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Methyl Folate (L-5-MTHF) for Red Blood Cell Formation and Energy Metabolism

Each capsule contains 1000mcg of L-5-methyltetrahydrofolate (L-5-MTHF), the active and highly bioavailable form of folate. Unlike folic acid, which requires conversion in the body, L-5-MTHF is the biologically active form ready for immediate use. Supports red blood cell formation, homocysteine metabolism, energy metabolism, and DNA synthesis. Health Canada approved (NPN 80138114). Made in Canada. 90 vegan capsules.

Key Benefits

• Supports red blood cell formation
• Supports homocysteine metabolism
• Supports energy metabolism
• Supports DNA synthesis
• 1000mcg L-5-MTHF per capsule
• Active, bioavailable form of folate
• No conversion required
• Health Canada approved (NPN 80138114)
• 90 vegan capsules
• Made in Canada
• Gluten-free, non-GMO

Why Choose Methyl Folate (L-5-MTHF)

Methyl folate offers advantages over regular folic acid:

Active Form: L-5-MTHF is the biologically active form of folate that the body uses directly, without requiring conversion.

Highly Bioavailable: L-5-MTHF is highly bioavailable and ready for the body to use immediately.

MTHFR Considerations: For individuals with MTHFR gene variations that affect folate metabolism, L-5-MTHF bypasses the conversion step that may be impaired.

Calcium Salt Form: This product uses the calcium salt form of L-5-MTHF for stability.

What Is Folate?

Folate is a B vitamin (vitamin B9) essential for many bodily functions. It plays a critical role in red blood cell formation, DNA synthesis, cell division, and homocysteine metabolism. Folate is found naturally in foods like leafy greens, legumes, and citrus fruits. The term "folate" refers to the natural form, while "folic acid" is the synthetic form used in supplements and fortified foods.

Understanding L-5-MTHF vs Folic Acid

Not all folate supplements are the same:

Folic Acid: The synthetic form of folate used in most supplements and fortified foods. Folic acid must be converted by the body into L-5-MTHF (the active form) through a series of enzymatic steps.

L-5-MTHF (Methyl Folate): The active, methylated form of folate that the body uses directly. L-5-MTHF does not require conversion and is ready for immediate use in metabolic processes.

Bioavailability Difference: L-5-MTHF is highly bioavailable because it's already in the active form. Folic acid requires conversion, which can be inefficient in some individuals.

MTHFR Gene Variations: Some people have genetic variations in the MTHFR gene that reduce their ability to convert folic acid to the active form. L-5-MTHF bypasses this conversion step.

Understanding the Dosage

Each capsule contains 1000mcg of L-5-MTHF:

L-5-Methyltetrahydrofolate: 1000mcg per capsule (as calcium salt)
Suggested Use: 1 capsule daily, or as directed by a healthcare practitioner

Consult your healthcare provider to determine the appropriate dosage for your individual needs.

Red Blood Cell Formation Support

Folate is essential for healthy red blood cell production:

Red Blood Cell Formation: Folate is required for the formation of healthy red blood cells. Adequate folate supports normal red blood cell production.

Cell Division: Folate plays a critical role in cell division, which is essential for red blood cell formation in the bone marrow.

DNA Synthesis: Folate is necessary for DNA synthesis, which is required for all rapidly dividing cells, including red blood cells.

Homocysteine Metabolism Support

Folate supports healthy homocysteine levels:

Homocysteine Metabolism: Folate, along with vitamins B6 and B12, supports the metabolism of homocysteine, an amino acid in the blood.

Methylation Support: L-5-MTHF provides methyl groups needed for converting homocysteine to methionine, supporting healthy homocysteine metabolism.

Cardiovascular Wellness: Maintaining healthy homocysteine levels is important for cardiovascular wellness.

Energy Metabolism and DNA Synthesis

Folate supports fundamental cellular processes:

Energy Metabolism: Folate plays a role in energy metabolism by supporting various metabolic pathways.

DNA Synthesis: Folate is essential for DNA synthesis and repair, which is critical for all cells in the body.

Cell Growth: Adequate folate supports normal cell growth and function throughout the body.

Who May Consider This Product

• Individuals seeking active folate supplementation
• Those with MTHFR gene variations
• People preferring methylated B vitamins
• Individuals supporting red blood cell formation
• Those supporting homocysteine metabolism
• People seeking highly bioavailable folate
• Individuals preferring L-5-MTHF over folic acid
• Vegans and vegetarians

Quality & Purity

• Health Canada approved (NPN 80138114)
• 1000mcg L-5-MTHF per capsule
• Active, methylated form of folate
• Calcium salt form for stability
• Vegan capsules (hypromellose)
• Gluten-free, non-GMO
• Made in Canada
• 90 capsules

Storage

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed.

Safety Information

Consult a healthcare professional before use if you are pregnant, nursing, taking medications, or have a medical condition. Folate supplementation may mask vitamin B12 deficiency; ensure adequate B12 intake. Use as part of a balanced diet and healthy lifestyle.

Keep out of reach of children.

This product is approved by Health Canada (NPN 80138114).

About Methyl Folate: The Active Form of Folate

L-5-methyltetrahydrofolate (L-5-MTHF) is the predominant form of folate found in the bloodstream and the form that crosses the blood-brain barrier. While folic acid has been used in supplements for decades, L-5-MTHF has gained recognition as a superior form because it's already in the active state. This is particularly important for individuals with MTHFR gene variations, which are relatively common in the population. By providing folate in its active form, L-5-MTHF ensures the body can use it effectively for red blood cell formation, homocysteine metabolism, DNA synthesis, and other critical functions.

Methyl Folate 1000mcg (L-5-MTHF) | Active Folate | 90 Vcaps

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Health Canada Licensed Natural Health Product (NPN 80138114)

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Methyl Folate (L-5-MTHF) for Red Blood Cell Formation and Energy Metabolism

Each capsule contains 1000mcg of L-5-methyltetrahydrofolate (L-5-MTHF), the active and highly bioavailable form of folate. Unlike folic acid, which requires conversion in the body, L-5-MTHF is the biologically active form ready for immediate use. Supports red blood cell formation, homocysteine metabolism, energy metabolism, and DNA synthesis. Health Canada approved (NPN 80138114). Made in Canada. 90 vegan capsules.

Key Benefits

• Supports red blood cell formation
• Supports homocysteine metabolism
• Supports energy metabolism
• Supports DNA synthesis
• 1000mcg L-5-MTHF per capsule
• Active, bioavailable form of folate
• No conversion required
• Health Canada approved (NPN 80138114)
• 90 vegan capsules
• Made in Canada
• Gluten-free, non-GMO

Why Choose Methyl Folate (L-5-MTHF)

Methyl folate offers advantages over regular folic acid:

Active Form: L-5-MTHF is the biologically active form of folate that the body uses directly, without requiring conversion.

Highly Bioavailable: L-5-MTHF is highly bioavailable and ready for the body to use immediately.

MTHFR Considerations: For individuals with MTHFR gene variations that affect folate metabolism, L-5-MTHF bypasses the conversion step that may be impaired.

Calcium Salt Form: This product uses the calcium salt form of L-5-MTHF for stability.

What Is Folate?

Folate is a B vitamin (vitamin B9) essential for many bodily functions. It plays a critical role in red blood cell formation, DNA synthesis, cell division, and homocysteine metabolism. Folate is found naturally in foods like leafy greens, legumes, and citrus fruits. The term "folate" refers to the natural form, while "folic acid" is the synthetic form used in supplements and fortified foods.

Understanding L-5-MTHF vs Folic Acid

Not all folate supplements are the same:

Folic Acid: The synthetic form of folate used in most supplements and fortified foods. Folic acid must be converted by the body into L-5-MTHF (the active form) through a series of enzymatic steps.

L-5-MTHF (Methyl Folate): The active, methylated form of folate that the body uses directly. L-5-MTHF does not require conversion and is ready for immediate use in metabolic processes.

Bioavailability Difference: L-5-MTHF is highly bioavailable because it's already in the active form. Folic acid requires conversion, which can be inefficient in some individuals.

MTHFR Gene Variations: Some people have genetic variations in the MTHFR gene that reduce their ability to convert folic acid to the active form. L-5-MTHF bypasses this conversion step.

Understanding the Dosage

Each capsule contains 1000mcg of L-5-MTHF:

L-5-Methyltetrahydrofolate: 1000mcg per capsule (as calcium salt)
Suggested Use: 1 capsule daily, or as directed by a healthcare practitioner

Consult your healthcare provider to determine the appropriate dosage for your individual needs.

Red Blood Cell Formation Support

Folate is essential for healthy red blood cell production:

Red Blood Cell Formation: Folate is required for the formation of healthy red blood cells. Adequate folate supports normal red blood cell production.

Cell Division: Folate plays a critical role in cell division, which is essential for red blood cell formation in the bone marrow.

DNA Synthesis: Folate is necessary for DNA synthesis, which is required for all rapidly dividing cells, including red blood cells.

Homocysteine Metabolism Support

Folate supports healthy homocysteine levels:

Homocysteine Metabolism: Folate, along with vitamins B6 and B12, supports the metabolism of homocysteine, an amino acid in the blood.

Methylation Support: L-5-MTHF provides methyl groups needed for converting homocysteine to methionine, supporting healthy homocysteine metabolism.

Cardiovascular Wellness: Maintaining healthy homocysteine levels is important for cardiovascular wellness.

Energy Metabolism and DNA Synthesis

Folate supports fundamental cellular processes:

Energy Metabolism: Folate plays a role in energy metabolism by supporting various metabolic pathways.

DNA Synthesis: Folate is essential for DNA synthesis and repair, which is critical for all cells in the body.

Cell Growth: Adequate folate supports normal cell growth and function throughout the body.

Who May Consider This Product

• Individuals seeking active folate supplementation
• Those with MTHFR gene variations
• People preferring methylated B vitamins
• Individuals supporting red blood cell formation
• Those supporting homocysteine metabolism
• People seeking highly bioavailable folate
• Individuals preferring L-5-MTHF over folic acid
• Vegans and vegetarians

Quality & Purity

• Health Canada approved (NPN 80138114)
• 1000mcg L-5-MTHF per capsule
• Active, methylated form of folate
• Calcium salt form for stability
• Vegan capsules (hypromellose)
• Gluten-free, non-GMO
• Made in Canada
• 90 capsules

Storage

Store in a cool, dry place away from direct sunlight. Keep bottle tightly sealed.

Safety Information

Consult a healthcare professional before use if you are pregnant, nursing, taking medications, or have a medical condition. Folate supplementation may mask vitamin B12 deficiency; ensure adequate B12 intake. Use as part of a balanced diet and healthy lifestyle.

Keep out of reach of children.

This product is approved by Health Canada (NPN 80138114).

About Methyl Folate: The Active Form of Folate

L-5-methyltetrahydrofolate (L-5-MTHF) is the predominant form of folate found in the bloodstream and the form that crosses the blood-brain barrier. While folic acid has been used in supplements for decades, L-5-MTHF has gained recognition as a superior form because it's already in the active state. This is particularly important for individuals with MTHFR gene variations, which are relatively common in the population. By providing folate in its active form, L-5-MTHF ensures the body can use it effectively for red blood cell formation, homocysteine metabolism, DNA synthesis, and other critical functions.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 90

Ingredient
Amount Per
Serving
% Daily
Value
Folate (L-5-Methyltetrahydrofolate, calcium salt)
1,000 mcg DFE

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate

Clinical Research

L-5-methyltetrahydrofolate versus folic acid: bioavailability and efficacy in folate deficient subjects

European Journal of Clinical Nutrition, 2004

This randomized controlled trial compared the bioavailability and efficacy of L-5-MTHF and folic acid in adults with low folate status. The study found that L-5-MTHF was at least as effective as folic acid in raising blood folate levels and significantly more effective in individuals with reduced MTHFR enzyme activity. The authors concluded that L-5-MTHF is a superior supplemental form of folate for individuals with impaired folic acid conversion capacity

Folate and homocysteine metabolism: clinical implications

American Journal of Clinical Nutrition, 1999

This comprehensive review examined the biochemical relationship between folate, L-5-MTHF, and homocysteine metabolism. The review established that L-5-MTHF provides the methyl groups required to convert homocysteine to methionine via methionine synthase, and that adequate folate status is essential for maintaining healthy homocysteine levels. The authors confirmed that L-5-MTHF is the active folate form directly involved in the methylation cycle.

MTHFR gene variants and folate metabolism: implications for supplementation

Nutrients, 2017

This review examined the clinical implications of common MTHFR gene variants (C677T and A1298C) on folate metabolism and supplementation strategy. The review found that individuals with reduced MTHFR enzyme activity have impaired conversion of folic acid to L-5-MTHF, and that direct supplementation with L-5-MTHF bypasses this enzymatic step. The authors concluded that L-5-MTHF is the preferred supplemental form of folate for individuals with MTHFR variants.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is methyl folate (L-5-MTHF) and what is it used for?

Methyl folate (L-5-methyltetrahydrofolate, or L-5-MTHF) is the biologically active form of folate (vitamin B9) found in the bloodstream and the form that crosses the blood brain barrier. Unlike folic acid, L-5-MTHF does not require enzymatic conversion and is ready for immediate use by the body. It supports red blood cell formation, homocysteine metabolism, energy metabolism, and DNA synthesis.

What is the difference between methyl folate and folic acid?

Folic acid is the synthetic form of folate used in most supplements and fortified foods. It must be converted by the body into L-5-MTHF through a series of enzymatic steps involving the MTHFR enzyme. L-5-MTHF is the active, methylated form that the body uses directly no conversion required. For individuals with reduced MTHFR enzyme activity, L-5-MTHF bypasses the conversion step that may be impaired.

What is the MTHFR gene and why does it matter for folate?

MTHFR (methylenetetrahydrofolate reductase) is the enzyme responsible for converting folic acid into the active form L-5-MTHF. Common genetic variations in the MTHFR gene (C677T and A1298C) reduce this enzyme's activity, impairing the conversion of folic acid to the usable form. Supplementing with L-5-MTHF directly bypasses this conversion step, providing active folate regardless of MTHFR genotype.

Does methyl folate support homocysteine metabolism?

Yes. Folate specifically L-5-MTHF provides the methyl groups needed to convert homocysteine to methionine via the methylation cycle. This is a key step in maintaining healthy homocysteine levels. Folate works alongside vitamins B6 and B12 in this pathway. Consult a healthcare practitioner for advice specific to your homocysteine levels.

Is methyl folate safe during pregnancy?

Folate is essential during pregnancy for normal fetal neural tube development. Consult a healthcare practitioner before use if you are pregnant or breastfeeding to determine the appropriate form and dose of folate for your individual needs. Do not self select a high dose folate supplement during pregnancy without professional guidance.

Who should consider taking methyl folate instead of folic acid?

L-5-MTHF is particularly relevant for individuals with known or suspected MTHFR gene variations, those who have not responded well to folic acid supplementation, individuals seeking a highly bioavailable form of folate, and those following a methylated B vitamin protocol. Consult a healthcare practitioner to determine whether L-5-MTHF is appropriate for your individual situation.