{"product_id":"joint-plus-ez-flex-liquid-9-ingredients-glucosamine-collagen-boswellia","title":"Joint Plus EZ Flex Liquid | 9 Ingredients | Glucosamine, Collagen, Boswellia","description":"\u003ch2\u003eJoint Plus EZ Flex Liquid | 9 Active Ingredients | Structural Support and Herbal Anti-Inflammatory | 450ml\u003c\/h2\u003e\n\n\u003cp\u003eNine medicinal ingredients per tablespoon in a single liquid formula. Two complementary categories: structural and cartilage matrix compounds (hydrolyzed collagen, glucosamine sulfate, chondroitin sulfate, hyaluronic acid, MSM) and standardized herbal anti-inflammatory extracts (Curcuma longa 95% curcuminoids, Boswellia serrata 40% boswellic acids, Devil's Claw 4:1, bromelain). Health Canada licensed NPN 80121785. Use for at least 2 to 3 months to see beneficial effects. Made in Canada.\u003c\/p\u003e\n\n\u003ch2\u003eAllergen and Suitability Notice\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eContains shellfish\u003c\/strong\u003e Glucosamine sulfate from crab exoskeleton. Do not use if you have a shellfish allergy\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eContains chicken\u003c\/strong\u003e Hydrolyzed collagen from chicken cartilage. Not suitable for vegetarians or vegans\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eContains bovine\u003c\/strong\u003e Chondroitin sulfate from Bos taurus cartilage. Not suitable for vegetarians or vegans\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHyaluronic acid is fermentation derived\u003c\/strong\u003e From Streptococcus equi bacterial extracellular capsule. Not from rooster comb or animal tissue\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHelps support joint health and relieve joint pain and swelling associated with osteoarthritis of the knee\u003c\/strong\u003e Health Canada licensed NPN 80121785\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eUsed in herbal medicine to relieve minor pain, swelling, and inflammation\u003c\/strong\u003e Licensed use NPN 80121785\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eUse for at least 2 to 3 months to see beneficial effects\u003c\/strong\u003e Per the licensed label\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e9 medicinal ingredients per tablespoon\u003c\/strong\u003e Structural and herbal categories in one liquid serving\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCurcuma longa 95% curcuminoids 400mg\u003c\/strong\u003e Highest common standardization level for curcumin\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eBoswellia serrata 40% boswellic acids 333mg\u003c\/strong\u003e Including AKBA, selective 5-LOX inhibitor\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eGlucosamine sulfate 500mg\u003c\/strong\u003e From crab exoskeleton | Sulfated form used in clinical trials\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHydrolyzed collagen 1,000mg\u003c\/strong\u003e From chicken cartilage | Type II collagen peptides\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eBromelain 540,000 FCC PU\u003c\/strong\u003e Proteolytic enzyme | Supports absorption of other ingredients\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eLiquid format\u003c\/strong\u003e No capsule dissolution | Flexible dosing | 9 ingredients in one tablespoon\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon GMO\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eJoint Plus EZ Flex Liquid delivers 9 medicinal ingredients per tablespoon (15ml) in two complementary categories. The structural category addresses the physical composition of joint cartilage, synovial fluid, and connective tissue. The herbal category targets the inflammatory pathways involved in joint pain and swelling through distinct and complementary mechanisms. Licensed by Health Canada with NPN 80121785. Manufactured in Canada to GMP standards under the Nutridom brand. Use for at least 2 to 3 months to see beneficial effects.\u003c\/p\u003e\n\n\u003ch2\u003eThe 9 Ingredients: What Each One Does\u003c\/h2\u003e\n\n\u003ch3\u003eStructural Category\u003c\/h3\u003e\n\n\u003ch4\u003eHydrolyzed Collagen (Chicken Cartilage) | 1,000mg\u003c\/h4\u003e\n\u003cp\u003eCollagen is the primary structural protein of cartilage, tendons, and ligaments, comprising approximately 60 to 70% of the dry weight of articular cartilage. The collagen in this formula is hydrolyzed from chicken cartilage, which is rich in Type II collagen, the predominant collagen type in articular cartilage. Enzymatic hydrolysis breaks the collagen into smaller peptide fragments that are more readily absorbed from the GI tract than intact collagen protein. Collagen peptides provide glycine, proline, and hydroxyproline, the three amino acids that form the repeating tripeptide sequence of the collagen triple helix and are the building blocks for endogenous collagen synthesis in cartilage tissue.\u003c\/p\u003e\n\n\u003ch4\u003eMSM (Methylsulfonylmethane) | 1,000mg\u003c\/h4\u003e\n\u003cp\u003eMSM is an organic sulfur compound. Sulfur is an essential element for the synthesis of collagen and glycosaminoglycans, the structural components of cartilage matrix, as sulfur containing amino acids (methionine and cysteine) are required for collagen cross-linking and glycosaminoglycan sulfation. MSM provides a bioavailable source of organic sulfur to support these structural synthesis pathways.\u003c\/p\u003e\n\n\u003ch4\u003eGlucosamine Sulfate (Crab Exoskeleton) | 500mg\u003c\/h4\u003e\n\u003cp\u003eGlucosamine is an amino monosaccharide and the primary building block for glycosaminoglycans, the long chain polysaccharides that form the backbone of proteoglycans in cartilage matrix. Proteoglycans (particularly aggrecan) are responsible for cartilage's ability to resist compressive forces by attracting and retaining water within the cartilage matrix. Glucosamine sulfate is the sulfated form used in the most extensively studied clinical trials on glucosamine for osteoarthritis. Source: crab exoskeleton. Contains shellfish.\u003c\/p\u003e\n\n\u003ch4\u003eChondroitin Sulfate (Bos taurus Cartilage) | 400mg\u003c\/h4\u003e\n\u003cp\u003eChondroitin sulfate is a sulfated glycosaminoglycan and a major structural component of cartilage matrix, attached to the core protein of aggrecan proteoglycans. Its highly negatively charged sulfate groups attract water molecules into the cartilage matrix, giving cartilage its compressive resilience. Chondroitin sulfate also inhibits cartilage degrading enzymes including matrix metalloproteinases (MMPs) and aggrecanases. Source: bovine (Bos taurus) cartilage.\u003c\/p\u003e\n\n\u003ch4\u003eHyaluronic Acid (Sodium Hyaluronate) | 61mg\u003c\/h4\u003e\n\u003cp\u003eHyaluronic acid is the primary structural component of synovial fluid, the viscous fluid that lubricates joint surfaces and nourishes articular cartilage. In healthy joints, hyaluronic acid gives synovial fluid its characteristic viscosity and viscoelastic properties. In osteoarthritis, the concentration and molecular weight of hyaluronic acid in synovial fluid decreases, reducing its lubricating and shock absorbing capacity. The hyaluronic acid in this formula is fermentation derived from Streptococcus equi bacterial extracellular capsule, not from rooster comb or animal tissue.\u003c\/p\u003e\n\n\u003ch3\u003eHerbal Anti-Inflammatory Category\u003c\/h3\u003e\n\n\u003ch4\u003eCurcuma longa (95% Curcuminoids) | 400mg\u003c\/h4\u003e\n\u003cp\u003eTurmeric root extract standardized to 95% curcuminoids, the highest common standardization level. The curcuminoid complex includes curcumin (the most abundant and most studied), demethoxycurcumin, and bisdemethoxycurcumin. Curcumin inhibits NF-kB, the master transcription factor that regulates the expression of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6. Curcumin also inhibits COX-2, the enzyme that produces prostaglandins involved in pain and inflammation.\u003c\/p\u003e\n\n\u003ch4\u003eBoswellia serrata (40% Boswellic Acids) | 333mg\u003c\/h4\u003e\n\u003cp\u003eIndian frankincense resin extract standardized to 40% boswellic acids. The primary active boswellic acid is AKBA (acetyl-11-keto-beta-boswellic acid), a selective inhibitor of 5-LOX (5-lipoxygenase), the enzyme that converts arachidonic acid to leukotrienes. By targeting the 5-LOX pathway rather than the COX pathway, Boswellia provides anti-inflammatory activity through a mechanism complementary to curcumin's COX-2 inhibition, addressing both major arachidonic acid inflammatory cascades simultaneously.\u003c\/p\u003e\n\n\u003ch4\u003eDevil's Claw (Harpagophytum zeyheri, 4:1) | 270mg\u003c\/h4\u003e\n\u003cp\u003eDevil's Claw secondary root tuber extract at a 4:1 concentration ratio (equivalent to 1,080mg of dry herb). The primary bioactive compounds are iridoid glycosides, particularly harpagoside, which inhibit both COX and LOX inflammatory enzymes. Devil's Claw has a long history of traditional use in southern African herbal medicine for musculoskeletal pain and is one of the most studied herbal medicines for joint health in the European herbal medicine tradition.\u003c\/p\u003e\n\n\u003ch4\u003eFruit Bromelain | 15mg (540,000 FCC PU)\u003c\/h4\u003e\n\u003cp\u003eBromelain is a mixture of proteolytic enzymes derived from pineapple (Ananas comosus) fruit. Activity is measured in FCC PU (Food Chemicals Codex Papain Units). Bromelain has anti-inflammatory properties through its ability to modulate inflammatory mediators and reduce pro-inflammatory cytokine production. Bromelain also enhances the absorption of other compounds in the formula, particularly curcumin, by breaking down proteins that can bind to and limit the absorption of polyphenolic compounds in the GI tract.\u003c\/p\u003e\n\n\u003ch2\u003eWhy Liquid Format?\u003c\/h2\u003e\n\u003cp\u003eA comprehensive joint formula with 9 active ingredients would require a large number of capsules to deliver equivalent doses. The liquid format consolidates all 9 ingredients into a single tablespoon serving with no capsule dissolution step. Liquid supplements reach the GI tract more rapidly than encapsulated formulas. The format also allows flexible dosing between 2 and 3 tablespoons per day as directed by a healthcare practitioner.\u003c\/p\u003e\n\n\u003ch2\u003eMedicinal Ingredients (per 1 tablespoon \/ 15ml)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eHydrolyzed collagen (Chicken, cartilage) 1,000mg\u003c\/li\u003e\n  \u003cli\u003eMSM (Methylsulfonylmethane) 1,000mg\u003c\/li\u003e\n  \u003cli\u003eGlucosamine sulfate (Crab, exoskeleton) 500mg\u003c\/li\u003e\n  \u003cli\u003eChondroitin sulfate (Bos taurus, cartilage) 400mg\u003c\/li\u003e\n  \u003cli\u003eCurcuma longa (rhizome, 95% curcuminoids) 400mg\u003c\/li\u003e\n  \u003cli\u003eBoswellia serrata (40% boswellic acids) 333mg\u003c\/li\u003e\n  \u003cli\u003eDevil's Claw (Harpagophytum zeyheri, secondary root tuber, 4:1, QCE 1,080mg) 270mg\u003c\/li\u003e\n  \u003cli\u003eHyaluronic acid (Streptococcus equi, bacterial extracellular capsule, sodium hyaluronate) 61mg\u003c\/li\u003e\n  \u003cli\u003eFruit bromelain (Ananas comosus, fruit) 15mg | 540,000 FCC PU\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNPN 80121785\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e9 medicinal ingredients per tablespoon\u003c\/strong\u003e Structural and herbal categories\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eCurcuma longa standardized to 95% curcuminoids\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eBoswellia serrata standardized to 40% boswellic acids\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eBromelain at 540,000 FCC PU\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eFermentation derived hyaluronic acid\u003c\/strong\u003e Not from animal tissue\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon GMO\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e450ml\u003c\/strong\u003e 30 tablespoon servings per bottle\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eAdults without shellfish allergy seeking comprehensive joint support combining structural compounds and standardized herbal anti-inflammatory extracts in a single liquid formula\u003c\/li\u003e\n  \u003cli\u003eThose seeking Health Canada licensed support for joint pain and swelling associated with osteoarthritis of the knee, and herbal medicine support for minor pain, swelling, and inflammation\u003c\/li\u003e\n  \u003cli\u003eThose who prefer a liquid format over multiple capsules for a multi-ingredient joint formula\u003c\/li\u003e\n  \u003cli\u003eAdults who have reviewed the cautions below and, where applicable, discussed this formula with their healthcare practitioner\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 tablespoon (15ml) 2 to 3 times per day. Use the calibrated measuring cup provided. Can be mixed with half a glass of water or juice. Take with food. Avoid taking at bedtime. Use for at least 2 to 3 months to see beneficial effects. Consult a healthcare practitioner to determine the appropriate dose for your individual needs.\u003c\/p\u003e\n\u003cp\u003eStorage: Store in an airtight container protected from light. Refrigerate after opening. Keep out of reach of children.\u003c\/p\u003e\n\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDo not use if you have a shellfish allergy.\u003c\/strong\u003e This product contains glucosamine sulfate from crab exoskeleton.\u003c\/p\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, have gallstones or bile duct obstruction, have stomach ulcers or excess stomach acid, have gastrointestinal lesions or ulcers, are scheduled for surgery, or are taking anticoagulant agents, anti-inflammatory agents, or antibiotics. Consult a healthcare practitioner if symptoms worsen.\u003c\/p\u003e\n\u003cp\u003eStop use and consult a healthcare practitioner if diarrhea, abdominal pain, heartburn, nausea, or vomiting occur. Stop use if hypersensitivity or allergic reaction occurs.\u003c\/p\u003e\n\u003cp\u003eKeep out of reach of children. Do not use if the seal is broken or missing.\u003c\/p\u003e\n\n\u003cp\u003eNPN 80121785. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":43197769187491,"sku":"N272","price":59.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/JOINT-PLUS.jpg?v=1772741704","url":"https:\/\/nutridom.ca\/products\/joint-plus-ez-flex-liquid-9-ingredients-glucosamine-collagen-boswellia","provider":"Nutridom","version":"1.0","type":"link"}