Magnesium and human health: perspectives and research directions
International Journal of Endocrinology, 2018
Each capsule delivers 150 mg of elemental magnesium from 967.7 mg of magnesium citrate (citrate de magnesium / citrato de magnesio) one of the most bioavailable and well tolerated forms of supplemental magnesium. Magnesium citrate is a chelated compound formed by bonding elemental magnesium to citric acid, improving solubility and gastrointestinal tolerability compared to inorganic forms such as magnesium oxide.
Magnesium oxide has high elemental magnesium content by weight but poor bioavailability absorption rates as low as 4% and commonly causes loose stools through osmotic action in the colon. Magnesium citrate, as a chelated organic acid salt, is absorbed more efficiently in the small intestine, leaving less unabsorbed magnesium to reach the colon. Each 967.7 mg of magnesium citrate provides 150 mg of elemental magnesium the biologically active form that participates in enzymatic reactions throughout the body.
ATP the cell’s primary energy currency must be bound to magnesium to be biologically active. Magnesium is a required cofactor for over 300 enzymatic reactions, including those governing glycolysis, the citric acid cycle, and oxidative phosphorylation the three core pathways of cellular energy metabolism. Adequate magnesium is essential for the body’s ability to produce and utilize cellular energy.
Approximately 60% of the body’s magnesium is stored in bone, where it is required for vitamin D activation which in turn regulates intestinal calcium absorption and bone mineralization. Calcium triggers muscle contraction; magnesium enables muscle relaxation by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. As a primary intracellular electrolyte, magnesium supports the sodium-potassium ATPase pump, nerve signal transmission, and neuromuscular coordination.
Each capsule delivers 150 mg of elemental magnesium from 967.7 mg of magnesium citrate (citrate de magnesium / citrato de magnesio) one of the most bioavailable and well tolerated forms of supplemental magnesium. Magnesium citrate is a chelated compound formed by bonding elemental magnesium to citric acid, improving solubility and gastrointestinal tolerability compared to inorganic forms such as magnesium oxide.
Magnesium oxide has high elemental magnesium content by weight but poor bioavailability absorption rates as low as 4% and commonly causes loose stools through osmotic action in the colon. Magnesium citrate, as a chelated organic acid salt, is absorbed more efficiently in the small intestine, leaving less unabsorbed magnesium to reach the colon. Each 967.7 mg of magnesium citrate provides 150 mg of elemental magnesium the biologically active form that participates in enzymatic reactions throughout the body.
ATP the cell’s primary energy currency must be bound to magnesium to be biologically active. Magnesium is a required cofactor for over 300 enzymatic reactions, including those governing glycolysis, the citric acid cycle, and oxidative phosphorylation the three core pathways of cellular energy metabolism. Adequate magnesium is essential for the body’s ability to produce and utilize cellular energy.
Approximately 60% of the body’s magnesium is stored in bone, where it is required for vitamin D activation which in turn regulates intestinal calcium absorption and bone mineralization. Calcium triggers muscle contraction; magnesium enables muscle relaxation by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. As a primary intracellular electrolyte, magnesium supports the sodium-potassium ATPase pump, nerve signal transmission, and neuromuscular coordination.
Serving Size: 1 Capsule
Servings Per Container: 120
Based on a 2,000 calorie diet. Daily Value based on 420mg for adults 19+
International Journal of Endocrinology, 2018
Journal of Pharmacy and Pharmacology, 2001
Nutrients, 2021
Research information is provided for educational purposes and does not replace the product's approved label information.