Milk Thistle 250mg | 80% Silymarin | 200mg Silymarin per Capsule | Liver Support | 300 Vegan Capsules

Each vegan capsule delivers 250mg of Milk Thistle seed extract (Silybum marianum (L.) Gaertn., Asteraceae, seed) standardized to 80% silymarin, providing 200mg of the complete silymarin flavonolignan complex per capsule. 80% standardization is the highest common standardization level for milk thistle extracts.

Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant. Used in Herbal Medicine to help support liver function. Use for a minimum of 3 weeks to see beneficial effects. Health Canada licensed NPN 80024649. Vegan. Non-GMO. Gluten free. Made in Canada. 300 vegan capsules, 150 to 300 day supply.

How This Product Is Made

Silymarin is extracted from the seeds (achenes) of Silybum marianum, a flowering plant in the Asteraceae family native to the Mediterranean region of Europe and western Asia. The seeds contain 1.5 to 3% silymarin by weight in raw form. The seeds are harvested, dried, and processed to yield a concentrated extract standardized to 80% silymarin by weight, verified by batch testing. Each 250mg capsule therefore contains 200mg of silymarin (250mg x 0.80). The standardized extract is encapsulated in Canada in a quality controlled facility using hypromellose (vegetable capsule shell), rice powder, and magnesium stearate.

What Is Silymarin and What Does 80% Standardization Mean?

Silymarin is not a single compound but a complex mixture of flavonolignans extracted from milk thistle seeds. The silymarin complex includes silybin A and B (the most abundant, comprising approximately 50 to 70% of silymarin and the most pharmacologically studied), silychristin (approximately 20%), silydianin, and isosilybin A and B. Standardization to 80% silymarin means every batch is tested and verified to contain 80% silymarin by weight of the extract, ensuring 200mg of the active flavonolignan complex per 250mg capsule regardless of natural variability in the raw seed material. The complete silymarin complex is considered more effective than isolated silybin alone, as the different flavonolignans have complementary activities.

What Is the Difference Between Milk Thistle Powder and Standardized Milk Thistle Extract?

Raw milk thistle seed powder contains variable amounts of silymarin (typically 1.5 to 3% by weight) depending on plant variety, growing conditions, and harvest time. A non-standardized 500mg milk thistle powder capsule may contain as little as 7.5 to 15mg of silymarin. This formula provides 250mg of extract standardized to 80% silymarin, delivering a consistent 200mg of silymarin per capsule regardless of raw material variability. Standardization is the only way to guarantee a defined, consistent silymarin dose.

Key Benefits

• Traditionally used in Herbal Medicine as a hepatoprotectant and liver protectant Health Canada licensed claim under NPN 80024649
• Used in Herbal Medicine to help support liver function Health Canada licensed claim under NPN 80024649
• 200mg silymarin per capsule From 250mg extract standardized to 80% silymarin | Highest common standardization level for milk thistle
• Complete silymarin flavonolignan complex Silybin A and B, silychristin, silydianin, isosilybin A and B
• Source: Silybum marianum seed Mediterranean origin | Seed is the plant part with the highest silymarin concentration | 1.5 to 3% silymarin in raw seed, concentrated to 80% in this extract
• Batch-tested standardization Every batch verified to contain 80% silymarin by weight
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Health Canada licensed NPN 80024649 | Made in Canada
• 300 vegan capsules 300 day supply at 1 capsule per day | 150 day supply at 2 capsules per day

How It Works

Antioxidant Protection in Hepatocytes

The liver is the primary site of metabolic detoxification and is exposed to high levels of oxidative stress from the metabolism of drugs, alcohol, environmental toxins, and normal metabolic byproducts. Silymarin scavenges free radicals and reactive oxygen species in hepatocytes (liver cells) and inhibits lipid peroxidation in hepatocyte cell membranes, protecting membrane integrity and cellular components from oxidative damage.

Anti-inflammatory Effects via NF-kB Modulation

Silymarin inhibits the NF-kB (nuclear factor kappa B) signaling pathway, a key regulator of inflammatory gene expression in liver tissue. By modulating NF-kB activity, silymarin helps reduce the production of pro-inflammatory cytokines and mediators, supporting a healthy inflammatory response in hepatic tissue.

Stimulation of Hepatocyte Regeneration

Silymarin stimulates ribosomal RNA synthesis in hepatocytes by activating RNA polymerase I, the enzyme responsible for producing ribosomal RNA. Increased ribosomal RNA synthesis supports protein synthesis and cell regeneration in liver tissue, contributing to the liver's natural regenerative capacity.

Inhibition of Toxin Uptake

Silymarin competes with certain hepatotoxic compounds for uptake transporters on hepatocyte membranes, reducing the entry of toxins into liver cells. This mechanism is particularly relevant to silymarin's traditional use as a liver protectant.

Why a Minimum of 3 Weeks Is Required

The Health Canada licensed duration of use for this formula is a minimum of 3 weeks to see beneficial effects. Milk thistle supports liver function through ongoing antioxidant and anti-inflammatory activity rather than producing immediate acute effects. Consistent daily use over at least 3 weeks is necessary to experience the liver-supporting benefits of silymarin. The 300 capsule bottle provides an extended supply that supports this consistent long-term use.

Medicinal Ingredient (per capsule)

• Milk Thistle seed extract (Silybum marianum (L.) Gaertn., Asteraceae, seed) 250mg Source: Silybum marianum seed, Mediterranean origin | Standardized to 80% silymarin (200mg silymarin per capsule) | Complete flavonolignan complex: silybin A and B, silychristin, silydianin, isosilybin A and B | Hepatoprotectant and liver protectant | NPN 80024649

Non-medicinal ingredients: Oryza sativa (rice) powder, magnesium stearate, hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free.

Quality and Trust

• NPN 80024649 Licensed by Health Canada as a Natural Health Product
• Made in Canada Quality-controlled facility under Health Canada oversight
• 80% silymarin standardization Batch-tested | 200mg silymarin per capsule | Highest common standardization level
• Source: Silybum marianum seed Mediterranean origin | Seed is the plant part with the highest silymarin concentration
• Complete silymarin complex Silybin A and B, silychristin, silydianin, isosilybin A and B
• Vegan capsule Hypromellose shell, no gelatin or animal derived ingredients
• Vegan, non-GMO, gluten free
• 300 vegan capsules 150 to 300 day supply

Who This Is For

Adults seeking a hepatoprotectant and liver protectant as approved by Health Canada, or herbal support for liver function, from a high-potency milk thistle extract standardized to 80% silymarin (200mg per capsule). A good fit if you want an extended 300 capsule supply for consistent long-term daily use, a vegan and non-GMO formula, and a Health Canada licensed, Canadian-made supplement.

Milk thistle belongs to the Asteraceae family. Individuals with known allergies to plants in this family (including ragweed, chrysanthemums, marigolds, and daisies) should consult a healthcare practitioner before use. Consult a healthcare practitioner before use if you are pregnant. Consult a healthcare practitioner if symptoms persist or worsen.

How to Use

Adults: Take 1 capsule, 1 to 2 times per day, or as directed by a healthcare practitioner. Use for a minimum of 3 weeks to see beneficial effects.

At 1 capsule per day, 300 capsules provides a 300 day supply. At 2 capsules per day, 300 capsules provides a 150 day supply.

Safety and Cautions

Use for a minimum of 3 weeks to see beneficial effects. Consult a healthcare practitioner before use if you are pregnant. Consult a healthcare practitioner if symptoms persist or worsen. Milk thistle belongs to the Asteraceae family; individuals with known allergies to plants in this family (including ragweed, chrysanthemums, marigolds, and daisies) should consult a healthcare practitioner before use. Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.

NPN 80024649. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.