{"product_id":"nmn-500mg-nicotinamide-mononucleotide-nad-precursor-cellular-energy-and-longevity-60-vcaps","title":"NMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor | Cellular Energy and Longevity | 60 Vcaps","description":"\u003ch2\u003eNMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor for Cellular Energy and Longevity Support\u003c\/h2\u003e\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports NAD+ (nicotinamide adenine dinucleotide) biosynthesis and helps maintain healthy NAD+ levels\u003c\/li\u003e\n\u003cli\u003eSupports cellular energy metabolism and helps maintain healthy mitochondrial function\u003c\/li\u003e\n\u003cli\u003eSupports DNA repair mechanisms and helps maintain genomic integrity\u003c\/li\u003e\n\u003cli\u003eSupports healthy aging and helps maintain cellular function associated with longevity\u003c\/li\u003e\n\u003cli\u003eSupports sirtuin activity, the NAD+-dependent longevity proteins involved in cellular stress response and metabolic regulation\u003c\/li\u003e\n\u003cli\u003e500mg pure NMN per capsule, a high potency research-aligned dose\u003c\/li\u003e\n\u003cli\u003e60 vegan capsules per bottle, two month supply at one capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eThis is a pure nicotinamide mononucleotide (NMN) supplement providing 500mg of NMN per capsule, one of the most direct and efficient precursors to NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes throughout the body. NAD+ levels decline significantly with age, and this decline is increasingly recognized as a central mechanism in the biology of aging. NMN supplementation supports NAD+ biosynthesis, helping to maintain the NAD+ levels needed for healthy cellular energy metabolism, DNA repair, and sirtuin-mediated longevity pathways. Health Canada licensed natural health product with NPN 80132879, manufactured in Canada to GMP standards.\u003c\/p\u003e\n\u003ch2\u003eThe Science\u003c\/h2\u003e\n\u003ch3\u003eWhat Is NAD+ and Why Does It Decline With Age?\u003c\/h3\u003e\n\u003cp\u003eNAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and is essential for life. It functions as an electron carrier in cellular energy metabolism (oxidative phosphorylation and glycolysis), as a substrate for sirtuins (NAD+-dependent deacetylases that regulate gene expression, DNA repair, and metabolic adaptation), as a substrate for PARPs (poly ADP-ribose polymerases, the primary DNA repair enzymes), and as a precursor to cyclic ADP-ribose (cADPR), a calcium signaling molecule. NAD+ is so central to cellular function that it participates in over 500 enzymatic reactions in the human body. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age, and continue to decline with advancing age. This age-related NAD+ decline is driven by increased NAD+ consumption (by PARPs responding to accumulated DNA damage, and by CD38, an NAD+-consuming enzyme that increases with age) combined with reduced NAD+ biosynthesis capacity. The resulting NAD+ deficit is associated with reduced mitochondrial function, impaired DNA repair, reduced sirtuin activity, and the metabolic and functional changes characteristic of biological aging.\u003c\/p\u003e\n\u003ch3\u003eWhat Is NMN and How Does It Raise NAD+ Levels?\u003c\/h3\u003e\n\u003cp\u003eNicotinamide mononucleotide (NMN) is a naturally occurring nucleotide that is the immediate precursor to NAD+ in the Preiss-Handler biosynthesis pathway. NMN is produced endogenously from nicotinamide riboside (NR) by the enzyme NRK (nicotinamide riboside kinase), and is converted directly to NAD+ by the enzyme NMNAT (nicotinamide mononucleotide adenylyltransferase). Because NMN is one step closer to NAD+ in the biosynthesis pathway than other NAD+ precursors such as niacin (vitamin B3) or nicotinamide, it is considered one of the most direct and efficient routes to raising cellular NAD+ levels. Research on NMN supplementation in both animal models and human clinical trials demonstrates that oral NMN supplementation effectively raises blood and tissue NAD+ levels, with human studies showing significant increases in NAD+ levels in blood within hours of supplementation.\u003c\/p\u003e\n\u003ch3\u003eNMN and Cellular Energy Metabolism\u003c\/h3\u003e\n\u003cp\u003eNAD+ is the primary electron carrier in cellular energy metabolism, shuttling electrons from metabolic substrates to the mitochondrial electron transport chain where ATP (the cell's energy currency) is produced. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy-dependent functions. By supporting NAD+ biosynthesis, NMN supplementation supports healthy mitochondrial function and cellular energy metabolism, helping to maintain the energy production capacity of cells throughout the body, particularly in high-energy-demand tissues such as muscle, brain, liver, and heart.\u003c\/p\u003e\n\u003ch3\u003eNMN and Sirtuin Activation\u003c\/h3\u003e\n\u003cp\u003eSirtuins (SIRT1 through SIRT7) are a family of NAD+-dependent deacetylase enzymes that regulate a wide range of cellular processes including gene expression, DNA repair, mitochondrial biogenesis, inflammatory response, and metabolic adaptation. Sirtuins are often called longevity proteins because of their central role in the cellular stress response pathways associated with healthy aging and longevity. Sirtuin activity is directly dependent on NAD+ availability — when NAD+ levels decline, sirtuin activity declines proportionally. By supporting NAD+ biosynthesis, NMN supplementation supports sirtuin activity, helping to maintain the cellular regulatory functions that sirtuins perform in aging tissues.\u003c\/p\u003e\n\u003ch3\u003eNMN and DNA Repair\u003c\/h3\u003e\n\u003cp\u003ePARP enzymes (poly ADP-ribose polymerases) are the primary DNA repair enzymes in human cells, responsible for detecting and initiating repair of DNA strand breaks and other forms of DNA damage. PARP enzymes consume NAD+ as their substrate, using it to synthesize poly ADP-ribose chains that signal and coordinate the DNA repair response. As DNA damage accumulates with age, PARP activity increases, consuming more NAD+ and contributing to the age-related NAD+ decline. By supporting NAD+ biosynthesis, NMN supplementation helps maintain the NAD+ substrate availability needed for healthy PARP-mediated DNA repair activity, supporting genomic integrity and cellular health.\u003c\/p\u003e\n\u003ch3\u003eHuman Clinical Research on NMN\u003c\/h3\u003e\n\u003cp\u003eHuman clinical research on NMN supplementation has demonstrated that oral NMN is well absorbed and effectively raises NAD+ levels in blood and tissues. Studies have examined NMN supplementation at doses ranging from 250mg to 1200mg per day, with the 500mg dose in this formula falling within the range most commonly studied in human clinical trials. Research outcomes have included increases in blood NAD+ levels, improvements in muscle insulin sensitivity, support for healthy physical performance and endurance, and favorable effects on markers of metabolic health. The field of NMN human clinical research is rapidly expanding, with multiple ongoing trials examining NMN's effects on aging-related outcomes.\u003c\/p\u003e\n\u003ch2\u003eIngredients\u003c\/h2\u003e\n\u003ch3\u003eMedicinal Ingredient (per capsule)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNicotinamide Mononucleotide (NMN) 500mg\u003c\/strong\u003e Direct NAD+ precursor | Supports NAD+ biosynthesis, cellular energy metabolism, DNA repair, sirtuin activity, and healthy aging\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eNon-Medicinal Ingredients\u003c\/h3\u003e\n\u003cp\u003eVegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNPN 80132879\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIndependently tested\u003c\/strong\u003e Purity and potency verified by a third party laboratory\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e500mg pure NMN per capsule\u003c\/strong\u003e High potency research-aligned dose\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDirect NAD+ precursor\u003c\/strong\u003e One biosynthetic step from NAD+, more direct than niacin or nicotinamide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVegan capsules\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNon GMO\u003c\/strong\u003e Free from genetically modified organisms\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGluten free\u003c\/strong\u003e Suitable for those with gluten sensitivities\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e60 capsules\u003c\/strong\u003e Two month supply at one capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWho This Product Is For\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAdults seeking to support NAD+ levels and cellular energy metabolism as part of a longevity-focused wellness routine\u003c\/li\u003e\n\u003cli\u003eThose interested in supporting healthy aging through sirtuin activation and DNA repair pathway support\u003c\/li\u003e\n\u003cli\u003eIndividuals experiencing age-related energy decline who want to support mitochondrial function at the cellular level\u003c\/li\u003e\n\u003cli\u003eHealth conscious consumers who prioritize Health Canada licensed, GMP manufactured, independently tested supplements\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eTake 1 capsule daily with or without food, or as directed by a healthcare practitioner. NMN can be taken at any time of day, though some individuals prefer morning dosing to align with the circadian rhythm of NAD+ metabolism. For best results, use consistently as part of a daily wellness routine. NMN may take several weeks of consistent use before effects on energy and cellular function are noticeable.\u003c\/p\u003e\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eNMN is generally well tolerated at supplemental doses studied in human clinical research. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and the implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKeep out of reach of children\u003c\/li\u003e\n\u003cli\u003eStore in a cool, dry place away from direct sunlight and moisture NMN is sensitive to heat and humidity\u003c\/li\u003e\n\u003cli\u003eDo not use if the seal is broken or missing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNPN 80132879. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":45461853405347,"sku":"N293","price":48.85,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/NMN_500_mg_supplement_NAD_precursor_60_vegan_capsules.jpg?v=1772742368","url":"https:\/\/nutridom.ca\/products\/nmn-500mg-nicotinamide-mononucleotide-nad-precursor-cellular-energy-and-longevity-60-vcaps","provider":"Nutridom","version":"1.0","type":"link"}