Berberine HCL 500mg | AMPK Activator | Metabolic and Blood Sugar Support | 60 Vegan Capsules

500mg of 97% pure berberine hydrochloride per vegan capsule, extracted from Berberis aristata root. Activates AMPK through five complementary mechanisms to support healthy blood glucose metabolism. Take with meals. Health Canada licensed NPN 80129371. Made in Canada.

Key Benefits

• Helps maintain healthy blood glucose levels already within the normal range Health Canada licensed claim under NPN 80129371
• AMPK activation Activates AMP-activated protein kinase by inhibiting mitochondrial complex I, governing glucose uptake, insulin sensitivity, and fatty acid oxidation
• GLUT4 translocation Promotes insulin-independent glucose uptake in skeletal muscle via GLUT4 transporter translocation
• Reduced hepatic glucose output Downregulates PEPCK and G6Pase, suppressing gluconeogenesis and glycogenolysis in the liver
• Alpha glucosidase inhibition Slows intestinal carbohydrate digestion, blunting postprandial blood glucose response
• Gut microbiome modulation Increases short-chain fatty acid producing bacteria, improving gut barrier integrity and insulin receptor expression

What This Is

A pure berberine hydrochloride supplement from Berberis aristata root. Berberine is a quaternary ammonium alkaloid and one of the most extensively studied botanical compounds in metabolic health research.

Intended for proactive metabolic wellness support in adults with blood glucose already within the normal range. Not a substitute for medical care or prescribed medications. Licensed by Health Canada under NPN 80129371. Vegan. Gluten free. Non-GMO.

How It Works

AMPK: The Master Metabolic Regulator

Berberine inhibits mitochondrial complex I, raising the AMP-to-ATP ratio and triggering the AMPK signalling cascade that governs glucose uptake, fatty acid oxidation, and suppression of gluconeogenesis. This mechanism is analogous to that of metformin, though berberine operates through partially distinct downstream pathways.

GLUT4 Translocation and Cellular Glucose Uptake

AMPK activation promotes GLUT4 transporter translocation to skeletal muscle cell membranes independently of insulin, increasing cellular glucose uptake in conditions of reduced insulin sensitivity.

Hepatic Glucose Production

Berberine-mediated AMPK activation in hepatocytes downregulates PEPCK and G6Pase, reducing fasting glucose output from the liver.

Alpha Glucosidase Inhibition

Berberine inhibits intestinal alpha glucosidase enzymes, slowing carbohydrate digestion and blunting the postprandial blood glucose rise after meals.

Gut Microbiome Modulation

Despite oral bioavailability estimated below 5%, berberine produces significant metabolic effects in the GI tract by selectively modulating gut microbiota, increasing short-chain fatty acid producing bacteria and improving gut barrier integrity and insulin receptor expression.

Medicinal Ingredient (per capsule)

• Berberine HCL (Berberis aristata, root) 500mg 97% pure | NPN 80129371

Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.

Per Daily Dose (2 Capsules)

• Berberine HCL: 1000mg

Quality and Trust

• NPN 80129371 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Independently tested Purity and potency verified by a third-party laboratory
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Non-GMO and gluten free
• 60 vegan capsules 30 day supply at 2 capsules per day

Who This Is For

• Do not use if pregnant or breastfeeding
• Consult a healthcare practitioner before use if you have gallstones, diabetes, liver disorder, cardiovascular disease, blood disorders, leucopenia, hypoglycemia, hypotension, or kidney disorder
• Individuals taking antidiabetic medications must consult a healthcare practitioner before use due to potential additive blood glucose lowering effects
• Adults with blood glucose within the normal range seeking proactive metabolic support through AMPK activation

How to Use

Adults: Take 1 capsule, 2 times per day, with meals. Taking with food supports alpha glucosidase inhibitory activity and reduces gastrointestinal discomfort. For use beyond 3 months, consult a healthcare practitioner.

Safety and Cautions

Do not use if pregnant or breastfeeding. Consult a healthcare practitioner before use if you have gallstones, diabetes, liver disorder, cardiovascular disease, blood disorders, leucopenia, hypoglycemia, hypotension, blood pressure problems, or kidney disorder. Individuals taking antidiabetic medications should consult a healthcare practitioner before use. May cause gastrointestinal discomfort including constipation, vomiting, abdominal pain, or diarrhea. Store in a cool, dry place. Keep out of reach of children.

NPN 80129371. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.