Calcium plus vitamin D supplementation and the risk of fractures
New England Journal of Medicine, 2006 Randomized controlled trial (Women's Health Initiative)
Three nutrients with distinct and interdependent roles in bone mineral metabolism in a single softgel. Calcium 300 mg (Calcium Carbonate) | Magnesium 150 mg (Magnesium Oxide) | Vitamin D3 200 IU / 5 mcg (Cholecalciferol). Helps in the development and maintenance of bones and teeth. Helps in the absorption and use of calcium and phosphorus.
Calcium (Calcium Carbonate) 300 mg
Calcium is the primary structural mineral of bone and tooth tissue, comprising approximately 70% of bone mineral as hydroxyapatite. Calcium Carbonate is the most concentrated supplemental form by elemental weight (40% elemental calcium), providing 300 mg of elemental calcium per softgel. Best absorbed when taken with food, as gastric acid produced during digestion facilitates dissolution and ionization. At 2 softgels per day, this formula provides 600 mg of elemental calcium.
Vitamin D3 (Cholecalciferol) 200 IU / 5 mcg
Cholecalciferol is the same form of Vitamin D produced in human skin upon UV-B exposure and the preferred supplemental form for raising serum 25(OH)D levels. In the body, it is converted in the liver to 25-hydroxyvitamin D and then in the kidneys to calcitriol its active hormonal form. Calcitriol stimulates the production of calcium-binding proteins (calbindins) in the intestinal wall, increasing calcium absorption from 10–15% (without adequate Vitamin D) to 30–40% (with sufficient Vitamin D). Without adequate Vitamin D3, dietary calcium cannot be efficiently absorbed regardless of intake.
Magnesium (Magnesium Oxide) 150 mg
Magnesium is required for the enzymatic activation of Vitamin D specifically, the hepatic and renal hydroxylation steps that convert cholecalciferol to calcitriol. Magnesium deficiency impairs this conversion, limiting the effectiveness of both Vitamin D and calcium supplementation. Magnesium also supports the active transport of calcium into bone tissue and is itself a structural component of the bone mineral matrix, with approximately 60% of the body’s magnesium stored in bone. It is a cofactor in over 300 enzymatic reactions including ATP synthesis, protein synthesis, and DNA repair.
Three nutrients with distinct and interdependent roles in bone mineral metabolism in a single softgel. Calcium 300 mg (Calcium Carbonate) | Magnesium 150 mg (Magnesium Oxide) | Vitamin D3 200 IU / 5 mcg (Cholecalciferol). Helps in the development and maintenance of bones and teeth. Helps in the absorption and use of calcium and phosphorus.
Calcium (Calcium Carbonate) 300 mg
Calcium is the primary structural mineral of bone and tooth tissue, comprising approximately 70% of bone mineral as hydroxyapatite. Calcium Carbonate is the most concentrated supplemental form by elemental weight (40% elemental calcium), providing 300 mg of elemental calcium per softgel. Best absorbed when taken with food, as gastric acid produced during digestion facilitates dissolution and ionization. At 2 softgels per day, this formula provides 600 mg of elemental calcium.
Vitamin D3 (Cholecalciferol) 200 IU / 5 mcg
Cholecalciferol is the same form of Vitamin D produced in human skin upon UV-B exposure and the preferred supplemental form for raising serum 25(OH)D levels. In the body, it is converted in the liver to 25-hydroxyvitamin D and then in the kidneys to calcitriol its active hormonal form. Calcitriol stimulates the production of calcium-binding proteins (calbindins) in the intestinal wall, increasing calcium absorption from 10–15% (without adequate Vitamin D) to 30–40% (with sufficient Vitamin D). Without adequate Vitamin D3, dietary calcium cannot be efficiently absorbed regardless of intake.
Magnesium (Magnesium Oxide) 150 mg
Magnesium is required for the enzymatic activation of Vitamin D specifically, the hepatic and renal hydroxylation steps that convert cholecalciferol to calcitriol. Magnesium deficiency impairs this conversion, limiting the effectiveness of both Vitamin D and calcium supplementation. Magnesium also supports the active transport of calcium into bone tissue and is itself a structural component of the bone mineral matrix, with approximately 60% of the body’s magnesium stored in bone. It is a cofactor in over 300 enzymatic reactions including ATP synthesis, protein synthesis, and DNA repair.
New England Journal of Medicine, 2006 Randomized controlled trial (Women's Health Initiative)
Molecular and Cellular Endocrinology, 2011 Peer reviewed review
Magnesium Research, 2021 Peer reviewed review
Research information is provided for educational purposes and does not replace the product's approved label information.