DIM 200mg | 호르몬 균형을 위한 디인돌릴메탄 | 120 V캡슐

DIM (3,3'-Diindolylmethane) is the bioactive compound formed from indole-3-carbinol (I3C) during digestion of cruciferous vegetables such as broccoli, cauliflower, Brussels sprouts, and cabbage. DIM is not found directly in food it is produced in the acidic environment of the stomach when I3C undergoes acid-catalyzed condensation during digestion. DIM supports healthy estrogen metabolism by promoting the 2-hydroxylation pathway increasing the ratio of beneficial 2-hydroxyestrone (2-OHE1) to less favorable 16-alpha-hydroxyestrone (16-OHE1). It also supports Phase I and Phase II hepatic detoxification enzymes involved in estrogen processing and elimination.

Estrogen is metabolized in the liver via competing hydroxylation pathways. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1) a weakly estrogenic metabolite considered favorable. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1) a strongly estrogenic metabolite associated with less favorable hormonal activity. DIM promotes the 2-hydroxylation pathway, increasing the 2-OHE1 to 16-OHE1 ratio. This shift in estrogen metabolism is the primary mechanism through which DIM supports healthy hormone balance. DIM also induces cytochrome P450 enzymes (CYP1A1 and CYP1A2) involved in Phase I estrogen hydroxylation and supports Phase II conjugation enzymes that facilitate estrogen elimination.

DIM supports healthy estrogen metabolism in both women and men. While DIM is most commonly associated with women's hormonal health, estrogen metabolism is relevant to both sexes. Men produce estrogen through aromatization of testosterone the enzyme aromatase (CYP19A1) converts androgens to estrogens. Age related increases in aromatase activity can shift the testosterone to estrogen ratio unfavorably in men. DIM supports healthy aromatase regulation and healthy estrogen clearance, making it relevant for men seeking to support healthy testosterone to estrogen balance. Ask a healthcare practitioner before use if you are taking medications or natural health products.

DIM supports both Phase I and Phase II hepatic detoxification pathways involved in estrogen processing and elimination. In Phase I, DIM induces cytochrome P450 enzymes particularly CYP1A1 and CYP1A2 that hydroxylate estrogen into water soluble metabolites for further processing. In Phase II, DIM supports conjugation enzymes including glutathione S-transferase that attach polar groups to estrogen metabolites, making them water soluble and ready for excretion in bile or urine. This dual support for hepatic detoxification pathways helps the body process and clear estrogen metabolites efficiently. Consult a healthcare practitioner before use if you have a liver disorder.

Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner before use if you are attempting to conceive. Ask a healthcare practitioner before use if you are taking any medications or natural health products. Ask a healthcare practitioner before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruation. Ask a healthcare practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance. Stop use and ask a healthcare practitioner if you develop liver related symptoms such as yellowing of the eyes or skin, dark urine, abdominal pain, or jaundice, or if symptoms of low estrogen develop.