{"product_id":"coq10-200mg-ubiquinone-cardiovascular-and-cellular-energy-support-120-softgels","title":"CoQ10 200mg | Ubiquinone | Cardiovascular and Cellular Energy Support | 120 Softgels","description":"\u003ch2\u003eCoQ10 200mg | Ubiquinone | Cardiovascular and Cellular Energy Support | 120 Softgels\u003c\/h2\u003e\n\u003cp\u003eEach softgel delivers 200mg of Coenzyme Q10 (CoQ10) as ubiquinone, the oxidized form used as an electron carrier in the mitochondrial electron transport chain. Supports cardiovascular health, cellular energy production, and provides antioxidant protection.\u003c\/p\u003e\n\u003cp\u003eHealth Canada licensed NPN 80134929. Made in Canada. 120 softgels, 120 day supply at 1 softgel per day.\u003c\/p\u003e\n\u003ch2\u003eHow This Product Is Made\u003c\/h2\u003e\n\u003cp\u003eCoQ10 (ubiquinone) is produced through microbial fermentation, the same biosynthetic pathway used by the human body to produce CoQ10 endogenously. Yeast or bacterial strains are fermented under controlled conditions to produce ubiquinone, which is then purified to pharmaceutical grade purity. The purified ubiquinone is formulated into a softgel with a lipid-based carrier to enhance absorption of this fat soluble compound. The softgels are manufactured in Canada in a GMP certified facility under Health Canada oversight.\u003c\/p\u003e\n\u003ch2\u003eWhat Is CoQ10 (Coenzyme Q10)?\u003c\/h2\u003e\n\u003cp\u003eCoenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble, vitamin-like compound found in every cell of the human body. It exists in two primary forms: ubiquinone (the oxidized form, used as an electron carrier) and ubiquinol (the reduced form, the active antioxidant). The body interconverts these two forms continuously as part of normal cellular function. CoQ10 is most concentrated in organs with the highest energy demands: the heart, liver, kidneys, and skeletal muscle. The body produces CoQ10 endogenously, but production peaks in the mid-20s and declines progressively with age.\u003c\/p\u003e\n\u003ch2\u003eWhat Is the Difference Between Ubiquinone and Ubiquinol?\u003c\/h2\u003e\n\u003cp\u003eUbiquinone is the oxidized form of CoQ10 and the form used in this formula. It is the form that functions as an electron carrier in the mitochondrial electron transport chain. Ubiquinol is the reduced form and the primary antioxidant form in the bloodstream. The body converts ubiquinone to ubiquinol after absorption. In healthy adults, the body efficiently converts supplemental ubiquinone to ubiquinol. Ubiquinol supplements are sometimes recommended for older adults or those with conditions that may impair this conversion, as conversion efficiency can decline with age.\u003c\/p\u003e\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports cardiovascular health\u003c\/strong\u003e The heart is the most energy-demanding organ in the body and contains the highest CoQ10 concentration of any tissue | CoQ10 is essential for cardiac ATP production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports cellular energy production\u003c\/strong\u003e CoQ10 is an essential electron carrier in the mitochondrial electron transport chain, the primary pathway for ATP synthesis in all cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant protection\u003c\/strong\u003e Ubiquinol (the reduced form, produced from supplemental ubiquinone after absorption) is one of the most potent lipid-soluble antioxidants in the body, protecting cell membranes and mitochondrial membranes from oxidative damage\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e200mg CoQ10 per softgel\u003c\/strong\u003e High-potency ubiquinone | At the upper end of commonly available supplemental doses\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource: fermentation-derived ubiquinone\u003c\/strong\u003e Produced via microbial fermentation, the same biosynthetic pathway as endogenous CoQ10\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSoftgel with lipid carrier\u003c\/strong\u003e Fat-soluble nutrient formulated for enhanced absorption\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed\u003c\/strong\u003e NPN 80134929 | GMP certified | Made in Canada\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e120 softgels\u003c\/strong\u003e 120 day supply at 1 softgel per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003ch3\u003eCoQ10 and the Mitochondrial Electron Transport Chain\u003c\/h3\u003e\n\u003cp\u003eCoQ10 (ubiquinone) is an essential mobile electron carrier in the inner mitochondrial membrane. It accepts electrons from NADH (via Complex I) and FADH2 (via Complex II) and transfers them to Complex III (cytochrome bc1 complex). This electron transfer drives proton pumping across the inner mitochondrial membrane, generating the electrochemical gradient that powers ATP synthase (Complex V) to produce ATP. Without CoQ10, the electron transport chain cannot function and ATP production is severely impaired. The heart, which cannot store significant ATP reserves and must continuously regenerate it, is particularly dependent on CoQ10 for normal function.\u003c\/p\u003e\n\u003ch3\u003eCoQ10 as a Lipid-Soluble Antioxidant\u003c\/h3\u003e\n\u003cp\u003eAfter absorption, ubiquinone is reduced to ubiquinol in the body. Ubiquinol is one of the most potent lipid-soluble antioxidants in the body, operating within cell membranes and mitochondrial membranes where water-soluble antioxidants such as vitamin C cannot reach. Ubiquinol directly quenches free radicals and regenerates vitamin E from its oxidized form (tocopheroxyl radical), extending the antioxidant network. Mitochondrial membranes are particularly vulnerable to oxidative damage due to their proximity to the electron transport chain, making CoQ10's antioxidant role in mitochondria especially important.\u003c\/p\u003e\n\u003ch3\u003eWhy CoQ10 Declines with Age and Statin Use\u003c\/h3\u003e\n\u003cp\u003eEndogenous CoQ10 synthesis shares the same biosynthetic pathway (the mevalonate pathway) as cholesterol synthesis. Statin medications inhibit HMG-CoA reductase, a key enzyme in the mevalonate pathway, which reduces not only cholesterol synthesis but also CoQ10 synthesis. This is why statin use is associated with reduced CoQ10 levels and why CoQ10 supplementation is commonly considered alongside statin therapy. Independently of statin use, endogenous CoQ10 production declines with age, with tissue CoQ10 levels in the heart declining by approximately 50% between the ages of 20 and 80.\u003c\/p\u003e\n\u003ch3\u003eWhy Softgel with Lipid Carrier Enhances Absorption\u003c\/h3\u003e\n\u003cp\u003eCoQ10 is highly lipophilic (fat-soluble) and has very low water solubility, which limits its absorption from the gastrointestinal tract. Formulating CoQ10 in a softgel with a lipid-based carrier significantly improves bioavailability by keeping CoQ10 in a dissolved, lipid-dispersed state that is more readily absorbed through the intestinal wall via the lymphatic system. Taking CoQ10 with a meal containing dietary fat further enhances absorption.\u003c\/p\u003e\n\u003ch2\u003eMedicinal Ingredient (per softgel)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoenzyme Q10 (ubiquinone) 200mg\u003c\/strong\u003e Source: fermentation-derived ubiquinone | Supports cardiovascular health, cellular energy production, and antioxidant protection | NPN 80134929\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Softgel shell (gelatin, glycerin, purified water), lipid carrier (soybean oil or medium chain triglycerides), beeswax or other stabilizer. Contains gelatin. Not suitable for vegans or vegetarians.\u003c\/p\u003e\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNPN 80134929\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e200mg ubiquinone per softgel\u003c\/strong\u003e High-potency, fermentation-derived CoQ10\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSoftgel with lipid carrier\u003c\/strong\u003e Enhanced bioavailability for this fat-soluble compound\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e120 softgels\u003c\/strong\u003e 120 day supply at 1 softgel per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications\u003c\/li\u003e\n\u003cli\u003eAdults seeking cardiovascular health and cellular energy support from a high-potency CoQ10 supplement\u003c\/li\u003e\n\u003cli\u003eIndividuals over 40 whose endogenous CoQ10 production has declined with age\u003c\/li\u003e\n\u003cli\u003eThose taking statin medications, which reduce CoQ10 synthesis via the mevalonate pathway\u003c\/li\u003e\n\u003cli\u003eThose seeking a lipid-soluble antioxidant that protects cell membranes and mitochondrial membranes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 softgel daily with a meal containing dietary fat, or as directed by a healthcare practitioner. Dietary fat enhances absorption of this fat-soluble compound.\u003c\/p\u003e\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\u003cp\u003eNPN 80134929. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":45404321808547,"sku":"N296","price":35.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/CoQ10_200_mg_high_potency_supplement_120_softgels.jpg?v=1773073077","url":"https:\/\/nutridom.ca\/products\/coq10-200mg-ubiquinone-cardiovascular-and-cellular-energy-support-120-softgels","provider":"Nutridom","version":"1.0","type":"link"}