Lion's Mane Mushroom and Mild Cognitive Impairment (Mori et al., 2009)
Phytotherapy Research, 2009
A high potency Lion's Mane supplement delivering 550 mg of Hericium erinaceus fruiting body extract per capsule a 10:1 concentration equivalent to 5,500 mg of raw fruiting body (QCE 5,500 mg), standardized to 40% polysaccharides (220 mg per capsule). Fruiting body source. Not mycelium on grain.
Lion's Mane (Hericium erinaceus) is a medicinal mushroom and the only known fungus to contain two classes of neuroactive compounds unique to this species: hericenones (concentrated in the fruiting body) and erinacines (concentrated in the mycelium). Both have been studied for their ability to stimulate the synthesis of Nerve Growth Factor (NGF) a neurotrophin essential for the growth, maintenance, and survival of neurons. NGF supports neuronal differentiation, synaptic plasticity, and the maintenance of cholinergic neurons involved in learning and memory.
Lion's Mane supplements vary significantly in source material. Fruiting body extracts are derived from the actual mushroom, which accumulates the highest concentrations of hericenones and beta-glucan polysaccharides. Mycelium on grain products are grown on a grain substrate (typically rice or oats) the final product contains significant undigested grain starch alongside the mycelium, diluting active mushroom content. This formula uses Hericium erinaceus fruiting body exclusively, providing a concentrated, standardized extract without grain dilution.
Standardization to 40% polysaccharides means each capsule is guaranteed to contain 220 mg of fungal polysaccharides primarily beta-glucans regardless of batch variation. Beta-glucans interact with pattern recognition receptors (Dectin-1 and TLR2) on immune cells including macrophages, dendritic cells, and NK cells, supporting normal immune function. Standardization ensures consistent bioactive content in every capsule.
A high potency Lion's Mane supplement delivering 550 mg of Hericium erinaceus fruiting body extract per capsule a 10:1 concentration equivalent to 5,500 mg of raw fruiting body (QCE 5,500 mg), standardized to 40% polysaccharides (220 mg per capsule). Fruiting body source. Not mycelium on grain.
Lion's Mane (Hericium erinaceus) is a medicinal mushroom and the only known fungus to contain two classes of neuroactive compounds unique to this species: hericenones (concentrated in the fruiting body) and erinacines (concentrated in the mycelium). Both have been studied for their ability to stimulate the synthesis of Nerve Growth Factor (NGF) a neurotrophin essential for the growth, maintenance, and survival of neurons. NGF supports neuronal differentiation, synaptic plasticity, and the maintenance of cholinergic neurons involved in learning and memory.
Lion's Mane supplements vary significantly in source material. Fruiting body extracts are derived from the actual mushroom, which accumulates the highest concentrations of hericenones and beta-glucan polysaccharides. Mycelium on grain products are grown on a grain substrate (typically rice or oats) the final product contains significant undigested grain starch alongside the mycelium, diluting active mushroom content. This formula uses Hericium erinaceus fruiting body exclusively, providing a concentrated, standardized extract without grain dilution.
Standardization to 40% polysaccharides means each capsule is guaranteed to contain 220 mg of fungal polysaccharides primarily beta-glucans regardless of batch variation. Beta-glucans interact with pattern recognition receptors (Dectin-1 and TLR2) on immune cells including macrophages, dendritic cells, and NK cells, supporting normal immune function. Standardization ensures consistent bioactive content in every capsule.
Serving Size: 1 Capsule
Servings Per Container: 180
† Daily Value not established.
Phytotherapy Research, 2009
Mycology: An International Journal on Fungal Biology, 2008
Annals of Translational Medicine, 2015
Research information is provided for educational purposes and does not replace the product's approved label information.