Methyl Folate 1000mcg | Active L-5-MTHF | 90 Vcaps — 3 Pack

A 3-pack of Methyl Folate 1000mcg L-5-methyltetrahydrofolate (L-5-MTHF), the active, bioavailable form of folate that the body can use directly without metabolic conversion. 1000mcg per vcap. No synthetic folic acid. Vegan capsule. Made in Canada. 3 x 90 vcaps, 270 vcaps total.

3 Pack at a Glance

• 270 vcaps total 3 bottles x 90 vcaps
• 1000mcg L-5-MTHF per vcap Active, bioavailable methylated folate
• No MTHFR conversion required Directly usable by the body
• No synthetic folic acid Methylated form only
• Vegan capsule
• Made in Canada

Recommended Use

Adults: As directed by a healthcare practitioner. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications.

Why L-5-MTHF Instead of Folic Acid

Folic acid is the synthetic, oxidized form of folate used in most supplements and fortified foods. Before the body can use folic acid, it must be converted through a multi-step enzymatic pathway to L-5-methyltetrahydrofolate (L-5-MTHF) the active form that participates directly in one-carbon metabolism, DNA synthesis, and the methylation cycle.

The key enzyme in this conversion pathway is methylenetetrahydrofolate reductase (MTHFR). Variants in the MTHFR gene particularly C677T and A1298C are among the most common genetic polymorphisms in the human population, estimated to affect 40–60% of people to varying degrees. Individuals with reduced MTHFR enzyme activity convert folic acid to L-5-MTHF less efficiently, which can result in suboptimal folate status even with adequate folic acid intake.

L-5-MTHF bypasses the MTHFR conversion step entirely. It is the end-product of the folate conversion pathway the form that enters the methylation cycle directly, donating methyl groups for the conversion of homocysteine to methionine, the synthesis of SAMe (S-adenosylmethionine), and the production of neurotransmitters including serotonin, dopamine, and norepinephrine. For individuals with MTHFR variants, or those who simply want the most direct and efficient form of folate supplementation, L-5-MTHF is the evidence-informed choice.

The 3-pack provides a 9-month supply at 1 vcap per day, supporting the kind of consistent, uninterrupted daily methylated folate intake that gives this formula the best opportunity to contribute to folate status and methylation cycle support over time.

Who This Is For

• Adults seeking active L-5-MTHF as a direct, bioavailable alternative to synthetic folic acid
• Those with known or suspected MTHFR gene variants who want methylated folate that bypasses the MTHFR conversion step
• Those who prefer an extended 9-month supply for consistent, uninterrupted daily methylated folate supplementation

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications including methotrexate or other folate-affecting drugs. Keep out of reach of children.

Medicinal Ingredient (per vcap)

• L-5-Methyltetrahydrofolate (L-5-MTHF) 1000mcg Active methylated folate.

Non-medicinal ingredients: Vegan capsule shell. Made in Canada.

Quality and Trust

• Made in Canada
• 1000mcg L-5-MTHF per vcap Active, bioavailable methylated folate
• No synthetic folic acid Methylated form only
• No MTHFR conversion required
• Vegan capsule
• 270 vcaps 3 x 90 vcaps

Storage

Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.

Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications including methotrexate or other folate-affecting drugs. Keep out of reach of children.