemental magnesium content by weight but poor bioavailability, with absorption rates as low as 4%. Unabsorbed magnesium oxide draws water into the colon via osmotic action, causing the laxative effect commonly associated with magnesium supplementation. Magnesium malate, as a chelated organic acid salt, is absorbed more efficiently in the small intestine, leaving less unabsorbed magnesium to reach the colon and significantly reducing the risk of digestive discomfort.
Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). Non-GMO. Gluten free. Dairy free. Soy free.
Adults 19 years and older: Take 1 to 2 capsules, 2 times per day, with or without food.
Start at the lower end of the dosage range and adjust as tolerated. Excessive intake may cause loose stools. Ask a healthcare practitioner for guidance on dosing for specific health conditions.
Do not use without medical supervision if you have kidney disease. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or are taking antibiotics, diuretics, or heart medications.
Excessive intake may cause loose stools. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Keep out of reach of children.
NPN 80142901. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Serving Size: 1–2 Capsules (2 Times Per Day)
Servings Per Container: 75–150
† Daily Value not established
Journal of Rheumatology, 1995
Nutrients, 2013
Magnesium Research, 2014
Research information is provided for educational purposes and does not replace the product's approved label information.