Omega-3 fatty acids and cognitive decline: a systematic review
Neurobiology of Aging, 2012
Each serving delivers 1200mg of total omega-3 fatty acids (EPA and DHA) in the re-esterified triglyceride (rTG) form, the most bioavailable and structurally natural form of fish oil. IFOS 5 Star certified, the highest independent third-party rating for fish oil purity, potency, and freshness.
Health Canada licensed NPN 80079451. Made in Canada. 120 softgels, up to a 2 month supply at 1 serving per day.
A pharmaceutical-grade omega-3 fish oil supplement providing 1200mg of total EPA and DHA per serving in the re-esterified triglyceride (rTG) form. EPA and DHA are long-chain omega-3 polyunsaturated fatty acids that must be obtained from diet or supplementation, as the body's ability to synthesize them from plant-source ALA is limited and highly variable.
IFOS 5 Star certified and licensed by Health Canada under NPN 80079451. Manufactured in Canada to GMP standards. Contains fish (gelatin softgel shell). Not suitable for individuals with fish or shellfish allergies.
Most fish oil supplements use the ethyl ester (EE) form because it is less expensive to produce. Ethyl ester fish oil has significantly lower bioavailability than triglyceride forms, with research showing 50 to 70% lower EPA and DHA absorption compared to natural triglyceride fish oil. Re-esterified triglyceride (rTG) fish oil is produced by converting ethyl ester fish oil back into the natural triglyceride structure, matching the form in which omega-3 fatty acids exist in fish. Research consistently demonstrates superior EPA and DHA absorption from rTG versus ethyl ester forms.
Eicosapentaenoic acid (EPA) is the primary omega-3 fatty acid involved in the production of Series 3 prostaglandins, thromboxanes, and leukotrienes, and in the synthesis of resolvins and protectins, specialized pro-resolving mediators that actively resolve inflammation. EPA competes with arachidonic acid for the same enzymatic pathways (COX and LOX), reducing the production of pro-inflammatory eicosanoids and supporting a balanced inflammatory response throughout the body, including in cardiovascular and joint tissue.
Docosahexaenoic acid (DHA) is the primary structural fatty acid in the brain and retina. It constitutes approximately 97% of the omega-3 fatty acids in brain tissue and approximately 93% in the retina, where it is essential for maintaining the fluidity and function of neuronal and photoreceptor cell membranes. Adequate DHA supports cognitive function, mental clarity, mood regulation, and visual acuity. DHA is also a precursor to neuroprotectin D1, a potent neuroprotective mediator synthesized in brain tissue.
IFOS (International Fish Oil Standards) is the world's most rigorous independent third-party testing program for fish oil. The IFOS 5 Star rating, the highest level awarded, confirms that the product meets or exceeds all IFOS standards for EPA and DHA label accuracy, total oxidation (TOTOX value), PCBs, dioxins, furans, mercury, lead, cadmium, and arsenic. IFOS 5 Star certification provides independent verification that the omega-3 content on the label is accurate and that the product is free from harmful levels of environmental contaminants.
EPA and DHA support cardiovascular health through multiple complementary mechanisms: modulating eicosanoid production to support a healthy inflammatory response in vascular tissue, supporting healthy triglyceride levels within normal ranges, supporting healthy platelet aggregation, and contributing to the structural integrity of cardiac cell membranes. These mechanisms are supported by thousands of peer-reviewed studies and are among the most extensively documented effects of any nutritional supplement.
Non-medicinal ingredients: Softgel shell (gelatin, glycerin, purified water), natural lemon flavour, mixed tocopherols (vitamin E, as antioxidant). No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Non-GMO.
Adults: Take the recommended serving daily with a meal containing dietary fat. Dietary fat stimulates bile secretion, which supports emulsification and absorption of the omega-3 fatty acids.
Refrigerate after opening to preserve freshness and prevent oxidation. For best results, use consistently as part of a daily wellness routine.
Not suitable for individuals with fish or shellfish allergies. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, taking blood-thinning medications such as warfarin or aspirin, or taking medications for blood pressure or cholesterol. Fish oil may have blood-thinning properties at higher doses.
Refrigerate after opening. Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing. Keep out of reach of children.
NPN 80079451. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Each serving delivers 1200mg of total omega-3 fatty acids (EPA and DHA) in the re-esterified triglyceride (rTG) form, the most bioavailable and structurally natural form of fish oil. IFOS 5 Star certified, the highest independent third-party rating for fish oil purity, potency, and freshness.
Health Canada licensed NPN 80079451. Made in Canada. 120 softgels, up to a 2 month supply at 1 serving per day.
A pharmaceutical-grade omega-3 fish oil supplement providing 1200mg of total EPA and DHA per serving in the re-esterified triglyceride (rTG) form. EPA and DHA are long-chain omega-3 polyunsaturated fatty acids that must be obtained from diet or supplementation, as the body's ability to synthesize them from plant-source ALA is limited and highly variable.
IFOS 5 Star certified and licensed by Health Canada under NPN 80079451. Manufactured in Canada to GMP standards. Contains fish (gelatin softgel shell). Not suitable for individuals with fish or shellfish allergies.
Most fish oil supplements use the ethyl ester (EE) form because it is less expensive to produce. Ethyl ester fish oil has significantly lower bioavailability than triglyceride forms, with research showing 50 to 70% lower EPA and DHA absorption compared to natural triglyceride fish oil. Re-esterified triglyceride (rTG) fish oil is produced by converting ethyl ester fish oil back into the natural triglyceride structure, matching the form in which omega-3 fatty acids exist in fish. Research consistently demonstrates superior EPA and DHA absorption from rTG versus ethyl ester forms.
Eicosapentaenoic acid (EPA) is the primary omega-3 fatty acid involved in the production of Series 3 prostaglandins, thromboxanes, and leukotrienes, and in the synthesis of resolvins and protectins, specialized pro-resolving mediators that actively resolve inflammation. EPA competes with arachidonic acid for the same enzymatic pathways (COX and LOX), reducing the production of pro-inflammatory eicosanoids and supporting a balanced inflammatory response throughout the body, including in cardiovascular and joint tissue.
Docosahexaenoic acid (DHA) is the primary structural fatty acid in the brain and retina. It constitutes approximately 97% of the omega-3 fatty acids in brain tissue and approximately 93% in the retina, where it is essential for maintaining the fluidity and function of neuronal and photoreceptor cell membranes. Adequate DHA supports cognitive function, mental clarity, mood regulation, and visual acuity. DHA is also a precursor to neuroprotectin D1, a potent neuroprotective mediator synthesized in brain tissue.
IFOS (International Fish Oil Standards) is the world's most rigorous independent third-party testing program for fish oil. The IFOS 5 Star rating, the highest level awarded, confirms that the product meets or exceeds all IFOS standards for EPA and DHA label accuracy, total oxidation (TOTOX value), PCBs, dioxins, furans, mercury, lead, cadmium, and arsenic. IFOS 5 Star certification provides independent verification that the omega-3 content on the label is accurate and that the product is free from harmful levels of environmental contaminants.
EPA and DHA support cardiovascular health through multiple complementary mechanisms: modulating eicosanoid production to support a healthy inflammatory response in vascular tissue, supporting healthy triglyceride levels within normal ranges, supporting healthy platelet aggregation, and contributing to the structural integrity of cardiac cell membranes. These mechanisms are supported by thousands of peer-reviewed studies and are among the most extensively documented effects of any nutritional supplement.
Non-medicinal ingredients: Softgel shell (gelatin, glycerin, purified water), natural lemon flavour, mixed tocopherols (vitamin E, as antioxidant). No artificial colours, flavours, sweeteners, or preservatives. Gluten free. Non-GMO.
Adults: Take the recommended serving daily with a meal containing dietary fat. Dietary fat stimulates bile secretion, which supports emulsification and absorption of the omega-3 fatty acids.
Refrigerate after opening to preserve freshness and prevent oxidation. For best results, use consistently as part of a daily wellness routine.
Not suitable for individuals with fish or shellfish allergies. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, taking blood-thinning medications such as warfarin or aspirin, or taking medications for blood pressure or cholesterol. Fish oil may have blood-thinning properties at higher doses.
Refrigerate after opening. Store in a cool, dry place away from direct sunlight and moisture. Do not use if the seal is broken or missing. Keep out of reach of children.
NPN 80079451. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Serving Size: 2 Softgels
Servings Per Container: 60
† Daily Value not established
Neurobiology of Aging, 2012
Archives of Ophthalmology, 2008
Nature, 2014
Research information is provided for educational purposes and does not replace the product's approved label information.