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A high potency Lion's Mane supplement delivering 550 mg of Hericium erinaceus fruiting body extract per capsule a 10:1 concentration equivalent to 5,500 mg of raw fruiting body (QCE 5,500 mg), standardized to 40% polysaccharides (220 mg per capsule). Fruiting body source. Not mycelium on grain.

What Is Lion's Mane?

Lion's Mane (Hericium erinaceus) is a medicinal mushroom and the only known fungus to contain two classes of neuroactive compounds unique to this species: hericenones (concentrated in the fruiting body) and erinacines (concentrated in the mycelium). Both have been studied for their ability to stimulate the synthesis of Nerve Growth Factor (NGF) a neurotrophin essential for the growth, maintenance, and survival of neurons. NGF supports neuronal differentiation, synaptic plasticity, and the maintenance of cholinergic neurons involved in learning and memory.

Why Fruiting Body Not Mycelium on Grain?

Lion's Mane supplements vary significantly in source material. Fruiting body extracts are derived from the actual mushroom, which accumulates the highest concentrations of hericenones and beta-glucan polysaccharides. Mycelium on grain products are grown on a grain substrate (typically rice or oats) the final product contains significant undigested grain starch alongside the mycelium, diluting active mushroom content. This formula uses Hericium erinaceus fruiting body exclusively, providing a concentrated, standardized extract without grain dilution.

What Does 40% Polysaccharides Mean?

Standardization to 40% polysaccharides means each capsule is guaranteed to contain 220 mg of fungal polysaccharides primarily beta-glucans regardless of batch variation. Beta-glucans interact with pattern recognition receptors (Dectin-1 and TLR2) on immune cells including macrophages, dendritic cells, and NK cells, supporting normal immune function. Standardization ensures consistent bioactive content in every capsule.

Key Features

  • 5,500 mg QCE per capsule 10:1 Hericium erinaceus fruiting body extract
  • Standardized to 40% polysaccharides 220 mg guaranteed beta-glucans per capsule
  • Fruiting body source not mycelium on grain
  • 180 vegan capsules 90-day supply at 2 capsules per day
  • Health Canada licensed NPN 80144496
  • Made in Canada GMP certified facility
  • Vegan | Non-GMO | Gluten Free

Lion's Mane 5500mg QCE | 40% Polysaccharides | Cognition & Immune Support | 180 Vcaps

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Health Canada Licensed Natural Health Product (NPN 80144496)

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A high potency Lion's Mane supplement delivering 550 mg of Hericium erinaceus fruiting body extract per capsule a 10:1 concentration equivalent to 5,500 mg of raw fruiting body (QCE 5,500 mg), standardized to 40% polysaccharides (220 mg per capsule). Fruiting body source. Not mycelium on grain.

What Is Lion's Mane?

Lion's Mane (Hericium erinaceus) is a medicinal mushroom and the only known fungus to contain two classes of neuroactive compounds unique to this species: hericenones (concentrated in the fruiting body) and erinacines (concentrated in the mycelium). Both have been studied for their ability to stimulate the synthesis of Nerve Growth Factor (NGF) a neurotrophin essential for the growth, maintenance, and survival of neurons. NGF supports neuronal differentiation, synaptic plasticity, and the maintenance of cholinergic neurons involved in learning and memory.

Why Fruiting Body Not Mycelium on Grain?

Lion's Mane supplements vary significantly in source material. Fruiting body extracts are derived from the actual mushroom, which accumulates the highest concentrations of hericenones and beta-glucan polysaccharides. Mycelium on grain products are grown on a grain substrate (typically rice or oats) the final product contains significant undigested grain starch alongside the mycelium, diluting active mushroom content. This formula uses Hericium erinaceus fruiting body exclusively, providing a concentrated, standardized extract without grain dilution.

What Does 40% Polysaccharides Mean?

Standardization to 40% polysaccharides means each capsule is guaranteed to contain 220 mg of fungal polysaccharides primarily beta-glucans regardless of batch variation. Beta-glucans interact with pattern recognition receptors (Dectin-1 and TLR2) on immune cells including macrophages, dendritic cells, and NK cells, supporting normal immune function. Standardization ensures consistent bioactive content in every capsule.

Key Features

  • 5,500 mg QCE per capsule 10:1 Hericium erinaceus fruiting body extract
  • Standardized to 40% polysaccharides 220 mg guaranteed beta-glucans per capsule
  • Fruiting body source not mycelium on grain
  • 180 vegan capsules 90-day supply at 2 capsules per day
  • Health Canada licensed NPN 80144496
  • Made in Canada GMP certified facility
  • Vegan | Non-GMO | Gluten Free

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 180

Ingredient
Amount Per
Serving
% Daily
Value
Lion's Mane (Hericium erinaceus, Fruiting Body) 10:1 Extract
550 mg

† Daily Value not established.

Other Ingredients:
Hypromellose, Magnesium Stearate, Microcrystalline Cellulose. Vegan. Non-GMO. Gluten Free. Made in Canada.

Clinical Research

Lion's Mane Mushroom and Mild Cognitive Impairment (Mori et al., 2009)

Phytotherapy Research, 2009

Double blind, placebo controlled trial in 50-80 year old adults with mild cognitive impairment. Participants taking 3g/day of Hericium erinaceus powder for 16 weeks showed significantly higher cognitive function scores than placebo. Scores declined after supplementation ceased.

Hericenones and Erinacines: Stimulators of Nerve Growth Factor (NGF) Biosynthesis

Mycology: An International Journal on Fungal Biology, 2008

Review of the neuroactive compounds unique to Hericium erinaceus hericenones (fruiting body) and erinacines (mycelium) and their demonstrated ability to stimulate NGF synthesis in vitro and in vivo, supporting neuronal growth and maintenance.

Beta Glucans and Immune Function: Mechanisms and Clinical Evidence

Annals of Translational Medicine, 2015

Review of beta glucan immunomodulatory mechanisms, including interaction with Dectin-1 and TLR2 receptors on macrophages, dendritic cells, and NK cells. Supports the role of standardized fungal polysaccharides in normal immune function the basis for Health Canada licensed uses in medicinal mushroom products.

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is Lion's Mane mushroom extract?

Lion's Mane (Hericium erinaceus) is a medicinal mushroom and the only known fungus to contain two classes of neuroactive compounds unique to this species: hericenones (found in the fruiting body) and erinacines (found in the mycelium). Both have been studied for their ability to stimulate Nerve Growth Factor (NGF) synthesis a neurotrophin essential for the growth, maintenance, and survival of neurons. This formula uses a 10:1 fruiting body extract standardized to 40% polysaccharides, delivering 550 mg per capsule (QCE 5,500 mg).

What does "standardized to 40% polysaccharides" mean?

Standardization to 40% polysaccharides means each capsule is guaranteed to contain 220 mg of fungal polysaccharides primarily beta glucans regardless of batch variation. Beta-glucans interact with pattern recognition receptors (Dectin-1 and TLR2) on immune cells including macrophages, dendritic cells, and NK cells, supporting normal immune function. Standardization ensures consistent bioactive content in every capsule, unlike non-standardized mushroom products where potency can vary significantly between batches.

What is the difference between Lion's Mane fruiting body and mycelium on grain?

Fruiting body extracts are derived from the actual mushroom the structure that accumulates the highest concentrations of hericenones and beta glucan polysaccharides. Mycelium on grain products are produced by growing mycelium on a grain substrate (typically rice or oats); the final product contains significant amounts of undigested grain starch alongside the mycelium, diluting the active mushroom content. This formula usesHericium erinaceusfruiting body exclusively, providing a concentrated, standardized extract without grain dilution.

What does QCE 5,500mg mean on a Lion's Mane supplement?

QCE stands for Quantity of Crude Equivalent the standardized Health Canada notation for expressing how much raw material was used to produce a concentrated herbal extract. Each capsule contains 550 mg of 10:1 Lion's Mane fruiting body extract: 550 mg × 10 = 5,500 mg QCE. This means each capsule delivers the concentrated bioactive compounds from 5,500 mg of rawHericium erinaceusfruiting body. When comparing Lion's Mane supplements, always check whether the stated milligram amount is the extract weight or the QCE this product clearly states both.

Who should not take Lion's Mane supplement?

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, have a medical condition, or are taking medications. If you have a known allergy to mushrooms or fungi, consult a healthcare practitioner before use. Keep out of reach of children. Consult a healthcare practitioner for prolonged use.