{"product_id":"resveratrol-500mg-99-trans-resveratrol-japanese-knotweed-60-vcaps-6-pack","title":"Resveratrol 500mg | 99% Trans-Resveratrol | Japanese Knotweed | 60 Vcaps | 6 Pack","description":"\u003ch2\u003eResveratrol 500mg | 99% Trans-Resveratrol | Japanese Knotweed | 60 Vcaps — 6 Pack\u003c\/h2\u003e\n\u003cp\u003eA 6-pack of Resveratrol 500mg 500mg of 99% pure trans-resveratrol per vegan capsule, extracted from Japanese Knotweed root (Reynoutria japonica). Polyphenol antioxidant. Cellular health and cardiovascular wellness support. The most economical format available.\u003c\/p\u003e\n\u003ch2\u003e6 Pack at a Glance\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e360 vcaps total\u003c\/strong\u003e 6 bottles x 60 vcaps. Approximately 1-year supply at 1 vcap per day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e500mg trans-resveratrol per vcap\u003c\/strong\u003e 99% purity. Active stilbenoid form.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eJapanese Knotweed root source\u003c\/strong\u003e Reynoutria japonica. Highest natural plant concentration of trans-resveratrol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed NPN 80140494\u003c\/strong\u003e Made in Canada.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose. No gelatin.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eNon-GMO. Gluten free. Dairy free.\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLowest cost per bottle\u003c\/strong\u003e Most economical format available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRecommended Use\u003c\/h2\u003e\n\u003cp\u003eAdults: 1 capsule daily, or as directed by a healthcare practitioner. Take with food. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition, or are taking medications including blood thinners or antiplatelet agents.\u003c\/p\u003e\n\u003ch2\u003eWhy a Full Year of Trans-Resveratrol\u003c\/h2\u003e\n\u003cp\u003eTrans-resveratrol’s primary molecular target, SIRT1 (sirtuin-1), is a NAD⁺-dependent deacetylase that functions as a cellular energy and stress sensor. SIRT1 activity is directly coupled to the intracellular NAD⁺\/NADH ratio a ratio that reflects the cell’s metabolic state and declines with age. By activating SIRT1, trans-resveratrol participates in a signalling network that includes PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), the master regulator of mitochondrial biogenesis, and FOXO transcription factors involved in cellular stress resistance and longevity signalling.\u003c\/p\u003e\n\u003cp\u003eThese are not acute pharmacological effects they are adaptive transcriptional responses that require sustained SIRT1 activation over time to produce meaningful changes in mitochondrial density, antioxidant enzyme expression, and cellular stress resilience. The research literature on resveratrol and sirtuin biology consistently frames these outcomes in the context of long-term, uninterrupted daily supplementation rather than short courses.\u003c\/p\u003e\n\u003cp\u003eTrans-resveratrol also modulates the AMPK (AMP-activated protein kinase) pathway a cellular energy sensor that works in concert with SIRT1 to regulate mitochondrial function and metabolic homeostasis. AMPK activation by resveratrol has been studied in the context of metabolic regulation and cardiovascular function, and like SIRT1-mediated effects, is most relevant when maintained consistently over an extended period.\u003c\/p\u003e\n\u003cp\u003eThe 6-pack provides a full year’s supply in a single purchase eliminating reorder decisions entirely, ensuring no interruptions to a daily trans-resveratrol routine, and delivering the lowest cost per bottle available for this formula.\u003c\/p\u003e\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAdults with a permanent daily trans-resveratrol routine who want a full year’s supply in a single purchase\u003c\/li\u003e\n\u003cli\u003eThose who want 360 days of 99% pure, Health Canada licensed trans-resveratrol from Japanese Knotweed without reordering\u003c\/li\u003e\n\u003cli\u003eThose seeking the absolute lowest cost per bottle on a vegan, non-GMO, Canadian made resveratrol supplement\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMedicinal Ingredient (per vcap)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrans-Resveratrol (Reynoutria japonica, root) 500mg\u003c\/strong\u003e 99% purity. Japanese Knotweed. NPN 80140494.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredient: Hypromellose (vegetable capsule shell). Vegan. Non-GMO. Gluten free. Dairy free.\u003c\/p\u003e\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNPN 80140494\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eMade in Canada\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e500mg trans-resveratrol per vcap\u003c\/strong\u003e 99% purity. Active stilbenoid form.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eJapanese Knotweed root\u003c\/strong\u003e Reynoutria japonica. Highest natural plant concentration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose. No gelatin.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eNon-GMO. Gluten free. Dairy free.\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e360 vcaps\u003c\/strong\u003e 6 x 60 vcaps. Lowest cost per bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eStorage\u003c\/h2\u003e\n\u003cp\u003eStore in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eCautions\u003c\/h2\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, or are taking blood-thinning or antiplatelet medications. Keep out of reach of children.\u003c\/p\u003e\n\u003cp\u003eNPN 80140494.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":47720180646051,"sku":"N343X6","price":161.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/Resveratrol_500mg_99_Trans-Resveratrol_Japanese_Knotweed_60_Vcaps_6_Pack.png?v=1780081746","url":"https:\/\/nutridom.ca\/products\/resveratrol-500mg-99-trans-resveratrol-japanese-knotweed-60-vcaps-6-pack","provider":"Nutridom","version":"1.0","type":"link"}