Glycine 1000mg | Sleep, Collagen, Protein Synthesis and Workout Recovery | 120 Vegan Capsules

Each vegan capsule delivers 1000mg of pure free-form glycine, the simplest and most abundant amino acid in the human body. Glycine functions simultaneously as a structural amino acid, an inhibitory neurotransmitter, a NMDA receptor co-agonist, and a precursor to collagen, creatine, and glutathione.

Health Canada licensed NPN 80139967. Made in Canada. 120 vegan capsules, up to a 4 month supply at 1 capsule per day.

Key Benefits

• Sleep quality support Glycine lowers core body temperature via peripheral vasodilation and modulates suprachiasmatic nucleus activity, supporting sleep onset and sleep depth without sedation or grogginess
• Collagen synthesis support Glycine occupies every third position in the collagen triple helix (Gly-X-Y repeating sequence) and is the rate-limiting amino acid for collagen production in skin, tendons, ligaments, cartilage, and bone
• Protein synthesis Fundamental non-essential amino acid used across multiple biosynthetic pathways including collagen, creatine, glutathione, heme, purines, and bile acids
• Workout recovery support Glycine is a precursor to creatine (alongside arginine and methionine), supporting ATP regeneration in muscle tissue, and supports connective tissue repair after training
• Cognitive function support Glycine is a co-agonist at NMDA glutamate receptors, which are essential for synaptic plasticity, learning, and memory consolidation
• Glutathione precursor One of three amino acids required for glutathione synthesis | Glycine availability is often the rate-limiting factor in glutathione production, particularly in older adults
• Healthy inflammatory response Supports cellular antioxidant defence via glutathione synthesis
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Health Canada licensed NPN 80139967 | GMP certified | Made in Canada
• 120 vegan capsules Up to a 4 month supply at 1 capsule per day

What This Is

A pure free-form glycine supplement providing 1000mg per vegan capsule. Glycine is the smallest of the 20 standard amino acids and the most abundant amino acid in collagen, comprising approximately 33% of all amino acids in the collagen triple helix.

Despite being classified as non-essential, glycine is considered conditionally essential. Endogenous synthesis provides approximately 2 to 3 grams per day, while total physiological demand may reach 10 to 15 grams per day, creating a significant glycine gap that dietary and supplemental glycine can help address. Licensed by Health Canada under NPN 80139967. Vegan. Gluten free. Non-GMO.

How It Works

Glycine and Sleep Quality

Glycine is an inhibitory neurotransmitter in the spinal cord and brainstem. It supports sleep onset by promoting peripheral vasodilation, which lowers core body temperature, a key physiological trigger for sleep. It also modulates neurotransmitter activity in the suprachiasmatic nucleus, the brain's circadian clock, supporting healthy sleep architecture. Clinical research on glycine supplementation (typically 3g before bed) demonstrates improvements in subjective sleep quality, reduced sleep onset time, and improved next-day alertness without sedation or grogginess.

Glycine and Collagen Synthesis

Collagen is the most abundant protein in the human body, found in skin, tendons, ligaments, cartilage, bone, and blood vessels. Glycine occupies every third position in the collagen triple helix (the repeating Gly-X-Y sequence) and is the rate-limiting amino acid for collagen production. Research suggests endogenous glycine synthesis is insufficient to fully support collagen production at optimal rates, making supplemental glycine an important contributor to skin integrity, joint health, and connective tissue maintenance.

Glycine as a Workout and Recovery Supplement

Glycine supports physical performance through two primary pathways. First, as a precursor to creatine (alongside arginine and methionine), glycine contributes to the body's creatine pool, which supports ATP regeneration in muscle tissue during high-intensity exercise. Second, as the primary structural amino acid in collagen, glycine supports the synthesis and repair of tendons, ligaments, and cartilage stressed during training. Glycine's sleep quality support further enhances recovery, as sleep is the primary window for muscle protein synthesis and physical adaptation.

Glycine and Cognitive Function

Glycine functions as a co-agonist at NMDA (N-methyl-D-aspartate) glutamate receptors in the brain. NMDA receptor activation requires both glutamate and glycine binding simultaneously. NMDA receptor activity is essential for long-term potentiation, synaptic plasticity, learning, and memory consolidation. By supporting healthy NMDA receptor function, glycine contributes to cognitive processes including learning, memory, and mental clarity.

Glycine as a Glutathione Precursor

Glycine is one of three amino acids (alongside glutamate and cysteine) required for glutathione synthesis, the body's primary endogenous antioxidant. Glycine availability is often the rate-limiting factor in glutathione production, particularly in older adults where both glycine intake and endogenous synthesis decline. Supporting glutathione synthesis through glycine supplementation contributes to antioxidant defence capacity and cellular protection against oxidative stress.

Medicinal Ingredient (per capsule)

• Glycine (free form amino acid) 1000mg Supports sleep quality, collagen synthesis, protein synthesis, workout recovery, cognitive function, and glutathione synthesis | NPN 80139967

Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives. Vegan. Gluten free. Non-GMO.

Per Daily Dose

• At 1 capsule per day: Glycine 1000mg | Up to 4 month supply
• At 3 capsules before bed: Glycine 3000mg | Sleep quality support dose used in clinical research | 40 day supply

Quality and Trust

• NPN 80139967 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Independently tested Purity and potency verified by a third-party laboratory
• 1000mg pure free-form glycine per capsule Optimal absorption as free-form amino acid
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Non-GMO and gluten free
• 120 vegan capsules Up to a 4 month supply at 1 capsule per day

Who This Is For

• Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have kidney disease, or are taking medications that affect NMDA receptor activity including certain antipsychotic or antiepileptic medications
• Adults seeking non-sedating, non-habit-forming sleep quality support from a fundamental amino acid
• Active individuals and athletes seeking connective tissue repair, creatine precursor support, and workout recovery
• Those supporting collagen synthesis, skin integrity, and joint health
• Individuals seeking cognitive function support and glutathione precursor activity from a single amino acid supplement

How to Use

Adults: Take 1 to 3 capsules daily, or as directed by a healthcare practitioner.

For sleep quality support: Take 3 capsules (3000mg) 30 to 60 minutes before bedtime.
For collagen, protein synthesis, and cognitive support: Take 1 to 2 capsules daily with or without food.
For workout recovery: Take 1 to 3 capsules post-workout or before bed.

Safety and Cautions

Glycine is generally well tolerated at supplemental doses. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have kidney disease, or are taking medications that affect NMDA receptor activity including certain antipsychotic or antiepileptic medications.

Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80139967. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.