Evening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels

Each softgel delivers 500mg of cold pressed evening primrose oil (Oenothera biennis, seed), standardized to 10% gamma-linolenic acid (GLA), providing a guaranteed 50mg of GLA per softgel. No solvents. No fillers.

Health Canada licensed NPN 80030725. Made in Canada. 200 softgels, up to a 6 month supply at 1 softgel per day.

Key Benefits

• 50mg GLA per softgel, guaranteed Standardized to 10% gamma-linolenic acid | 100mg GLA per daily dose of 2 softgels
• Skin health and barrier support GLA is a critical structural component of the skin lipid barrier, supporting moisture retention, elasticity, and barrier integrity
• Hormonal balance and menstrual cycle support GLA and its metabolite DGLA influence prostaglandin synthesis pathways involved in hormonal signalling and premenstrual comfort
• Healthy inflammatory response GLA is converted to DGLA and then to prostaglandin E1 (PGE1), a Series 1 prostaglandin that supports inflammatory balance rather than promoting inflammation
• Cold pressed extraction Preserves heat-sensitive GLA and linoleic acid without chemical solvents or high heat
• Natural source of omega-6 GLA One of the richest plant sources of GLA, a conditionally essential fatty acid not widely available in the diet
• Health Canada licensed NPN 80030725 | GMP certified | Made in Canada
• 200 softgels Up to a 6 month supply at 1 softgel per day

What This Is

A cold pressed evening primrose oil supplement providing 500mg of pure Oenothera biennis seed oil per softgel, standardized to a guaranteed 10% GLA (50mg per softgel). Evening primrose oil is one of the richest plant sources of GLA, a conditionally essential omega-6 fatty acid not widely found in the diet.

GLA must be synthesized from linoleic acid by the delta-6-desaturase enzyme, a conversion routinely impaired by aging, stress, nutritional deficiencies, and hormonal fluctuations. Evening primrose oil delivers GLA directly, bypassing this enzymatic step. Licensed by Health Canada under NPN 80030725. Contains gelatin (softgel shell). Not suitable for vegans or vegetarians.

How It Works

Why GLA Requires Direct Supplementation

GLA is synthesized from dietary linoleic acid via the delta-6-desaturase enzyme. This conversion is routinely impaired by aging, chronic stress, insulin resistance, alcohol consumption, and hormonal fluctuations. When delta-6-desaturase activity is reduced, linoleic acid accumulates without converting to GLA. Evening primrose oil delivers GLA directly, bypassing this enzymatic bottleneck entirely.

How GLA Becomes Prostaglandin E1

Absorbed GLA is elongated to dihomo-gamma-linolenic acid (DGLA) by elongase enzymes. DGLA is the immediate precursor to prostaglandin E1 (PGE1) via cyclooxygenase-1. PGE1 is a vasodilatory, anti-aggregatory, and anti-inflammatory eicosanoid. DGLA is preferentially converted to PGE1 rather than to pro-inflammatory arachidonic acid, making GLA a net anti-inflammatory intervention.

GLA and Skin Barrier Function

GLA is incorporated into ceramides and phospholipids that form the skin lipid barrier, the lamellar structure between corneocytes that governs transepidermal water loss (TEWL) and barrier integrity. GLA deficiency is associated with increased TEWL, dry skin, and impaired barrier function. Supplementation with evening primrose oil supports ceramide synthesis and barrier repair, improving skin hydration and elasticity.

GLA and Hormonal Signalling

DGLA, the elongation product of GLA, is a precursor to PGE1 and to 15-HETrE, both of which modulate estrogen-sensitive tissue responses and luteal phase signalling. This prostaglandin pathway is the mechanism through which evening primrose oil supports premenstrual comfort, cyclical breast tenderness, and menstrual cycle regularity.

Why Cold Pressed and Not Solvent Extracted

Cold pressing uses mechanical pressure at controlled low temperatures, preserving the full fatty acid profile including heat-sensitive GLA and linoleic acid. Solvent extraction using hexane at elevated temperatures degrades polyunsaturated fatty acids, destroys native tocopherols, and may leave trace solvent residues. Cold pressed EPO retains its complete fatty acid composition and natural antioxidant content.

Medicinal Ingredient (per softgel)

• Evening Primrose Oil (Oenothera biennis, seed, cold pressed) 500mg Standardized to 10% GLA | 50mg GLA per softgel | Linoleic acid approximately 360mg | NPN 80030725

Non-medicinal ingredients: Gelatin (softgel shell), glycerin, purified water. No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Non-GMO.

Per Daily Dose (2 Softgels)

• Evening Primrose Oil: 1000mg
• Gamma-Linolenic Acid (GLA): 100mg
• Linoleic Acid (LA): approximately 720mg

Quality and Trust

• NPN 80030725 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Independently tested Purity and potency verified by a third-party laboratory
• Cold pressed No solvents, no high heat, full fatty acid profile preserved
• Standardized to 10% GLA 50mg GLA guaranteed per softgel
• Non-GMO and gluten free
• 200 softgels Up to a 6 month supply at 1 softgel per day

Who This Is For

• Do not use if you have a seizure disorder or are taking phenothiazine medications
• Not suitable for vegans or vegetarians (gelatin softgel shell)
• Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking anticoagulants such as warfarin
• Adults seeking daily GLA supplementation for skin barrier support, hormonal balance, or inflammatory response support
• Women experiencing PMS, premenstrual breast tenderness, or menstrual cycle irregularity who want a licensed, evidence-informed option
• Individuals whose delta-6-desaturase conversion may be impaired by aging, stress, or hormonal fluctuations

How to Use

Adults: Take 1 to 2 softgels daily with a meal containing dietary fat. Dietary fat stimulates bile secretion and supports lymphatic absorption of the oil.

Refrigerate after opening to preserve fatty acid integrity. For best results, use consistently over 8 to 12 weeks based on clinical trial protocols for GLA supplementation.

Safety and Cautions

Do not use if you have a seizure disorder or are taking phenothiazine medications. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications such as warfarin.

Refrigerate after opening. Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80030725. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.