{"product_id":"methyl-folate-1000mcg-active-l-5-mthf-90-vcaps-3-pack","title":"Methyl Folate 1000mcg | Active L-5-MTHF | 90 Vcaps | 3 Pack","description":"\u003ch2\u003eMethyl Folate 1000mcg | Active L-5-MTHF | 90 Vcaps — 3 Pack\u003c\/h2\u003e\n\u003cp\u003eA 3-pack of Methyl Folate 1000mcg L-5-methyltetrahydrofolate (L-5-MTHF), the active, bioavailable form of folate that the body can use directly without metabolic conversion. 1000mcg per vcap. No synthetic folic acid. Vegan capsule. Made in Canada. 3 x 90 vcaps, 270 vcaps total.\u003c\/p\u003e\n\u003ch2\u003e3 Pack at a Glance\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e270 vcaps total\u003c\/strong\u003e 3 bottles x 90 vcaps\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e1000mcg L-5-MTHF per vcap\u003c\/strong\u003e Active, bioavailable methylated folate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo MTHFR conversion required\u003c\/strong\u003e Directly usable by the body\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo synthetic folic acid\u003c\/strong\u003e Methylated form only\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eVegan capsule\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eMade in Canada\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRecommended Use\u003c\/h2\u003e\n\u003cp\u003eAdults: As directed by a healthcare practitioner. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications.\u003c\/p\u003e\n\u003ch2\u003eWhy L-5-MTHF Instead of Folic Acid\u003c\/h2\u003e\n\u003cp\u003eFolic acid is the synthetic, oxidized form of folate used in most supplements and fortified foods. Before the body can use folic acid, it must be converted through a multi-step enzymatic pathway to L-5-methyltetrahydrofolate (L-5-MTHF) the active form that participates directly in one-carbon metabolism, DNA synthesis, and the methylation cycle.\u003c\/p\u003e\n\u003cp\u003eThe key enzyme in this conversion pathway is methylenetetrahydrofolate reductase (MTHFR). Variants in the MTHFR gene particularly C677T and A1298C are among the most common genetic polymorphisms in the human population, estimated to affect 40–60% of people to varying degrees. Individuals with reduced MTHFR enzyme activity convert folic acid to L-5-MTHF less efficiently, which can result in suboptimal folate status even with adequate folic acid intake.\u003c\/p\u003e\n\u003cp\u003eL-5-MTHF bypasses the MTHFR conversion step entirely. It is the end-product of the folate conversion pathway the form that enters the methylation cycle directly, donating methyl groups for the conversion of homocysteine to methionine, the synthesis of SAMe (S-adenosylmethionine), and the production of neurotransmitters including serotonin, dopamine, and norepinephrine. For individuals with MTHFR variants, or those who simply want the most direct and efficient form of folate supplementation, L-5-MTHF is the evidence-informed choice.\u003c\/p\u003e\n\u003cp\u003eThe 3-pack provides a 9-month supply at 1 vcap per day, supporting the kind of consistent, uninterrupted daily methylated folate intake that gives this formula the best opportunity to contribute to folate status and methylation cycle support over time.\u003c\/p\u003e\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAdults seeking active L-5-MTHF as a direct, bioavailable alternative to synthetic folic acid\u003c\/li\u003e\n\u003cli\u003eThose with known or suspected MTHFR gene variants who want methylated folate that bypasses the MTHFR conversion step\u003c\/li\u003e\n\u003cli\u003eThose who prefer an extended 9-month supply for consistent, uninterrupted daily methylated folate supplementation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications including methotrexate or other folate-affecting drugs. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eMedicinal Ingredient (per vcap)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-5-Methyltetrahydrofolate (L-5-MTHF) 1000mcg\u003c\/strong\u003e Active methylated folate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Vegan capsule shell. Made in Canada.\u003c\/p\u003e\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eMade in Canada\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e1000mcg L-5-MTHF per vcap\u003c\/strong\u003e Active, bioavailable methylated folate\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo synthetic folic acid\u003c\/strong\u003e Methylated form only\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eNo MTHFR conversion required\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eVegan capsule\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e270 vcaps\u003c\/strong\u003e 3 x 90 vcaps\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eStorage\u003c\/h2\u003e\n\u003cp\u003eStore in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eCautions\u003c\/h2\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications including methotrexate or other folate-affecting drugs. Keep out of reach of children.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":47365064032419,"sku":"N321X3","price":57.93,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Methyl_Folate_1000mcg_Active_L-5-MTHF_90_Vcaps_3_Pack.jpg?v=1779991935","url":"https:\/\/nutridom.ca\/products\/methyl-folate-1000mcg-active-l-5-mthf-90-vcaps-3-pack","provider":"Nutridom","version":"1.0","type":"link"}