Milk Thistle 250mg | 80% Silymarin Standardized | Liver Support | 300 Vegan Capsules
Each capsule contains 250mg of Milk Thistle seed extract (Silybum marianum (L.) Gaertn., Asteraceae) standardized to 80% silymarin, delivering 200mg of silymarin per capsule. Silymarin is the flavonolignan complex extracted from milk thistle seeds and is the primary bioactive responsible for milk thistle's hepatoprotective properties. Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant. Used in Herbal Medicine to help support liver function. Use for a minimum of 3 weeks to see beneficial effects. Health Canada approved (NPN 80024649). 100% vegan, non GMO, gluten free. Made in Canada in a quality controlled facility. 300 vegan capsules (150 to 300 day supply).
Key Features
• Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant
• Used in Herbal Medicine to help support liver function
• 250mg milk thistle seed extract per capsule, standardized to 80% silymarin
• 200mg silymarin per capsule: the highest common standardization level
• Silymarin: the complete flavonolignan complex including silybin A and B, silychristin, silydianin, and isosilybin
• Seed extract: the part of Silybum marianum with the highest silymarin concentration
• Use for a minimum of 3 weeks to see beneficial effects
• 1 to 2 capsules per day: flexible dosing
• 300 vegan capsules (150 to 300 day supply)
• Health Canada approved (NPN 80024649)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free
Understanding 250mg 80% Silymarin: What the Numbers Mean
The label notation "250mg 80% Silymarin" describes two distinct measurements that together define the potency of this extract. Understanding both is essential for accurately comparing milk thistle supplements.
250mg: The Extract Weight. This is the total weight of milk thistle seed extract in each capsule. The extract is produced by concentrating the bioactive compounds from raw milk thistle seeds and standardizing the result to a defined silymarin content.
80% Silymarin: The Standardization Level. Standardization means the extract has been tested and confirmed to contain 80% silymarin by weight. Of the 250mg of extract in each capsule, 80% (200mg) is silymarin, the flavonolignan complex responsible for milk thistle's hepatoprotective properties. The remaining 20% consists of other naturally occurring compounds in the seed extract.
200mg Silymarin per Capsule. The actual silymarin dose per capsule is 200mg (250mg x 0.80 = 200mg). This is the most meaningful measure of potency for a milk thistle supplement, as silymarin is the active fraction. 80% standardization is the highest common standardization level for milk thistle extracts and represents a high potency product.
Why Standardization Matters. Raw milk thistle seed powder contains variable amounts of silymarin depending on the plant variety, growing conditions, and harvest time. Standardization ensures that every capsule contains a consistent, defined amount of the active fraction regardless of natural variability in the raw material. A non-standardized milk thistle product may contain significantly less silymarin per gram than a standardized extract.
What Is Silymarin?
Silymarin is not a single compound but a complex mixture of flavonolignans extracted from the seeds of Silybum marianum. Flavonolignans are a class of polyphenolic compounds formed by the oxidative coupling of a flavonoid (taxifolin) with a lignan (coniferyl alcohol). The silymarin complex consists of several closely related flavonolignans:
• Silybin A and Silybin B (together called silybin): the most abundant flavonolignans in silymarin, comprising approximately 50 to 70% of the silymarin complex. Silybin is the most pharmacologically studied component and is considered the primary active compound
• Silychristin: the second most abundant flavonolignan, comprising approximately 20% of silymarin
• Silydianin: present in smaller amounts
• Isosilybin A and Isosilybin B: present in smaller amounts
The complete silymarin complex is considered more effective than isolated silybin alone, as the different flavonolignans have complementary activities and the complex as a whole reflects the traditional use of milk thistle seed extract.
Silybum marianum: The Plant
Milk thistle (Silybum marianum (L.) Gaertn.) is a flowering plant belonging to the Asteraceae family, the same plant family as artichoke, dandelion, echinacea, and chamomile. It is native to the Mediterranean region of Europe and western Asia and has been naturalized across much of the world. The plant is characterized by its distinctive spiny leaves with white marbling and its purple thistle flowers. It grows to 30 to 200cm in height and produces seeds (technically achenes) that are the source of silymarin.
The Seed as the Source. Silymarin is concentrated in the seeds (achenes) of Silybum marianum, specifically in the seed coat (pericarp). The seeds contain 1.5 to 3% silymarin by weight in raw form. Extraction and standardization concentrates this to the 80% silymarin level in this formula. The leaves and other parts of the plant contain much lower concentrations of silymarin and are not used in standardized milk thistle supplements.
Traditional Use. Milk thistle has been used in European herbal medicine for over 2,000 years. The ancient Greek physician Dioscorides described its use for liver conditions in the first century CE. It has been used continuously in European herbal medicine for liver and gallbladder support and is one of the most extensively studied medicinal plants in the modern scientific literature.
Hepatoprotectant: How Silymarin Supports Liver Function
Health Canada has approved this product (NPN 80024649) as a hepatoprotectant and liver protectant, and for use in Herbal Medicine to help support liver function. The hepatoprotective properties of silymarin are attributed to several complementary mechanisms that have been studied extensively in the scientific literature.
Antioxidant Activity. Silymarin is a potent antioxidant that scavenges free radicals and reactive oxygen species in hepatocytes (liver cells). The liver is the primary site of metabolic detoxification in the body and is therefore exposed to high levels of oxidative stress from the metabolism of drugs, alcohol, environmental toxins, and normal metabolic byproducts. Silymarin's antioxidant activity helps protect hepatocyte membranes and cellular components from oxidative damage.
Inhibition of Lipid Peroxidation. Silymarin inhibits lipid peroxidation in hepatocyte cell membranes, a process in which free radicals attack the polyunsaturated fatty acids in cell membranes, causing chain reactions that damage membrane integrity. By interrupting this chain reaction, silymarin helps maintain the structural integrity of hepatocyte membranes.
Anti-inflammatory Effects. Silymarin inhibits the NF-kB (nuclear factor kappa B) signaling pathway, a key regulator of inflammatory gene expression. By modulating NF-kB activity, silymarin helps reduce the production of pro-inflammatory cytokines and mediators in liver tissue.
Stimulation of Hepatocyte Regeneration. Silymarin stimulates ribosomal RNA synthesis in hepatocytes by activating RNA polymerase I, the enzyme responsible for producing ribosomal RNA. Increased ribosomal RNA synthesis supports protein synthesis and cell regeneration in liver tissue, contributing to the liver's natural regenerative capacity.
Inhibition of Toxin Uptake. Silymarin competes with certain hepatotoxic compounds for uptake transporters on hepatocyte membranes, reducing the entry of toxins into liver cells. This mechanism is particularly relevant to silymarin's traditional use as a liver protectant.
Duration of Use: Minimum 3 Weeks
Health Canada requires the following duration of use statement for this product: use for a minimum of 3 weeks to see beneficial effects. This reflects the nature of milk thistle's hepatoprotective action, which supports liver function through ongoing antioxidant and anti-inflammatory activity rather than producing immediate acute effects. Consistent daily use over at least 3 weeks is necessary to experience the liver supporting benefits of silymarin. The 300 capsule bottle provides an extended supply that supports this consistent long term use.
Understanding the Dosage
Milk Thistle seed extract (Silybum marianum, 80% silymarin): 250mg per capsule (200mg silymarin)
Suggested Use: Adults: 1 capsule, 1 to 2 times per day
Total Capsules: 300
Supply Duration: Approximately 300 days at 1 capsule per day; approximately 150 days at 2 capsules per day
Non Medicinal Ingredients: Oryza Sativa (Rice) Powder, Magnesium Stearate, Hypromellose (capsule shell)
Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs.
Who May Consider This Product
• Adults seeking a hepatoprotectant and liver protectant as approved by Health Canada
• Those wanting herbal support for liver function
• Individuals wanting a high potency milk thistle extract standardized to 80% silymarin (200mg per capsule)
• Those wanting an extended supply: 300 capsules for consistent long term daily use
• Vegans and vegetarians
• Those seeking a Health Canada approved, Canadian made milk thistle supplement
Quality and Purity
• Health Canada approved (NPN 80024649)
• 250mg milk thistle seed extract per capsule, standardized to 80% silymarin (200mg silymarin)
• Silybum marianum (L.) Gaertn., Asteraceae, Seed
• 300 vegan capsules (hypromellose)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free
Storage
Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed after each use.
Safety Information
Consult a health care practitioner prior to use if you are pregnant. Consult a health care practitioner if symptoms persist or worsen. Use for a minimum of 3 weeks to see beneficial effects. Milk thistle belongs to the Asteraceae family; individuals with known allergies to plants in this family (including ragweed, chrysanthemums, marigolds, and daisies) should consult a healthcare provider before use. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children.
This product is approved by Health Canada (NPN 80024649).
About Milk Thistle 250mg 80% Silymarin | Liver Support | 300 Vegan Capsules
This high potency milk thistle supplement delivers 250mg of Silybum marianum seed extract standardized to 80% silymarin per capsule, providing 200mg of the complete silymarin flavonolignan complex including silybin A and B, silychristin, silydianin, and isosilybin per capsule. Silymarin supports liver function through multiple complementary mechanisms: antioxidant activity in hepatocytes, inhibition of lipid peroxidation, anti-inflammatory effects through NF-kB modulation, stimulation of hepatocyte regeneration through RNA polymerase I activation, and inhibition of toxin uptake into liver cells. Health Canada approved (NPN 80024649) as a hepatoprotectant and liver protectant and for use in Herbal Medicine to help support liver function. Use for a minimum of 3 weeks to see beneficial effects. 300 vegan capsules (150 to 300 day supply). 100% vegan and made in Canada in a quality controlled facility.
Milk Thistle 250mg | 80% Silymarin Standardized | Liver Support | 300 Vegan Capsules
Each capsule contains 250mg of Milk Thistle seed extract (Silybum marianum (L.) Gaertn., Asteraceae) standardized to 80% silymarin, delivering 200mg of silymarin per capsule. Silymarin is the flavonolignan complex extracted from milk thistle seeds and is the primary bioactive responsible for milk thistle's hepatoprotective properties. Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant. Used in Herbal Medicine to help support liver function. Use for a minimum of 3 weeks to see beneficial effects. Health Canada approved (NPN 80024649). 100% vegan, non GMO, gluten free. Made in Canada in a quality controlled facility. 300 vegan capsules (150 to 300 day supply).
Key Features
• Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant
• Used in Herbal Medicine to help support liver function
• 250mg milk thistle seed extract per capsule, standardized to 80% silymarin
• 200mg silymarin per capsule: the highest common standardization level
• Silymarin: the complete flavonolignan complex including silybin A and B, silychristin, silydianin, and isosilybin
• Seed extract: the part of Silybum marianum with the highest silymarin concentration
• Use for a minimum of 3 weeks to see beneficial effects
• 1 to 2 capsules per day: flexible dosing
• 300 vegan capsules (150 to 300 day supply)
• Health Canada approved (NPN 80024649)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free
Understanding 250mg 80% Silymarin: What the Numbers Mean
The label notation "250mg 80% Silymarin" describes two distinct measurements that together define the potency of this extract. Understanding both is essential for accurately comparing milk thistle supplements.
250mg: The Extract Weight. This is the total weight of milk thistle seed extract in each capsule. The extract is produced by concentrating the bioactive compounds from raw milk thistle seeds and standardizing the result to a defined silymarin content.
80% Silymarin: The Standardization Level. Standardization means the extract has been tested and confirmed to contain 80% silymarin by weight. Of the 250mg of extract in each capsule, 80% (200mg) is silymarin, the flavonolignan complex responsible for milk thistle's hepatoprotective properties. The remaining 20% consists of other naturally occurring compounds in the seed extract.
200mg Silymarin per Capsule. The actual silymarin dose per capsule is 200mg (250mg x 0.80 = 200mg). This is the most meaningful measure of potency for a milk thistle supplement, as silymarin is the active fraction. 80% standardization is the highest common standardization level for milk thistle extracts and represents a high potency product.
Why Standardization Matters. Raw milk thistle seed powder contains variable amounts of silymarin depending on the plant variety, growing conditions, and harvest time. Standardization ensures that every capsule contains a consistent, defined amount of the active fraction regardless of natural variability in the raw material. A non-standardized milk thistle product may contain significantly less silymarin per gram than a standardized extract.
What Is Silymarin?
Silymarin is not a single compound but a complex mixture of flavonolignans extracted from the seeds of Silybum marianum. Flavonolignans are a class of polyphenolic compounds formed by the oxidative coupling of a flavonoid (taxifolin) with a lignan (coniferyl alcohol). The silymarin complex consists of several closely related flavonolignans:
• Silybin A and Silybin B (together called silybin): the most abundant flavonolignans in silymarin, comprising approximately 50 to 70% of the silymarin complex. Silybin is the most pharmacologically studied component and is considered the primary active compound
• Silychristin: the second most abundant flavonolignan, comprising approximately 20% of silymarin
• Silydianin: present in smaller amounts
• Isosilybin A and Isosilybin B: present in smaller amounts
The complete silymarin complex is considered more effective than isolated silybin alone, as the different flavonolignans have complementary activities and the complex as a whole reflects the traditional use of milk thistle seed extract.
Silybum marianum: The Plant
Milk thistle (Silybum marianum (L.) Gaertn.) is a flowering plant belonging to the Asteraceae family, the same plant family as artichoke, dandelion, echinacea, and chamomile. It is native to the Mediterranean region of Europe and western Asia and has been naturalized across much of the world. The plant is characterized by its distinctive spiny leaves with white marbling and its purple thistle flowers. It grows to 30 to 200cm in height and produces seeds (technically achenes) that are the source of silymarin.
The Seed as the Source. Silymarin is concentrated in the seeds (achenes) of Silybum marianum, specifically in the seed coat (pericarp). The seeds contain 1.5 to 3% silymarin by weight in raw form. Extraction and standardization concentrates this to the 80% silymarin level in this formula. The leaves and other parts of the plant contain much lower concentrations of silymarin and are not used in standardized milk thistle supplements.
Traditional Use. Milk thistle has been used in European herbal medicine for over 2,000 years. The ancient Greek physician Dioscorides described its use for liver conditions in the first century CE. It has been used continuously in European herbal medicine for liver and gallbladder support and is one of the most extensively studied medicinal plants in the modern scientific literature.
Hepatoprotectant: How Silymarin Supports Liver Function
Health Canada has approved this product (NPN 80024649) as a hepatoprotectant and liver protectant, and for use in Herbal Medicine to help support liver function. The hepatoprotective properties of silymarin are attributed to several complementary mechanisms that have been studied extensively in the scientific literature.
Antioxidant Activity. Silymarin is a potent antioxidant that scavenges free radicals and reactive oxygen species in hepatocytes (liver cells). The liver is the primary site of metabolic detoxification in the body and is therefore exposed to high levels of oxidative stress from the metabolism of drugs, alcohol, environmental toxins, and normal metabolic byproducts. Silymarin's antioxidant activity helps protect hepatocyte membranes and cellular components from oxidative damage.
Inhibition of Lipid Peroxidation. Silymarin inhibits lipid peroxidation in hepatocyte cell membranes, a process in which free radicals attack the polyunsaturated fatty acids in cell membranes, causing chain reactions that damage membrane integrity. By interrupting this chain reaction, silymarin helps maintain the structural integrity of hepatocyte membranes.
Anti-inflammatory Effects. Silymarin inhibits the NF-kB (nuclear factor kappa B) signaling pathway, a key regulator of inflammatory gene expression. By modulating NF-kB activity, silymarin helps reduce the production of pro-inflammatory cytokines and mediators in liver tissue.
Stimulation of Hepatocyte Regeneration. Silymarin stimulates ribosomal RNA synthesis in hepatocytes by activating RNA polymerase I, the enzyme responsible for producing ribosomal RNA. Increased ribosomal RNA synthesis supports protein synthesis and cell regeneration in liver tissue, contributing to the liver's natural regenerative capacity.
Inhibition of Toxin Uptake. Silymarin competes with certain hepatotoxic compounds for uptake transporters on hepatocyte membranes, reducing the entry of toxins into liver cells. This mechanism is particularly relevant to silymarin's traditional use as a liver protectant.
Duration of Use: Minimum 3 Weeks
Health Canada requires the following duration of use statement for this product: use for a minimum of 3 weeks to see beneficial effects. This reflects the nature of milk thistle's hepatoprotective action, which supports liver function through ongoing antioxidant and anti-inflammatory activity rather than producing immediate acute effects. Consistent daily use over at least 3 weeks is necessary to experience the liver supporting benefits of silymarin. The 300 capsule bottle provides an extended supply that supports this consistent long term use.
Understanding the Dosage
Milk Thistle seed extract (Silybum marianum, 80% silymarin): 250mg per capsule (200mg silymarin)
Suggested Use: Adults: 1 capsule, 1 to 2 times per day
Total Capsules: 300
Supply Duration: Approximately 300 days at 1 capsule per day; approximately 150 days at 2 capsules per day
Non Medicinal Ingredients: Oryza Sativa (Rice) Powder, Magnesium Stearate, Hypromellose (capsule shell)
Consult your healthcare provider to determine the appropriate dosage and duration of use for your individual needs.
Who May Consider This Product
• Adults seeking a hepatoprotectant and liver protectant as approved by Health Canada
• Those wanting herbal support for liver function
• Individuals wanting a high potency milk thistle extract standardized to 80% silymarin (200mg per capsule)
• Those wanting an extended supply: 300 capsules for consistent long term daily use
• Vegans and vegetarians
• Those seeking a Health Canada approved, Canadian made milk thistle supplement
Quality and Purity
• Health Canada approved (NPN 80024649)
• 250mg milk thistle seed extract per capsule, standardized to 80% silymarin (200mg silymarin)
• Silybum marianum (L.) Gaertn., Asteraceae, Seed
• 300 vegan capsules (hypromellose)
• Made in Canada in a quality controlled facility
• 100% vegan and non GMO
• Gluten free
Storage
Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed after each use.
Safety Information
Consult a health care practitioner prior to use if you are pregnant. Consult a health care practitioner if symptoms persist or worsen. Use for a minimum of 3 weeks to see beneficial effects. Milk thistle belongs to the Asteraceae family; individuals with known allergies to plants in this family (including ragweed, chrysanthemums, marigolds, and daisies) should consult a healthcare provider before use. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children.
This product is approved by Health Canada (NPN 80024649).
About Milk Thistle 250mg 80% Silymarin | Liver Support | 300 Vegan Capsules
This high potency milk thistle supplement delivers 250mg of Silybum marianum seed extract standardized to 80% silymarin per capsule, providing 200mg of the complete silymarin flavonolignan complex including silybin A and B, silychristin, silydianin, and isosilybin per capsule. Silymarin supports liver function through multiple complementary mechanisms: antioxidant activity in hepatocytes, inhibition of lipid peroxidation, anti-inflammatory effects through NF-kB modulation, stimulation of hepatocyte regeneration through RNA polymerase I activation, and inhibition of toxin uptake into liver cells. Health Canada approved (NPN 80024649) as a hepatoprotectant and liver protectant and for use in Herbal Medicine to help support liver function. Use for a minimum of 3 weeks to see beneficial effects. 300 vegan capsules (150 to 300 day supply). 100% vegan and made in Canada in a quality controlled facility.
Canadian-Made
Lab-Tested
Health Canada Approved
