Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
Journal of Strength and Conditioning Research, 2010
Each capsule delivers 750mg of pure free form L-citrulline, a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. Supports healthy circulation and exercise performance as part of a balanced diet and active lifestyle.
L-citrulline was first isolated from watermelon (Citrullus vulgaris) in 1930, which remains one of the richest natural food sources of L-citrulline. L-citrulline used in supplements is synthetically produced by fermentation or chemical synthesis, yielding a compound chemically identical to the L-citrulline found naturally in watermelon and other foods.
L-arginine is the direct substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first-pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine consistently shows that L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself. This is why L-citrulline is the preferred form for nitric oxide and circulation support.
Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate. Non-GMO, gluten free, soy free. No artificial colours, flavours, sweeteners, or preservatives.
Adults: Take 2 capsules 2 times per day, with or without food. Commonly taken before exercise for circulation and performance support. At 4 capsules per day, one bottle of 120 capsules provides a 30 day supply.
Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.
Ask a healthcare practitioner before use if you are taking medication for cardiovascular diseases, erectile dysfunction, or blood thinners. Ask a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Ask a healthcare practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children.
NPN 80139498. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Each capsule delivers 750mg of pure free form L-citrulline, a non-essential amino acid that serves as a precursor to L-arginine and nitric oxide in the body. L-citrulline is absorbed intact from the gastrointestinal tract and converted to L-arginine in the kidneys, supporting sustained L-arginine availability and nitric oxide production. Supports healthy circulation and exercise performance as part of a balanced diet and active lifestyle.
L-citrulline was first isolated from watermelon (Citrullus vulgaris) in 1930, which remains one of the richest natural food sources of L-citrulline. L-citrulline used in supplements is synthetically produced by fermentation or chemical synthesis, yielding a compound chemically identical to the L-citrulline found naturally in watermelon and other foods.
L-arginine is the direct substrate for nitric oxide synthase (NOS), the enzyme that produces nitric oxide. However, oral L-arginine supplementation is limited by significant first-pass metabolism in the intestinal wall and liver, where the enzyme arginase rapidly degrades L-arginine before it reaches systemic circulation. L-citrulline bypasses this limitation entirely because it is not a substrate for arginase. It is absorbed intact and converted to L-arginine in the kidneys, where it enters systemic circulation. Research comparing oral L-citrulline to oral L-arginine consistently shows that L-citrulline produces greater and more sustained increases in plasma L-arginine levels than equivalent doses of L-arginine itself. This is why L-citrulline is the preferred form for nitric oxide and circulation support.
Non-medicinal ingredients: Hypromellose (vegetable capsule shell), microcrystalline cellulose, magnesium stearate. Non-GMO, gluten free, soy free. No artificial colours, flavours, sweeteners, or preservatives.
Adults: Take 2 capsules 2 times per day, with or without food. Commonly taken before exercise for circulation and performance support. At 4 capsules per day, one bottle of 120 capsules provides a 30 day supply.
Store in a cool, dry place away from direct sunlight and moisture. Keep the bottle tightly sealed after each use. Do not use if the seal is broken or missing. Keep out of reach of children.
Ask a healthcare practitioner before use if you are taking medication for cardiovascular diseases, erectile dysfunction, or blood thinners. Ask a healthcare practitioner before use if you have a cardiovascular disease and are attempting an increase in physical activity. Ask a healthcare practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children.
NPN 80139498. All health claims are consistent with Health Canada's Natural Health Products Regulations.
Serving Size: 2 Capsules (Twice Daily — 1,500mg per dose, 3,000mg per day)
Servings Per Container: 30 (at 4 capsules per day)
† Daily Value not established
Journal of Strength and Conditioning Research, 2010
Journal of Applied Physiology, 2015
British Journal of Clinical Pharmacology, 2008
Research information is provided for educational purposes and does not replace the product's approved label information.