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Milk Thistle 600mg | Silybum marianum | Standardized to 80% Silymarin | Liver Support | Extra Strength | 120 Vegan Capsules

Each vegan capsule delivers 600mg of Silybum marianum seed extract standardized to 80% silymarin the concentrated flavonolignan complex responsible for milk thistle's hepatoprotective activity. Traditionally used in herbal medicine as a hepatoprotectant and liver protectant. Used in herbal medicine to help support liver function.

Health Canada licensed NPN 80086006. Vegan. Non-GMO. Gluten free. Made in Canada. 120 vegan capsules up to a 4 month supply at 1 capsule per day.

Key Benefits

  • Hepatoprotectant | Liver protectant — Traditionally used in herbal medicine as a hepatoprotectant and liver protectant | Health Canada licensed under NPN 80086006
  • Supports liver function — Used in herbal medicine to help support liver function | Health Canada licensed under NPN 80086006
  • 600mg Silybum marianum seed extract per capsule — Standardized to 80% silymarin | 480mg silymarin per capsule
  • 80% silymarin standardization — Ensures consistent potency of the active flavonolignan complex per capsule
  • Silymarin complex — Silybin, silydianin, and silychristin — the primary hepatoprotective flavonolignans of milk thistle seed
  • Extra strength formula — 600mg per capsule at the upper end of commonly available milk thistle supplemental doses
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed — NPN 80086006 | GMP certified | Made in Canada
  • 120 vegan capsules — Up to a 4 month supply at 1 capsule per day

What Is Milk Thistle?

Milk thistle (Silybum marianum) is a flowering herb in the Asteraceae family native to the Mediterranean region and naturalized worldwide. It has been used in traditional European herbal medicine for over 2,000 years as a liver and gallbladder remedy. The medicinal activity of milk thistle is concentrated in the seed, which contains silymarin — a complex of flavonolignans including silybin (the most biologically active component), silydianin, and silychristin.

Silymarin is standardized in this formula to 80% of the extract weight, providing 480mg of silymarin per 600mg capsule a consistent, high-potency dose aligned with the clinical research literature on milk thistle hepatoprotection.

How It Works

Silymarin and Hepatoprotection

Silymarin exerts hepatoprotective activity through multiple mechanisms: it stabilizes hepatocyte cell membranes by altering their surface structure to prevent toxin penetration; it acts as an antioxidant by scavenging free radicals and inhibiting lipid peroxidation in liver tissue; it stimulates ribosomal RNA synthesis to support hepatocyte regeneration; and it inhibits the binding of toxins to hepatocyte membrane receptors. These combined mechanisms underlie milk thistle's traditional and evidence-informed use as a hepatoprotectant.

Silybin: The Primary Active Flavonolignan

Silybin (also called silibinin) is the most abundant and most biologically active component of the silymarin complex, accounting for approximately 50 to 70% of silymarin by weight. It is the primary contributor to milk thistle's antioxidant and hepatoprotective activity and is the component most extensively studied in clinical research.

Why Standardization to 80% Silymarin Matters

Non-standardized milk thistle products may contain highly variable amounts of silymarin depending on the plant source, growing conditions, and extraction method. Standardization to 80% silymarin ensures that each 600mg capsule delivers a consistent 480mg of the active flavonolignan complex — the same potency in every capsule, every bottle.

Medicinal Ingredient (per capsule)

  • Milk Thistle Seed Extract (Silybum marianum) 600mg — Standardized to 80% silymarin (480mg silymarin per capsule) | Hepatoprotectant | Supports liver function | NPN 80086006

Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives. Vegan. Gluten free. Non-GMO.

Quality and Trust

  • NPN 80086006 — Licensed by Health Canada as a Natural Health Product
  • Made in Canada — GMP certified facility under Health Canada oversight
  • Standardized to 80% silymarin — Consistent potency guaranteed per capsule
  • 600mg per capsule — Extra strength, 480mg silymarin per capsule
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO and gluten free
  • 120 vegan capsules — Up to a 4 month supply at 1 capsule per day

Who This Is For

  • Adults seeking traditional herbal liver support from a standardized, high-potency milk thistle extract
  • Those wanting a consistent 80% silymarin standardized extract rather than non-standardized milk thistle powder
  • Vegans and vegetarians seeking a plant-derived liver support supplement with no gelatin capsule
  • Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, have a known allergy to plants in the Asteraceae/Compositae family, or are taking prescription medications
  • Do not use if you have a known allergy to milk thistle or other Asteraceae family plants (ragweed, chrysanthemums, marigolds, daisies)

How to Use

Adults: Take 1 capsule once per day, or as directed by a healthcare practitioner. May be taken with or without food.

Safety and Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition (milk thistle may have mild estrogenic activity), have a known allergy to Asteraceae/Compositae family plants, or are taking prescription medications including immunosuppressants or medications metabolized by the liver. Gastrointestinal upset may occur in sensitive individuals. Store in a cool, dry place. Keep out of reach of children.

NPN 80086006. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Milk Thistle 600mg | Silybum marianum | Standardized to 80% Silymarin | Liver Support | 120 Vegan Capsules

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Milk Thistle 600mg | Silybum marianum | Standardized to 80% Silymarin | Liver Support | Extra Strength | 120 Vegan Capsules

Each vegan capsule delivers 600mg of Silybum marianum seed extract standardized to 80% silymarin the concentrated flavonolignan complex responsible for milk thistle's hepatoprotective activity. Traditionally used in herbal medicine as a hepatoprotectant and liver protectant. Used in herbal medicine to help support liver function.

Health Canada licensed NPN 80086006. Vegan. Non-GMO. Gluten free. Made in Canada. 120 vegan capsules up to a 4 month supply at 1 capsule per day.

Key Benefits

  • Hepatoprotectant | Liver protectant — Traditionally used in herbal medicine as a hepatoprotectant and liver protectant | Health Canada licensed under NPN 80086006
  • Supports liver function — Used in herbal medicine to help support liver function | Health Canada licensed under NPN 80086006
  • 600mg Silybum marianum seed extract per capsule — Standardized to 80% silymarin | 480mg silymarin per capsule
  • 80% silymarin standardization — Ensures consistent potency of the active flavonolignan complex per capsule
  • Silymarin complex — Silybin, silydianin, and silychristin — the primary hepatoprotective flavonolignans of milk thistle seed
  • Extra strength formula — 600mg per capsule at the upper end of commonly available milk thistle supplemental doses
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Health Canada licensed — NPN 80086006 | GMP certified | Made in Canada
  • 120 vegan capsules — Up to a 4 month supply at 1 capsule per day

What Is Milk Thistle?

Milk thistle (Silybum marianum) is a flowering herb in the Asteraceae family native to the Mediterranean region and naturalized worldwide. It has been used in traditional European herbal medicine for over 2,000 years as a liver and gallbladder remedy. The medicinal activity of milk thistle is concentrated in the seed, which contains silymarin — a complex of flavonolignans including silybin (the most biologically active component), silydianin, and silychristin.

Silymarin is standardized in this formula to 80% of the extract weight, providing 480mg of silymarin per 600mg capsule a consistent, high-potency dose aligned with the clinical research literature on milk thistle hepatoprotection.

How It Works

Silymarin and Hepatoprotection

Silymarin exerts hepatoprotective activity through multiple mechanisms: it stabilizes hepatocyte cell membranes by altering their surface structure to prevent toxin penetration; it acts as an antioxidant by scavenging free radicals and inhibiting lipid peroxidation in liver tissue; it stimulates ribosomal RNA synthesis to support hepatocyte regeneration; and it inhibits the binding of toxins to hepatocyte membrane receptors. These combined mechanisms underlie milk thistle's traditional and evidence-informed use as a hepatoprotectant.

Silybin: The Primary Active Flavonolignan

Silybin (also called silibinin) is the most abundant and most biologically active component of the silymarin complex, accounting for approximately 50 to 70% of silymarin by weight. It is the primary contributor to milk thistle's antioxidant and hepatoprotective activity and is the component most extensively studied in clinical research.

Why Standardization to 80% Silymarin Matters

Non-standardized milk thistle products may contain highly variable amounts of silymarin depending on the plant source, growing conditions, and extraction method. Standardization to 80% silymarin ensures that each 600mg capsule delivers a consistent 480mg of the active flavonolignan complex — the same potency in every capsule, every bottle.

Medicinal Ingredient (per capsule)

  • Milk Thistle Seed Extract (Silybum marianum) 600mg — Standardized to 80% silymarin (480mg silymarin per capsule) | Hepatoprotectant | Supports liver function | NPN 80086006

Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives. Vegan. Gluten free. Non-GMO.

Quality and Trust

  • NPN 80086006 — Licensed by Health Canada as a Natural Health Product
  • Made in Canada — GMP certified facility under Health Canada oversight
  • Standardized to 80% silymarin — Consistent potency guaranteed per capsule
  • 600mg per capsule — Extra strength, 480mg silymarin per capsule
  • Vegan capsule — Hypromellose shell, no gelatin or animal derived ingredients
  • Non-GMO and gluten free
  • 120 vegan capsules — Up to a 4 month supply at 1 capsule per day

Who This Is For

  • Adults seeking traditional herbal liver support from a standardized, high-potency milk thistle extract
  • Those wanting a consistent 80% silymarin standardized extract rather than non-standardized milk thistle powder
  • Vegans and vegetarians seeking a plant-derived liver support supplement with no gelatin capsule
  • Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition, have a known allergy to plants in the Asteraceae/Compositae family, or are taking prescription medications
  • Do not use if you have a known allergy to milk thistle or other Asteraceae family plants (ragweed, chrysanthemums, marigolds, daisies)

How to Use

Adults: Take 1 capsule once per day, or as directed by a healthcare practitioner. May be taken with or without food.

Safety and Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone-sensitive condition (milk thistle may have mild estrogenic activity), have a known allergy to Asteraceae/Compositae family plants, or are taking prescription medications including immunosuppressants or medications metabolized by the liver. Gastrointestinal upset may occur in sensitive individuals. Store in a cool, dry place. Keep out of reach of children.

NPN 80086006. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Ingredient
Amount Per
Serving
% Daily
Value
Milk Thistle Seed Extract (Silybum marianum, seed)
600 mg

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Silymarin as supportive treatment in liver diseases: a narrative review

Advances in Therapy, 2020

This comprehensive narrative review examined the clinical evidence for silymarin across a range of liver conditions including non-alcoholic fatty liver disease, alcoholic liver disease, and drug-induced liver injury. The review found consistent evidence that silymarin exerts hepatoprotective activity through membrane stabilization, antioxidant activity, anti inflammatory effects, and stimulation of hepatocyte regeneration. The authors concluded that silymarin is a well tolerated and evidence supported hepatoprotectant

Milk thistle (Silybum marianum) for the therapy of liver disease

Drugs, 2001

This systematic review evaluated clinical trials of silymarin for liver disease and found that standardized milk thistle extract significantly improved liver enzyme levels (ALT, AST) and supported liver function in patients with chronic liver conditions. The review identified silymarin's hepatocyte membrane-stabilizing and antioxidant mechanisms as the primary basis for its hepatoprotective activity, and confirmed that standardization to a consistent silymarin content is essential for reliable clinical outcomes directly supporting the use of an 80% standardized extract.

Antioxidant and hepatoprotective activity of silymarin in patients with chronic liver disease

Digestive and Liver Disease, 2002

This clinical study measured oxidative stress markers and liver function parameters in patients with chronic liver disease before and after silymarin supplementation. The study found that silymarin significantly reduced markers of hepatic oxidative stress including lipid peroxidation products and improved liver enzyme profiles, confirming silymarin's dual role as both an antioxidant and hepatoprotectant in liver tissue consistent with the traditional herbal medicine use of milk thistle as a liver protectant

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is milk thistle used for?

Milk thistle (Silybum marianum) is traditionally used in herbal medicine as a hepatoprotectant and liver protectant, and to help support liver function. Licensed by Health Canada under NPN 80086006. Each capsule provides 600mg ofSilybum marianumseed extract standardized to 80% silymarin (480mg silymarin per capsule). Suitable for adults seeking traditional herbal liver support. Consult a healthcare practitioner before use if pregnant, breastfeeding, or taking prescription medications. Source:Silybum marianumseed, standardized extract.

What is silymarin and why does standardization matter?

Silymarin is the flavonolignan complex in milk thistle seed responsible for its hepatoprotective activity, comprising silybin, silydianin, and silychristin. Non-standardized milk thistle products contain highly variable silymarin amounts. This formula is standardized to 80% silymarin delivering a consistent 480mg of the active complex per 600mg capsule, every capsule, every bottle. Suitable for adults wanting consistent, high potency milk thistle. Source:Silybum marianumseed extract, 80% silymarin standardization.

How much milk thistle should I take per day?

dults take 1 capsule once per day. Each capsule provides 600mg ofSilybum marianumseed extract standardized to 80% silymarin (480mg silymarin per capsule). One bottle of 120 capsules provides up to a 4 month supply at 1 capsule per day. May be taken with or without food. Consult a healthcare practitioner for personalized dosing guidance or for use beyond the recommended duration.

Who should not take milk thistle?

Do not use if you have a known allergy to milk thistle or other Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds, daisies). Consult a healthcare practitioner before use if you have a hormone-sensitive condition, are pregnant or breastfeeding, or are taking prescription medications including immunosuppressants or medications metabolized by the liver. Suitable for healthy adults seeking traditional herbal liver support with no contraindicated conditions. Keep out of reach of children.

Can milk thistle interact with medications?

Silymarin may affect the metabolism of medications processed by liver enzymes (CYP450 pathways), potentially altering drug levels. Consult a healthcare practitioner before use if you are taking immunosuppressants, statins, anticoagulants, antidiabetic medications, or any prescription drugs metabolized by the liver. Do not use milk thistle as a substitute for prescribed liver medications. Source:Silybum marianumseed extract, 80% silymarin, 600mg per capsule.

What are the benefits of taking milk thistle?

Milk thistle (Silybum marianum) seed extract standardized to 80% silymarin is traditionally used in herbal medicine as a hepatoprotectant and liver protectant, and to help support liver function. Silymarin stabilizes hepatocyte cell membranes, scavenges free radicals in liver tissue, inhibits lipid peroxidation, and supports hepatocyte regeneration. Each capsule provides 600mg ofSilybum marianumseed extract (480mg silymarin).

Does milk thistle help detox the liver?

Milk thistle silymarin stabilizes hepatocyte cell membranes to prevent toxin penetration and inhibits the binding of toxins to hepatocyte membrane receptors the primary mechanisms underlying its traditional use as a hepatoprotectant and liver protectant in herbal medicine