Indole-3-Carbinol 400mg | Estrogen Metabolism and Hormonal Wellness Support

Key Benefits

• Supports healthy estrogen metabolism and helps maintain balanced estrogen activity
• Helps maintain hormonal wellness and supports overall hormonal balance in adults
• Supports antioxidant defences and helps maintain cellular healthHelps maintain healthy detoxification pathways involved in estrogen clearance
• Supports a healthy inflammatory response
• Derived from cruciferous vegetables, a natural phytochemical with extensive research support
• 400mg per capsule, 60 vegan capsules per bottle

What This Is

This is a high potency Indole-3-Carbinol (I3C) supplement providing 400mg per capsule, a phytochemical naturally found in cruciferous vegetables including broccoli, cauliflower, Brussels sprouts, cabbage, and kale. I3C is one of the most extensively researched phytochemicals for supporting healthy estrogen metabolism and hormonal wellness. In the acidic environment of the stomach, I3C is converted to diindolylmethane (DIM) and other bioactive indole compounds that support the liver's estrogen detoxification pathways, promoting a healthier ratio of estrogen metabolites. Health Canada licensed and manufactured in Canada to GMP standards.

The Science

What Is Indole-3-Carbinol (I3C)?

Indole-3-Carbinol (I3C) is a naturally occurring phytochemical found in cruciferous vegetables of the Brassica family, including broccoli, cauliflower, Brussels sprouts, cabbage, kale, and bok choy. It is formed when glucobrassicin, a glucosinolate compound in these vegetables, is hydrolyzed by the enzyme myrosinase upon cutting, chewing, or cooking. I3C has been studied extensively in nutritional science for its role in supporting healthy estrogen metabolism, antioxidant defence, and cellular health. Supplemental I3C provides a concentrated, consistent dose of this phytochemical that would be difficult to obtain from diet alone at clinically meaningful levels.

I3C and Estrogen Metabolism

Estrogen is metabolized in the liver through two primary pathways that produce different metabolites with distinct biological activities. The 2-hydroxylation pathway produces 2-hydroxyestrone (2-OHE1), a metabolite associated with a more favorable hormonal balance. The 16-alpha-hydroxylation pathway produces 16-alpha-hydroxyestrone (16-OHE1), a more potent estrogen metabolite. Research on I3C and its primary metabolite DIM (diindolylmethane) consistently demonstrates that these compounds support the 2-hydroxylation pathway, promoting a healthier 2-OHE1 to 16-OHE1 ratio and supporting balanced estrogen activity. This mechanism makes I3C one of the most studied natural compounds for supporting healthy estrogen metabolism.

I3C and DIM: The Relationship

When I3C reaches the acidic environment of the stomach, it undergoes acid-catalyzed condensation reactions to form diindolylmethane (DIM) and other bioactive indole oligomers. DIM is considered the primary active metabolite responsible for many of I3C's estrogen metabolism supporting effects. Supplementing with I3C provides the precursor that the body converts to DIM and other bioactive indoles in the stomach, delivering a broader spectrum of bioactive indole compounds compared to supplementing with DIM alone. The 400mg dose of I3C in this formula provides a clinically meaningful amount aligned with research on I3C and estrogen metabolism support.

I3C and Liver Detoxification

The liver is the primary site of estrogen metabolism and detoxification. I3C and its metabolites support the liver's phase I and phase II detoxification pathways involved in estrogen clearance, particularly by supporting cytochrome P450 enzyme activity (especially CYP1A1 and CYP1A2) involved in the 2-hydroxylation of estrogens. By supporting these detoxification pathways, I3C helps maintain the liver's ability to efficiently metabolize and clear estrogens, contributing to overall hormonal balance.

I3C and Antioxidant Defence

I3C and its metabolites support antioxidant defence through multiple mechanisms including supporting the activity of Nrf2, a transcription factor that regulates the expression of endogenous antioxidant and detoxification enzymes. This antioxidant activity contributes to I3C's role in supporting cellular health and maintaining the integrity of cells exposed to oxidative stress from estrogen metabolites and environmental factors.

Ingredients

Medicinal Ingredient (per capsule)

• Indole-3-Carbinol (I3C) 400mg Derived from cruciferous vegetables (Brassica family) | Supports healthy estrogen metabolism, hormonal wellness, antioxidant defences, and liver detoxification pathways

Non Medicinal Ingredients

Vegetable capsule (hypromellose), microcrystalline cellulose, magnesium stearate (vegetable source). No artificial colours, flavours, sweeteners, or preservatives.

Quality and Trust

• NPN 80069955 Licensed by Health Canada as a Natural Health Product
• Made in Canada GMP certified facility under Health Canada oversight
• Independently tested Purity and potency verified by a third party laboratory
• 400mg I3C per capsule High potency, clinically aligned dose
• Natural phytochemical Derived from cruciferous vegetables of the Brassica family
• Vegan capsules Hypromellose shell, no gelatin or animal derived ingredients
• Non GMO Free from genetically modified organisms
• Gluten free Suitable for those with gluten sensitivities
• 60 capsules Two month supply at one capsule per day

Who This Product Is For

• Adults seeking support for healthy estrogen metabolism and hormonal balance
• Women looking to support a healthier estrogen metabolite ratio through natural phytochemical supplementation
• Those seeking liver detoxification pathway support for estrogen clearance
• Individuals wanting antioxidant and cellular health support from a cruciferous vegetable phytochemical
• Health conscious consumers who prioritize Health Canada licensed, GMP manufactured products

How to Use

Take 1 capsule daily with food and a full glass of water, or as directed by a healthcare practitioner. For best results, use consistently as part of a daily wellness routine.

Safety and Cautions

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a hormone sensitive condition such as breast, uterine, ovarian, or prostate cancer, are taking medications metabolized by cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP3A4), or are taking oral contraceptives or hormone replacement therapy.

• Not recommended for individuals under 18 years of age
• Keep out of reach of children
• Store in a cool, dry place away from direct sunlight and moisture
• Do not use if the seal is broken or missing

NPN 80069955. This product is not intended to diagnose, treat, cure, or prevent any disease. All health claims are consistent with Health Canada's Natural Health Products Regulations.