CoQ10 200mg | Ubiquinone | Cardiovascular and Cellular Energy Support | 120 Softgels

Each softgel delivers 200mg of Coenzyme Q10 (CoQ10) as ubiquinone, the oxidized form used as an electron carrier in the mitochondrial electron transport chain. Supports cardiovascular health, cellular energy production, and provides antioxidant protection.

Health Canada licensed NPN 80134929. Made in Canada. 120 softgels, 120 day supply at 1 softgel per day.

How This Product Is Made

CoQ10 (ubiquinone) is produced through microbial fermentation, the same biosynthetic pathway used by the human body to produce CoQ10 endogenously. Yeast or bacterial strains are fermented under controlled conditions to produce ubiquinone, which is then purified to pharmaceutical grade purity. The purified ubiquinone is formulated into a softgel with a lipid-based carrier to enhance absorption of this fat soluble compound. The softgels are manufactured in Canada in a GMP certified facility under Health Canada oversight.

What Is CoQ10 (Coenzyme Q10)?

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble, vitamin-like compound found in every cell of the human body. It exists in two primary forms: ubiquinone (the oxidized form, used as an electron carrier) and ubiquinol (the reduced form, the active antioxidant). The body interconverts these two forms continuously as part of normal cellular function. CoQ10 is most concentrated in organs with the highest energy demands: the heart, liver, kidneys, and skeletal muscle. The body produces CoQ10 endogenously, but production peaks in the mid-20s and declines progressively with age.

What Is the Difference Between Ubiquinone and Ubiquinol?

Ubiquinone is the oxidized form of CoQ10 and the form used in this formula. It is the form that functions as an electron carrier in the mitochondrial electron transport chain. Ubiquinol is the reduced form and the primary antioxidant form in the bloodstream. The body converts ubiquinone to ubiquinol after absorption. In healthy adults, the body efficiently converts supplemental ubiquinone to ubiquinol. Ubiquinol supplements are sometimes recommended for older adults or those with conditions that may impair this conversion, as conversion efficiency can decline with age.

Key Benefits

• Supports cardiovascular health The heart is the most energy-demanding organ in the body and contains the highest CoQ10 concentration of any tissue | CoQ10 is essential for cardiac ATP production
• Supports cellular energy production CoQ10 is an essential electron carrier in the mitochondrial electron transport chain, the primary pathway for ATP synthesis in all cells
• Antioxidant protection Ubiquinol (the reduced form, produced from supplemental ubiquinone after absorption) is one of the most potent lipid-soluble antioxidants in the body, protecting cell membranes and mitochondrial membranes from oxidative damage
• 200mg CoQ10 per softgel High-potency ubiquinone | At the upper end of commonly available supplemental doses
• Source: fermentation-derived ubiquinone Produced via microbial fermentation, the same biosynthetic pathway as endogenous CoQ10
• Softgel with lipid carrier Fat-soluble nutrient formulated for enhanced absorption
• Health Canada licensed NPN 80134929 | GMP certified | Made in Canada
• 120 softgels 120 day supply at 1 softgel per day

How It Works

CoQ10 and the Mitochondrial Electron Transport Chain

CoQ10 (ubiquinone) is an essential mobile electron carrier in the inner mitochondrial membrane. It accepts electrons from NADH (via Complex I) and FADH2 (via Complex II) and transfers them to Complex III (cytochrome bc1 complex). This electron transfer drives proton pumping across the inner mitochondrial membrane, generating the electrochemical gradient that powers ATP synthase (Complex V) to produce ATP. Without CoQ10, the electron transport chain cannot function and ATP production is severely impaired. The heart, which cannot store significant ATP reserves and must continuously regenerate it, is particularly dependent on CoQ10 for normal function.

CoQ10 as a Lipid-Soluble Antioxidant

After absorption, ubiquinone is reduced to ubiquinol in the body. Ubiquinol is one of the most potent lipid-soluble antioxidants in the body, operating within cell membranes and mitochondrial membranes where water-soluble antioxidants such as vitamin C cannot reach. Ubiquinol directly quenches free radicals and regenerates vitamin E from its oxidized form (tocopheroxyl radical), extending the antioxidant network. Mitochondrial membranes are particularly vulnerable to oxidative damage due to their proximity to the electron transport chain, making CoQ10's antioxidant role in mitochondria especially important.

Why CoQ10 Declines with Age and Statin Use

Endogenous CoQ10 synthesis shares the same biosynthetic pathway (the mevalonate pathway) as cholesterol synthesis. Statin medications inhibit HMG-CoA reductase, a key enzyme in the mevalonate pathway, which reduces not only cholesterol synthesis but also CoQ10 synthesis. This is why statin use is associated with reduced CoQ10 levels and why CoQ10 supplementation is commonly considered alongside statin therapy. Independently of statin use, endogenous CoQ10 production declines with age, with tissue CoQ10 levels in the heart declining by approximately 50% between the ages of 20 and 80.

Why Softgel with Lipid Carrier Enhances Absorption

CoQ10 is highly lipophilic (fat-soluble) and has very low water solubility, which limits its absorption from the gastrointestinal tract. Formulating CoQ10 in a softgel with a lipid-based carrier significantly improves bioavailability by keeping CoQ10 in a dissolved, lipid-dispersed state that is more readily absorbed through the intestinal wall via the lymphatic system. Taking CoQ10 with a meal containing dietary fat further enhances absorption.

Medicinal Ingredient (per softgel)

• Coenzyme Q10 (ubiquinone) 200mg Source: fermentation-derived ubiquinone | Supports cardiovascular health, cellular energy production, and antioxidant protection | NPN 80134929

Non-medicinal ingredients: Softgel shell (gelatin, glycerin, purified water), lipid carrier (soybean oil or medium chain triglycerides), beeswax or other stabilizer. Contains gelatin. Not suitable for vegans or vegetarians.

Quality and Trust

• NPN 80134929 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• 200mg ubiquinone per softgel High-potency, fermentation-derived CoQ10
• Softgel with lipid carrier Enhanced bioavailability for this fat-soluble compound
• 120 softgels 120 day supply at 1 softgel per day

Who This Is For

• Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications
• Adults seeking cardiovascular health and cellular energy support from a high-potency CoQ10 supplement
• Individuals over 40 whose endogenous CoQ10 production has declined with age
• Those taking statin medications, which reduce CoQ10 synthesis via the mevalonate pathway
• Those seeking a lipid-soluble antioxidant that protects cell membranes and mitochondrial membranes

How to Use

Adults: Take 1 softgel daily with a meal containing dietary fat, or as directed by a healthcare practitioner. Dietary fat enhances absorption of this fat-soluble compound.

Safety and Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80134929. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.