DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

Each capsule delivers 200mg of pure 3,3-Diindolylmethane (DIM), the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. Supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of beneficial estrogen metabolites.

Health Canada licensed NPN 80141933. Made in Canada. 120 vegan capsules, 2 to 4 month supply at 1 capsule per day.

Key Benefits

• 200mg pure 3,3-Diindolylmethane (DIM) per capsule The bioactive end-product of indole-3-carbinol metabolism, derived from cruciferous vegetables
• Estrogen metabolism support Promotes the 2-hydroxylation pathway, increasing the ratio of 2-hydroxyestrone (2-OHE1) to 16-alpha-hydroxyestrone (16-OHE1)
• Hormone balance support Supports healthy estrogen clearance and helps maintain balanced estrogen activity in both women and men
• Liver detoxification pathway support DIM supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination
• Aromatase modulation DIM has been studied for its ability to modulate aromatase activity, the enzyme responsible for converting androgens to estrogens
• Cruciferous vegetable concentrate 200mg DIM is equivalent to the I3C content of several pounds of cruciferous vegetables per day
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Health Canada licensed NPN 80141933
• Made in Canada GMP certified facility under Health Canada oversight
• 120 capsules 2 to 4 month supply at 1 capsule per day

What This Is

A pure DIM (3,3-Diindolylmethane) supplement providing 200mg per vegan capsule. DIM is not found directly in food. It is formed in the acidic environment of the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables, undergoes acid-catalyzed condensation during digestion.

DIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with DIM delivers the active compound directly, bypassing the variable conversion efficiency of dietary I3C.

Licensed by Health Canada under NPN 80141933. Manufactured in Canada to GMP standards. Vegan. Gluten free. Dairy free. Soy free.

How It Works

Estrogen Metabolism and the 2-Hydroxylation Pathway

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a strongly estrogenic metabolite associated with less favorable hormonal activity.

DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance.

Phase I and Phase II Liver Detoxification

DIM induces cytochrome P450 enzymes (particularly CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.

Aromatase Modulation

Aromatase (CYP19A1) is the enzyme that converts androgens (testosterone, androstenedione) to estrogens. DIM has been studied for its ability to modulate aromatase activity, which is relevant to hormone balance in both women and men. In men, excess aromatase activity can shift the testosterone-to-estrogen ratio unfavorably; DIM supports healthy aromatase regulation.

DIM Versus Indole-3-Carbinol (I3C)

I3C is the precursor found in cruciferous vegetables. In the stomach, I3C undergoes acid-catalyzed condensation to form DIM and other oligomeric products. The conversion of I3C to DIM is variable and incomplete, depending on gastric acid levels and digestive conditions. Supplementing with DIM directly provides the stable, active end-product without dependence on this conversion step.

Relevance for Both Women and Men

While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormonal balance, particularly in the context of age-related increases in aromatase activity. DIM supports healthy estrogen metabolism in both women and men.

Medicinal Ingredient (per capsule)

• 3,3-Diindolylmethane (DIM) 200mg Bioactive cruciferous vegetable compound | Supports estrogen metabolism, hormone balance, and hepatic detoxification pathways | NPN 80141933

Non-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Dairy free. Soy free.

Quality and Trust

• NPN 80141933 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• 200mg pure DIM per capsule Stable bioactive end-product of I3C metabolism
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Non-GMO, gluten free, dairy free, soy free
• 120 capsules 2 to 4 month supply at 1 capsule per day

Who This Is For

• Do not use if pregnant or breastfeeding
• Consult a healthcare practitioner before use if attempting to conceive, taking hormone-related medications, or have a liver disorder
• Women seeking support for healthy estrogen metabolism, hormone balance, and estrogen clearance
• Men seeking support for healthy aromatase regulation and testosterone-to-estrogen balance
• Adults interested in the estrogen-modulating benefits of cruciferous vegetables in a concentrated, standardized capsule format

How to Use

Adults: Take 1 capsule daily with food, or as directed by a healthcare practitioner.

Consistent daily use over several weeks is recommended before assessing effects on hormonal balance. Ask a healthcare practitioner for use beyond the recommended duration.

Safety and Cautions

Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are attempting to conceive, taking medications (particularly hormone-related medications or medications metabolized by cytochrome P450 enzymes), or have a liver disorder.

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not refrigerate. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80141933. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.