Magnesium malate and malic acid supplementation in fibromyalgia: a randomized double blind placebo controlled crossover trial
Journal of Rheumatology, 1995
Each vegan capsule delivers 100 mg of elemental magnesium from 500 mg of magnesium malate a chelated form in which magnesium is bound to malic acid, a direct intermediate in the Krebs cycle. Magnesium malate (also written magnesium malate, malate de magnésium) provides both elemental magnesium and malic acid in a single ingredient for dual support of magnesium replenishment and cellular energy metabolism. Gentle on digestion.
Magnesium malate capsules deliver 100 mg of elemental magnesium from 500 mg of magnesium malate per capsule. At 2 capsules per day: 200 mg elemental magnesium, 150-day supply. At 4 capsules per day: 400 mg elemental magnesium, 75-day supply. Chelated organic acid forms like magnesium malate are recognized for superior absorption and gastrointestinal tolerability compared to inorganic magnesium oxide, which has absorption rates as low as 4% and commonly causes loose stools through osmotic action in the colon.
Malic acid is a four carbon dicarboxylic acid and a direct intermediate in the Krebs cycle the mitochondrial pathway that generates NADH and FADH2 for ATP production. ATP exists primarily as a magnesium ATP complex inside cells, making magnesium essential for every ATP dependent reaction. Magnesium malate delivers both the mineral cofactor and the Krebs cycle substrate simultaneously.
Calcium triggers muscle contraction; magnesium facilitates muscle relaxation by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. This balance governs normal skeletal and cardiac muscle function. Approximately 60% of the body’s magnesium is stored in bone, where it is required for vitamin D activation which in turn regulates intestinal calcium absorption and bone mineralization. As a primary intracellular electrolyte, magnesium also supports the sodium potassium ATPase pump, nerve signal transmission, and neuromuscular coordination.
Each vegan capsule delivers 100 mg of elemental magnesium from 500 mg of magnesium malate a chelated form in which magnesium is bound to malic acid, a direct intermediate in the Krebs cycle. Magnesium malate (also written magnesium malate, malate de magnésium) provides both elemental magnesium and malic acid in a single ingredient for dual support of magnesium replenishment and cellular energy metabolism. Gentle on digestion.
Magnesium malate capsules deliver 100 mg of elemental magnesium from 500 mg of magnesium malate per capsule. At 2 capsules per day: 200 mg elemental magnesium, 150-day supply. At 4 capsules per day: 400 mg elemental magnesium, 75-day supply. Chelated organic acid forms like magnesium malate are recognized for superior absorption and gastrointestinal tolerability compared to inorganic magnesium oxide, which has absorption rates as low as 4% and commonly causes loose stools through osmotic action in the colon.
Malic acid is a four carbon dicarboxylic acid and a direct intermediate in the Krebs cycle the mitochondrial pathway that generates NADH and FADH2 for ATP production. ATP exists primarily as a magnesium ATP complex inside cells, making magnesium essential for every ATP dependent reaction. Magnesium malate delivers both the mineral cofactor and the Krebs cycle substrate simultaneously.
Calcium triggers muscle contraction; magnesium facilitates muscle relaxation by competing with calcium at binding sites and supporting calcium reuptake into the sarcoplasmic reticulum. This balance governs normal skeletal and cardiac muscle function. Approximately 60% of the body’s magnesium is stored in bone, where it is required for vitamin D activation which in turn regulates intestinal calcium absorption and bone mineralization. As a primary intracellular electrolyte, magnesium also supports the sodium potassium ATPase pump, nerve signal transmission, and neuromuscular coordination.
Serving Size: 1–2 Capsules (2 Times Per Day)
Servings Per Container: 75–150
† Daily Value not established
Journal of Rheumatology, 1995
Nutrients, 2013
Magnesium Research, 2014
Research information is provided for educational purposes and does not replace the product's approved label information.