{"product_id":"curcumin-with-piperine-turmeric-rhizome-and-black-pepper-joint-inflammation-60-vegan-capsules","title":"Curcumin with Piperine | Turmeric Rhizome and Black Pepper | Joint Inflammation | 60 Vegan Capsules","description":"\u003ch2\u003eCurcumin with Piperine | Turmeric Rhizome and Black Pepper | Joint Inflammation\u003c\/h2\u003e\n\u003cp\u003eEach vegan capsule delivers Curcumin 400mg (\u003cem\u003eCurcuma longa\u003c\/em\u003e, rhizome) and Piperine 4mg from Black Pepper extract 80mg (\u003cem\u003ePiper nigrum\u003c\/em\u003e, fruit, 2:1, QCE 160mg). Piperine inhibits the enzymes that break down curcumin, significantly enhancing its absorption.\u003c\/p\u003e\n\u003cp\u003eUsed in Herbal Medicine to help relieve joint inflammation. Health Canada licensed NPN 80068970. Vegan. Non-GMO. Gluten free. Dairy free. Made in Canada. 60 vegan capsules, 20 day supply at 3 capsules per day.\u003c\/p\u003e\n\u003ch2\u003eSource\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCurcumin source:\u003c\/strong\u003e \u003cem\u003eCurcuma longa\u003c\/em\u003e rhizome (underground stem), a member of the Zingiberaceae (ginger) family native to South and Southeast Asia. Raw turmeric rhizome contains approximately 2 to 5% curcuminoids by weight, of which curcumin is the most abundant. Curcumin is what gives turmeric its characteristic yellow colour.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePiperine source:\u003c\/strong\u003e \u003cem\u003ePiper nigrum\u003c\/em\u003e fruit (black pepper), 2:1 concentrated extract providing 4mg of piperine per 80mg of extract (QCE 160mg raw black pepper fruit). Piperine is the alkaloid responsible for black pepper's pungent taste and its enzyme-inhibiting properties.\u003c\/p\u003e\n\u003ch2\u003eWhat Is Curcumin and Why Does It Need Piperine?\u003c\/h2\u003e\n\u003cp\u003eCurcumin is the primary active curcuminoid in turmeric (\u003cem\u003eCurcuma longa\u003c\/em\u003e), used in Herbal Medicine to help relieve joint inflammation. On its own, curcumin has low oral bioavailability: it is rapidly broken down by gut and liver enzymes (particularly CYP3A4) and eliminated before meaningful amounts reach the bloodstream. Piperine inhibits CYP3A4 and the P-glycoprotein transporter, slowing curcumin's breakdown and significantly increasing the amount absorbed into systemic circulation.\u003c\/p\u003e\n\u003ch2\u003eWhat Is Piperine and How Does It Enhance Absorption?\u003c\/h2\u003e\n\u003cp\u003ePiperine is the active alkaloid in black pepper (\u003cem\u003ePiper nigrum\u003c\/em\u003e). It inhibits CYP3A4, the primary liver enzyme responsible for curcumin metabolism, and P-glycoprotein, an intestinal efflux transporter that pumps curcumin back into the gut lumen before it can be absorbed. By inhibiting both pathways, piperine slows curcumin's breakdown and increases its bioavailability. Because piperine inhibits the same enzymes that metabolize many medications, it can also increase blood levels of other drugs and natural health products, which is the basis for the medication interaction caution.\u003c\/p\u003e\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUsed in Herbal Medicine to help relieve joint inflammation\u003c\/strong\u003e Health Canada licensed claim under NPN 80068970\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCurcumin 400mg per capsule\u003c\/strong\u003e Curcuma longa rhizome | Primary active curcuminoid in turmeric\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePiperine 4mg per capsule\u003c\/strong\u003e From 80mg Black Pepper extract (Piper nigrum, fruit, 2:1, QCE 160mg) | Inhibits CYP3A4 and P-glycoprotein for enhanced curcumin absorption\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource: Curcuma longa rhizome\u003c\/strong\u003e South and Southeast Asian ginger family plant | Ayurvedic and traditional herbal medicine use\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource: Piper nigrum fruit extract\u003c\/strong\u003e 2:1 concentrate | QCE 160mg raw black pepper fruit per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed\u003c\/strong\u003e NPN 80068970 | GMP certified | Made in Canada\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e60 vegan capsules\u003c\/strong\u003e 20 day supply at 3 capsules per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003ch3\u003eCurcumin and Joint Inflammation\u003c\/h3\u003e\n\u003cp\u003eCurcumin is the primary curcuminoid in turmeric rhizome and the compound responsible for its traditional use in Herbal Medicine to help relieve joint inflammation. The Health Canada licensed use for this formula is: used in Herbal Medicine to help relieve joint inflammation (NPN 80068970).\u003c\/p\u003e\n\u003ch3\u003eWhy Curcumin Has Low Bioavailability Without Piperine\u003c\/h3\u003e\n\u003cp\u003eCurcumin is rapidly metabolized by CYP3A4 in the intestinal wall and liver, and actively pumped back into the gut lumen by P-glycoprotein before it can be absorbed. These two mechanisms together result in very low systemic bioavailability from oral curcumin alone. Piperine inhibits both CYP3A4 and P-glycoprotein, slowing curcumin's breakdown and increasing the amount that reaches systemic circulation.\u003c\/p\u003e\n\u003ch3\u003eWhy Piperine Affects Other Medications\u003c\/h3\u003e\n\u003cp\u003eCYP3A4 and P-glycoprotein are responsible for the metabolism and elimination of a wide range of medications, not just curcumin. By inhibiting these pathways, piperine can increase the blood levels of other drugs and natural health products that use the same routes, potentially altering their effectiveness or increasing side effect risk. This is why it is important to consult a healthcare practitioner before use if taking any medications or natural health products.\u003c\/p\u003e\n\u003ch3\u003eUnderstanding the QCE: Black Pepper Extract Potency\u003c\/h3\u003e\n\u003cp\u003eThe black pepper component is a 2:1 concentrated extract, meaning 2 grams of raw black pepper fruit were used to produce 1 gram of extract. Each 80mg capsule therefore contains the concentrated compounds from 160mg of raw black pepper fruit (QCE 160mg), providing 4mg of piperine per capsule.\u003c\/p\u003e\n\u003ch2\u003eMedicinal Ingredients (per capsule)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCurcumin (Curcuma longa, rhizome) 400mg\u003c\/strong\u003e Source: turmeric rhizome, South and Southeast Asia | Used in Herbal Medicine to help relieve joint inflammation | NPN 80068970\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlack Pepper Extract (Piper nigrum, fruit, 2:1) 80mg\u003c\/strong\u003e QCE 160mg | Providing Piperine 4mg | Source: black pepper fruit concentrate | Enhances curcumin absorption via CYP3A4 and P-glycoprotein inhibition | NPN 80068970\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.\u003c\/p\u003e\n\u003ch2\u003ePer Daily Dose (3 Capsules)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCurcumin (Curcuma longa, rhizome): 1200mg\u003c\/li\u003e\n\u003cli\u003eBlack Pepper Extract (Piper nigrum, fruit, 2:1): 240mg | QCE 480mg\u003c\/li\u003e\n\u003cli\u003ePiperine: 12mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNPN 80068970\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCurcumin from Curcuma longa rhizome\u003c\/strong\u003e Traditional Ayurvedic and herbal medicine source\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePiperine from Piper nigrum fruit extract\u003c\/strong\u003e 2:1 concentrate | QCE 160mg per capsule\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eNon-GMO, gluten free, dairy free\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e60 vegan capsules\u003c\/strong\u003e 20 day supply at 3 capsules per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cp\u003eAdults seeking a Herbal Medicine remedy to help relieve joint inflammation, using curcumin from turmeric rhizome combined with piperine from black pepper for enhanced absorption. A good fit if you want a Health Canada licensed, vegan, Canadian-made curcumin and piperine formula.\u003c\/p\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are taking antiplatelet medications, blood thinners, or any other medications or natural health products, as piperine may increase their blood levels. Also consult before use if you are pregnant or breastfeeding, or have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid. For use beyond 12 weeks, consult a healthcare practitioner.\u003c\/p\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule, 3 times per day, or as directed by a healthcare practitioner. For use beyond 12 weeks, consult a healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eAt 3 capsules per day, 60 capsules provides a 20 day supply.\u003c\/p\u003e\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eFor use beyond 12 weeks, consult a healthcare practitioner.\u003c\/strong\u003e Consult a healthcare practitioner before use if you are taking antiplatelet medication, blood thinners, or any other medications or natural health products, as piperine may alter their effectiveness. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or have gallstones, bile duct obstruction, stomach ulcers, or excess stomach acid. Consult a healthcare practitioner if symptoms persist or worsen. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\u003cp\u003eNPN 80068970. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":42910820532387,"sku":"N222","price":28.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Curcumin_with_piperine_supplement_60_vegan_capsules.jpg?v=1775500700","url":"https:\/\/nutridom.ca\/products\/curcumin-with-piperine-turmeric-rhizome-and-black-pepper-joint-inflammation-60-vegan-capsules","provider":"Nutridom","version":"1.0","type":"link"}