Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1
Cell, 2006
500mg of 99% pure trans-resveratrol per vegan capsule, extracted from Japanese Knotweed root (Reynoutria japonica) one of the richest natural plant sources of trans resveratrol. Polyphenol antioxidant. Cellular health and cardiovascular wellness support.
Adults: 1 capsule daily, or as directed by a healthcare practitioner. Take with food. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking medications including blood thinners or antiplatelet agents.
Resveratrol is a stilbenoid polyphenol produced by certain plants as a phytoalexin a defense compound synthesized in response to stress, injury, UV radiation, or fungal infection. It exists in two geometric isomers: trans-resveratrol and cis-resveratrol. Trans resveratrol is the biologically active form it is more stable, more bioavailable, and the form that has been most extensively studied for its antioxidant and cellular health properties. Cis-resveratrol is less stable and converts readily to the trans form under light exposure.
Japanese Knotweed root (Reynoutria japonica) is the primary commercial source of high purity trans resveratrol. It contains significantly higher concentrations of trans resveratrol than grapes, berries, or red wine making it the most practical botanical source for concentrated supplementation. This formula provides 500mg of 99% pure trans-resveratrol per capsule, standardized to the active isomer.
Trans resveratrol acts as a direct antioxidant, scavenging reactive oxygen species and chelating metal ions that catalyze free radical generation. It also activates SIRT1 (sirtuin-1), a NAD⁺-dependent deacetylase involved in cellular energy sensing, mitochondrial biogenesis, and the regulation of cellular stress response pathways. SIRT1 activation by resveratrol has been studied in the context of cellular longevity signalling, metabolic regulation, and cardiovascular function. Additionally, trans-resveratrol modulates NF-κB signalling, supporting healthy inflammatory response at the cellular level.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking blood-thinning or antiplatelet medications. Keep out of reach of children.
Non-medicinal ingredient: Hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.
Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, or are taking blood thinning or antiplatelet medications. Keep out of reach of children.
NPN 80140494.
500mg of 99% pure trans-resveratrol per vegan capsule, extracted from Japanese Knotweed root (Reynoutria japonica) one of the richest natural plant sources of trans resveratrol. Polyphenol antioxidant. Cellular health and cardiovascular wellness support.
Adults: 1 capsule daily, or as directed by a healthcare practitioner. Take with food. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking medications including blood thinners or antiplatelet agents.
Resveratrol is a stilbenoid polyphenol produced by certain plants as a phytoalexin a defense compound synthesized in response to stress, injury, UV radiation, or fungal infection. It exists in two geometric isomers: trans-resveratrol and cis-resveratrol. Trans resveratrol is the biologically active form it is more stable, more bioavailable, and the form that has been most extensively studied for its antioxidant and cellular health properties. Cis-resveratrol is less stable and converts readily to the trans form under light exposure.
Japanese Knotweed root (Reynoutria japonica) is the primary commercial source of high purity trans resveratrol. It contains significantly higher concentrations of trans resveratrol than grapes, berries, or red wine making it the most practical botanical source for concentrated supplementation. This formula provides 500mg of 99% pure trans-resveratrol per capsule, standardized to the active isomer.
Trans resveratrol acts as a direct antioxidant, scavenging reactive oxygen species and chelating metal ions that catalyze free radical generation. It also activates SIRT1 (sirtuin-1), a NAD⁺-dependent deacetylase involved in cellular energy sensing, mitochondrial biogenesis, and the regulation of cellular stress response pathways. SIRT1 activation by resveratrol has been studied in the context of cellular longevity signalling, metabolic regulation, and cardiovascular function. Additionally, trans-resveratrol modulates NF-κB signalling, supporting healthy inflammatory response at the cellular level.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking blood-thinning or antiplatelet medications. Keep out of reach of children.
Non-medicinal ingredient: Hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.
Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.
Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, or are taking blood thinning or antiplatelet medications. Keep out of reach of children.
NPN 80140494.
Serving Size: 1 Capsule (Twice Daily)
Servings Per Container: 60 (30-day supply at 2 capsules per day)
† Daily Value not established
Cell, 2006
Nutrients, 2016
Dose Response, 2010
Research information is provided for educational purposes and does not replace the product's approved label information.