{"product_id":"berberine-hcl-500mg-ampk-activator-metabolic-and-blood-sugar-support-60-vegan-capsules","title":"Berberine HCL 500mg | AMPK Activator | Metabolic and Blood Sugar Support | 60 Vegan Capsules","description":"\u003ch2\u003eBerberine HCL 500mg | AMPK Activator | Metabolic and Blood Sugar Support | 60 Vegan Capsules\u003c\/h2\u003e\n\n\u003cp\u003e500mg of 97% pure berberine hydrochloride per vegan capsule, extracted from \u003cem\u003eBerberis aristata\u003c\/em\u003e root. Activates AMPK through five complementary mechanisms to support healthy blood glucose metabolism. Take with meals. Health Canada licensed NPN 80129371. Made in Canada.\u003c\/p\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHelps maintain healthy blood glucose levels already within the normal range\u003c\/strong\u003e Health Canada licensed claim under NPN 80129371\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAMPK activation\u003c\/strong\u003e Activates AMP-activated protein kinase by inhibiting mitochondrial complex I, governing glucose uptake, insulin sensitivity, and fatty acid oxidation\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eGLUT4 translocation\u003c\/strong\u003e Promotes insulin-independent glucose uptake in skeletal muscle via GLUT4 transporter translocation\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eReduced hepatic glucose output\u003c\/strong\u003e Downregulates PEPCK and G6Pase, suppressing gluconeogenesis and glycogenolysis in the liver\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAlpha glucosidase inhibition\u003c\/strong\u003e Slows intestinal carbohydrate digestion, blunting postprandial blood glucose response\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eGut microbiome modulation\u003c\/strong\u003e Increases short-chain fatty acid producing bacteria, improving gut barrier integrity and insulin receptor expression\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eA pure berberine hydrochloride supplement from \u003cem\u003eBerberis aristata\u003c\/em\u003e root. Berberine is a quaternary ammonium alkaloid and one of the most extensively studied botanical compounds in metabolic health research.\u003c\/p\u003e\n\u003cp\u003eIntended for proactive metabolic wellness support in adults with blood glucose already within the normal range. Not a substitute for medical care or prescribed medications. Licensed by Health Canada under NPN 80129371. Vegan. Gluten free. Non-GMO.\u003c\/p\u003e\n\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\n\u003ch3\u003eAMPK: The Master Metabolic Regulator\u003c\/h3\u003e\n\u003cp\u003eBerberine inhibits mitochondrial complex I, raising the AMP-to-ATP ratio and triggering the AMPK signalling cascade that governs glucose uptake, fatty acid oxidation, and suppression of gluconeogenesis. This mechanism is analogous to that of metformin, though berberine operates through partially distinct downstream pathways.\u003c\/p\u003e\n\n\u003ch3\u003eGLUT4 Translocation and Cellular Glucose Uptake\u003c\/h3\u003e\n\u003cp\u003eAMPK activation promotes GLUT4 transporter translocation to skeletal muscle cell membranes independently of insulin, increasing cellular glucose uptake in conditions of reduced insulin sensitivity.\u003c\/p\u003e\n\n\u003ch3\u003eHepatic Glucose Production\u003c\/h3\u003e\n\u003cp\u003eBerberine-mediated AMPK activation in hepatocytes downregulates PEPCK and G6Pase, reducing fasting glucose output from the liver.\u003c\/p\u003e\n\n\u003ch3\u003eAlpha Glucosidase Inhibition\u003c\/h3\u003e\n\u003cp\u003eBerberine inhibits intestinal alpha glucosidase enzymes, slowing carbohydrate digestion and blunting the postprandial blood glucose rise after meals.\u003c\/p\u003e\n\n\u003ch3\u003eGut Microbiome Modulation\u003c\/h3\u003e\n\u003cp\u003eDespite oral bioavailability estimated below 5%, berberine produces significant metabolic effects in the GI tract by selectively modulating gut microbiota, increasing short-chain fatty acid producing bacteria and improving gut barrier integrity and insulin receptor expression.\u003c\/p\u003e\n\n\u003ch2\u003eMedicinal Ingredient (per capsule)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eBerberine HCL (Berberis aristata, root) 500mg\u003c\/strong\u003e 97% pure | NPN 80129371\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\n\u003ch2\u003ePer Daily Dose (2 Capsules)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eBerberine HCL: 1000mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNPN 80129371\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eIndependently tested\u003c\/strong\u003e Purity and potency verified by a third-party laboratory\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon-GMO and gluten free\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e60 vegan capsules\u003c\/strong\u003e 30 day supply at 2 capsules per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eDo not use if pregnant or breastfeeding\u003c\/li\u003e\n  \u003cli\u003eConsult a healthcare practitioner before use if you have gallstones, diabetes, liver disorder, cardiovascular disease, blood disorders, leucopenia, hypoglycemia, hypotension, or kidney disorder\u003c\/li\u003e\n  \u003cli\u003eIndividuals taking antidiabetic medications must consult a healthcare practitioner before use due to potential additive blood glucose lowering effects\u003c\/li\u003e\n  \u003cli\u003eAdults with blood glucose within the normal range seeking proactive metabolic support through AMPK activation\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule, 2 times per day, with meals. Taking with food supports alpha glucosidase inhibitory activity and reduces gastrointestinal discomfort. For use beyond 3 months, consult a healthcare practitioner.\u003c\/p\u003e\n\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eDo not use if pregnant or breastfeeding. Consult a healthcare practitioner before use if you have gallstones, diabetes, liver disorder, cardiovascular disease, blood disorders, leucopenia, hypoglycemia, hypotension, blood pressure problems, or kidney disorder. Individuals taking antidiabetic medications should consult a healthcare practitioner before use. May cause gastrointestinal discomfort including constipation, vomiting, abdominal pain, or diarrhea. Store in a cool, dry place. Keep out of reach of children.\u003c\/p\u003e\n\n\u003cp\u003eNPN 80129371. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":44666829799587,"sku":"N283","price":28.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Berberine_HCl_500_mg_97_percent_pure_60_vegan_capsules.jpg?v=1772742363","url":"https:\/\/nutridom.ca\/products\/berberine-hcl-500mg-ampk-activator-metabolic-and-blood-sugar-support-60-vegan-capsules","provider":"Nutridom","version":"1.0","type":"link"}