{"product_id":"evening-primrose-oil-500mg-cold-pressed-10-gla-natural-omega-6-200-softgels","title":"Evening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels","description":"\u003ch2\u003eEvening Primrose Oil 500mg | Cold Pressed | 10% GLA | Natural Omega-6 | 200 Softgels\u003c\/h2\u003e\n\n\u003cp\u003eEach softgel delivers 500mg of cold pressed evening primrose oil (\u003cem\u003eOenothera biennis\u003c\/em\u003e, seed), standardized to 10% gamma-linolenic acid (GLA), providing a guaranteed 50mg of GLA per softgel. No solvents. No fillers.\u003c\/p\u003e\n\u003cp\u003eHealth Canada licensed NPN 80030725. Made in Canada. 200 softgels, up to a 6 month supply at 1 softgel per day.\u003c\/p\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003e50mg GLA per softgel, guaranteed\u003c\/strong\u003e Standardized to 10% gamma-linolenic acid | 100mg GLA per daily dose of 2 softgels\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSkin health and barrier support\u003c\/strong\u003e GLA is a critical structural component of the skin lipid barrier, supporting moisture retention, elasticity, and barrier integrity\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHormonal balance and menstrual cycle support\u003c\/strong\u003e GLA and its metabolite DGLA influence prostaglandin synthesis pathways involved in hormonal signalling and premenstrual comfort\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHealthy inflammatory response\u003c\/strong\u003e GLA is converted to DGLA and then to prostaglandin E1 (PGE1), a Series 1 prostaglandin that supports inflammatory balance rather than promoting inflammation\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCold pressed extraction\u003c\/strong\u003e Preserves heat-sensitive GLA and linoleic acid without chemical solvents or high heat\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNatural source of omega-6 GLA\u003c\/strong\u003e One of the richest plant sources of GLA, a conditionally essential fatty acid not widely available in the diet\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed\u003c\/strong\u003e NPN 80030725 | GMP certified | Made in Canada\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e200 softgels\u003c\/strong\u003e Up to a 6 month supply at 1 softgel per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eA cold pressed evening primrose oil supplement providing 500mg of pure \u003cem\u003eOenothera biennis\u003c\/em\u003e seed oil per softgel, standardized to a guaranteed 10% GLA (50mg per softgel). Evening primrose oil is one of the richest plant sources of GLA, a conditionally essential omega-6 fatty acid not widely found in the diet.\u003c\/p\u003e\n\u003cp\u003eGLA must be synthesized from linoleic acid by the delta-6-desaturase enzyme, a conversion routinely impaired by aging, stress, nutritional deficiencies, and hormonal fluctuations. Evening primrose oil delivers GLA directly, bypassing this enzymatic step. Licensed by Health Canada under NPN 80030725. Contains gelatin (softgel shell). Not suitable for vegans or vegetarians.\u003c\/p\u003e\n\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\n\u003ch3\u003eWhy GLA Requires Direct Supplementation\u003c\/h3\u003e\n\u003cp\u003eGLA is synthesized from dietary linoleic acid via the delta-6-desaturase enzyme. This conversion is routinely impaired by aging, chronic stress, insulin resistance, alcohol consumption, and hormonal fluctuations. When delta-6-desaturase activity is reduced, linoleic acid accumulates without converting to GLA. Evening primrose oil delivers GLA directly, bypassing this enzymatic bottleneck entirely.\u003c\/p\u003e\n\n\u003ch3\u003eHow GLA Becomes Prostaglandin E1\u003c\/h3\u003e\n\u003cp\u003eAbsorbed GLA is elongated to dihomo-gamma-linolenic acid (DGLA) by elongase enzymes. DGLA is the immediate precursor to prostaglandin E1 (PGE1) via cyclooxygenase-1. PGE1 is a vasodilatory, anti-aggregatory, and anti-inflammatory eicosanoid. DGLA is preferentially converted to PGE1 rather than to pro-inflammatory arachidonic acid, making GLA a net anti-inflammatory intervention.\u003c\/p\u003e\n\n\u003ch3\u003eGLA and Skin Barrier Function\u003c\/h3\u003e\n\u003cp\u003eGLA is incorporated into ceramides and phospholipids that form the skin lipid barrier, the lamellar structure between corneocytes that governs transepidermal water loss (TEWL) and barrier integrity. GLA deficiency is associated with increased TEWL, dry skin, and impaired barrier function. Supplementation with evening primrose oil supports ceramide synthesis and barrier repair, improving skin hydration and elasticity.\u003c\/p\u003e\n\n\u003ch3\u003eGLA and Hormonal Signalling\u003c\/h3\u003e\n\u003cp\u003eDGLA, the elongation product of GLA, is a precursor to PGE1 and to 15-HETrE, both of which modulate estrogen-sensitive tissue responses and luteal phase signalling. This prostaglandin pathway is the mechanism through which evening primrose oil supports premenstrual comfort, cyclical breast tenderness, and menstrual cycle regularity.\u003c\/p\u003e\n\n\u003ch3\u003eWhy Cold Pressed and Not Solvent Extracted\u003c\/h3\u003e\n\u003cp\u003eCold pressing uses mechanical pressure at controlled low temperatures, preserving the full fatty acid profile including heat-sensitive GLA and linoleic acid. Solvent extraction using hexane at elevated temperatures degrades polyunsaturated fatty acids, destroys native tocopherols, and may leave trace solvent residues. Cold pressed EPO retains its complete fatty acid composition and natural antioxidant content.\u003c\/p\u003e\n\n\u003ch2\u003eMedicinal Ingredient (per softgel)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eEvening Primrose Oil (Oenothera biennis, seed, cold pressed) 500mg\u003c\/strong\u003e Standardized to 10% GLA | 50mg GLA per softgel | Linoleic acid approximately 360mg | NPN 80030725\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Gelatin (softgel shell), glycerin, purified water. No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Non-GMO.\u003c\/p\u003e\n\n\u003ch2\u003ePer Daily Dose (2 Softgels)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eEvening Primrose Oil: 1000mg\u003c\/li\u003e\n  \u003cli\u003eGamma-Linolenic Acid (GLA): 100mg\u003c\/li\u003e\n  \u003cli\u003eLinoleic Acid (LA): approximately 720mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNPN 80030725\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eIndependently tested\u003c\/strong\u003e Purity and potency verified by a third-party laboratory\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCold pressed\u003c\/strong\u003e No solvents, no high heat, full fatty acid profile preserved\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eStandardized to 10% GLA\u003c\/strong\u003e 50mg GLA guaranteed per softgel\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon-GMO and gluten free\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e200 softgels\u003c\/strong\u003e Up to a 6 month supply at 1 softgel per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eDo not use if you have a seizure disorder or are taking phenothiazine medications\u003c\/li\u003e\n  \u003cli\u003eNot suitable for vegans or vegetarians (gelatin softgel shell)\u003c\/li\u003e\n  \u003cli\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking anticoagulants such as warfarin\u003c\/li\u003e\n  \u003cli\u003eAdults seeking daily GLA supplementation for skin barrier support, hormonal balance, or inflammatory response support\u003c\/li\u003e\n  \u003cli\u003eWomen experiencing PMS, premenstrual breast tenderness, or menstrual cycle irregularity who want a licensed, evidence-informed option\u003c\/li\u003e\n  \u003cli\u003eIndividuals whose delta-6-desaturase conversion may be impaired by aging, stress, or hormonal fluctuations\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 to 2 softgels daily with a meal containing dietary fat. Dietary fat stimulates bile secretion and supports lymphatic absorption of the oil.\u003c\/p\u003e\n\u003cp\u003eRefrigerate after opening to preserve fatty acid integrity. For best results, use consistently over 8 to 12 weeks based on clinical trial protocols for GLA supplementation.\u003c\/p\u003e\n\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eDo not use if you have a seizure disorder or are taking phenothiazine medications. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or taking blood-thinning medications such as warfarin.\u003c\/p\u003e\n\u003cp\u003eRefrigerate after opening. Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\n\u003cp\u003eNPN 80030725. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":42910820761763,"sku":"N126","price":35.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Evening_primrose_oil_500_mg_cold_pressed_10_percent_GLA_200_softgels.jpg?v=1776450648","url":"https:\/\/nutridom.ca\/products\/evening-primrose-oil-500mg-cold-pressed-10-gla-natural-omega-6-200-softgels","provider":"Nutridom","version":"1.0","type":"link"}