USA CUSTOMERS - SAME PRICE. NO DUTY. NO HIDDEN FEES.

FREE SHIPPING OVER $55

GET 10% OFF FIRST ORDER

Your cart

Your cart is empty

Continue shopping
Nutridom DIM 200 mg Diindolylmethane supplement 120 vegan capsules hormone balance support
DIM 200 mg supplement bottle Diindolylmethane 120 V-Capsules made in Canada
DIM 200 mg hormone balance supplement for estrogen metabolism support
DIM 200 mg vegan capsules Diindolylmethane dietary supplement
Nutridom DIM 200 mg supplement facts label Diindolylmethane hormone metabolism support
DIM 200 mg
Nutridom DIM 200 mg Diindolylmethane supplement 120 vegan capsules hormone balance support

DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

Each capsule delivers 200mg of pure 3,3-Diindolylmethane (DIM), the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. Supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of beneficial estrogen metabolites.

Health Canada licensed NPN 80141933. Made in Canada. 120 vegan capsules, 2 to 4 month supply at 1 capsule per day.

Key Benefits

  • 200mg pure 3,3-Diindolylmethane (DIM) per capsule The bioactive end-product of indole-3-carbinol metabolism, derived from cruciferous vegetables
  • Estrogen metabolism support Promotes the 2-hydroxylation pathway, increasing the ratio of 2-hydroxyestrone (2-OHE1) to 16-alpha-hydroxyestrone (16-OHE1)
  • Hormone balance support Supports healthy estrogen clearance and helps maintain balanced estrogen activity in both women and men
  • Liver detoxification pathway support DIM supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination
  • Aromatase modulation DIM has been studied for its ability to modulate aromatase activity, the enzyme responsible for converting androgens to estrogens
  • Cruciferous vegetable concentrate 200mg DIM is equivalent to the I3C content of several pounds of cruciferous vegetables per day
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed NPN 80141933
  • Made in Canada GMP certified facility under Health Canada oversight
  • 120 capsules 2 to 4 month supply at 1 capsule per day

What This Is

A pure DIM (3,3-Diindolylmethane) supplement providing 200mg per vegan capsule. DIM is not found directly in food. It is formed in the acidic environment of the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables, undergoes acid-catalyzed condensation during digestion.

DIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with DIM delivers the active compound directly, bypassing the variable conversion efficiency of dietary I3C.

Licensed by Health Canada under NPN 80141933. Manufactured in Canada to GMP standards. Vegan. Gluten free. Dairy free. Soy free.

How It Works

Estrogen Metabolism and the 2-Hydroxylation Pathway

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a strongly estrogenic metabolite associated with less favorable hormonal activity.

DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance.

Phase I and Phase II Liver Detoxification

DIM induces cytochrome P450 enzymes (particularly CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.

Aromatase Modulation

Aromatase (CYP19A1) is the enzyme that converts androgens (testosterone, androstenedione) to estrogens. DIM has been studied for its ability to modulate aromatase activity, which is relevant to hormone balance in both women and men. In men, excess aromatase activity can shift the testosterone-to-estrogen ratio unfavorably; DIM supports healthy aromatase regulation.

DIM Versus Indole-3-Carbinol (I3C)

I3C is the precursor found in cruciferous vegetables. In the stomach, I3C undergoes acid-catalyzed condensation to form DIM and other oligomeric products. The conversion of I3C to DIM is variable and incomplete, depending on gastric acid levels and digestive conditions. Supplementing with DIM directly provides the stable, active end-product without dependence on this conversion step.

Relevance for Both Women and Men

While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormonal balance, particularly in the context of age-related increases in aromatase activity. DIM supports healthy estrogen metabolism in both women and men.

Quality and Trust

  • NPN 80141933 Licensed by Health Canada as a Natural Health Product
  • Made in Canada GMP certified facility under Health Canada oversight
  • 200mg pure DIM per capsule Stable bioactive end-product of I3C metabolism
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO, gluten free, dairy free, soy free
  • 120 capsules 2 to 4 month supply at 1 capsule per day

Who This Is For

  • Do not use if pregnant or breastfeeding
  • Consult a healthcare practitioner before use if attempting to conceive, taking hormone-related medications, or have a liver disorder
  • Women seeking support for healthy estrogen metabolism, hormone balance, and estrogen clearance
  • Men seeking support for healthy aromatase regulation and testosterone-to-estrogen balance
  • Adults interested in the estrogen-modulating benefits of cruciferous vegetables in a concentrated, standardized capsule format

How to Use

Adults: Take 1 capsule daily with food, or as directed by a healthcare practitioner.

Consistent daily use over several weeks is recommended before assessing effects on hormonal balance. Ask a healthcare practitioner for use beyond the recommended duration.

Safety and Cautions

Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are attempting to conceive, taking medications (particularly hormone-related medications or medications metabolized by cytochrome P450 enzymes), or have a liver disorder.

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not refrigerate. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80141933. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

$26.99
5.0 (1)

Health Canada Licensed Natural Health Product (NPN 80141933)

Auto-renews, skip or cancel anytime.

To add to cart, go to the product page and select a purchase option
Shipping calculated at checkout.

DIM 200mg | Diindolylmethane | Estrogen Metabolism and Hormone Balance | 120 Vcaps

Each capsule delivers 200mg of pure 3,3-Diindolylmethane (DIM), the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables. Supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway and the production of beneficial estrogen metabolites.

Health Canada licensed NPN 80141933. Made in Canada. 120 vegan capsules, 2 to 4 month supply at 1 capsule per day.

Key Benefits

  • 200mg pure 3,3-Diindolylmethane (DIM) per capsule The bioactive end-product of indole-3-carbinol metabolism, derived from cruciferous vegetables
  • Estrogen metabolism support Promotes the 2-hydroxylation pathway, increasing the ratio of 2-hydroxyestrone (2-OHE1) to 16-alpha-hydroxyestrone (16-OHE1)
  • Hormone balance support Supports healthy estrogen clearance and helps maintain balanced estrogen activity in both women and men
  • Liver detoxification pathway support DIM supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination
  • Aromatase modulation DIM has been studied for its ability to modulate aromatase activity, the enzyme responsible for converting androgens to estrogens
  • Cruciferous vegetable concentrate 200mg DIM is equivalent to the I3C content of several pounds of cruciferous vegetables per day
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed NPN 80141933
  • Made in Canada GMP certified facility under Health Canada oversight
  • 120 capsules 2 to 4 month supply at 1 capsule per day

What This Is

A pure DIM (3,3-Diindolylmethane) supplement providing 200mg per vegan capsule. DIM is not found directly in food. It is formed in the acidic environment of the stomach when indole-3-carbinol (I3C), present in cruciferous vegetables, undergoes acid-catalyzed condensation during digestion.

DIM is the primary stable bioactive product of I3C metabolism and the compound responsible for the estrogen-modulating effects associated with cruciferous vegetable consumption. Supplementing with DIM delivers the active compound directly, bypassing the variable conversion efficiency of dietary I3C.

Licensed by Health Canada under NPN 80141933. Manufactured in Canada to GMP standards. Vegan. Gluten free. Dairy free. Soy free.

How It Works

Estrogen Metabolism and the 2-Hydroxylation Pathway

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a strongly estrogenic metabolite associated with less favorable hormonal activity.

DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance.

Phase I and Phase II Liver Detoxification

DIM induces cytochrome P450 enzymes (particularly CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation, and supports Phase II conjugation enzymes including glutathione S-transferase that facilitate estrogen elimination. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently.

Aromatase Modulation

Aromatase (CYP19A1) is the enzyme that converts androgens (testosterone, androstenedione) to estrogens. DIM has been studied for its ability to modulate aromatase activity, which is relevant to hormone balance in both women and men. In men, excess aromatase activity can shift the testosterone-to-estrogen ratio unfavorably; DIM supports healthy aromatase regulation.

DIM Versus Indole-3-Carbinol (I3C)

I3C is the precursor found in cruciferous vegetables. In the stomach, I3C undergoes acid-catalyzed condensation to form DIM and other oligomeric products. The conversion of I3C to DIM is variable and incomplete, depending on gastric acid levels and digestive conditions. Supplementing with DIM directly provides the stable, active end-product without dependence on this conversion step.

Relevance for Both Women and Men

While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone, and healthy estrogen clearance supports male hormonal balance, particularly in the context of age-related increases in aromatase activity. DIM supports healthy estrogen metabolism in both women and men.

Quality and Trust

  • NPN 80141933 Licensed by Health Canada as a Natural Health Product
  • Made in Canada GMP certified facility under Health Canada oversight
  • 200mg pure DIM per capsule Stable bioactive end-product of I3C metabolism
  • Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO, gluten free, dairy free, soy free
  • 120 capsules 2 to 4 month supply at 1 capsule per day

Who This Is For

  • Do not use if pregnant or breastfeeding
  • Consult a healthcare practitioner before use if attempting to conceive, taking hormone-related medications, or have a liver disorder
  • Women seeking support for healthy estrogen metabolism, hormone balance, and estrogen clearance
  • Men seeking support for healthy aromatase regulation and testosterone-to-estrogen balance
  • Adults interested in the estrogen-modulating benefits of cruciferous vegetables in a concentrated, standardized capsule format

How to Use

Adults: Take 1 capsule daily with food, or as directed by a healthcare practitioner.

Consistent daily use over several weeks is recommended before assessing effects on hormonal balance. Ask a healthcare practitioner for use beyond the recommended duration.

Safety and Cautions

Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are attempting to conceive, taking medications (particularly hormone-related medications or medications metabolized by cytochrome P450 enzymes), or have a liver disorder.

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not refrigerate. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80141933. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule (Once Daily with Food)

Servings Per Container: 120 (2 to 4-month supply at 1 capsule per day)

Ingredient
Amount Per
Serving
% Daily
Value
3,3'-Diindolylmethane (DIM)
200 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Clinical pharmacology of 3,3'-diindolylmethane administered as a single agent and in combination with tamoxifen in women with breast cancer

Nutrition and Cancer, 2004

This clinical study examined the pharmacokinetics and effects of oral DIM supplementation on urinary estrogen metabolite ratios in women. The study found that DIM supplementation significantly increased the urinary 2-OHE1 to 16-OHE1 ratio confirming that oral DIM supplementation produces measurable shifts in estrogen metabolism toward the favorable 2-hydroxylation pathway in humans. This is one of the key clinical studies confirming that the mechanism observed in cell studies translates to measurable estrogen metabolism changes in human subjects, directly supporting DIM's licensed use for estrogen metabolism and hormone balance support.

Diindolylmethane (DIM) selectively inhibits cancer stem cells

Annals of the New York Academy of Sciences, 1999

This comprehensive review by Bradlow and colleagues the leading researchers on indole phytochemicals and estrogen metabolism examined the multifunctional mechanisms of indole-3-carbinol and its primary metabolite DIM on estrogen metabolism and hormonal balance. The review established that DIM promotes the 2-hydroxylation pathway of estrogen metabolism, supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing, and modulates aromatase activity. The review confirmed DIM as the primary bioactive end product of I3C metabolism responsible for the estrogen-modulating effects of cruciferous vegetable consumption directly supporting all three of this formula's licensed mechanism claims.

Indole-3-carbinol and 3,3'-diindolylmethane induce expression of estrogen metabolism genes in normal breast epithelial cells

Journal of Nutrition, 2003

This study examined the effects of DIM (3,3'-Diindolylmethane) on estrogen metabolism gene expression in normal human breast epithelial cells. The study found that DIM significantly induced the expression of CYP1A1 and CYP1A2 the cytochrome P450 enzymes responsible for 2-hydroxylation of estrogen increasing the production of 2-hydroxyestrone (2-OHE1) relative to 16-alpha-hydroxyestrone (16-OHE1). The findings directly establish DIM's mechanism of action for supporting healthy estrogen metabolism via the 2-hydroxylation pathway the primary licensed mechanism underlying this formula's estrogen metabolism and hormone balance support claims.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is DIM and what does it do?

DIM (3,3'-Diindolylmethane) is the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables such as broccoli, cauliflower, Brussels sprouts, and cabbage. DIM is not found directly in food it is produced in the acidic environment of the stomach when I3C undergoes acid-catalyzed condensation during digestion. DIM supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway increasing the ratio of beneficial 2-hydroxyestrone (2-OHE1) to less favorable 16-alpha-hydroxyestrone (16-OHE1). It also supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination.

How does DIM support estrogen metabolism?

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1) a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1) a strongly estrogenic metabolite associated with less favorable hormonal activity. DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance. DIM also induces cytochrome P450 enzymes (CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation and supports Phase II conjugation enzymes that facilitate estrogen elimination.

Is DIM only for women or can men take it too?

DIM supports healthy estrogen metabolism in both women and men. While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone the enzyme aromatase (CYP19A1) converts androgens to estrogens. Age related increases in aromatase activity can shift the testosterone to estrogen ratio unfavorably in men. DIM supports healthy aromatase regulation and healthy estrogen clearance, making it relevant for men seeking to support healthy testosterone to estrogen balance. Ask a healthcare practitioner before use if you are taking medications or natural health products.

How does DIM support liver detoxification?

DIM supports both Phase I and Phase II hepatic detoxification pathways involved in estrogen processing and elimination. In Phase I, DIM induces cytochrome P450 enzymes particularly CYP1A1 and CYP1A2 that hydroxylate estrogen into water soluble metabolites for further processing. In Phase II, DIM supports conjugation enzymes including glutathione S-transferase that attach polar groups to estrogen metabolites, making them water soluble and ready for excretion in bile or urine. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently. Consult a healthcare practitioner before use if you have a liver disorder.

Who should not take DIM?

Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner before use if you are attempting to conceive. Ask a healthcare practitioner before use if you are taking any medications or natural health products. Ask a healthcare practitioner before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruation. Ask a healthcare practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance. Stop use and ask a healthcare practitioner if you develop liver related symptoms such as yellowing of the eyes or skin, dark urine, abdominal pain, or jaundice, or if symptoms of low estrogen develop.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

Related Product

Recently viewed