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Nutridom L Citrulline 750 mg 120 Vegan Capsules Amino Acid Supplement
L Citrulline 750 mg Free Form Amino Acid Supplement Nutridom
750 mg L Citrulline Per Capsule Nitric Oxide Support
L Citrulline Vegan Capsules 120 Count Bottle
L Citrulline 750 mg Supplement Facts Label 120 Capsules
Made in Canada L Citrulline Supplement Nutridom
Nutridom L Citrulline 750 mg 120 Vegan Capsules Amino Acid Supplement

Each capsule delivers 750mg of pure free form L-citrulline, a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. Supports healthy circulation and exercise performance as part of a balanced diet and active lifestyle. 

Who This Is For

  • Athletes and active adults seeking circulation and exercise performance support from a Health Canada licensed free form L-citrulline supplement
  • Those who prefer L-citrulline over L-arginine for its superior bioavailability and more sustained plasma L-arginine elevation
  • Those wanting a clean, vegan, non-GMO amino acid supplement with no artificial additives
  • Those seeking a Canadian made supplement with full Health Canada licensing

Where Does L-Citrulline Come From?

L-citrulline was first isolated from watermelon (Citrullus vulgaris) in 1930, which remains one of the richest natural food sources of L-citrulline. L-citrulline used in supplements is synthetically produced by fermentation or chemical synthesis, yielding a compound chemically identical to the L-citrulline found naturally in watermelon and other foods. 

Why Is L-Citrulline Better Than L-Arginine for Nitric Oxide Support?

L-arginine is the direct substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first-pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine consistently shows that L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself. This is why L-citrulline is the preferred form for nitric oxide and circulation support.

L-Citrulline 750mg | Circulation and Nitric Oxide Support | Free Form Amino Acid

$23.99

Health Canada Licensed Natural Health Product (NPN 80139498)

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Each capsule delivers 750mg of pure free form L-citrulline, a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. Supports healthy circulation and exercise performance as part of a balanced diet and active lifestyle. 

Who This Is For

  • Athletes and active adults seeking circulation and exercise performance support from a Health Canada licensed free form L-citrulline supplement
  • Those who prefer L-citrulline over L-arginine for its superior bioavailability and more sustained plasma L-arginine elevation
  • Those wanting a clean, vegan, non-GMO amino acid supplement with no artificial additives
  • Those seeking a Canadian made supplement with full Health Canada licensing

Where Does L-Citrulline Come From?

L-citrulline was first isolated from watermelon (Citrullus vulgaris) in 1930, which remains one of the richest natural food sources of L-citrulline. L-citrulline used in supplements is synthetically produced by fermentation or chemical synthesis, yielding a compound chemically identical to the L-citrulline found naturally in watermelon and other foods. 

Why Is L-Citrulline Better Than L-Arginine for Nitric Oxide Support?

L-arginine is the direct substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first-pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine consistently shows that L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself. This is why L-citrulline is the preferred form for nitric oxide and circulation support.

Supplement Facts

Supplement Facts

Serving Size: 2 Capsules (Twice Daily — 1,500mg per dose, 3,000mg per day)

Servings Per Container: 30 (at 4 capsules per day)

Ingredient
Amount Per
Serving
% Daily
Value
L-Citrulline (Free Form)
1,500 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness

Journal of Strength and Conditioning Research, 2010

This randomized, double blind, placebo controlled crossover trial administered citrulline malate to trained male athletes before a resistance exercise protocol and measured repetitions to failure, muscle soreness, and fatigue. The study found that citrulline malate supplementation significantly increased the number of repetitions performed across all sets compared to placebo a 52.92% increase in repetitions to failure and significantly reduced muscle soreness at 24 and 48 hours post exercise. The authors attributed the performance benefit to L-citrulline's role in supporting nitric oxide production, improving oxygen delivery to working muscles, and supporting urea cycle function and ammonia clearance during high-intensity exercise. The findings directly support L-citrulline's licensed use for exercise performance support.

L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans

Journal of Applied Physiology, 2015

This randomized, double blind, placebo controlled crossover trial examined the effects of free form L-citrulline supplementation on oxygen uptake kinetics and high-intensity exercise performance in healthy adults. The study found that L-citrulline supplementation significantly improved oxygen uptake kinetics during moderate-intensity exercise and significantly improved performance during high-intensity exercise compared to placebo. The authors attributed the effects to L-citrulline's role in supporting nitric oxide production and improving oxygen delivery to working muscles via vasodilation. The findings directly support free form L-citrulline's licensed use for circulation and exercise performance support and specifically validate the free form (not malate) at supplemental doses.

Plasma and urine kinetics of L-citrulline and L-arginine following oral L-citrulline supplementation in healthy adults

British Journal of Clinical Pharmacology, 2008

This pharmacokinetic study examined plasma and urine levels of L-citrulline and L-arginine following oral L-citrulline supplementation in healthy adults, and directly compared the plasma L-arginine response to oral L-citrulline versus oral L-arginine at equivalent doses. The study found that oral L-citrulline produced significantly greater and more sustained increases in plasma L-arginine levels than equivalent doses of oral L-arginine confirming that L-citrulline bypasses first pass arginase metabolism in the intestinal wall and liver. The study also confirmed that L-citrulline supplementation significantly increased plasma nitric oxide metabolites (nitrite and nitrate), directly supporting L-citrulline's mechanism of action for circulation support through the L-citrulline → L-arginine → nitric oxide pathway.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is L-citrulline and what does it do?

L-citrulline is a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. It was first isolated from watermelon (Citrullus vulgaris) in 1930 one of the richest natural food sources of L-citrulline. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. Nitric oxide is a potent vasodilator that relaxes vascular smooth muscle, supporting healthy blood vessel tone and circulation

Why is L-citrulline better than L-arginine for nitric oxide support?

L-arginine is the direct substrate for nitric oxide synthase (NOS) the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research consistently shows that oral L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of oral L-arginine itself making L-citrulline the preferred form for nitric oxide and circulation support.

How does L-citrulline support circulation?

L-citrulline supports circulation through the L-citrulline → L-arginine → nitric oxide pathway. Nitric oxide (NO) is produced by nitric oxide synthase (NOS) from L-arginine and acts as a potent vasodilator it relaxes vascular smooth muscle in blood vessel walls, causing them to widen and reducing resistance to blood flow. This mechanism supports healthy blood vessel tone, healthy endothelial function, and healthy circulation throughout the cardiovascular system. L-citrulline supplementation increases plasma L-arginine availability, supporting sustained nitric oxide production and healthy vascular function.

How does L-citrulline support exercise performance?

L-citrulline supports exercise performance through two complementary mechanisms. First, by supporting nitric oxide production and vasodilation, L-citrulline improves oxygen and nutrient delivery to working muscles during exercise supporting stamina and endurance. Second, L-citrulline is a key intermediate in the urea cycle the metabolic pathway that clears ammonia from the body. Ammonia accumulation in muscle tissue is a primary contributor to exercise-induced fatigue. By supporting urea cycle function and ammonia clearance, L-citrulline helps reduce the buildup of fatigue-inducing metabolites during high-intensity exercise.

Is L-citrulline safe and are there any side effects?

L-citrulline is generally well tolerated in healthy adults at supplemental doses. Ask a healthcare practitioner before use if you are taking medication for cardiovascular diseases, erectile dysfunction, or blood thinners L-citrulline supports nitric oxide production and vasodilation, which may interact with medications that affect blood pressure or vascular tone. Ask a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Ask a healthcare practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children.

Canadian-Made

Lab-Tested

Health Canada Approved

20 Years of Research

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