{"product_id":"nmn-500mg-nicotinamide-mononucleotide-nad-precursor-cellular-energy-and-longevity-60-vcaps","title":"NMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor | Cellular Energy and Longevity | 60 Vcaps","description":"\u003ch2\u003eNMN 500mg | Nicotinamide Mononucleotide | NAD+ Precursor | Cellular Energy and Longevity | 60 Vcaps\u003c\/h2\u003e\n\n\u003cp\u003eEach capsule delivers 500mg of pure nicotinamide mononucleotide (NMN), the immediate biosynthetic precursor to NAD+ (nicotinamide adenine dinucleotide). One step from NAD+. No fillers beyond standard capsule excipients.\u003c\/p\u003e\n\u003cp\u003eHealth Canada licensed NPN 80132879. Made in Canada. 60 vegan capsules, 60 day supply at 1 capsule per day.\u003c\/p\u003e\n\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003e500mg pure NMN per capsule\u003c\/strong\u003e Direct NAD+ precursor, one biosynthetic step from NAD+, more direct than niacin or nicotinamide\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNAD+ biosynthesis support\u003c\/strong\u003e Helps maintain healthy NAD+ levels, which decline by approximately 50% between young adulthood and middle age\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCellular energy metabolism\u003c\/strong\u003e NAD+ is the primary electron carrier in mitochondrial energy production, supporting ATP synthesis in high-demand tissues including muscle, brain, liver, and heart\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSirtuin activation\u003c\/strong\u003e NAD+ is the required substrate for SIRT1 through SIRT7, the longevity-associated proteins that regulate gene expression, DNA repair, and metabolic adaptation\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDNA repair pathway support\u003c\/strong\u003e PARP enzymes consume NAD+ to initiate DNA strand break repair; maintaining NAD+ levels supports healthy PARP-mediated genomic integrity\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHealthy aging support\u003c\/strong\u003e Supports the cellular energy, repair, and regulatory pathways that decline with age-related NAD+ depletion\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHealth Canada licensed\u003c\/strong\u003e NPN 80132879\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e60 capsules\u003c\/strong\u003e 60 day supply at 1 capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhat This Is\u003c\/h2\u003e\n\u003cp\u003eA pure nicotinamide mononucleotide (NMN) supplement providing 500mg per vegan capsule. NMN is a naturally occurring nucleotide and the immediate precursor to NAD+ in the Preiss-Handler biosynthesis pathway.\u003c\/p\u003e\n\u003cp\u003eNAD+ is a coenzyme found in every living cell, essential for cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes. NAD+ levels decline significantly with age, a decline now recognized as a central mechanism in the biology of aging. NMN supplementation supports NAD+ biosynthesis, helping to restore the NAD+ levels needed for healthy cellular function.\u003c\/p\u003e\n\u003cp\u003eLicensed by Health Canada under NPN 80132879. Manufactured in Canada to GMP standards. Vegan. Gluten free. Non-GMO.\u003c\/p\u003e\n\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\n\u003ch3\u003eWhy NAD+ Declines With Age\u003c\/h3\u003e\n\u003cp\u003eNAD+ participates in over 500 enzymatic reactions in the human body. Despite its fundamental importance, NAD+ levels decline by approximately 50% between young adulthood and middle age. This decline is driven by increased NAD+ consumption by PARP enzymes responding to accumulated DNA damage, and by CD38, an NAD+-consuming enzyme that increases with age, combined with reduced biosynthesis capacity.\u003c\/p\u003e\n\n\u003ch3\u003eHow NMN Raises NAD+ Levels\u003c\/h3\u003e\n\u003cp\u003eNMN is produced endogenously from nicotinamide riboside (NR) by the enzyme NRK, and is converted directly to NAD+ by NMNAT (nicotinamide mononucleotide adenylyltransferase). Because NMN is one step closer to NAD+ than other precursors such as niacin or nicotinamide, it is one of the most direct and efficient routes to raising cellular NAD+ levels. Human clinical studies show significant increases in blood NAD+ levels within hours of oral NMN supplementation.\u003c\/p\u003e\n\n\u003ch3\u003eNMN, Mitochondria, and Cellular Energy\u003c\/h3\u003e\n\u003cp\u003eNAD+ is the primary electron carrier in oxidative phosphorylation, the mitochondrial process that produces ATP. Without adequate NAD+, mitochondrial energy production is impaired, reducing the cell's capacity to generate ATP and perform energy-dependent functions. NMN supports NAD+ biosynthesis, helping to maintain mitochondrial function and energy production capacity across tissues.\u003c\/p\u003e\n\n\u003ch3\u003eNMN and Sirtuin Activity\u003c\/h3\u003e\n\u003cp\u003eSirtuins (SIRT1 through SIRT7) are NAD+-dependent enzymes that regulate gene expression, DNA repair, mitochondrial biogenesis, inflammatory response, and metabolic adaptation. Sirtuin activity is directly proportional to NAD+ availability. By supporting NAD+ biosynthesis, NMN helps maintain sirtuin-mediated cellular regulatory functions in aging tissues.\u003c\/p\u003e\n\n\u003ch3\u003eNMN and DNA Repair\u003c\/h3\u003e\n\u003cp\u003ePARP enzymes are the primary DNA repair enzymes in human cells, consuming NAD+ to synthesize poly ADP-ribose chains that coordinate the DNA repair response. Maintaining NAD+ substrate availability through NMN supplementation supports healthy PARP-mediated DNA repair activity and genomic integrity.\u003c\/p\u003e\n\n\u003ch3\u003eHuman Clinical Research on NMN\u003c\/h3\u003e\n\u003cp\u003eHuman studies have examined NMN supplementation at doses of 250mg to 1200mg per day. The 500mg dose in this formula falls within the range most commonly studied. Research outcomes include increases in blood NAD+ levels, improvements in muscle insulin sensitivity, support for physical performance and endurance, and favorable effects on markers of metabolic health.\u003c\/p\u003e\n\n\u003ch2\u003eMedicinal Ingredient (per capsule)\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNicotinamide Mononucleotide (NMN) 500mg\u003c\/strong\u003e Direct NAD+ precursor | Supports NAD+ biosynthesis, cellular energy metabolism, DNA repair, sirtuin activity, and healthy aging | NPN 80132879\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNon-medicinal ingredients: Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.\u003c\/p\u003e\n\n\u003ch2\u003eQuality and Trust\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNPN 80132879\u003c\/strong\u003e Licensed by Health Canada as a Natural Health Product\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMade in Canada\u003c\/strong\u003e GMP certified facility under Health Canada oversight\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eIndependently tested\u003c\/strong\u003e Purity and potency verified by a third party laboratory\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e500mg pure NMN per capsule\u003c\/strong\u003e High potency, research-aligned dose\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDirect NAD+ precursor\u003c\/strong\u003e One biosynthetic step from NAD+\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eVegan capsule\u003c\/strong\u003e Hypromellose shell, no gelatin or animal derived ingredients\u003c\/li\u003e\n  \u003cli\u003e\u003cstrong\u003eNon-GMO and gluten free\u003c\/strong\u003e\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e60 capsules\u003c\/strong\u003e 60 day supply at 1 capsule per day\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWho This Is For\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eAdults seeking to support NAD+ levels and cellular energy metabolism as part of a longevity-focused wellness routine\u003c\/li\u003e\n  \u003cli\u003eThose interested in supporting healthy aging through sirtuin activation and DNA repair pathway support\u003c\/li\u003e\n  \u003cli\u003eIndividuals experiencing age-related energy decline who want to support mitochondrial function at the cellular level\u003c\/li\u003e\n  \u003cli\u003eHealth conscious consumers who prioritize Health Canada licensed, GMP manufactured, independently tested supplements\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eAdults: Take 1 capsule daily with or without food, or as directed by a healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003eNMN can be taken at any time of day. Some individuals prefer morning dosing to align with the circadian rhythm of NAD+ metabolism. Consistent daily use over several weeks is recommended before assessing effects on energy and cellular function.\u003c\/p\u003e\n\n\u003ch2\u003eSafety and Cautions\u003c\/h2\u003e\n\u003cp\u003eConsult a healthcare practitioner before use if you are pregnant or breastfeeding, have a history of cancer or are undergoing cancer treatment (NAD+ supports cellular proliferation pathways and implications for cancer biology are an active area of research), or are taking medications that affect NAD+ metabolism.\u003c\/p\u003e\n\u003cp\u003eStore in a cool, dry place away from direct sunlight and moisture. NMN is sensitive to heat and humidity. Keep bottle tightly sealed. Do not use if the seal is broken or missing. Keep out of reach of children.\u003c\/p\u003e\n\n\u003cp\u003eNPN 80132879. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.\u003c\/p\u003e","brand":"Nutridom","offers":[{"title":"Default Title","offer_id":45461853405347,"sku":"N293","price":48.85,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0623\/6589\/2771\/files\/NMN_500_mg_supplement_NAD_precursor_60_vegan_capsules.jpg?v=1772742368","url":"https:\/\/nutridom.ca\/zh\/products\/nmn-500mg-nicotinamide-mononucleotide-nad-precursor-cellular-energy-and-longevity-60-vcaps","provider":"Nutridom","version":"1.0","type":"link"}