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Nattokinase 100 mg provides 2,000 fibrinolytic units (FU) per delayed release vegan capsule. Standardized to 20,000 FU per gram, this formula is made through fermentation with Bacillus subtilis var. natto. Each bottle contains 120 capsules.

About Nattokinase

Nattokinase is an enzyme produced during the fermentation of soybeans used to make natto. This product is derived from soy.

Strength and Activity

Milligrams describe ingredient weight; FU describe enzyme activity. Each capsule contains 100 mg of nattokinase and provides 2,000 FU of activity.

Delayed Release Vegan Capsule

The formula is supplied in a delayed release hypromellose capsule. The bottle contains 120 vegan capsules, a 120 day supply at one capsule daily.

Nattokinase 100 mg | 2,000 FU | Delayed Release Vegan Capsules | 120 Count

Regular price $34.99
Unit price
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Health Canada Licensed Natural Health Product (NPN 80135521)

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Nattokinase 100 mg provides 2,000 fibrinolytic units (FU) per delayed release vegan capsule. Standardized to 20,000 FU per gram, this formula is made through fermentation with Bacillus subtilis var. natto. Each bottle contains 120 capsules.

About Nattokinase

Nattokinase is an enzyme produced during the fermentation of soybeans used to make natto. This product is derived from soy.

Strength and Activity

Milligrams describe ingredient weight; FU describe enzyme activity. Each capsule contains 100 mg of nattokinase and provides 2,000 FU of activity.

Delayed Release Vegan Capsule

The formula is supplied in a delayed release hypromellose capsule. The bottle contains 120 vegan capsules, a 120 day supply at one capsule daily.

Supplement Facts

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 120

Ingredient
Amount Per
Serving
% Daily
Value
Nattokinase (Bacillus subtilis var. natto, whole) — 2,000 FU
100 mg
†

† Daily Value not established

Other Ingredients:
Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source)

Clinical Research

Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects

Nutrition Research, 2009

This randomized, double blind, placebo controlled trial administered nattokinase supplementation to healthy human subjects and measured coagulation factors and blood flow markers over the study period. The study found that nattokinase significantly decreased plasma levels of fibrinogen, factor VII, and factor VIII key proteins involved in blood clot formation compared to placebo.

Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases

Biomarkers in Medicine, 2017

This comprehensive review examined the clinical and preclinical evidence for nattokinase in cardiovascular health. The review found that nattokinase exerts fibrinolytic activity by directly cleaving fibrin and activating endogenous plasminogen, supporting healthy blood flow and vascular function. The authors documented evidence for nattokinase's effects on blood pressure, blood viscosity, and vascular health markers across multiple human and animal studies

Effects of nattokinase on blood pressure: a randomized, controlled trial

Hypertension Research, 2008

This randomized, double blind, placebo controlled trial administered nattokinase to subjects with pre hypertension and stage 1 hypertension over 8 weeks and measured blood pressure and vascular health markers. The study found that nattokinase supplementation significantly reduced systolic and diastolic blood pressure compared to placebo, with the effect attributed to nattokinase's fibrinolytic activity and its effects on vascular tone and blood flow. The findings support nattokinase's role in cardiovascular and vascular health support

Research information is provided for educational purposes and does not replace the product's approved label information.

Frequently Asked Questions

What is nattokinase and what does it do?

Nattokinase is a serine protease enzyme produced during the fermentation of soybeans withBacillus subtilisvar.natto the same fermentation process used to produce natto, a traditional Japanese food consumed for over 1,000 years. Each delayed release capsule provides 100mg of nattokinase standardized to 20,000 FU/g, delivering 2,000 Fibrinolytic Units (FU) of enzymatic activity. Licensed by Health Canada to support cardiovascular health, vascular health, and healthy blood flow (NPN 80135521). Suitable for adults. For use beyond 4 weeks, consult a healthcare practitioner. Do not use if pregnant, breastfeeding, or taking anticoagulants.

What are Fibrinolytic Units (FU) and why do they matter?

Fibrinolytic Units (FU) is the standardized measure of nattokinase enzymatic activity quantifying the enzyme's ability to cleave fibrin, the protein that forms the structural scaffold of blood clots. Higher FU indicates greater enzymatic activity per capsule. This formula provides 2,000 FU per capsule from 100mg of nattokinase standardized to 20,000 FU/g a consistent, high-activity dose aligned with the clinical research literature on nattokinase. Licensed by Health Canada (NPN 80135521).

Why does nattokinase need delayed release capsules?

Nattokinase is a protein based enzyme susceptible to denaturation in the highly acidic stomach environment (pH 1.5 to 3.5). Standard capsules release their contents immediately in the stomach, exposing the enzyme to acid before it can reach the intestines where absorption occurs. Delayed release (enteric) capsules remain intact in the acidic stomach and dissolve only in the higher pH of the small intestine (pH 5.5 to 7.5) protecting the enzyme from acid degradation and ensuring delivery to the intestinal environment for optimal absorption. This is a critical distinction for enzyme supplements.

How does nattokinase support cardiovascular health?

Nattokinase is a serine protease enzyme with fibrinolytic activity it cleaves fibrin, the protein scaffold of blood clots. It has been studied for its effects on blood flow, vascular function, and cardiovascular health markers. Licensed by Health Canada to support cardiovascular health, vascular health, and healthy blood flow. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Do not use if taking anticoagulants or antiplatelet drugs.

Should I take nattokinase with food or on an empty stomach?

Take 1 capsule on an empty stomach or between meals. Taking on an empty stomach maximizes intestinal transit time and reduces competition from dietary proteins for enzymatic activity. The delayed release capsule protects the enzyme from stomach acid regardless of food intake, but taking between meals is generally recommended for enzyme supplements. For use beyond 4 weeks, consult a healthcare practitioner.

Can I take nattokinase if I am on blood thinners?

No. Do not use if you are taking health products that affect blood coagulation including anticoagulants such as warfarin or antiplatelet drugs. Nattokinase has fibrinolytic enzymatic activity and may enhance the effects of blood thinning medications, increasing the risk of bleeding. Consult a healthcare practitioner before use if you have a cardiovascular disorder or are taking any medications. Stop use 7 days before any scheduled surgery.

Who should not take nattokinase?

Do not use if you are pregnant or breastfeeding, taking health products that affect blood coagulation (anticoagulants, antiplatelet drugs), or have a bleeding disorder. Do not use if you have a soy allergy this product is derived from fermented soy (Bacillus subtilisvar.natto). Stop use 7 days before any scheduled surgery, or immediately if you have unscheduled surgery or suffer an injury resulting in bruising or bleeding. Consult a healthcare practitioner before use if you have a cardiovascular, kidney, or liver disorder.

Does nattokinase contain soy or allergens?

Yes. Nattokinase is derived from the fermentation of soybeans withBacillus subtilisvar.natto. Do not use if you have a soy allergy. The capsule shell is vegan hypromellose no gelatin. Non-medicinal ingredients: Hypromellose (Delayed Release Vegetable Capsule Shell), Microcrystalline Cellulose, Magnesium Stearate (Vegetable Source). Non-GMO. Gluten free. Suitable for vegans and vegetarians with no soy allergy.