Melatonin for the prevention and treatment of jet lag
Cochrane Database of Systematic Reviews, 2002
Each tablet delivers 10mg of melatonin (N-acetyl-5-methoxytryptamine) in a sublingual mint format that dissolves under the tongue for direct absorption into the bloodstream, bypassing digestion and first-pass liver metabolism. Helps reset the body's sleep wake cycle. Supports sleep onset. Jet lag and shift work support
Do not use if you are pregnant or breastfeeding. Not for use by individuals under 18 years of age.
Melatonin (N-acetyl-5-methoxytryptamine) in this formula is synthetically produced, not derived from animal pineal glands. Synthetic melatonin is chemically identical to the hormone produced endogenously by the human pineal gland and is the standard source used in pharmaceutical grade melatonin supplements worldwide, ensuring consistent purity and potency.
Melatonin is a hormone produced by the pineal gland in response to darkness. As light levels fall in the evening, the suprachiasmatic nucleus (the brain's master circadian clock) signals the pineal gland to begin melatonin secretion. Melatonin does not cause sleep directly the way a sedative does. It acts as a chronobiotic, signalling the timing of sleep by communicating to the circadian clock that it is nighttime and shifting the body toward sleep-readiness. Supplemental melatonin mimics this endogenous signal, helping to shift or reinforce the circadian timing of sleep onset. It is most effective when taken at the right time relative to the desired sleep onset, not simply as a sleep-inducing agent taken at any time.
Sublingual means under the tongue. The sublingual mucosa is highly vascularized, containing a dense network of capillaries. When the tablet dissolves under the tongue, melatonin is absorbed directly through this tissue into the bloodstream, bypassing digestion in the stomach and intestine and first-pass metabolism in the liver. This results in faster onset compared to swallowing a tablet. Croscarmellose sodium in this tablet is a disintegrant that causes rapid tablet breakdown on contact with moisture, accelerating dissolution. Take 10 to 30 minutes before bedtime.
Adults 18 years and older: Take 1 tablet once per day. Place under the tongue and allow to dissolve completely. Do not swallow whole. Take 10 to 30 minutes before bedtime. For jet lag: take at the target bedtime in the new time zone. For shift work: take at the desired sleep time on the new schedule.
Store in a cool, dry place away from direct sunlight. Keep the bottle tightly sealed after each use. Melatonin is sensitive to light. Keep out of reach of children.
Do not use if you are pregnant or breastfeeding. Not for use by individuals under 18 years of age. Ask a healthcare practitioner before use if you are taking medications for seizure, blood pressure, immune suppression, mental state or increased sedation, steroids, or blood thinners, or if you have cardiovascular, immune, liver, or kidney disease, seizure disorder, asthma, or diabetes. Ask a healthcare practitioner if sleeplessness persists for more than 4 weeks. Stop use if allergy occurs or if you experience headache, confusion, or nausea. Keep out of reach of children.
NPN 80135538. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Each tablet delivers 10mg of melatonin (N-acetyl-5-methoxytryptamine) in a sublingual mint format that dissolves under the tongue for direct absorption into the bloodstream, bypassing digestion and first-pass liver metabolism. Helps reset the body's sleep wake cycle. Supports sleep onset. Jet lag and shift work support
Do not use if you are pregnant or breastfeeding. Not for use by individuals under 18 years of age.
Melatonin (N-acetyl-5-methoxytryptamine) in this formula is synthetically produced, not derived from animal pineal glands. Synthetic melatonin is chemically identical to the hormone produced endogenously by the human pineal gland and is the standard source used in pharmaceutical grade melatonin supplements worldwide, ensuring consistent purity and potency.
Melatonin is a hormone produced by the pineal gland in response to darkness. As light levels fall in the evening, the suprachiasmatic nucleus (the brain's master circadian clock) signals the pineal gland to begin melatonin secretion. Melatonin does not cause sleep directly the way a sedative does. It acts as a chronobiotic, signalling the timing of sleep by communicating to the circadian clock that it is nighttime and shifting the body toward sleep-readiness. Supplemental melatonin mimics this endogenous signal, helping to shift or reinforce the circadian timing of sleep onset. It is most effective when taken at the right time relative to the desired sleep onset, not simply as a sleep-inducing agent taken at any time.
Sublingual means under the tongue. The sublingual mucosa is highly vascularized, containing a dense network of capillaries. When the tablet dissolves under the tongue, melatonin is absorbed directly through this tissue into the bloodstream, bypassing digestion in the stomach and intestine and first-pass metabolism in the liver. This results in faster onset compared to swallowing a tablet. Croscarmellose sodium in this tablet is a disintegrant that causes rapid tablet breakdown on contact with moisture, accelerating dissolution. Take 10 to 30 minutes before bedtime.
Adults 18 years and older: Take 1 tablet once per day. Place under the tongue and allow to dissolve completely. Do not swallow whole. Take 10 to 30 minutes before bedtime. For jet lag: take at the target bedtime in the new time zone. For shift work: take at the desired sleep time on the new schedule.
Store in a cool, dry place away from direct sunlight. Keep the bottle tightly sealed after each use. Melatonin is sensitive to light. Keep out of reach of children.
Do not use if you are pregnant or breastfeeding. Not for use by individuals under 18 years of age. Ask a healthcare practitioner before use if you are taking medications for seizure, blood pressure, immune suppression, mental state or increased sedation, steroids, or blood thinners, or if you have cardiovascular, immune, liver, or kidney disease, seizure disorder, asthma, or diabetes. Ask a healthcare practitioner if sleeplessness persists for more than 4 weeks. Stop use if allergy occurs or if you experience headache, confusion, or nausea. Keep out of reach of children.
NPN 80135538. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Serving Size: 1 Tablet
Servings Per Container: 300
† Daily Value not established
Cochrane Database of Systematic Reviews, 2002
PLOS ONE, 2013
Journal of Biological Rhythms, 2010
Research information is provided for educational purposes and does not replace the product's approved label information.