Vitamin B12 5000mcg | Methylcobalamin | Active Coenzyme Form | High Potency | 60 Vegan Capsules

Each vegan capsule delivers 5000mcg of Vitamin B12 as methylcobalamin, the active coenzyme form found in human blood and tissues, directly usable without conversion. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, effective even for those with reduced intrinsic factor function.

Helps to form red blood cells. Helps in energy metabolism in the body. Helps in the normal function of the immune system. Helps to maintain the body's ability to metabolize nutrients. Health Canada licensed NPN 80070568. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.

Source

Methylcobalamin is produced synthetically via microbial fermentation and chemical synthesis, yielding pharmaceutical-grade vitamin B12 in the active coenzyme form. It is not derived from animal sources and is suitable for vegans and vegetarians. Methylcobalamin is the form of B12 found naturally in human blood and tissues, identical in structure to the endogenous active form.

What Is Vitamin B12?

Vitamin B12 (cobalamin) is an essential water-soluble vitamin and the largest and most structurally complex of all vitamins. It is unique in containing a metal ion (cobalt) at its centre, which is why it is called cobalamin. B12 is found almost exclusively in animal-derived foods including meat, fish, shellfish, dairy, and eggs. Plant foods do not contain meaningful amounts of bioavailable B12, making supplementation particularly important for vegans and vegetarians. B12 is required for DNA synthesis, red blood cell formation, and normal nervous system function, and works closely with folate (vitamin B9) in one-carbon metabolism.

What Is the Difference Between Methylcobalamin and Cyanocobalamin?

Cyanocobalamin is the synthetic form used in most B12 supplements and fortified foods. It must be converted to methylcobalamin or adenosylcobalamin in the body before it can be used, releasing a small amount of cyanide in the process (at non-toxic levels). Methylcobalamin is the active coenzyme form found in human blood and tissues and is directly usable without conversion. This formula provides methylcobalamin exclusively, the form the body uses without any intermediate metabolic step.

Key Benefits

• Helps to form red blood cells Health Canada licensed claim under NPN 80070568
• Helps in energy metabolism in the body Health Canada licensed claim under NPN 80070568
• Helps in the normal function of the immune system Health Canada licensed claim under NPN 80070568
• Helps to maintain the body's ability to metabolize nutrients Health Canada licensed claim under NPN 80070568
• 5000mcg methylcobalamin per capsule Active coenzyme form | Directly usable without conversion
• High potency dose At 5000mcg, passive diffusion absorbs approximately 50mcg independent of intrinsic factor | Effective for those with reduced intrinsic factor function
• Source: synthetically produced methylcobalamin Vegan, not animal derived | Identical to the endogenous active form in human blood and tissues
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Health Canada licensed NPN 80070568 | GMP certified | Made in Canada
• 60 vegan capsules 60 day supply at 1 capsule per day

How It Works

B12 Absorption: Intrinsic Factor and Passive Diffusion

B12 is absorbed through two distinct mechanisms. The primary mechanism is intrinsic factor (IF) mediated absorption: intrinsic factor is a protein produced by the parietal cells of the stomach lining, and the B12-IF complex is absorbed in the terminal ileum. This mechanism is highly efficient but saturable, absorbing a maximum of approximately 1.5 to 2mcg per meal regardless of dose. The secondary mechanism is passive diffusion: approximately 1% of any oral B12 dose is absorbed by passive diffusion across the intestinal lining, independent of intrinsic factor and without saturation. At 5000mcg, passive diffusion alone absorbs approximately 50mcg, a clinically meaningful amount that does not depend on intrinsic factor function.

Why Intrinsic Factor Function Matters

Intrinsic factor production can be impaired by aging, autoimmune conditions (pernicious anemia), gastric surgery, atrophic gastritis, and long-term use of proton pump inhibitors or H2 blockers. Metformin also reduces B12 absorption in the intestine. When intrinsic factor function is reduced, the high potency 5000mcg dose ensures that passive diffusion alone delivers a meaningful amount of B12, making this formula effective across a wide range of absorption capacities.

Methylcobalamin in One-Carbon Metabolism

Methylcobalamin is the active coenzyme form of B12 required for methionine synthase, the enzyme that converts homocysteine to methionine using a methyl group donated by methyltetrahydrofolate (MTHF). This reaction is central to one-carbon metabolism, which supports DNA synthesis, red blood cell formation, and methylation reactions throughout the body. B12 and folate work together in this pathway, which is why B12 deficiency and folate deficiency produce similar hematological effects (megaloblastic anemia).

Who May Particularly Benefit from High Potency B12

Vegans and vegetarians, as B12 is found almost exclusively in animal-derived foods. Older adults, as intrinsic factor production declines with age. Those taking metformin, proton pump inhibitors, or H2 blockers long-term, as these reduce B12 absorption. Those with confirmed low B12 levels who want a high-potency oral supplement. Those who prefer methylcobalamin (active form) over cyanocobalamin (synthetic form requiring conversion).

Medicinal Ingredient (per capsule)

• Vitamin B12 (Methylcobalamin) 5000mcg Source: synthetically produced methylcobalamin | Active coenzyme form | Directly usable without conversion | Helps to form red blood cells | Helps in energy metabolism | Helps in the normal function of the immune system | Helps to maintain the body's ability to metabolize nutrients | NPN 80070568

Non-medicinal ingredients: Magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO.

Quality and Trust

• NPN 80070568 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Methylcobalamin form Active coenzyme B12, directly usable without conversion
• Source: synthetically produced methylcobalamin Vegan, not animal derived
• 5000mcg per capsule High potency dose supporting absorption via passive diffusion
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Non-GMO
• 60 vegan capsules 60 day supply at 1 capsule per day

Who This Is For

• Consult a healthcare practitioner for use beyond 4 months Health Canada licensed duration of use restriction
• Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes
• Adults seeking high-potency methylcobalamin B12 for red blood cell formation, energy metabolism, immune function, and nutrient metabolism support
• Vegans and vegetarians with limited dietary B12 intake
• Older adults, those taking metformin, or those on long-term proton pump inhibitors or H2 blockers with reduced B12 absorption capacity
• Those who prefer the active methylcobalamin form over cyanocobalamin

How to Use

Adults: Take 1 capsule once daily, with or without food. Consult a healthcare practitioner for use beyond 4 months.

Safety and Cautions

Consult a healthcare practitioner for use beyond 4 months. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Store in a cool, dry place away from direct sunlight and moisture. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80070568. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.