Medicinal Ingredient (per capsule):
Glucsosamine (Glucosamine sulfate)… 500mg
MSM (Methylsulfonylmethane, Dimethyl sulfone)… 500mg

Non-Medicinal Ingredients:
Magnesium stearate, Microcrystalline celulose, Hypromellose

Recommended Dose:
Adults: 1 Tablet 3 times per day.
Take with food. Avoid taking at bedtime. Store in airtight container, protected from light.

Duration of Use:
Use for a minimum of 1 month to see beneficial effects.

Cautions and Warnings:
If you are pregnant or breastfeeding, consult a health care practitioner prior to use.
If symptoms worsen, consult a health care practitioner.

Known Adverse Reactions:
Some people may experience mild gastrointestinal disturbances such as diarrhea, abdominal pain, heartburn, nausea and vomiting; in which case, discontinue use.

Q: What does this product do?
A: This formula helps to relieve joint pain associated with osteoarthritis (of the knee). It helps to protect against the deterioration of cartilage. It is a factor in maintaining healthy cartilage and/or joint health. These are the Health Canada approved uses (NPN 80058087). This product is not intended to diagnose, treat, cure, or prevent any disease.

Q: What is glucosamine and what does it do in the body?
A: Glucosamine is an amino sugar a sugar molecule with an amino group attached. It is a natural component of cartilage, specifically a building block of glycosaminoglycans (GAGs), which are the long chains of sugar molecules that form the structural matrix of cartilage. Cartilage is the connective tissue that cushions the ends of bones in joints. Glycosaminoglycans give cartilage its ability to absorb compressive forces. The body produces glucosamine endogenously, but production may decline with age.

Q: Why does this formula use glucosamine sulfate rather than glucosamine HCl?
A: There are two main forms of glucosamine used in supplements: glucosamine sulfate and glucosamine hydrochloride (HCl). Glucosamine sulfate provides both glucosamine and sulfate. Sulfate is a component of cartilage proteoglycans the large molecules that give cartilage its water-retaining and shock-absorbing properties. Glucosamine HCl provides glucosamine without the sulfate. Most clinical research on glucosamine and osteoarthritis has been conducted using glucosamine sulfate. This formula uses glucosamine sulfate at 500mg per capsule, providing 1,500mg per daily dose.

Q: What is MSM and what does it do in the body?
A: Methylsulfonylmethane (MSM), also known as dimethyl sulfone (DMSO2), is an organosulfur compound a naturally occurring sulfur-containing compound found in small amounts in many foods including fruits, vegetables, milk, fish, and grains. MSM is a white, odourless, water-soluble crystalline solid and a source of bioavailable organic sulfur. Sulfur is a component of collagen, keratin, and other structural proteins, and is involved in the formation of disulfide bonds that contribute to the structural integrity of connective tissue. Sulfur is also a component of cartilage proteoglycans.

Q: Why are glucosamine sulfate and MSM combined in this formula?
A: Both glucosamine sulfate and MSM provide sulfur to the body, but through different mechanisms. Glucosamine sulfate provides glucosamine (a cartilage building block) and sulfate (a component of cartilage proteoglycans). MSM provides organic sulfur (dimethyl sulfone) as an additional source of bioavailable sulfur for connective tissue. The combination provides both the structural building block (glucosamine) and additional sulfur support (MSM) in a single formula. Each is provided at 500mg per capsule, delivering 1,500mg of each per daily dose.

Q: Why is the dose 3 times per day rather than once daily?
A: The recommended dose is 1 capsule, 3 times per day with food. Dividing the daily dose into 3 separate doses maintains more consistent levels of glucosamine and MSM in the body throughout the day compared to taking all 3 capsules at once. The instruction to avoid taking at bedtime means the 3 doses should be spread through waking hours for example with breakfast, lunch, and dinner.

Q: How long does it take to see results and why?
A: Use for a minimum of 1 month to see beneficial effects. This is the Health Canada approved duration of use for this formula. Glucosamine and MSM are not fast-acting like pain medications. They work by providing building blocks and sulfur for cartilage and connective tissue, which are slow-turnover tissues that change gradually over time. One month is generally considered the minimum period to determine whether this formula is effective for an individual. The 300-capsule bottle provides a 100-day supply at 3 capsules per day approximately 3.3 months which is well suited to the minimum trial period and allows for continued use beyond the initial month.

Q: How do I take this product and how long will 300 capsules last?
A: Adults: 1 capsule, 3 times per day with food. Avoid taking at bedtime. At 300 capsules and 3 capsules per day, one bottle provides a 100 day supply (approximately 3.3 months). Per daily dose (3 capsules): Glucosamine sulfate 1,500mg, MSM 1,500mg.

Q: Does this product contain shellfish?
A: Glucosamine sulfate is typically derived from crustacean shells (chitin). Verify the source of glucosamine sulfate in this formula with Nutridom before use if you have a shellfish allergy or follow a vegan diet. The metafield does not specify whether the glucosamine sulfate in this formula is crustacean-derived or produced by bacterial fermentation of grains (a shellfish-free alternative). Contact Nutridom directly to confirm the source before purchasing if this is a concern.

Q: Are there any cautions I should know about?
A: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. If symptoms worsen, consult a health care practitioner. Some people may experience mild gastrointestinal disturbances such as diarrhea, abdominal pain, heartburn, nausea and vomiting; in which case, discontinue use. Verify the complete contraindications against the NPN 80058087 licence before publishing and update this answer with the complete verbatim cautions. Keep out of reach of children. This product is not intended to diagnose, treat, cure, or prevent any disease.

Q: How should I store this product?
A: Store in an airtight container, protected from light, in a cool dry place. Keep out of reach of children.