{"product_id":"dim-200mg-diindolylmethane-estrogen-metabolism-and-hormone-balance-120-vcaps","title":"DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps","description":"\u003ch2\u003eDIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps\u003c\/h2\u003e\n\n\u003cp\u003eEach capsule delivers 200mg of pure 3,3-Diindolylmethane (DIM), the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. Supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of beneficial estrogen metabolites.\u003c\/p\u003e\n\u003cp\u003eHealth Canada licensed NPN 80141933. Made in Canada. 120 vegan capsules, 2 to 4 month supply at 1 capsule per day.\u003c\/p\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003e200mg pure 3,3-Diindolylmethane (DIM) per capsule\u003c\/strong\u003e The bioactive end-product of indole-3-carbinol metabolism, derived from cruciferous vegetables\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eEstrogen metabolism support\u003c\/strong\u003e Promotes the 2-hydroxylation pathway, increasing the ratio of 2-hydroxyestrone (2-OHE1) to 16-alpha-hydroxyestrone (16-OHE1)\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHormone balance support\u003c\/strong\u003e Supports healthy estrogen clearance and helps maintain balanced estrogen activity in both women and men\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eLiver detoxification pathway support\u003c\/strong\u003e DIM supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAromatase modulation\u003c\/strong\u003e DIM has been studied for its ability to modulate aromatase activity, the enzyme responsible for converting androgens to estrogens\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCruciferous vegetable concentrate\u003c\/strong\u003e 200mg DIM is equivalent to the I3C content of several pounds of cruciferous vegetables per day\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed\u003c\/strong\u003e NPN 80141933\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e120 capsules\u003c\/strong\u003e 2 to 4 month supply at 1 capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eA pure DIM (3,3-Diindolylmethane) supplement providing 200mg per vegan capsule. DIM is not found directly in food. It is formed in the acidic environment of the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables, undergoes acid-catalyzed condensation during digestion.\u003c\/p\u003e\n\u003cp\u003eDIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with DIM delivers the active compound directly, bypassing the variable conversion efficiency of dietary I3C.\u003c\/p\u003e\n\u003cp\u003eLicensed by Health Canada under NPN 80141933. Manufactured in Canada to GMP standards. Vegan. Gluten free. Dairy free. Soy free.\u003c\/p\u003e\n\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\n\u003ch3\u003eEstrogen Metabolism and the 2-Hydroxylation Pathway\u003c\/h3\u003e\n\u003cp\u003eEstrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a strongly estrogenic metabolite associated with less favorable hormonal activity.\u003c\/p\u003e\n\u003cp\u003eDIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance.\u003c\/p\u003e\n\n\u003ch3\u003ePhase I and Phase II Liver Detoxification\u003c\/h3\u003e\n\u003cp\u003eDIM induces cytochrome P450 enzymes (particularly CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.\u003c\/p\u003e\n\n\u003ch3\u003eAromatase Modulation\u003c\/h3\u003e\n\u003cp\u003eAromatase (CYP19A1) is the enzyme that converts androgens (testosterone, androstenedione) to estrogens. DIM has been studied for its ability to modulate aromatase activity, which is relevant to hormone balance in both women and men. In men, excess aromatase activity can shift the testosterone-to-estrogen ratio unfavorably; DIM supports healthy aromatase regulation.\u003c\/p\u003e\n\n\u003ch3\u003eDIM Versus Indole-3-Carbinol (I3C)\u003c\/h3\u003e\n\u003cp\u003eI3C is the precursor found in cruciferous vegetables. In the stomach, I3C undergoes acid-catalyzed condensation to form DIM and other oligomeric products. The conversion of I3C to DIM is variable and incomplete, depending on gastric acid levels and digestive conditions. Supplementing with DIM directly provides the stable, active end-product without dependence on this conversion step.\u003c\/p\u003e\n\n\u003ch3\u003eRelevance for Both Women and Men\u003c\/h3\u003e\n\u003cp\u003eWhile DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormonal balance, particularly in the context of age-related increases in aromatase activity. DIM supports healthy estrogen metabolism in both women and men.\u003c\/p\u003e\n\n\u003ch2\u003eMedicinal Ingredient (per capsule)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003e3,3-Diindolylmethane (DIM) 200mg\u003c\/strong\u003e Bioactive cruciferous vegetable compound | Supports estrogen metabolism, hormone balance, and hepatic detoxification pathways | NPN 80141933\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Dairy free. Soy free.\u003c\/p\u003e\n\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNPN 80141933\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e200mg pure DIM per capsule\u003c\/strong\u003e Stable bioactive end-product of I3C metabolism\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon-GMO, gluten free, dairy free, soy free\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e120 capsules\u003c\/strong\u003e 2 to 4 month supply at 1 capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eDo not use if pregnant or breastfeeding\u003c\/li\u003e\n  \u003cli\u003eConsult a healthcare practitioner before use if attempting to conceive, taking hormone-related medications, or have a liver disorder\u003c\/li\u003e\n  \u003cli\u003eWomen seeking support for healthy estrogen metabolism, hormone balance, and estrogen clearance\u003c\/li\u003e\n  \u003cli\u003eMen seeking support for healthy aromatase regulation and testosterone-to-estrogen balance\u003c\/li\u003e\n  \u003cli\u003eAdults interested in the estrogen-modulating benefits of cruciferous vegetables in a concentrated, standardized capsule format\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule daily with food, or as directed by a healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eConsistent daily use over several weeks is recommended before assessing effects on hormonal balance. Ask a healthcare practitioner for use beyond the recommended duration.\u003c\/p\u003e\n\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eDo not use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are attempting to conceive, taking medications (particularly hormone-related medications or medications metabolized by cytochrome P450 enzymes), or have a liver disorder.\u003c\/p\u003e\n\u003cp\u003eStore in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not refrigerate. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\n\u003cp\u003eNPN 80141933. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":46246816088227,"sku":"N341","price":26.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Nutridom_DIM_200_mg_Diindolylmethane_supplement_120_vegan_capsules_hormone_balance_support.jpg?v=1772742457","url":"https:\/\/nutridom.ca\/products\/dim-200mg-diindolylmethane-estrogen-metabolism-and-hormone-balance-120-vcaps","provider":"Nutridom","version":"1.0","type":"link"}