NMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor for Cellular Energy and Longevity Support

Key Benefits

• Supports NAD+ (nicotinamide adenine dinucleotide) biosynthesis and helps maintain healthy NAD+ levels
• Supports cellular energy metabolism and helps maintain healthy mitochondrial function
• Supports DNA repair mechanisms and helps maintain genomic integrity
• Supports healthy aging and helps maintain cellular function associated with longevity
• Supports sirtuin activity, the NAD+-dependent longevity proteins involved in cellular stress response and metabolic regulation
• 500mg pure NMN per capsule, a high potency research-aligned dose
• 60 vegan capsules per bottle, two month supply at one capsule per day

What This Is

This is a pure nicotinamide mononucleotide (NMN) supplement providing 500mg of NMN per capsule, one of the most direct and efficient precursors to NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes throughout the body. NAD+ levels decline significantly with age, and this decline is increasingly recognized as a central mechanism in the biology of aging. NMN supplementation supports NAD+ biosynthesis, helping to maintain the NAD+ levels needed for healthy cellular energy metabolism, DNA repair, and sirtuin-mediated longevity pathways. Health Canada licensed natural health product with NPN 80132879, manufactured in Canada to GMP standards.

The Science

What Is NAD+ and Why Does It Decline With Age?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and is essential for life. It functions as an electron carrier in cellular energy metabolism (oxidative phosphorylation and glycolysis), as a substrate for sirtuins (NAD+-dependent deacetylases that regulate gene expression, DNA repair, and metabolic adaptation), as a substrate for PARPs (poly ADP-ribose polymerases, the primary DNA repair enzymes), and as a precursor to cyclic ADP-ribose (cADPR), a calcium signaling molecule. NAD+ is so central to cellular function that it participates in over 500 enzymatic reactions in the human body. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age, and continue to decline with advancing age. This age-related NAD+ decline is driven by increased NAD+ consumption (by PARPs responding to accumulated DNA damage, and by CD38, an NAD+-consuming enzyme that increases with age) combined with reduced NAD+ biosynthesis capacity. The resulting NAD+ deficit is associated with reduced mitochondrial function, impaired DNA repair, reduced sirtuin activity, and the metabolic and functional changes characteristic of biological aging.

What Is NMN and How Does It Raise NAD+ Levels?

Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide that is the immediate precursor to NAD+ in the Preiss-Handler biosynthesis pathway. NMN is produced endogenously from nicotinamide riboside (NR) by the enzyme NRK (nicotinamide riboside kinase), and is converted directly to NAD+ by the enzyme NMNAT (nicotinamide mononucleotide adenylyltransferase). Because NMN is one step closer to NAD+ in the biosynthesis pathway than other NAD+ precursors such as niacin (vitamin B3) or nicotinamide, it is considered one of the most direct and efficient routes to raising cellular NAD+ levels. Research on NMN supplementation in both animal models and human clinical trials demonstrates that oral NMN supplementation effectively raises blood and tissue NAD+ levels, with human studies showing significant increases in NAD+ levels in blood within hours of supplementation.

NMN and Cellular Energy Metabolism

NAD+ is the primary electron carrier in cellular energy metabolism, shuttling electrons from metabolic substrates to the mitochondrial electron transport chain where ATP (the cell's energy currency) is produced. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy-dependent functions. By supporting NAD+ biosynthesis, NMN supplementation supports healthy mitochondrial function and cellular energy metabolism, helping to maintain the energy production capacity of cells throughout the body, particularly in high-energy-demand tissues such as muscle, brain, liver, and heart.

NMN and Sirtuin Activation

Sirtuins (SIRT1 through SIRT7) are a family of NAD+-dependent deacetylase enzymes that regulate a wide range of cellular processes including gene expression, DNA repair, mitochondrial biogenesis, inflammatory response, and metabolic adaptation. Sirtuins are often called longevity proteins because of their central role in the cellular stress response pathways associated with healthy aging and longevity. Sirtuin activity is directly dependent on NAD+ availability — when NAD+ levels decline, sirtuin activity declines proportionally. By supporting NAD+ biosynthesis, NMN supplementation supports sirtuin activity, helping to maintain the cellular regulatory functions that sirtuins perform in aging tissues.

NMN and DNA Repair

PARP enzymes (poly ADP-ribose polymerases) are the primary DNA repair enzymes in human cells, responsible for detecting and initiating repair of DNA strand breaks and other forms of DNA damage. PARP enzymes consume NAD+ as their substrate, using it to synthesize poly ADP-ribose chains that signal and coordinate the DNA repair response. As DNA damage accumulates with age, PARP activity increases, consuming more NAD+ and contributing to the age-related NAD+ decline. By supporting NAD+ biosynthesis, NMN supplementation helps maintain the NAD+ substrate availability needed for healthy PARP-mediated DNA repair activity, supporting genomic integrity and cellular health.

Human Clinical Research on NMN

Human clinical research on NMN supplementation has demonstrated that oral NMN is well absorbed and effectively raises NAD+ levels in blood and tissues. Studies have examined NMN supplementation at doses ranging from 250mg to 1200mg per day, with the 500mg dose in this formula falling within the range most commonly studied in human clinical trials. Research outcomes have included increases in blood NAD+ levels, improvements in muscle insulin sensitivity, support for healthy physical performance and endurance, and favorable effects on markers of metabolic health. The field of NMN human clinical research is rapidly expanding, with multiple ongoing trials examining NMN's effects on aging-related outcomes.

Ingredients

Medicinal Ingredient (per capsule)

• Nicotinamide Mononucleotide (NMN) 500mg Direct NAD+ precursor | Supports NAD+ biosynthesis, cellular energy metabolism, DNA repair, sirtuin activity, and healthy aging

Non-Medicinal Ingredients

Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.

Quality and Trust

• NPN 80132879 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Independently tested Purity and potency verified by a third party laboratory
• 500mg pure NMN per capsule High potency research-aligned dose
• Direct NAD+ precursor One biosynthetic step from NAD+, more direct than niacin or nicotinamide
• Vegan capsules Hypromellose shell, no gelatin or animal derived ingredients
• Non GMO Free from genetically modified organisms
• Gluten free Suitable for those with gluten sensitivities
• 60 capsules Two month supply at one capsule per day

Who This Product Is For

• Adults seeking to support NAD+ levels and cellular energy metabolism as part of a longevity-focused wellness routine
• Those interested in supporting healthy aging through sirtuin activation and DNA repair pathway support
• Individuals experiencing age-related energy decline who want to support mitochondrial function at the cellular level
• Health conscious consumers who prioritize Health Canada licensed, GMP manufactured, independently tested supplements

How to Use

Take 1 capsule daily with or without food, or as directed by a healthcare practitioner. NMN can be taken at any time of day, though some individuals prefer morning dosing to align with the circadian rhythm of NAD+ metabolism. For best results, use consistently as part of a daily wellness routine. NMN may take several weeks of consistent use before effects on energy and cellular function are noticeable.

Safety and Cautions

NMN is generally well tolerated at supplemental doses studied in human clinical research. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and the implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism.

• Keep out of reach of children
• Store in a cool, dry place away from direct sunlight and moisture NMN is sensitive to heat and humidity
• Do not use if the seal is broken or missing

NPN 80132879. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.