USA CUSTOMERS - SAME PRICE. NO DUTY. NO HIDDEN FEES.

FREE SHIPPING OVER $55

GET 10% OFF FIRST ORDER

Your cart

Your cart is empty

Resveratrol 500mg | 99% Trans Resveratrol | Japanese Knotweed | 60 Vcaps

500mg of 99% pure trans-resveratrol per vegan capsule, extracted from Japanese Knotweed root (Reynoutria japonica) one of the richest natural plant sources of trans resveratrol. Polyphenol antioxidant. Cellular health and cardiovascular wellness support. 

Key Features

  • 500mg trans-resveratrol per vcap 99% purity. Active stilbenoid form.
  • Japanese Knotweed root source Reynoutria japonica. Highest natural plant concentration of trans-resveratrol.
  • Health Canada licensed NPN 80140494 Made in Canada.
  • Vegan capsule Hypromellose. No gelatin.
  • Non-GMO. Gluten free. Dairy free.
  • 60 vcaps 60 day supply at 1 vcap per day.

Recommended Use

Adults: 1 capsule daily, or as directed by a healthcare practitioner. Take with food. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking medications including blood thinners or antiplatelet agents.

Trans-Resveratrol: Source, Form, and Mechanism

Resveratrol is a stilbenoid polyphenol produced by certain plants as a phytoalexin a defense compound synthesized in response to stress, injury, UV radiation, or fungal infection. It exists in two geometric isomers: trans-resveratrol and cis-resveratrol. Trans resveratrol is the biologically active form it is more stable, more bioavailable, and the form that has been most extensively studied for its antioxidant and cellular health properties. Cis-resveratrol is less stable and converts readily to the trans form under light exposure.

Japanese Knotweed root (Reynoutria japonica) is the primary commercial source of high purity trans resveratrol. It contains significantly higher concentrations of trans resveratrol than grapes, berries, or red wine making it the most practical botanical source for concentrated supplementation. This formula provides 500mg of 99% pure trans-resveratrol per capsule, standardized to the active isomer.

Trans resveratrol acts as a direct antioxidant, scavenging reactive oxygen species and chelating metal ions that catalyze free radical generation. It also activates SIRT1 (sirtuin-1), a NAD⁺-dependent deacetylase involved in cellular energy sensing, mitochondrial biogenesis, and the regulation of cellular stress response pathways. SIRT1 activation by resveratrol has been studied in the context of cellular longevity signalling, metabolic regulation, and cardiovascular function. Additionally, trans-resveratrol modulates NF-κB signalling, supporting healthy inflammatory response at the cellular level.

Who This Is For

  • Adults seeking a high purity, high-potency trans resveratrol supplement for daily antioxidant and cellular health support
  • Those who want 99% pure trans resveratrol from Japanese Knotweed in a Health Canada licensed, vegan, Canadian made formula
  • Those interested in polyphenol supplementation for cardiovascular wellness and healthy aging support

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking blood-thinning or antiplatelet medications. Keep out of reach of children.

Medicinal Ingredient (per vcap)

  • Trans-Resveratrol (Reynoutria japonica, root) 500mg 99% purity. Japanese Knotweed. NPN 80140494.

Non-medicinal ingredient: Hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.

Quality and Trust

  • NPN 80140494 Licensed by Health Canada as a Natural Health Product
  • Made in Canada
  • 500mg trans-resveratrol per vcap 99% purity. Active stilbenoid form.
  • Japanese Knotweed root Reynoutria japonica. Highest natural plant concentration.
  • Vegan capsule Hypromellose. No gelatin.
  • Non-GMO. Gluten free. Dairy free.
  • 60 vcaps

Storage

Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.

Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, or are taking blood thinning or antiplatelet medications. Keep out of reach of children.

NPN 80140494.

Sale

Resveratrol 500mg | 99% Trans Resveratrol | Japanese Knotweed | 60 Vcaps

Regular price $39.99 $29.9925% off
Unit price
per 
5.0 (1)

Health Canada Licensed Natural Health Product (NPN 80140494)

Auto-renews, skip or cancel anytime.

To add to cart, go to the product page and select a purchase option
Shipping calculated at checkout.

Resveratrol 500mg | 99% Trans Resveratrol | Japanese Knotweed | 60 Vcaps

500mg of 99% pure trans-resveratrol per vegan capsule, extracted from Japanese Knotweed root (Reynoutria japonica) one of the richest natural plant sources of trans resveratrol. Polyphenol antioxidant. Cellular health and cardiovascular wellness support. 

Key Features

  • 500mg trans-resveratrol per vcap 99% purity. Active stilbenoid form.
  • Japanese Knotweed root source Reynoutria japonica. Highest natural plant concentration of trans-resveratrol.
  • Health Canada licensed NPN 80140494 Made in Canada.
  • Vegan capsule Hypromellose. No gelatin.
  • Non-GMO. Gluten free. Dairy free.
  • 60 vcaps 60 day supply at 1 vcap per day.

Recommended Use

Adults: 1 capsule daily, or as directed by a healthcare practitioner. Take with food. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking medications including blood thinners or antiplatelet agents.

Trans-Resveratrol: Source, Form, and Mechanism

Resveratrol is a stilbenoid polyphenol produced by certain plants as a phytoalexin a defense compound synthesized in response to stress, injury, UV radiation, or fungal infection. It exists in two geometric isomers: trans-resveratrol and cis-resveratrol. Trans resveratrol is the biologically active form it is more stable, more bioavailable, and the form that has been most extensively studied for its antioxidant and cellular health properties. Cis-resveratrol is less stable and converts readily to the trans form under light exposure.

Japanese Knotweed root (Reynoutria japonica) is the primary commercial source of high purity trans resveratrol. It contains significantly higher concentrations of trans resveratrol than grapes, berries, or red wine making it the most practical botanical source for concentrated supplementation. This formula provides 500mg of 99% pure trans-resveratrol per capsule, standardized to the active isomer.

Trans resveratrol acts as a direct antioxidant, scavenging reactive oxygen species and chelating metal ions that catalyze free radical generation. It also activates SIRT1 (sirtuin-1), a NAD⁺-dependent deacetylase involved in cellular energy sensing, mitochondrial biogenesis, and the regulation of cellular stress response pathways. SIRT1 activation by resveratrol has been studied in the context of cellular longevity signalling, metabolic regulation, and cardiovascular function. Additionally, trans-resveratrol modulates NF-κB signalling, supporting healthy inflammatory response at the cellular level.

Who This Is For

  • Adults seeking a high purity, high-potency trans resveratrol supplement for daily antioxidant and cellular health support
  • Those who want 99% pure trans resveratrol from Japanese Knotweed in a Health Canada licensed, vegan, Canadian made formula
  • Those interested in polyphenol supplementation for cardiovascular wellness and healthy aging support

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking blood-thinning or antiplatelet medications. Keep out of reach of children.

Medicinal Ingredient (per vcap)

  • Trans-Resveratrol (Reynoutria japonica, root) 500mg 99% purity. Japanese Knotweed. NPN 80140494.

Non-medicinal ingredient: Hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.

Quality and Trust

  • NPN 80140494 Licensed by Health Canada as a Natural Health Product
  • Made in Canada
  • 500mg trans-resveratrol per vcap 99% purity. Active stilbenoid form.
  • Japanese Knotweed root Reynoutria japonica. Highest natural plant concentration.
  • Vegan capsule Hypromellose. No gelatin.
  • Non-GMO. Gluten free. Dairy free.
  • 60 vcaps

Storage

Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.

Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, or are taking blood thinning or antiplatelet medications. Keep out of reach of children.

NPN 80140494.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule (Twice Daily)

Servings Per Container: 60 (30-day supply at 2 capsules per day)

Ingredient
Amount Per
Serving
% Daily
Value
Trans-Resveratrol (Reynoutria japonica, Root, 99% Purity)
500 mg

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1

Cell, 2006

This study examined the effects of resveratrol on mitochondrial function and metabolic health through SIRT1 and PGC-1α activation. The study found that resveratrol significantly improved mitochondrial biogenesis, oxidative capacity, and energy metabolism through the SIRT1-PGC-1α pathway the same pathway activated by caloric restriction and exercise. Resveratrol treated subjects showed significantly improved mitochondrial function and protection against metabolic dysfunction. The findings directly support trans resveratrol's role in cellular energy metabolism and mitochondrial health key aspects of its cellular health support properties

Cardiovascular effects of resveratrol: a critical review

Nutrients, 2016

This comprehensive critical review examined the clinical and preclinical evidence for resveratrol's cardiovascular effects. The review found that trans resveratrol supports cardiovascular health through multiple complementary mechanisms: direct antioxidant activity protecting vascular endothelial cells from oxidative damage, modulation of NF-κB signalling supporting a healthy inflammatory response in vascular tissue, inhibition of platelet aggregation, and SIRT1 activation supporting mitochondrial function in cardiac cells. The review concluded that the totality of evidence supports trans resveratrol as a polyphenol with meaningful cardiovascular wellness support properties, directly supporting this formula's cardiovascular health claims.

Resveratrol as an antioxidant and pro oxidant agent: mechanisms and clinical implications

Dose Response, 2010

This review examined the antioxidant mechanisms of trans resveratrol at the molecular level, including direct free radical scavenging, metal ion chelation that prevents catalytic free radical generation, and upregulation of endogenous antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) through Nrf2 pathway activation. The review established that trans resveratrol's antioxidant activity operates through both direct and indirect mechanisms making it a more comprehensive antioxidant than simple free radical scavengers. The findings directly support trans-resveratrol's role as a polyphenol antioxidant for cellular health protection against oxidative damage.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is resveratrol and what does it do?

Resveratrol is a stilbenoid polyphenol produced by certain plants as a phytoalexin a defense compound synthesized in response to stress, injury, UV radiation, or fungal infection. It is one of the most extensively studied plant polyphenols for antioxidant and cellular health properties. Trans resveratrol is the biologically active isomer more stable, more bioavailable, and the form studied in clinical research. This formula provides 500mg of 99% pure trans-resveratrol per capsule, extracted from Japanese Knotweed root (Reynoutria japonica) one of the richest natural plant sources of trans resveratrol.

Why is Japanese Knotweed the best source of resveratrol?

Japanese Knotweed root (Reynoutria japonica) contains significantly higher concentrations of trans resveratrol than grapes, berries, or red wine making it the most practical and concentrated botanical source for high-potency resveratrol supplementation.

How does resveratrol work as an antioxidant?

Trans-resveratrol acts as a direct antioxidant by scavenging reactive oxygen species (free radicals) and chelating metal ions that catalyze free radical generation. It also activates SIRT1 (sirtuin-1) a NAD⁺-dependent deacetylase involved in cellular energy sensing, mitochondrial biogenesis, and the regulation of cellular stress response pathways. Additionally, trans-resveratrol modulates NF-κB signalling, supporting a healthy inflammatory response at the cellular level. These complementary mechanisms make trans-resveratrol one of the most studied polyphenols for cellular health and healthy aging support.

Is resveratrol good for cardiovascular health?

Trans resveratrol supports cardiovascular wellness through multiple complementary mechanisms direct antioxidant activity protecting vascular cells from oxidative damage, modulation of NF-κB signalling supporting a healthy inflammatory response in cardiovascular tissue, and SIRT1 activation supporting mitochondrial function in cardiac cells. These mechanisms are among the most studied aspects of resveratrol's cellular health properties. Each capsule provides 500mg of 99% pure trans resveratrol from Japanese Knotweed root (Reynoutria japonica).

What are the side effects of resveratrol?

When using resveratrol supplements, some people may experience gastrointestinal discomfort or disturbances particularly at higher doses. Taking resveratrol with food can help minimize gastrointestinal effects. Ask a healthcare practitioner before use if you are taking any medications, as resveratrol may alter their effectiveness. Ask a healthcare practitioner before use if you are pregnant or breastfeeding. Ask a healthcare practitioner for use beyond 3 months. Stop use and consult a healthcare practitioner if symptoms persist or worsen.

Should resveratrol be taken with NMN or NAD+ precursors?

Resveratrol and NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) are commonly combined because they work on complementary aspects of the same cellular pathway. SIRT1 the enzyme activated by trans resveratrol requires NAD⁺ as a cofactor to function. NMN and NR are NAD⁺ precursors that raise intracellular NAD⁺ levels. The combination provides both the SIRT1 activator (resveratrol) and the NAD⁺ substrate (NMN or NR) supporting SIRT1 activity more completely than either alone. Consult a healthcare practitioner before combining supplements if you are taking any medications.